BG64676B1 - МЕТОД ЗА ПОЛУЧАВАНЕ НА HMG-CoA РЕДУКТАЗНИ ИНХИБИТОРИ С ВИСОКА ЧИСТОТА - Google Patents

МЕТОД ЗА ПОЛУЧАВАНЕ НА HMG-CoA РЕДУКТАЗНИ ИНХИБИТОРИ С ВИСОКА ЧИСТОТА Download PDF

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Publication number
BG64676B1
BG64676B1 BG105348A BG10534801A BG64676B1 BG 64676 B1 BG64676 B1 BG 64676B1 BG 105348 A BG105348 A BG 105348A BG 10534801 A BG10534801 A BG 10534801A BG 64676 B1 BG64676 B1 BG 64676B1
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BG
Bulgaria
Prior art keywords
mobile phase
hmg
column
coa reductase
fractions
Prior art date
Application number
BG105348A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG105348A (en
Inventor
Rok Grahek
Dusan Milivojevic
Andrej Bastarda
Original Assignee
Lek Pharmaceutical And Chemical Company D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceutical And Chemical Company D.D. filed Critical Lek Pharmaceutical And Chemical Company D.D.
Publication of BG105348A publication Critical patent/BG105348A/xx
Publication of BG64676B1 publication Critical patent/BG64676B1/bg

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/422—Displacement mode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
BG105348A 1998-09-18 2001-03-16 МЕТОД ЗА ПОЛУЧАВАНЕ НА HMG-CoA РЕДУКТАЗНИ ИНХИБИТОРИ С ВИСОКА ЧИСТОТА BG64676B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9800241A SI20072A (sl) 1998-09-18 1998-09-18 Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze

Publications (2)

Publication Number Publication Date
BG105348A BG105348A (en) 2001-11-30
BG64676B1 true BG64676B1 (bg) 2005-11-30

Family

ID=20432332

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105348A BG64676B1 (bg) 1998-09-18 2001-03-16 МЕТОД ЗА ПОЛУЧАВАНЕ НА HMG-CoA РЕДУКТАЗНИ ИНХИБИТОРИ С ВИСОКА ЧИСТОТА

Country Status (22)

Country Link
US (1) US6695969B1 (de)
EP (1) EP1114040B1 (de)
JP (1) JP3795755B2 (de)
KR (1) KR100607608B1 (de)
CN (1) CN1186335C (de)
AT (1) ATE284396T1 (de)
AU (1) AU766630B2 (de)
BG (1) BG64676B1 (de)
CA (1) CA2343645A1 (de)
DE (1) DE69922519T2 (de)
HR (1) HRP20010045B1 (de)
HU (1) HUP0102997A2 (de)
IL (2) IL142056A0 (de)
IS (1) IS2149B (de)
NZ (1) NZ509582A (de)
PL (1) PL200336B1 (de)
RO (1) RO121116B1 (de)
RS (1) RS49996B (de)
RU (1) RU2235098C2 (de)
SI (1) SI20072A (de)
SK (1) SK285868B6 (de)
WO (1) WO2000017182A1 (de)

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* Cited by examiner, † Cited by third party
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SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
MXPA02005283A (es) * 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
CZ20021998A3 (cs) * 1999-12-14 2003-02-12 Biogal Gyogyszergyar Rt. Nové formy sodné soli pravastatinu
PL357533A1 (en) 2000-03-03 2004-07-26 Plus Chemicals, S.A. A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
US6936731B2 (en) * 2000-10-05 2005-08-30 TEVA Gyógyszergyár Részvénytársaság Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
KR100435078B1 (ko) * 2002-02-08 2004-06-09 종근당바이오 주식회사 심바스타틴의 정제방법
JP3463881B2 (ja) 2002-08-06 2003-11-05 三共株式会社 プラバスタチン又はその薬理上許容される塩の単離・精製方法
CA2521276A1 (en) * 2003-04-01 2004-10-14 Ranbaxy Laboratories Limited Fermentation process for the preparation of pravastatin
US6978908B2 (en) * 2003-09-15 2005-12-27 Gerber Products Company Drinking vessel with adjustable handles
PL1641447T3 (pl) * 2003-11-24 2009-04-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania prawastatyny
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
KR100923939B1 (ko) * 2004-09-28 2009-10-29 테바 파마슈티컬 인더스트리즈 리미티드 실질적으로 불순물을 함유하지 않는 아토르바스타틴 칼슘의형태를 제조하는 방법
CN102043030A (zh) * 2009-10-22 2011-05-04 北京万全阳光医学技术有限公司 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法
CN102621238A (zh) * 2011-02-01 2012-08-01 北京北大维信生物科技有限公司 一种测定HMG-CoA还原酶抑制剂浓度的方法
CN105985244A (zh) * 2015-02-04 2016-10-05 北京北大维信生物科技有限公司 化合物、其分离方法、合成方法及用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416416A1 (de) * 1989-09-04 1991-03-13 SCLAVO S.p.A. Verfahren zur Reinigung von Verbindungen, die ein niedriges Molekulargewicht und eine Peptid- oder Peptid-ähnliche Struktur besitzen
WO1992016276A1 (en) * 1991-03-13 1992-10-01 Merck & Co., Inc. PROCESS FOR PURIFICATION OF HMG-CoA REDUCTASE INHIBITORS

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US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
SU1319352A1 (ru) * 1985-01-07 1995-09-10 Ленинградский государственный университет им.А.А.Жданова Способ очистки препарата гистона н4 из ткани тимуса
US5407050A (en) * 1991-03-14 1995-04-18 Kabushiki Kaisha Ace Denken Article control system
US5420024A (en) * 1993-05-11 1995-05-30 Merck & Co., Inc. Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5427686A (en) 1994-04-05 1995-06-27 Sri International Process for separating material from mixture using displacement chromatography
EP0877089A1 (de) * 1997-05-07 1998-11-11 Gist-Brocades B.V. Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416416A1 (de) * 1989-09-04 1991-03-13 SCLAVO S.p.A. Verfahren zur Reinigung von Verbindungen, die ein niedriges Molekulargewicht und eine Peptid- oder Peptid-ähnliche Struktur besitzen
US5043423A (en) * 1989-09-04 1991-08-27 Sclavo S.P.A. Method for purifying low molecular weight compounds of peptide or pseudo-peptide structure
WO1992016276A1 (en) * 1991-03-13 1992-10-01 Merck & Co., Inc. PROCESS FOR PURIFICATION OF HMG-CoA REDUCTASE INHIBITORS

Also Published As

Publication number Publication date
SK285868B6 (sk) 2007-10-04
RU2235098C2 (ru) 2004-08-27
HRP20010045A2 (en) 2001-12-31
PL200336B1 (pl) 2008-12-31
JP2002526486A (ja) 2002-08-20
US6695969B1 (en) 2004-02-24
SK20022000A3 (sk) 2001-08-06
DE69922519D1 (de) 2005-01-13
IL142056A0 (en) 2002-03-10
BG105348A (en) 2001-11-30
DE69922519T2 (de) 2005-12-08
JP3795755B2 (ja) 2006-07-12
CA2343645A1 (en) 2000-03-30
RS49996B (sr) 2008-09-29
IL142056A (en) 2006-08-01
EP1114040B1 (de) 2004-12-08
WO2000017182A1 (en) 2000-03-30
HRP20010045B1 (en) 2005-08-31
CN1186335C (zh) 2005-01-26
RO121116B1 (ro) 2006-12-29
IS5886A (is) 2001-03-12
IS2149B (is) 2006-10-13
YU81800A (sh) 2003-02-28
CN1318063A (zh) 2001-10-17
HUP0102997A2 (hu) 2001-12-28
AU5528499A (en) 2000-04-10
SI20072A (sl) 2000-04-30
NZ509582A (en) 2003-10-31
EP1114040A1 (de) 2001-07-11
KR20010099584A (ko) 2001-11-09
PL345883A1 (en) 2002-01-14
KR100607608B1 (ko) 2006-08-02
AU766630B2 (en) 2003-10-23
ATE284396T1 (de) 2004-12-15

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