BG96041A - Антивирусни тетрахидроимидазо /1,4/ бензодиазепини - Google Patents

Антивирусни тетрахидроимидазо /1,4/ бензодиазепини

Info

Publication number
BG96041A
BG96041A BG096041A BG9604192A BG96041A BG 96041 A BG96041 A BG 96041A BG 096041 A BG096041 A BG 096041A BG 9604192 A BG9604192 A BG 9604192A BG 96041 A BG96041 A BG 96041A
Authority
BG
Bulgaria
Prior art keywords
6alkyl
compounds
aryl
amino
hydrogen
Prior art date
Application number
BG096041A
Other languages
English (en)
Other versions
BG60681B1 (bg
Inventor
Michael Kukla
Henry Breslin
Josephus Ludovicus H. Gelder
Paul Adriaan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG96041A publication Critical patent/BG96041A/bg
Publication of BG60681B1 publication Critical patent/BG60681B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до тетрахидроимидазо[1,4] бензодиазепинови съединения с формула в която r1 е с1-6алкил, по желание заместен с арил, с3-6алкинил, с3-6циклоалкил или радикал с формула r2, r3 и r7 означават водород или с1-6алкил, r4 и r5 са водород, с1-6алкил, хало, циано, нитро, трифлуорометил, хидрокси, с1-6алкилокси, амино, моноили ди(с1-6алкил)амино, (с1-6алкил или арил)-карбониламино, r6 е с1-6алкил и х е он, sн или nr16r17. Изобретението се отнася също до техните присъединителни с киселина соли и стереохимичните им изомерни форми, до фармацевтични състави, които ги включват като активни компоненти и до методите за получаването на съединенията и съставите. Съединенията имат антиретровирусна активност. 14 претенции
BG96041A 1989-09-13 1992-03-12 Антивирусни тетрахидроимидазо [1,4] бензодиазепини BG60681B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40662589A 1989-09-13 1989-09-13
PCT/EP1990/001546 WO1991004255A1 (en) 1989-09-13 1990-09-06 Antiviral tetrahydroimidazo[1,4]benzodiazepines

Publications (2)

Publication Number Publication Date
BG96041A true BG96041A (bg) 1993-12-24
BG60681B1 BG60681B1 (bg) 1995-12-29

Family

ID=23608794

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96041A BG60681B1 (bg) 1989-09-13 1992-03-12 Антивирусни тетрахидроимидазо [1,4] бензодиазепини

Country Status (30)

Country Link
EP (2) EP0491751A1 (bg)
JP (1) JPH05500053A (bg)
KR (1) KR927003596A (bg)
CN (1) CN1029971C (bg)
AP (1) AP174A (bg)
AT (1) ATE115144T1 (bg)
AU (1) AU635328B2 (bg)
BG (1) BG60681B1 (bg)
CA (1) CA2064782A1 (bg)
DE (1) DE69014784T2 (bg)
DK (1) DK0417840T3 (bg)
ES (1) ES2067652T3 (bg)
FI (1) FI98816C (bg)
GR (1) GR3015270T3 (bg)
HU (1) HUT62297A (bg)
IE (1) IE65357B1 (bg)
IL (3) IL108074A (bg)
MA (1) MA21948A1 (bg)
MY (1) MY106961A (bg)
NO (1) NO300328B1 (bg)
NZ (1) NZ235137A (bg)
OA (1) OA09565A (bg)
PT (1) PT95303B (bg)
RO (1) RO109199B1 (bg)
RU (1) RU2099341C1 (bg)
TN (1) TNSN90121A1 (bg)
TW (1) TW199160B (bg)
WO (1) WO1991004255A1 (bg)
YU (1) YU169090A (bg)
ZA (1) ZA907278B (bg)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
EP0475231A1 (en) * 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepines
US7067148B2 (en) 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075206A (en) * 1977-02-25 1978-02-21 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv Tetrahydroimidazo (1,4) benzodiazepin-2-thione derivatives, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2067652T3 (es) 1995-04-01
IL95638A0 (en) 1991-06-30
CN1050192A (zh) 1991-03-27
IL95638A (en) 1995-01-24
KR927003596A (ko) 1992-12-18
IE65357B1 (en) 1995-10-18
HUT62297A (en) 1993-04-28
EP0491751A1 (en) 1992-07-01
OA09565A (fr) 1993-01-31
NO920505L (no) 1992-02-07
ZA907278B (en) 1992-05-27
IL108074A0 (en) 1994-04-12
DE69014784D1 (de) 1995-01-19
MY106961A (en) 1995-08-30
MA21948A1 (fr) 1991-04-01
NO300328B1 (no) 1997-05-12
IE903313A1 (en) 1991-04-10
FI921070A0 (fi) 1992-03-12
BG60681B1 (bg) 1995-12-29
AU6293490A (en) 1991-04-18
RO109199B1 (ro) 1994-12-30
TW199160B (bg) 1993-02-01
IL108074A (en) 1995-06-29
DE69014784T2 (de) 1995-04-13
ATE115144T1 (de) 1994-12-15
AP174A (en) 1992-03-16
CA2064782A1 (en) 1991-03-14
DK0417840T3 (da) 1995-02-13
AU635328B2 (en) 1993-03-18
AP9000205A0 (en) 1990-10-31
WO1991004255A1 (en) 1991-04-04
PT95303A (pt) 1991-05-22
GR3015270T3 (en) 1995-06-30
JPH05500053A (ja) 1993-01-14
EP0417840B1 (en) 1994-12-07
FI98816C (fi) 1997-08-25
EP0417840A1 (en) 1991-03-20
CN1029971C (zh) 1995-10-11
RU2099341C1 (ru) 1997-12-20
NO920505D0 (no) 1992-02-07
TNSN90121A1 (fr) 1991-03-05
FI98816B (fi) 1997-05-15
YU169090A (sh) 1993-10-20
NZ235137A (en) 1992-02-25
PT95303B (pt) 1997-06-30

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