BG96579A - Метод за получаване на рибонуклеазни димери - Google Patents

Метод за получаване на рибонуклеазни димери

Info

Publication number
BG96579A
BG96579A BG096579A BG9657992A BG96579A BG 96579 A BG96579 A BG 96579A BG 096579 A BG096579 A BG 096579A BG 9657992 A BG9657992 A BG 9657992A BG 96579 A BG96579 A BG 96579A
Authority
BG
Bulgaria
Prior art keywords
ribonuclease
monomers
obtaining
dimers
purified
Prior art date
Application number
BG096579A
Other languages
English (en)
Other versions
BG60685B1 (bg
Inventor
Peter Herrmann
Peter Klein
Original Assignee
Nika Health Products Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nika Health Products Limited filed Critical Nika Health Products Limited
Publication of BG96579A publication Critical patent/BG96579A/bg
Publication of BG60685B1 publication Critical patent/BG60685B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Exposure Control For Cameras (AREA)
  • Structure And Mechanism Of Cameras (AREA)
  • Adjustment Of Camera Lenses (AREA)
  • Studio Devices (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Пречистените рибонуклеазни димери може да се използват за третиране на вирусни и бактериални инфекции без цитотоксичните ефекти, свързвани обикновено с рибонуклеазните мономери. Методът включва димеризиране на мономерна рибонуклеаза със суберимидатен свързващ агент, филтриране на недимеризиралите мономери и олигомери от димерния разтвор с помощта на серия от етапи на хроматографиране с йонообменна смола и събиране на пречистения рибонуклеазен димерен продукт, който е в голямо количество и по-евтин. 23 претенции, 2 фигури
BG96579A 1990-01-08 1992-07-07 Метод за получаване на рибонуклеазни димери BG60685B1 (bg)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SU905052819A RU2067617C1 (ru) 1990-01-08 1990-01-08 Способ получения димера лизоцима
HU9202251A HU212929B (en) 1990-01-08 1990-01-08 Method of preraring ribonuclease dimers
PCT/US1990/000141 WO1991010730A1 (en) 1990-01-08 1990-01-08 Method of preparing ribonuclease dimers
SG1996003125A SG47607A1 (en) 1990-01-08 1990-01-08 Method of preparing ribonuclease dimers
OA60243A OA09707A (en) 1990-01-08 1992-07-07 Method of preparing ribonuclease dimers

Publications (2)

Publication Number Publication Date
BG96579A true BG96579A (bg) 1993-12-24
BG60685B1 BG60685B1 (bg) 1995-12-29

Family

ID=33136228

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96579A BG60685B1 (bg) 1990-01-08 1992-07-07 Метод за получаване на рибонуклеазни димери

Country Status (21)

Country Link
EP (1) EP0509989B1 (bg)
JP (1) JP2732515B2 (bg)
KR (1) KR0142172B1 (bg)
AT (1) ATE136056T1 (bg)
AU (1) AU645252B2 (bg)
BG (1) BG60685B1 (bg)
BR (1) BR9007970A (bg)
DE (1) DE69026275T2 (bg)
DK (1) DK0509989T3 (bg)
ES (1) ES2086403T3 (bg)
FI (1) FI100724B (bg)
HK (1) HK166796A (bg)
HU (1) HU212929B (bg)
LT (1) LT3424B (bg)
LV (1) LV10118B (bg)
NO (1) NO922625D0 (bg)
OA (1) OA09707A (bg)
PL (1) PL165863B1 (bg)
RU (2) RU2067617C1 (bg)
SG (1) SG47607A1 (bg)
WO (1) WO1991010730A1 (bg)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ1964A1 (fr) * 1995-01-13 2002-10-15 Nika Health Products Ltd Nouvelle applications d'un dimère de lysozyme.
RU2359270C2 (ru) * 2003-07-29 2009-06-20 Зольвай Фармасьютиклз Гмбх Способ анализа панкреатита и содержащих его композиций
FR3115037B1 (fr) * 2020-10-12 2025-02-21 Cie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0649659B2 (ja) * 1988-05-26 1994-06-29 ニカヘルス プロダクツ，リミテッド 抗ウイルス及び抗菌組成物並びに使用方法
US7850731B2 (en) 2006-10-04 2010-12-14 Seaspine, Inc. Articulating spinal implant

Also Published As

Publication number Publication date
SG47607A1 (en) 1998-04-17
FI923124L (fi) 1992-07-07
LV10118A (lv) 1994-05-10
RU2067617C1 (ru) 1996-10-10
FI923124A0 (fi) 1992-07-07
FI100724B (fi) 1998-02-13
BG60685B1 (bg) 1995-12-29
WO1991010730A1 (en) 1991-07-25
ATE136056T1 (de) 1996-04-15
DE69026275D1 (de) 1996-05-02
DE69026275T2 (de) 1996-10-02
HK166796A (en) 1996-09-13
ES2086403T3 (es) 1996-07-01
EP0509989B1 (en) 1996-03-27
EP0509989A1 (en) 1992-10-28
KR920703802A (ko) 1992-12-18
LT3424B (en) 1995-09-25
LV10118B (en) 1995-02-20
AU645252B2 (en) 1994-01-13
KR0142172B1 (ko) 1998-07-01
HUT65395A (en) 1994-06-28
PL165863B1 (pl) 1995-02-28
AU5640190A (en) 1991-08-05
DK0509989T3 (da) 1996-07-08
JPH05505094A (ja) 1993-08-05
LTIP595A (en) 1994-12-27
BR9007970A (pt) 1992-11-17
OA09707A (en) 1993-08-30
PL288268A1 (en) 1991-09-09
RU2060274C1 (ru) 1996-05-20
NO922625D0 (no) 1992-07-03
HU212929B (en) 1996-12-30
JP2732515B2 (ja) 1998-03-30

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