BG97068A - Фармацевтичен състав и метод за постигане на терапевтичен ефект - Google Patents

Фармацевтичен състав и метод за постигане на терапевтичен ефект Download PDF

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Publication number
BG97068A
BG97068A BG097068A BG9706892A BG97068A BG 97068 A BG97068 A BG 97068A BG 097068 A BG097068 A BG 097068A BG 9706892 A BG9706892 A BG 9706892A BG 97068 A BG97068 A BG 97068A
Authority
BG
Bulgaria
Prior art keywords
pharmaceutical composition
therapeutic effect
angiotensin
achieving therapeutic
composition
Prior art date
Application number
BG097068A
Other languages
English (en)
Other versions
BG61831B1 (bg
Inventor
Anthony FOSSA
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24080550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG97068(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG97068A publication Critical patent/BG97068A/bg
Publication of BG61831B1 publication Critical patent/BG61831B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретението се отнася до фармацевтичен състав и до метод за постигане на синергичен ефект при понижаване на кръвното налягане и при лечение на конгестивната сърдечна недостатъчност при бозайници. Съставът съдържа достатъчни количества поне от две терапевтични средства от групата, включваща инхибитор на ренина и инхибитор на ензима, конвертиращ ангиотензин I, и антагонист на ангиотензин II. По метода последователно се подават в произволен ред или едновременно количества най-малко от две терапевтични средства, включени в състава до постигането на синергичен терапевтичен ефект. 13 претенции
BG97068A 1990-05-11 1992-11-10 Фармацевтичен състав и метод за постигане на терапевтиченефект BG61831B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52236090A 1990-05-11 1990-05-11
PCT/US1991/002733 WO1991017771A1 (en) 1990-05-11 1991-04-22 Synergistic therapeutic compositions and methods

Publications (2)

Publication Number Publication Date
BG97068A true BG97068A (bg) 1993-12-24
BG61831B1 BG61831B1 (bg) 1998-07-31

Family

ID=24080550

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97068A BG61831B1 (bg) 1990-05-11 1992-11-10 Фармацевтичен състав и метод за постигане на терапевтиченефект

Country Status (33)

Country Link
US (2) US6900234B1 (bg)
EP (1) EP0527879B1 (bg)
JP (2) JPH0729938B2 (bg)
KR (1) KR970005839B1 (bg)
CN (7) CN1915428A (bg)
AP (1) AP240A (bg)
AT (1) ATE148632T1 (bg)
AU (1) AU653724B2 (bg)
BG (1) BG61831B1 (bg)
BR (1) BR9106438A (bg)
CA (1) CA2081564C (bg)
DE (1) DE69124598T2 (bg)
DK (1) DK0527879T3 (bg)
EG (1) EG19648A (bg)
ES (1) ES2097208T3 (bg)
GR (1) GR3022997T3 (bg)
GT (1) GT199100032A (bg)
HU (1) HU227346B1 (bg)
IE (1) IE911592A1 (bg)
IL (1) IL98055A (bg)
IS (1) IS2042B (bg)
MA (1) MA22150A1 (bg)
MY (1) MY114347A (bg)
NO (1) NO924321L (bg)
NZ (1) NZ238118A (bg)
PE (1) PE30891A1 (bg)
PT (1) PT97615B (bg)
RO (1) RO115786B1 (bg)
RU (1) RU2147875C1 (bg)
TW (1) TW203553B (bg)
WO (1) WO1991017771A1 (bg)
YU (1) YU49094B (bg)
ZA (1) ZA913539B (bg)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2147875C1 (ru) * 1990-05-11 2000-04-27 Пфайзер Инк. Способ и композиция для снижения кровяного давления и лечения застойной сердечной недостаточности у млекопитающего
EP0629408A1 (en) * 1993-06-16 1994-12-21 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET Combination of angiotensin converting enzyme inhibitors and AII antagonists
DE4340437C1 (de) * 1993-11-27 1995-05-24 Karla Dr Lehmann Verwendung von Lithiumverbindungen zur Behandlung von Herzinsuffizienz einschließlich ihrer Folgeerkrankungen
WO1996031234A1 (en) * 1995-04-07 1996-10-10 Novartis Ag Combination compositions containing benazepril or benazeprilat and valsartan
CA2224451A1 (en) * 1995-06-30 1997-01-23 Merck & Co., Inc. Method of treating renal disease using an ace inhibitor and an aii antagonist
US6107323A (en) 1996-04-05 2000-08-22 Takeda Chemical Industries, Ltd. Pharmaceutical composition
ATE216881T1 (de) * 1996-06-24 2002-05-15 Merck & Co Inc Zusammensetzung auf basis von enalapril und losartan
US6087386A (en) * 1996-06-24 2000-07-11 Merck & Co., Inc. Composition of enalapril and losartan
AU9509798A (en) * 1997-09-25 1999-04-12 University Of Florida Antisense oligonucleotide compositions targeted to angiotensi n converting enzy me mrna and methods of use
KR20010033473A (ko) * 1997-12-23 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 Ａｃｅ 저해제-ｍｍｐ 저해제의 병용 제제
US6087343A (en) * 1998-09-14 2000-07-11 University Of Florida Antisense oligonucleotides targeted to β-1 adrenoceptor and methods of use
US6387894B1 (en) * 1999-06-11 2002-05-14 Pfizer Inc. Use of CRF antagonists and renin-angiotensin system inhibitors
US8168616B1 (en) * 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
WO2004002549A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds
HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
EP2248520A3 (en) * 2004-10-08 2010-11-17 Novartis AG Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
CN101171010B (zh) * 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
US8546418B2 (en) 2007-03-29 2013-10-01 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
AR077692A1 (es) 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
CN102423483A (zh) * 2011-11-24 2012-04-25 西北农林科技大学 一种复方雷米普利纳米乳抗高血压药物
CN114032273B (zh) * 2021-11-17 2024-02-02 山东省科学院生物研究所 一种多功能西洋参水解肽及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US324377A (en) * 1885-08-18 Roller-skate
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4749688A (en) 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1334092C (en) 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
DE3633861A1 (de) * 1986-10-04 1988-04-07 Thomae Gmbh Dr K Neue imidazo-benzoxazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4814342A (en) 1986-10-31 1989-03-21 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
US4895834A (en) * 1986-12-15 1990-01-23 Warner-Lambert Company Renin inhibitors III
WO1988005432A1 (fr) * 1987-01-23 1988-07-28 Yoshitomi Pharmaceutical Industries, Ltd. Compose de 5-hydroxyindole-3-carboxamide et son usage en medecine
US4962105A (en) 1987-10-19 1990-10-09 Ciba-Geigy Corporation Potentiation of antihypertensive effect of ace inhibitors
US5015651A (en) 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
IL91780A (en) 1988-10-04 1995-08-31 Abbott Lab History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
RU2147875C1 (ru) * 1990-05-11 2000-04-27 Пфайзер Инк. Способ и композиция для снижения кровяного давления и лечения застойной сердечной недостаточности у млекопитающего

Also Published As

Publication number Publication date
TW203553B (bg) 1993-04-11
EP0527879A1 (en) 1993-02-24
YU49094B (sh) 2003-12-31
MA22150A1 (fr) 1991-12-31
HU227346B1 (en) 2011-04-28
GT199100032A (es) 1992-10-31
IS2042B (is) 2005-09-15
HUT62804A (en) 1993-06-28
CN1879884A (zh) 2006-12-20
EG19648A (en) 1995-09-30
ES2097208T3 (es) 1997-04-01
DE69124598D1 (de) 1997-03-20
CN1915428A (zh) 2007-02-21
ATE148632T1 (de) 1997-02-15
CN1502370A (zh) 2004-06-09
CN1065140C (zh) 2001-05-02
PT97615A (pt) 1992-03-31
IL98055A (en) 1996-10-31
AU7859191A (en) 1991-12-10
IS3703A7 (is) 1991-11-12
JP2635291B2 (ja) 1997-07-30
GR3022997T3 (en) 1997-07-30
US6900234B1 (en) 2005-05-31
CA2081564A1 (en) 1991-11-12
YU81991A (sh) 1994-06-24
ZA913539B (en) 1992-12-30
JPH0729938B2 (ja) 1995-04-05
JPH05505618A (ja) 1993-08-19
NO924321D0 (no) 1992-11-10
DE69124598T2 (de) 1997-05-28
AU653724B2 (en) 1994-10-13
PT97615B (pt) 1998-08-31
JPH0748280A (ja) 1995-02-21
CN1824315B (zh) 2011-01-12
CN100358578C (zh) 2008-01-02
NZ238118A (en) 1997-06-24
MY114347A (en) 2002-10-31
PE30891A1 (es) 1991-11-27
RO115786B1 (ro) 2000-06-30
CN1056426A (zh) 1991-11-27
NO924321L (no) 1993-01-08
BG61831B1 (bg) 1998-07-31
AP240A (en) 1993-02-18
RU2147875C1 (ru) 2000-04-27
WO1991017771A1 (en) 1991-11-28
US6716875B1 (en) 2004-04-06
CN101156949A (zh) 2008-04-09
IL98055A0 (en) 1992-06-21
AP9100258A0 (en) 1991-07-31
HK1094148A1 (en) 2007-03-23
BR9106438A (pt) 1993-05-18
KR970005839B1 (ko) 1997-04-21
EP0527879B1 (en) 1997-02-05
IE911592A1 (en) 1991-11-20
DK0527879T3 (da) 1997-07-14
CN1307901A (zh) 2001-08-15
HU9203522D0 (en) 1993-01-28
CA2081564C (en) 1998-02-03
CN1824315A (zh) 2006-08-30

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