BG99141A - Моноклонално антитяло срещу рецептора за човешкиинтерферон - Google Patents

Моноклонално антитяло срещу рецептора за човешкиинтерферон Download PDF

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Publication number
BG99141A
BG99141A BG99141A BG9914194A BG99141A BG 99141 A BG99141 A BG 99141A BG 99141 A BG99141 A BG 99141A BG 9914194 A BG9914194 A BG 9914194A BG 99141 A BG99141 A BG 99141A
Authority
BG
Bulgaria
Prior art keywords
human
cells
ifn
monoclonal antibody
interferon
Prior art date
Application number
BG99141A
Other languages
Bulgarian (bg)
English (en)
Inventor
Patrick Benoit
Francois Meyer
Debborah Maguire
Ivan Plavec
Michael Tovey
Original Assignee
Laboratore Europeen De Biotechnologie S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratore Europeen De Biotechnologie S.A. filed Critical Laboratore Europeen De Biotechnologie S.A.
Publication of BG99141A publication Critical patent/BG99141A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG99141A 1992-03-31 1994-10-28 Моноклонално антитяло срещу рецептора за човешкиинтерферон BG99141A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92400902A EP0563487A1 (fr) 1992-03-31 1992-03-31 Anticorps monoclonaux contre le récepteur d'interféron avec une activité contre l'interféron du type I
PCT/EP1993/000770 WO1993020187A1 (fr) 1992-03-31 1993-03-30 Anticorps monoclonaux dresses contre le recepteur d'interferon et dotes d'une activite neutralisante dirigee contre l'interferon de type i

Publications (1)

Publication Number Publication Date
BG99141A true BG99141A (bg) 1995-07-28

Family

ID=8211644

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99141A BG99141A (bg) 1992-03-31 1994-10-28 Моноклонално антитяло срещу рецептора за човешкиинтерферон

Country Status (18)

Country Link
US (5) US5919453A (fr)
EP (3) EP0563487A1 (fr)
JP (2) JP3836500B2 (fr)
AT (2) ATE241008T1 (fr)
AU (2) AU679909B2 (fr)
BG (1) BG99141A (fr)
CA (1) CA2133106C (fr)
CZ (1) CZ236994A3 (fr)
DE (2) DE69334158T2 (fr)
DK (2) DK0633931T3 (fr)
ES (2) ES2199941T3 (fr)
FI (1) FI944509L (fr)
HU (1) HUT69995A (fr)
NO (1) NO943625L (fr)
NZ (1) NZ251343A (fr)
PT (2) PT633931E (fr)
RU (1) RU94045826A (fr)
WO (1) WO1993020187A1 (fr)

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AU7782894A (en) * 1993-09-17 1995-04-03 Laboratoire Europeen De Biotechnologie S.A. Pharmaceutical composition comprising monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon
IL118096A0 (en) * 1996-05-01 1996-09-12 Yeda Res & Dev Antibodies against interferon alpha/beta receptor
US6713609B1 (en) 1996-07-16 2004-03-30 Genentech, Inc. Monoclonal antibodies to type I interferon receptor
CN1068524C (zh) * 1997-06-23 2001-07-18 叶庆炜 一种治疗顽症牛皮癣的药物
US6376067B1 (en) * 1998-12-21 2002-04-23 Mitsubishi Polyester Film, Llc Silicone coated film with back side slip control coating and method of controlling slip of such film
GB0001712D0 (en) * 2000-01-25 2000-03-15 Pharma Pacific Pty Ltd Therapeutic peptides
JP4394350B2 (ja) * 2001-01-09 2010-01-06 ベイラー リサーチ インスティテュート 対象における自己免疫疾患の治療法及びｉｎｖｉｔｒｏ診断アッセイ
AU2007202840B2 (en) * 2001-01-09 2011-07-28 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
AU2007203559B2 (en) * 2003-04-23 2010-09-02 E. R. Squibb & Sons, L.L.C. Compositions and methods for the therapy of inflammatory bowel disease
CA2522957C (fr) * 2003-04-23 2013-10-22 Medarex, Inc. Compositions et techniques destinees a la therapie d'une maladie intestinale inflammatoire
NZ542988A (en) * 2003-04-23 2008-07-31 Medarex Inc Humanised antibodies directed against the IFNAR-1 receptor in which murine CDR sequences have been grafted directly into unmodified human framework sequences, resulting in high affinity, functional antibodies
PT2418220T (pt) 2003-12-10 2017-10-04 Squibb & Sons Llc Anticorpos contra interferão alfa e suas utilizações
EP1789453A2 (fr) * 2004-05-18 2007-05-30 Genentech, Inc. Principaux variants de la proteine de coque majeure du virus m13 pour affichage c-terminal et bi-terminal d'une proteine heterologue
ES2643237T3 (es) * 2004-06-21 2017-11-21 E. R. Squibb & Sons, L.L.C. Anticuerpos del receptor 1 de interferón alfa y sus usos
NZ554065A (en) * 2004-10-07 2010-12-24 Univ Zuerich Use of an anti-interferon-alpha antibody for prevention and treatment of psoriasis
EP1851248B1 (fr) * 2005-02-10 2016-08-10 Baylor Research Institute Anticorps monoclonaux anti-interferon alpha et procedes d'utilisation
US7888481B2 (en) * 2005-02-10 2011-02-15 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
JP2008543335A (ja) * 2005-06-22 2008-12-04 ジェネンテック・インコーポレーテッド Ｉｆｎａｒ２を標的とするための方法と組成物
CN101678100A (zh) 2006-12-06 2010-03-24 米迪缪尼有限公司 治疗系统性红斑狼疮的方法
US8685400B2 (en) 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
MX2010008578A (es) 2008-02-08 2010-11-10 Medimmune Llc Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
ES2549903T3 (es) 2008-05-07 2015-11-03 Argos Therapeutics, Inc. Anticuerpos humanizados contra interferón alfa humano
WO2011109338A1 (fr) * 2010-03-01 2011-09-09 Alexion Pharmaceuticals Inc. Méthodes et compositions pour le traitement de la maladie de degos
WO2013134146A1 (fr) * 2012-03-07 2013-09-12 The Regents Of The University Of California Procédés et compositions pour le traitement d'infections virales par blocage de l'activité de l'interféron de type i
MA45554A (fr) 2016-07-01 2019-05-08 Resolve Therapeutics Llc Fusions de binucléase optimisées.
CN107074943B (zh) * 2016-07-14 2018-08-24 中国科学院生物物理研究所 I型干扰素受体抗体及其用途
CN111315767B (zh) 2017-08-22 2025-03-18 萨纳生物有限责任公司 可溶性干扰素受体及其用途
JP7386877B2 (ja) * 2019-01-31 2023-11-27 イミューンセント バイオテクノロジー，インコーポレイテッド 新規の抗ｉｆｎａｒ１抗体
JP2024531480A (ja) 2021-08-26 2024-08-29 デュアリティ バイオロジクス（スーチョウ）カンパニー，リミティド ステロイド化合物及びそのコンジュゲート
CN115028730B (zh) * 2022-05-17 2022-11-08 诺赛联合(北京)生物医学科技有限公司 一种成体干细胞衍生的类器官制备方法

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EP0671926B1 (fr) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Peptides immunomodulateurs
CA2148907C (fr) * 1992-12-29 2008-07-08 Rebecca H. R. Ward Traitement d'une maladie inflammatoire de l'intestin par des inhibiteurs de l'ifn gamma
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Also Published As

Publication number Publication date
DK1329459T3 (da) 2007-11-26
AU2349697A (en) 1997-07-24
DE69334158D1 (de) 2007-09-06
HU9402823D0 (en) 1995-01-30
JPH07505526A (ja) 1995-06-22
AU706473B2 (en) 1999-06-17
HUT69995A (en) 1995-09-28
FI944509A0 (fi) 1994-09-29
EP1329459A2 (fr) 2003-07-23
FI944509A7 (fi) 1994-11-29
EP0633931B1 (fr) 2003-05-21
EP0563487A1 (fr) 1993-10-06
US20080226647A1 (en) 2008-09-18
ATE368055T1 (de) 2007-08-15
FI944509L (fi) 1994-11-29
EP0633931A1 (fr) 1995-01-18
DE69332997D1 (de) 2003-06-26
PT633931E (pt) 2003-09-30
US5919453A (en) 1999-07-06
EP1329459A3 (fr) 2003-09-10
NO943625L (no) 1994-11-11
US6787634B2 (en) 2004-09-07
DK0633931T3 (da) 2003-09-15
US7179465B2 (en) 2007-02-20
JP3836500B2 (ja) 2006-10-25
CA2133106A1 (fr) 1993-10-14
JP2006089494A (ja) 2006-04-06
WO1993020187A1 (fr) 1993-10-14
ES2199941T3 (es) 2004-03-01
DE69332997T2 (de) 2004-05-19
US20040191840A1 (en) 2004-09-30
RU94045826A (ru) 1996-11-10
US20070128701A1 (en) 2007-06-07
NO943625D0 (no) 1994-09-29
ES2290241T3 (es) 2008-02-16
EP1329459B1 (fr) 2007-07-25
AU679909B2 (en) 1997-07-17
CA2133106C (fr) 2009-06-30
DE69334158T2 (de) 2008-04-10
CZ236994A3 (en) 1995-02-15
NZ251343A (en) 1997-07-27
ATE241008T1 (de) 2003-06-15
PT1329459E (pt) 2007-11-07
AU3890793A (en) 1993-11-08
US20020055492A1 (en) 2002-05-09
US7465451B2 (en) 2008-12-16

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