BG93979A - Производни на n-(4-пиперидинил)(дихидробензофуран или дихидро-2н-бензопиран)карбоксамид, фармацевтичен състав, който ги съдържа, метод за получаване на производните и приложението им - Google Patents

Производни на n-(4-пиперидинил)(дихидробензофуран или дихидро-2н-бензопиран)карбоксамид, фармацевтичен състав, който ги съдържа, метод за получаване на производните и приложението им

Info

Publication number
BG93979A
BG93979A BG093979A BG9397991A BG93979A BG 93979 A BG93979 A BG 93979A BG 093979 A BG093979 A BG 093979A BG 9397991 A BG9397991 A BG 9397991A BG 93979 A BG93979 A BG 93979A
Authority
BG
Bulgaria
Prior art keywords
derivatives
dihydrobenzofuran
benzopyran
piperidinyl
dihydro
Prior art date
Application number
BG093979A
Other languages
English (en)
Other versions
BG60381B1 (bg
Inventor
Georges Henri Paul Daele
Jean-Paul Bosmans
Michel Anna Jozef Cleyn
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG93979A publication Critical patent/BG93979A/bg
Publication of BG60381B1 publication Critical patent/BG60381B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Съединенията стимулират перисталтиката на стомашно-чревния тракт. Те имат формула в която а е радикал с формула -сн2-сн2-, -сн2-сн2-сн2или -сн2-сн2-сн2-сн2-, като един или два водородни атома в тези радикали могат да бъдат заместени с с1-6алкилов радикал; r1 е хало, r2 е водород, амино, моноили ди(с1-6алкил)амино или с1-6 алкилкарбониламино; r3 е водород или с1-6алкил; l е с3-6циклоалкил, с5-6циклоалканон, с3-6алкенил, незадължително заместен с арил, или l е радикал с формула -аiк-r4, -аiк-х-r5, -аiк-y-с(=0)-r7 или -аiк-y-с(=0)-nr9r10. Изобретението се отнася и до техните n-оксидни форми, до присъединителните им соли и стереохимичните им изомерни форми, до фармацевтичните състави, включващи като активно вещество тези съединения, а също така и до метод за получаването им. 13 претенции
BG93979A 1990-03-06 1991-03-05 Производни на n-(4-пиперидинил)(дихидробензофуранили дихидро-2н-бензопиран)карбоксамид, фармацевтичен състав, който ги съдържа, метод за получаване на производните и приложението им BG60381B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (2)

Publication Number Publication Date
BG93979A true BG93979A (bg) 1993-12-24
BG60381B1 BG60381B1 (bg) 1995-01-31

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
BG93979A BG60381B1 (bg) 1990-03-06 1991-03-05 Производни на n-(4-пиперидинил)(дихидробензофуранили дихидро-2н-бензопиран)карбоксамид, фармацевтичен състав, който ги съдържа, метод за получаване на производните и приложението им

Country Status (38)

Country Link
US (2) US5185335A (bg)
EP (1) EP0445862B1 (bg)
JP (1) JP2601566B2 (bg)
KR (1) KR0177521B1 (bg)
CN (1) CN1038936C (bg)
AT (1) ATE191912T1 (bg)
AU (1) AU636012B2 (bg)
BG (1) BG60381B1 (bg)
CA (1) CA2037575C (bg)
CY (1) CY2235B1 (bg)
CZ (1) CZ286617B6 (bg)
DE (1) DE69132119T2 (bg)
DK (1) DK0445862T3 (bg)
ES (1) ES2147175T3 (bg)
FI (1) FI101622B1 (bg)
GB (1) GB9005014D0 (bg)
GR (1) GR3033461T3 (bg)
HR (1) HRP930483B1 (bg)
HU (2) HU221627B1 (bg)
IE (1) IE910710A1 (bg)
IL (1) IL97018A (bg)
LT (1) LT3708B (bg)
LV (1) LV10085B (bg)
MA (1) MA22076A1 (bg)
MY (1) MY108831A (bg)
NO (1) NO177424C (bg)
NZ (1) NZ237189A (bg)
PL (6) PL168693B1 (bg)
PT (1) PT96937B (bg)
RU (1) RU2070884C1 (bg)
SG (1) SG47482A1 (bg)
SI (1) SI9110396B (bg)
SK (2) SK282407B6 (bg)
TN (1) TNSN91010A1 (bg)
UA (1) UA25969A1 (bg)
YU (1) YU48854B (bg)
ZA (1) ZA911611B (bg)
ZW (1) ZW2391A1 (bg)

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MY108831A (en) 1996-11-30
SK282407B6 (sk) 2002-01-07
HU211350A9 (en) 1995-11-28
NO910863D0 (no) 1991-03-05
KR0177521B1 (ko) 1999-03-20
CA2037575A1 (en) 1991-09-07
GR3033461T3 (en) 2000-09-29
SG47482A1 (en) 1998-04-17
BG60381B1 (bg) 1995-01-31
HK1010727A1 (en) 1999-06-25
TNSN91010A1 (fr) 1992-10-25
SI9110396B (sl) 2000-06-30
LV10085B (en) 1995-02-20
ES2147175T3 (es) 2000-09-01
FI911096A0 (fi) 1991-03-05
PL289323A1 (en) 1992-03-09
RU2070884C1 (ru) 1996-12-27
ATE191912T1 (de) 2000-05-15
EP0445862B1 (en) 2000-04-19
PL169238B1 (pl) 1996-06-28
PL168356B1 (pl) 1996-02-29
ZA911611B (en) 1992-11-25
CA2037575C (en) 2003-09-16
CN1038936C (zh) 1998-07-01
KR910016744A (ko) 1991-11-05
NO910863L (no) 1991-09-09
NO177424B (no) 1995-06-06
YU39691A (sh) 1994-06-10
JPH04211685A (ja) 1992-08-03
ZW2391A1 (en) 1992-09-07
SI9110396A (en) 1997-12-31
LT3708B (en) 1996-02-26
FI101622B (fi) 1998-07-31
PL168693B1 (pl) 1996-03-29
PL168686B1 (pl) 1996-03-29
DE69132119T2 (de) 2000-12-21
LTIP846A (en) 1995-02-27
HU221627B1 (hu) 2002-12-28
DE69132119D1 (de) 2000-05-25
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
GB9005014D0 (en) 1990-05-02
UA25969A1 (uk) 1999-02-26
IL97018A0 (en) 1992-03-29
JP2601566B2 (ja) 1997-04-16
PL168811B1 (pl) 1996-04-30
US5185335A (en) 1993-02-09
LV10085A (lv) 1994-05-10
NO177424C (no) 1995-09-13
NZ237189A (en) 1992-11-25
HUT60733A (en) 1992-10-28
US5262418A (en) 1993-11-16
SK282406B6 (sk) 2002-01-07
DK0445862T3 (da) 2000-09-04
AU636012B2 (en) 1993-04-08
PT96937A (pt) 1991-10-31
PT96937B (pt) 1998-07-31
CN1054598A (zh) 1991-09-18
HU910706D0 (en) 1991-09-30
AU7207991A (en) 1991-09-12
IL97018A (en) 1995-11-27
MA22076A1 (fr) 1991-10-01
FI911096A7 (fi) 1991-09-07
HRP930483A2 (en) 1995-12-31
YU48854B (sh) 2002-06-19
IE910710A1 (en) 1991-09-11
HRP930483B1 (en) 2001-04-30
FI101622B1 (fi) 1998-07-31
PL168384B1 (en) 1996-02-29
EP0445862A2 (en) 1991-09-11
CZ286617B6 (cs) 2000-05-17
EP0445862A3 (en) 1992-05-20

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