BG99495A - Фармацевтични съединения - Google Patents

Фармацевтични съединения

Info

Publication number
BG99495A
BG99495A BG99495A BG9949595A BG99495A BG 99495 A BG99495 A BG 99495A BG 99495 A BG99495 A BG 99495A BG 9949595 A BG9949595 A BG 9949595A BG 99495 A BG99495 A BG 99495A
Authority
BG
Bulgaria
Prior art keywords
nhco
alkyl
diketopiperazines
substituents
optionally substituted
Prior art date
Application number
BG99495A
Other languages
English (en)
Inventor
Mark Collins
Maria Chicarelli-Robinson
John Shaw
Justin Bryans
Christopher Latham
Stephen Brocchini
Original Assignee
Xenova Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Limited filed Critical Xenova Limited
Publication of BG99495A publication Critical patent/BG99495A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Изобретението се отнася до дикетопиперазини с формула, в която заместителите R1 до R10 могат да бъдат еднакви или различни и независимо един от друг означават водород, С1-С6 алкил, незаместен или заместен с един или повече халогенни атоми, С1-С6 алкокси, С1-С6 алкилтио, халоген, хидрокси, нитро, в даден случай субституиран фенил, -циано, -СН2ОН, -СН2СООН, -СО2R11, -NHCOR11, -NHSO2R13, -SO2R13, -CON(R11R12), -SOR13, -SO2N(R11R12), -N(R11R12), -O(CH2)nN(R11R12), -O(CH2)nCO2R11, -OCOR11, -CH2OCOR11, -CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, -CH2S(O)mR13, като m означава 1 или 2, -СН2NHCO(CH2)nCO2R11, -N(R11)COR12, -NHCOCF3, -NHCO(CH2)nCO2R11, -NHCO(CH2)nOCOR11 и -NHCO(CH2)nOR11, като n има стойност 0 или от 1 до 6, всеки от заместителите R11 и R12, независимо един от друг, е водород или С1-С6 алкил и R13 означава С1-С6 алкил, или R1 и R2, R2 и R3, R3 и R4 и R4 и R5 или R6 и R7, R7 иR8, R8 и R9 и R9 и R10 образуват заедно с въглеродните атоми, с които са свързани, бензенов пръстен, който в даден случай е заместен. Изобретението се отнася и до фармацевтично приемливи соли или естери на дикетопиперазините, които намират приложение за производство на лекарства и на инхибитори на плазминогена.
BG99495A 1992-08-14 1995-03-13 Фармацевтични съединения BG99495A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds
PCT/GB1993/001734 WO1994004512A1 (en) 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines

Publications (1)

Publication Number Publication Date
BG99495A true BG99495A (bg) 1995-12-29

Family

ID=10720385

Family Applications (2)

Application Number Title Priority Date Filing Date
BG99495A BG99495A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения
BG99496A BG99496A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG99496A BG99496A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения

Country Status (24)

Country Link
US (1) US5700804A (bg)
EP (2) EP0655060B1 (bg)
JP (2) JPH08504175A (bg)
KR (2) KR950702967A (bg)
AT (1) ATE162186T1 (bg)
AU (2) AU678172B2 (bg)
BG (2) BG99495A (bg)
BR (2) BR9306905A (bg)
CA (2) CA2141939A1 (bg)
CZ (2) CZ38195A3 (bg)
DE (1) DE69316370T2 (bg)
DK (1) DK0655060T3 (bg)
ES (1) ES2111169T3 (bg)
FI (2) FI950616L (bg)
GB (2) GB9217331D0 (bg)
GR (1) GR3026272T3 (bg)
HU (2) HUT71593A (bg)
IL (2) IL106695A0 (bg)
PL (2) PL307438A1 (bg)
RU (2) RU95108387A (bg)
SK (2) SK19595A3 (bg)
TW (1) TW334427B (bg)
WO (2) WO1994004512A1 (bg)
ZA (2) ZA935969B (bg)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
DK85193D0 (da) 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402805D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
IL112627A0 (en) * 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
GB2310854B (en) * 1994-12-23 1998-09-09 Xenova Ltd Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426090D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2311781B (en) * 1994-12-23 1998-09-16 Xenova Ltd Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB9426071D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
US5891877A (en) * 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
EP1242379A1 (en) * 1999-12-03 2002-09-25 Emory University Curcumin analogues for treating cancer
JP5101781B2 (ja) * 2000-05-09 2012-12-19 アンギオアールエックス コーポレイション ピペラジンジオン化合物
US7288545B2 (en) 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
DE60131177T2 (de) 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2002062797A2 (en) * 2000-12-29 2002-08-15 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) * 2001-01-17 2002-09-04 Xenova Ltd Diketopiperazines
EP1572078A4 (en) * 2002-03-08 2006-08-09 Univ Emory NEW CURCUMINOID FACTOR VIIa CONSTRUCTS AS MEANS OF SUPPRESSING TUMOR GROWTH AND ANGIOGENESIS
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
DE60316688T2 (de) 2002-08-02 2008-07-17 Nereus Pharmaceuticals, Inc., San Diego Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
DE10238144A1 (de) * 2002-08-15 2004-02-26 Basf Ag Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
ATE520981T1 (de) 2002-10-02 2011-09-15 Dmi Biosciences Inc Diagnose und überwachung von krankheiten
CA3050734A1 (en) 2003-05-15 2004-12-02 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
WO2006105051A2 (en) * 2005-03-29 2006-10-05 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
WO2007098504A1 (en) * 2006-02-24 2007-08-30 Emory University Prodrugs of curcumin analogs
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
JP6018586B2 (ja) * 2011-02-10 2016-11-02 マンカインド・コーポレイシヨン Ｎ−保護ビス−３，６−（４−アミノアルキル）−２，５，ジケトピペラジンの生成
EP2766029B1 (en) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
EA027343B1 (ru) 2011-10-10 2017-07-31 Ампио Фармасьютикалз, Инк. Имплантируемые устройства медицинского назначения с повышенной иммунной толерантностью и способы изготовления и имплантирования
CA2846394A1 (en) 2011-10-28 2013-05-02 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) * 2014-06-10 2018-03-13 首都医科大学 (3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
AU2015305611B2 (en) 2014-08-18 2020-04-23 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104610170B (zh) * 2015-01-14 2017-02-01 中国科学院南海海洋研究所 2,5‑二酮哌嗪衍生物及其制备方法和应用
SG10202008673WA (en) 2015-03-06 2020-10-29 Beyondspring Pharmaceuticals Inc Method of treating cancer associated with a ras mutation
AU2016229295B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
JP2019511565A (ja) 2016-02-08 2019-04-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド ツカレゾールまたはそのアナログを含む組成物
AU2017278245B2 (en) 2016-06-06 2022-09-15 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing neutropenia
EP3565812B1 (en) 2017-01-06 2023-12-27 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
KR20240110997A (ko) 2017-02-01 2024-07-16 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
CN110054619A (zh) * 2018-01-18 2019-07-26 西北农林科技大学 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
EP3743074A4 (en) 2018-01-24 2021-12-15 Beyondspring Pharmaceuticals Inc. COMPOSITION AND METHOD FOR REDUCING THROMBOCYTOPENIA BY THE ADMINISTRATION OF PLINABULINE
WO2021195265A1 (en) 2020-03-24 2021-09-30 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses
WO2022216908A1 (en) 2021-04-09 2022-10-13 Beyondspring Pharmaceuticals, Inc. Therapeutic compositions and methods for treating tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE621862C (de) * 1932-07-01 1935-11-14 Guenther Schiemann Dr Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (bg) * 1958-11-24
JPS5747357A (en) * 1980-09-04 1982-03-18 Ricoh Co Ltd Novel disazo compound and its preparation
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
JPH08504175A (ja) 1996-05-07
TW334427B (en) 1998-06-21
IL106696A0 (en) 1993-12-08
US5700804A (en) 1997-12-23
AU678172B2 (en) 1997-05-22
GB9502859D0 (en) 1995-04-05
KR950702968A (ko) 1995-08-23
GB2284420B (en) 1996-09-25
PL307437A1 (en) 1995-05-29
DE69316370T2 (de) 1998-07-16
ES2111169T3 (es) 1998-03-01
WO1994004512A1 (en) 1994-03-03
SK19595A3 (en) 1995-09-13
GB2284420A (en) 1995-06-07
FI950617A7 (fi) 1995-04-13
CZ38395A3 (en) 1995-10-18
FI950616A7 (fi) 1995-04-13
SK19495A3 (en) 1995-11-08
HUT71592A (en) 1996-01-29
BR9306905A (pt) 1998-12-08
ZA935969B (en) 1995-02-16
ATE162186T1 (de) 1998-01-15
IL106695A0 (en) 1993-12-08
JPH08504176A (ja) 1996-05-07
HU9500436D0 (en) 1995-04-28
AU693420B2 (en) 1998-07-02
EP0655060A1 (en) 1995-05-31
BR9306904A (pt) 1998-12-08
PL307438A1 (en) 1995-05-29
CZ38195A3 (en) 1995-09-13
CA2141939A1 (en) 1994-03-03
RU95108759A (ru) 1996-12-10
GB9217331D0 (en) 1992-09-30
GR3026272T3 (en) 1998-06-30
EP0672036A1 (en) 1995-09-20
FI950616L (fi) 1995-04-13
BG99496A (bg) 1995-12-29
FI950616A0 (fi) 1995-02-13
EP0655060B1 (en) 1998-01-14
FI950617A0 (fi) 1995-02-13
AU4726593A (en) 1994-03-15
WO1994004513A1 (en) 1994-03-03
ZA935968B (en) 1995-02-16
HUT71593A (en) 1996-01-29
DK0655060T3 (da) 1998-02-09
DE69316370D1 (de) 1998-02-19
AU4726493A (en) 1994-03-15
RU95108387A (ru) 1996-12-10
KR950702967A (ko) 1995-08-23
HU9500437D0 (en) 1995-04-28
CA2141938A1 (en) 1994-03-03

Similar Documents

Publication Publication Date Title
BG99496A (bg) Фармацевтични съединения
ATE12492T1 (de) Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
CA2475432A1 (en) 2,4,6-triamino-1,3,5-triazine derivative
SE9702799D0 (sv) New compounds
BG98216A (bg) Бензофуранови производни
SE9703377D0 (sv) New compounds
IL98681A (en) Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives
PT1021405E (pt) Derivados de azetidinona para o tratamento de infeccoes de hcmv
TR200100603T2 (tr) Pirazin bileşikleri
DK304289A (da) Benzenderivater
GB9825554D0 (en) Novel Compounds
EA200100059A3 (ru) Новые бензолсульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
EA200100631A1 (ru) Ингибиторы вирусов герпеса, представляющие собой гетероциклические карбоксамидсодержащие тиомочевины, имеющие фенилендиаминогруппу
AU568122B2 (en) Pharmaceutical bis(piperazinyl or homopiperazinyl) compounds
ATE165362T1 (de) Neue derivate des 2-(1h)-chinolinones, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3174132D1 (en) New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof
DE69835966D1 (de) Medizinische anwendungen von phenylalkanolen und derivaten davon
NO950529L (no) Farmasöytisk aktive diketopiperaziner