BG99496A - Фармацевтични съединения - Google Patents

Фармацевтични съединения

Info

Publication number
BG99496A
BG99496A BG99496A BG9949695A BG99496A BG 99496 A BG99496 A BG 99496A BG 99496 A BG99496 A BG 99496A BG 9949695 A BG9949695 A BG 9949695A BG 99496 A BG99496 A BG 99496A
Authority
BG
Bulgaria
Prior art keywords
alkyl
nhco
hydrogen
independently
same
Prior art date
Application number
BG99496A
Other languages
English (en)
Inventor
Mark Collins
Maria Chicarelli-Robinson
Justin Bryans
Christopher Latham
Stephen Brocchini
Original Assignee
Xenova Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Limited filed Critical Xenova Limited
Publication of BG99496A publication Critical patent/BG99496A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретението се отнася до дикетопиперазини с формула в която R14 и R15 могат да бъдат еднакви или различни и независимо един от друг означават водород и С1-С6 алкил, при условие, че поне единият от тях означава С1-С6 алкил, R1 до R10 могатда бъдат еднакви или различни и независимо един от друг означават водород, С1-С6 алкил, незаместен или заместен с един или повече халогенни атоми, С1-С6 алкокси, С1-С6 алкилтио, халоген, хидрокси, нитро, в даден случай субституиран фенил, -циано, -СН2ОН, -СН2СООН, -СО2R11, -NHCOR11, -NHSO2R13, -SO2R13, -CON(R11R12), -SOR13, -SO2N(R11R12), -N(R11R12), -O(CH2)nN(R11R12), -O(CH2)nCO2R11, -OCOR11, -CH2OCOR11, -CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, -CH2S(O)mR13, като m означава 1 или 2, -CH2NHCO(CH2)nCO2R11, -N(R11)COR12, -NHCOCF3, -NHCO(CH2)nCO2R11, -NHCO(CH2)nOCOR11 и -NHCO(CH2)nOR11, като n има стойност 0 или от 1 до 6, R11 R12, независимо един от друг, означават водород или С1-С6 алкил или, когато R11 и R12 са свързани със същия азотен атом, могат да образуват с него наситен 5- или 6-членен хетероциклен пръстен, и R13 означава С1-С6 алкил, или R1 и R2, R2 и R3, R3 и R4 и R4 и R5 или R6 и R7, R7 и R8, R8 и R9 и R9 и R10 образуват заедно с въглеродните атоми, с които са свързани, бензенов пръстен, който в даден случай е заместен. Изобретението се отнася и до фармацевтично приемливи соли или естери на дикетопиперазините, които намират приложение като модулатори на устойчивостта към множество лекарствени средства.
BG99496A 1992-08-14 1995-03-13 Фармацевтични съединения BG99496A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds
PCT/GB1993/001735 WO1994004513A1 (en) 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines

Publications (1)

Publication Number Publication Date
BG99496A true BG99496A (bg) 1995-12-29

Family

ID=10720385

Family Applications (2)

Application Number Title Priority Date Filing Date
BG99496A BG99496A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения
BG99495A BG99495A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG99495A BG99495A (bg) 1992-08-14 1995-03-13 Фармацевтични съединения

Country Status (24)

Country Link
US (1) US5700804A (bg)
EP (2) EP0672036A1 (bg)
JP (2) JPH08504175A (bg)
KR (2) KR950702968A (bg)
AT (1) ATE162186T1 (bg)
AU (2) AU693420B2 (bg)
BG (2) BG99496A (bg)
BR (2) BR9306905A (bg)
CA (2) CA2141938A1 (bg)
CZ (2) CZ38195A3 (bg)
DE (1) DE69316370T2 (bg)
DK (1) DK0655060T3 (bg)
ES (1) ES2111169T3 (bg)
FI (2) FI950616L (bg)
GB (2) GB9217331D0 (bg)
GR (1) GR3026272T3 (bg)
HU (2) HUT71592A (bg)
IL (2) IL106695A0 (bg)
PL (2) PL307437A1 (bg)
RU (2) RU95108759A (bg)
SK (2) SK19495A3 (bg)
TW (1) TW334427B (bg)
WO (2) WO1994004512A1 (bg)
ZA (2) ZA935969B (bg)

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GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
DK85193D0 (da) 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9402805D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
IL112627A0 (en) * 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
GB9426090D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426071D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2310854B (en) * 1994-12-23 1998-09-09 Xenova Ltd Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB2311781B (en) * 1994-12-23 1998-09-16 Xenova Ltd Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
US5891877A (en) * 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
CA2393440A1 (en) * 1999-12-03 2001-06-07 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
ATE417614T1 (de) * 2000-05-09 2009-01-15 Angiorx Corp Piperazindion-verbindungen
US7288545B2 (en) * 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
EP1315777B1 (en) 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
AU2001297611A1 (en) * 2000-12-29 2002-08-19 Celltech R And D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
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DE10238144A1 (de) * 2002-08-15 2004-02-26 Basf Ag Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
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EP1622633B1 (en) 2003-05-15 2016-02-24 Ampio Pharmaceuticals, Inc. Treatment of t-cell mediated diseases
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WO2006105051A2 (en) * 2005-03-29 2006-10-05 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
US20070270464A1 (en) * 2006-02-24 2007-11-22 Emory University Prodrugs of curcumin analogs
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SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
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GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
GR3026272T3 (en) 1998-06-30
EP0672036A1 (en) 1995-09-20
EP0655060B1 (en) 1998-01-14
DE69316370D1 (de) 1998-02-19
PL307438A1 (en) 1995-05-29
RU95108387A (ru) 1996-12-10
SK19595A3 (en) 1995-09-13
CA2141938A1 (en) 1994-03-03
ES2111169T3 (es) 1998-03-01
FI950617A0 (fi) 1995-02-13
GB9217331D0 (en) 1992-09-30
RU95108759A (ru) 1996-12-10
BG99495A (bg) 1995-12-29
ZA935968B (en) 1995-02-16
AU693420B2 (en) 1998-07-02
CZ38195A3 (en) 1995-09-13
TW334427B (en) 1998-06-21
FI950616A7 (fi) 1995-04-13
PL307437A1 (en) 1995-05-29
HU9500437D0 (en) 1995-04-28
ATE162186T1 (de) 1998-01-15
EP0655060A1 (en) 1995-05-31
GB9502859D0 (en) 1995-04-05
JPH08504176A (ja) 1996-05-07
HUT71592A (en) 1996-01-29
AU4726493A (en) 1994-03-15
FI950616L (fi) 1995-04-13
FI950616A0 (fi) 1995-02-13
AU678172B2 (en) 1997-05-22
WO1994004513A1 (en) 1994-03-03
KR950702968A (ko) 1995-08-23
GB2284420B (en) 1996-09-25
DK0655060T3 (da) 1998-02-09
BR9306905A (pt) 1998-12-08
HUT71593A (en) 1996-01-29
WO1994004512A1 (en) 1994-03-03
AU4726593A (en) 1994-03-15
HU9500436D0 (en) 1995-04-28
KR950702967A (ko) 1995-08-23
IL106695A0 (en) 1993-12-08
FI950617A7 (fi) 1995-04-13
BR9306904A (pt) 1998-12-08
JPH08504175A (ja) 1996-05-07
CA2141939A1 (en) 1994-03-03
CZ38395A3 (en) 1995-10-18
ZA935969B (en) 1995-02-16
DE69316370T2 (de) 1998-07-16
SK19495A3 (en) 1995-11-08
US5700804A (en) 1997-12-23
IL106696A0 (en) 1993-12-08
GB2284420A (en) 1995-06-07

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