BR0008552A - Células tronco e redes derivadas de tecido adiposo - Google Patents
Células tronco e redes derivadas de tecido adiposoInfo
- Publication number
- BR0008552A BR0008552A BR0008552-9A BR0008552A BR0008552A BR 0008552 A BR0008552 A BR 0008552A BR 0008552 A BR0008552 A BR 0008552A BR 0008552 A BR0008552 A BR 0008552A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- derived
- adipose tissue
- stem cells
- provides
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 5
- 210000000577 adipose tissue Anatomy 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 210000001789 adipocyte Anatomy 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003636 conditioned culture medium Substances 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1305—Adipocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"CéLULAS TRONCO E REDES DERIVADAS DE TECIDO ADIPOSO". A presente invenção fornece células tronco e redes derivadas de tecido adiposo. Em um aspecto, a presente invenção fornece uma célula tronco lipo-derivada substancialmente livre de adipócitos e células vermelhas sang³íneas e populações clonais de células tronco de tecido conectivo. As células podem ser empregadas, isoladas ou em composições biologicamente compatíveis, para gerar tecidos e estruturas diferenciadas, tanto in vivo como in vitro. Adicionalmente, as células podem ser expandidas e cultivadas para produzir hormónios e para fornecer meios de cultura condicionados para suportar o crescimento e expansão de outras populações de células. Em um outro aspecto, a presente invenção fornece uma rede lipo-derivada substancialmente desprovida de células, que inclui material de matriz extracelular de tecido adiposo. A rede pode ser usada como um substrato para facilitar o crescimento e diferenciação de células, seja in vivo ou in vitro, em tecidos ou estruturas primordiais ou mesmo maduros.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12371199P | 1999-03-10 | 1999-03-10 | |
| US16246299P | 1999-10-29 | 1999-10-29 | |
| PCT/US2000/006232 WO2000053795A1 (en) | 1999-03-10 | 2000-03-10 | Adipose-derived stem cells and lattices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0008552A true BR0008552A (pt) | 2002-05-07 |
Family
ID=26821819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0008552-9A BR0008552A (pt) | 1999-03-10 | 2000-03-10 | Células tronco e redes derivadas de tecido adiposo |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20020076400A1 (pt) |
| EP (1) | EP1165830B1 (pt) |
| JP (3) | JP2002537849A (pt) |
| KR (4) | KR100979664B1 (pt) |
| CN (1) | CN1352696A (pt) |
| AU (1) | AU784580B2 (pt) |
| BR (1) | BR0008552A (pt) |
| CA (1) | CA2366078C (pt) |
| IL (1) | IL145002A0 (pt) |
| RU (2) | RU2306335C2 (pt) |
| WO (1) | WO2000053795A1 (pt) |
Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| IL164568A0 (en) | 1997-05-14 | 2005-12-18 | Atherogenics Inc | Compounds and methods for the inhibition of the expression of vcam-1 |
| CA2312847C (en) | 1997-12-02 | 2014-09-30 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| US7001746B1 (en) | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| US20050153442A1 (en) * | 1999-03-10 | 2005-07-14 | Adam Katz | Adipose-derived stem cells and lattices |
| US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| US7078232B2 (en) | 1999-08-19 | 2006-07-18 | Artecel, Inc. | Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof |
| US6429013B1 (en) | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| US7582292B2 (en) | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
| EP1918366A1 (en) | 2000-02-26 | 2008-05-07 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
| ES2300320T3 (es) * | 2000-02-26 | 2008-06-16 | Artecel, Inc. | Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos. |
| FR2819265B1 (fr) * | 2001-01-10 | 2004-01-02 | Centre Nat Rech Scient | Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques |
| EP1385935A4 (en) | 2001-03-29 | 2004-09-15 | Ixion Biotechnology Inc | METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLS IN THE PANCREAS DIFFERENTIATION PATHWAY |
| JPWO2003008592A1 (ja) * | 2001-07-19 | 2004-11-11 | 田畑 泰彦 | 脂肪組織由来多能性幹細胞 |
| US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
| RU2331668C2 (ru) * | 2001-11-09 | 2008-08-20 | Артесел Сайенсиз, Инк. | Стромальные клетки, полученные из жировой ткани, для заживления дефектов роговицы и внутриглазных дефектов и их использование |
| KR20050044393A (ko) * | 2001-11-09 | 2005-05-12 | 아르테셀 사이언스, 인크. | 지방 조직 유래된 스트로마 세포의 내분비 췌장 분화 및이의 용도 |
| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
| US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| JP4653952B2 (ja) | 2001-12-07 | 2011-03-16 | サイトリ セラピューティクス インコーポレイテッド | 処理済み脂肪吸引細胞で患者を治療するためのシステムと方法 |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US20050048035A1 (en) | 2001-12-07 | 2005-03-03 | Fraser John K. | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| AU2003230792A1 (en) * | 2002-04-03 | 2003-10-20 | Artecel Sciences, Inc. | Improvements of adipocytic differentiated adipose derived adult stem cells and uses thereof |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7992725B2 (en) * | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| DE10392686T5 (de) | 2002-05-24 | 2005-07-07 | Biomet Mfg. Corp., Warsaw | Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| EP1558086A4 (en) | 2002-06-14 | 2008-03-05 | Univ Case Western Reserve | Cell taring process and compositions |
| JP4603883B2 (ja) * | 2002-07-31 | 2010-12-22 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | 脂肪組織由来の幹細胞および前記細胞から分化した細胞 |
| FR2843123B1 (fr) * | 2002-07-31 | 2007-11-02 | Saint Laurent Parfums | Cellules souches issues de tissu adipeux humain |
| US20040235121A1 (en) * | 2002-08-29 | 2004-11-25 | Integrigen, Inc. | High copy number plasmids and their derivatives |
| KR100539371B1 (ko) * | 2002-10-21 | 2005-12-27 | 메디칸(주) | 인체 세포의 체외배양 방법 |
| US7233684B2 (en) * | 2002-11-25 | 2007-06-19 | Eastman Kodak Company | Imaging method and system using affective information |
| CA2516510C (en) * | 2003-02-20 | 2012-07-10 | Macropore Biosurgery, Inc. | Method of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US20040193274A1 (en) * | 2003-03-28 | 2004-09-30 | Trieu Hai H. | Materials and methods for augmenting and/or repairing intervertebral discs |
| JP5055613B2 (ja) * | 2003-06-13 | 2012-10-24 | 学校法人日本大学 | 前駆脂肪細胞由来の分化細胞及びその取得方法 |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| EP2399990B1 (en) | 2003-06-27 | 2015-07-22 | DePuy Synthes Products, Inc. | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system |
| FR2859381B1 (fr) * | 2003-09-05 | 2008-07-25 | Centre Nat Rech Scient | Utilisaton de cellules issues du tissu adipeux pour induire la formation d'un reseau vasculaire fonctionnel |
| CA2539346A1 (en) * | 2003-09-17 | 2005-04-21 | Macropore Biosurgery, Inc. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| JP2007508018A (ja) | 2003-10-08 | 2007-04-05 | べト−ステム インコーポレイテッド | 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット |
| DE10349484A1 (de) * | 2003-10-21 | 2005-05-25 | Universität Leipzig | Verfahren und Bioreaktor zum Kultivieren und Stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen Zelltransplantaten |
| KR100821128B1 (ko) * | 2003-11-04 | 2008-04-14 | 가부시키가이샤 바이오마스타 | 지방 조직으로부터 줄기세포를 생성하는 방법 및 시스템 |
| WO2005061695A1 (en) * | 2003-12-23 | 2005-07-07 | Carag Ag | Method for isolating cells from mammary secretion |
| EP1713513B1 (en) | 2004-01-16 | 2014-06-04 | Carnegie Mellon University | Cellular labeling for nuclear magnetic resonance techniques |
| EP2298864B1 (en) | 2004-03-22 | 2017-10-11 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| RU2265443C1 (ru) * | 2004-05-14 | 2005-12-10 | ЗАО "РеМеТэкс" | Биотрансплантат и способ лечения сахарного диабета i и ii типа (варианты) |
| RU2271818C1 (ru) * | 2004-08-18 | 2006-03-20 | ЗАО "РеМеТэкс" | Биотрансплантат, способ его получения и способ лечения косметических дефектов кожи (варианты) |
| RU2271819C1 (ru) * | 2004-08-18 | 2006-03-20 | ЗАО "РеМеТэкс" | Биотрансплантат, способ его получения (варианты) и способ лечения алопеции |
| ES2313805B1 (es) * | 2004-10-04 | 2009-12-23 | Cellerix, S.L. | Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral. |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| EP1805300A4 (en) * | 2004-09-14 | 2009-09-09 | Univ Columbia | DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO THE HEART REPAIR PROMOTING CARDIOVASCULAR CELLS |
| US8431397B2 (en) * | 2004-09-14 | 2013-04-30 | The Trustees Of Columbia University In The City Of New York | Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair |
| US20060134781A1 (en) * | 2004-12-07 | 2006-06-22 | Bacterin International, Inc. | Three-dimensional cell culture system |
| US20230332095A1 (en) * | 2004-12-23 | 2023-10-19 | Tissue Genesis International Llc | Cell separation apparatus and methods of use |
| CA2589041C (en) | 2004-12-23 | 2019-08-20 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
| EP1830862B1 (en) * | 2004-12-30 | 2012-12-19 | PrimeGen Biotech LLC | Adipose-derived stem cells for tissue regeneration and wound healing |
| WO2006086199A1 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| WO2006086201A2 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| WO2006128029A2 (en) * | 2005-05-25 | 2006-11-30 | University Of Virginia Patent Foundation | Production of osteoclasts from adipose tissues |
| US8796020B2 (en) * | 2005-06-17 | 2014-08-05 | Inha-Industry Partnership Institute | Manufacturing process for fresh and frozen stem cells |
| JP4907908B2 (ja) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | 駆動回路及び表示装置 |
| TW200726474A (en) * | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
| US7531355B2 (en) | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
| EP1909581A4 (en) * | 2005-07-29 | 2008-12-31 | Univ Virginia | Adipose tissue stem cells, perivascular cells and pericytes |
| CN1912109B (zh) * | 2005-08-09 | 2010-09-15 | 中国人民解放军军事医学科学院野战输血研究所 | 一种组织工程化脂肪组织的构建方法与应用 |
| BRPI0617085A2 (pt) * | 2005-09-02 | 2016-11-08 | Agency Science Tech & Res | método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada |
| WO2007030469A2 (en) * | 2005-09-06 | 2007-03-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Transplantable cell growth niche and related compositions and methods |
| EP3184630B1 (en) | 2005-09-23 | 2019-07-17 | TiGenix, S.A.U. | Cell populations having immunoregulatory activity, method for isolation and uses |
| KR100679642B1 (ko) * | 2005-11-16 | 2007-02-06 | 주식회사 알앤엘바이오 | 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제 |
| WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| US8592209B2 (en) | 2006-01-30 | 2013-11-26 | University Of Virginia Patent Foundation | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof |
| WO2007091790A1 (en) * | 2006-02-07 | 2007-08-16 | Korea Institute Of Radiological & Medical Sciences | A composition for treating damage of central or peripheral nerve system |
| US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US8163018B2 (en) * | 2006-02-14 | 2012-04-24 | Warsaw Orthopedic, Inc. | Treatment of the vertebral column |
| US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
| US20110171182A1 (en) * | 2006-03-23 | 2011-07-14 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| EP2548951B1 (en) * | 2006-03-23 | 2016-05-04 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| CN101558151B (zh) * | 2006-03-23 | 2015-10-21 | 普拉里斯坦有限公司 | 细胞扩增方法和藉此产生的细胞和条件培养基用于治疗的用途 |
| EP2010646A2 (en) | 2006-04-14 | 2009-01-07 | Carnegie Mellon University | Cellular labeling and quantification for nuclear magnetic resonance techniques |
| FR2901136B1 (fr) * | 2006-05-18 | 2010-10-01 | Centre Nat Rech Scient | Utilisation de cellules derivees du tissu adipeux pour la preparation d'un medicament anti-tumoral |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20100023129A1 (en) * | 2008-07-22 | 2010-01-28 | Guo-Feng Xu | Jawbone prosthesis and method of manufacture |
| EP2617428A1 (en) | 2006-08-15 | 2013-07-24 | Agency for Science, Technology and Research | Mesenchymal stem cell conditioned medium |
| JP5191386B2 (ja) | 2006-09-25 | 2013-05-08 | 国立大学法人大阪大学 | 歯周硬組織再生用組成物及び歯周硬組織を再生する方法 |
| JP2010505849A (ja) | 2006-10-06 | 2010-02-25 | ユニバーシティ オブ バージニア パテント ファウンデーション | 糖尿病性創傷治癒に有用な方法および組成物 |
| US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| WO2008127639A1 (en) | 2007-04-12 | 2008-10-23 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| JP2008278822A (ja) * | 2007-05-11 | 2008-11-20 | Olympus Corp | 生体組織分解方法 |
| JP2008278842A (ja) * | 2007-05-14 | 2008-11-20 | Nippon Inst For Biological Science | 脂肪組織間質細胞の神経細胞への分化誘導方法並びに分化誘導された該神経細胞 |
| WO2008150001A1 (ja) * | 2007-06-08 | 2008-12-11 | Biomaster, Inc. | アディポクラスタ- |
| WO2008153180A1 (ja) | 2007-06-14 | 2008-12-18 | Akifumi Matsuyama | 脂肪組織由来細胞から肝小葉様細胞塊を得る方法 |
| JP5645658B2 (ja) | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
| KR20140107677A (ko) * | 2007-09-19 | 2014-09-04 | 플루리스템 리미티드 | 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도 |
| US20090192528A1 (en) * | 2008-01-29 | 2009-07-30 | Biomet Biologics, Inc. | Method and device for hernia repair |
| BRPI0908087A2 (pt) * | 2008-02-11 | 2015-08-25 | Univ Johns Hopkins | Composições e métodos para implante de tecido adipose e produtos de tecido adiposo |
| EP2620139B1 (en) | 2008-02-27 | 2016-07-20 | Biomet Biologics, LLC | Interleukin-1 receptor antagonist rich solutions |
| WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
| SG188918A1 (pt) | 2008-03-17 | 2013-04-30 | Agency Science Tech & Res | |
| US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| AU2009201915C1 (en) | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
| RU2539786C2 (ru) | 2008-09-02 | 2015-01-27 | Плуристем Лтд. | Выращенные в прикрепленной к субстрату культуре клетки из ткани плаценты и их использование при лечении |
| JP5518893B2 (ja) | 2008-12-19 | 2014-06-11 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 肺ならびに肺の疾患および障害の治療 |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| EP2411504B1 (en) | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| KR101738324B1 (ko) | 2009-05-01 | 2017-05-19 | 비미니 테크놀로지스 엘엘씨 | 조직 및 세포 부유화 이식편의 최적화 시스템, 방법 및 조성물 |
| US8740383B2 (en) | 2009-05-06 | 2014-06-03 | University Of Virginia Patent Foundation | Self-illuminated handheld lens for retinal examination and photography and related method thereof |
| IT1394570B1 (it) * | 2009-07-02 | 2012-07-05 | Fidia Farmaceutici | Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni. |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| CA2770490C (en) * | 2009-08-11 | 2024-04-16 | The Johns Hopkins University | Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products |
| MX2012006759A (es) * | 2009-12-17 | 2012-07-30 | Univ Kingston | Tejido adiposo descelularizado. |
| EP2542249A4 (en) | 2010-03-05 | 2013-08-07 | Tissue Genesis Inc | METHOD AND COMPOSITIONS FOR SUPPORTING TISSUE INTEGRATION AND INOCULATION OF TRANSPLANTED TISSUE AND TRANSPLANTED TREATED PENIS FABRIC WITH FAT FABRIC ACETIC COSTS |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| HRP20182039T1 (hr) | 2010-04-23 | 2019-02-08 | Cold Spring Harbor Laboratory | NOVE STRUKTURNO DIZAJNIRANE MOLEKULE shRNA |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9296984B2 (en) | 2010-07-09 | 2016-03-29 | The Gid Group, Inc. | Tissue processing apparatus and method for processing adipose tissue |
| WO2013106655A1 (en) | 2012-01-11 | 2013-07-18 | The Gid Group, Inc. | Method for processing adipose tissue and processing apparatus |
| US9206387B2 (en) | 2010-07-09 | 2015-12-08 | The Gid Group, Inc. | Method and apparatus for processing adipose tissue |
| US9260697B2 (en) | 2010-07-09 | 2016-02-16 | The Gid Group, Inc. | Apparatus and methods relating to collecting and processing human biological material containing adipose |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| KR101951055B1 (ko) * | 2010-12-16 | 2019-02-21 | 인제네론 인코포레이티드 | 조직 검체로부터 세포 및 세포가 풍부한 기질의 강화된 회수를 위한 방법 및 기구 |
| US9730964B2 (en) * | 2011-03-15 | 2017-08-15 | Cell Ideas Pty Ltd. | Pharmaceutical compositions and topical use thereof |
| KR101903339B1 (ko) | 2011-03-22 | 2018-10-01 | 플루리스템 리미티드 | 방사선 또는 화학적 손상을 치료하는 방법 |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| EP2864472A4 (en) * | 2012-06-20 | 2015-12-30 | Celula Inc | MATERIALS AND METHOD FOR PROCESSING CELL POPULATIONS |
| EP2863927A4 (en) * | 2012-06-26 | 2015-12-02 | Rusty Property Holdings Pty Ltd | COMPOSITIONS AND METHODS FOR REDUCING THE FREQUENCY AND / OR INTENSITY OF THE CEPHALA |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| CN102816796B (zh) * | 2012-09-04 | 2013-10-16 | 中国科学院广州生物医药与健康研究院 | c-Jun的N端缺失诱导多能性干细胞的方法和应用 |
| BR112015004003B1 (pt) | 2012-09-06 | 2020-05-19 | The Gid Group, Inc. | aparelho para processar material biológico humano contendo tecido fibroso e método para processar tecido adiposo |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| CN105531366A (zh) * | 2013-07-10 | 2016-04-27 | 新加坡科技研究局 | 用于分离基质血管组分的方法 |
| MX2016001247A (es) | 2013-07-30 | 2016-08-17 | Musculoskeletal Transplant Foundation | Matrices derivadas de tejido suave acelular y metodos para preparar las mismas. |
| WO2015035221A1 (en) | 2013-09-05 | 2015-03-12 | The Gid Group, Inc. | Tissue processing apparatus and method for processing adipose tissue |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| CA2956681A1 (en) * | 2014-07-30 | 2016-02-04 | Claudia Eder | Transdifferentiated tissue graft |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| KR101719743B1 (ko) | 2015-04-06 | 2017-03-24 | 박준한 | 지방 조직으로부터 지방줄기세포를 수득하는 방법 |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| CA3177726A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| CN107810015A (zh) * | 2015-05-27 | 2018-03-16 | 库克瑞根泰克有限责任公司 | 薄片形式的细胞生长支架颗粒和移植物及其方法 |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| BR112019003871A2 (pt) | 2016-08-30 | 2019-07-16 | Lifecell Corp | sistemas e métodos para controle de dispositivo médico |
| CN106434522A (zh) * | 2016-09-29 | 2017-02-22 | 广州赛莱拉干细胞科技股份有限公司 | 一种自体软骨细胞的三维培养方法 |
| CN106318902A (zh) * | 2016-09-29 | 2017-01-11 | 广州赛莱拉干细胞科技股份有限公司 | 一种软骨细胞的培养方法 |
| USD851777S1 (en) | 2017-01-30 | 2019-06-18 | Lifecell Corporation | Canister-type device for tissue processing |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11732233B2 (en) | 2017-07-18 | 2023-08-22 | Gid Bio, Inc. | Adipose tissue digestion system and tissue processing method |
| CN111542350B (zh) * | 2018-04-02 | 2022-10-18 | 联合技术实验室公司 | 用于制备脂肪来源干细胞的系统和方法 |
| KR102233530B1 (ko) | 2018-11-22 | 2021-03-31 | (주)프로스테믹스 | 엑소좀 및 이의 다양한 용도 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US211602A (en) * | 1879-01-21 | Improvement in towing canal-boats | ||
| US13510A (en) * | 1855-08-28 | Nathan thompson | ||
| US171146A (en) * | 1875-12-14 | Improvement in stove-pipe shelves | ||
| US82152A (en) * | 1868-09-15 | Improvement in hay-knives | ||
| US282275A (en) * | 1883-07-31 | Cooke | ||
| US153442A (en) * | 1874-07-28 | Improvement in rosettes | ||
| US76400A (en) * | 1868-04-07 | Joseph collins and john knox | ||
| US161817A (en) * | 1875-04-06 | Improvement in farm-gates | ||
| US76396A (en) * | 1868-04-07 | John burke | ||
| US153441A (en) * | 1874-07-28 | Improvement in boiler-flue cleaners | ||
| US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
| DE3171608D1 (en) * | 1981-10-28 | 1985-09-05 | Ibm | Line circuit containing impedance adaptation means |
| US5510254A (en) * | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
| SU1739777A1 (ru) * | 1989-05-05 | 1995-01-27 | Институт клинической иммунологии СО АМН СССР | Способ ингибирования пролиферации стволовых кроветворных клеток костного мозга |
| US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| US5811094A (en) * | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| FR2723315B1 (fr) * | 1994-08-02 | 1996-10-25 | Cird Galderma | Procede et composition pour stimuler la differenciation des cellules preadipocytaires et traitements therapeutiques associes |
| US5688531A (en) * | 1994-12-23 | 1997-11-18 | Ramot University Authority For Applied Research And Industrial Development, Ltd. | Method for regulating bone forming cells |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5765567A (en) * | 1995-03-22 | 1998-06-16 | Knowlton; Edward W. | Surgical method for breast reconstruction using a tissue flap |
| JP3781433B2 (ja) | 1995-11-16 | 2006-05-31 | ケース ウエスターン リザーブ ユニバーシティ | ヒト間葉幹細胞の試験管内軟骨形成誘導 |
| EP0877795A4 (en) * | 1996-01-16 | 2003-03-05 | Depuy Orthopaedics Inc | INSULATION OF PROCUREMENT CELLS FROM HEMATOPOIETIC AND NON-HEMATOPOIETIC TISSUES AND THEIR USE |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5827740A (en) * | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US5786207A (en) | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
| US5817050A (en) * | 1997-05-29 | 1998-10-06 | Klein; Jeffrey A. | Liposuction cannula |
| CA2294944A1 (en) * | 1997-07-03 | 1999-01-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
| WO1999003980A1 (en) * | 1997-07-16 | 1999-01-28 | Kirin Beer Kabushiki Kaisha | Agm-derived stroma cells |
| FR2771102B1 (fr) * | 1997-11-14 | 2000-12-15 | Biocoral Inc | Procede pour induire la differenciation osteoblastique de cellules de tissu adipeux extramedullaire humain |
| CA2312847C (en) * | 1997-12-02 | 2014-09-30 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| CA2311729A1 (en) * | 1998-01-23 | 1999-07-29 | Imclone Systems Incorporated | Purified populations of stem cells |
| US20030082152A1 (en) * | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| US7266457B1 (en) * | 1999-05-21 | 2007-09-04 | Hesperos, Llc | High throughput functional genomics |
| AUPQ147799A0 (en) * | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| US7078232B2 (en) * | 1999-08-19 | 2006-07-18 | Artecel, Inc. | Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof |
| US6555374B1 (en) * | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| US6429013B1 (en) * | 1999-08-19 | 2002-08-06 | Artecel Science, Inc. | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
| ES2300320T3 (es) * | 2000-02-26 | 2008-06-16 | Artecel, Inc. | Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos. |
| FR2819265B1 (fr) * | 2001-01-10 | 2004-01-02 | Centre Nat Rech Scient | Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques |
-
2000
- 2000-03-10 BR BR0008552-9A patent/BR0008552A/pt not_active Application Discontinuation
- 2000-03-10 AU AU35223/00A patent/AU784580B2/en not_active Expired
- 2000-03-10 RU RU2001127430/13A patent/RU2306335C2/ru not_active IP Right Cessation
- 2000-03-10 KR KR1020077009385A patent/KR100979664B1/ko not_active Expired - Fee Related
- 2000-03-10 KR KR1020017011443A patent/KR100870508B1/ko not_active Expired - Fee Related
- 2000-03-10 EP EP00913860.3A patent/EP1165830B1/en not_active Expired - Lifetime
- 2000-03-10 WO PCT/US2000/006232 patent/WO2000053795A1/en not_active Ceased
- 2000-03-10 CN CN00807461A patent/CN1352696A/zh active Pending
- 2000-03-10 KR KR1020097007343A patent/KR100968165B1/ko not_active Expired - Fee Related
- 2000-03-10 IL IL14500200A patent/IL145002A0/xx unknown
- 2000-03-10 KR KR1020087014477A patent/KR100968164B1/ko not_active Expired - Fee Related
- 2000-03-10 CA CA2366078A patent/CA2366078C/en not_active Expired - Lifetime
- 2000-03-10 JP JP2000603416A patent/JP2002537849A/ja active Pending
-
2001
- 2001-09-06 US US09/947,985 patent/US20020076400A1/en not_active Abandoned
-
2005
- 2005-08-24 US US11/211,114 patent/US20050282275A1/en not_active Abandoned
-
2007
- 2007-04-19 RU RU2007114846/13A patent/RU2007114846A/ru not_active Application Discontinuation
-
2010
- 2010-10-27 JP JP2010241400A patent/JP2011078416A/ja active Pending
-
2014
- 2014-11-20 JP JP2014235177A patent/JP2015109834A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015109834A (ja) | 2015-06-18 |
| CN1352696A (zh) | 2002-06-05 |
| EP1165830A4 (en) | 2003-10-08 |
| KR100979664B1 (ko) | 2010-09-02 |
| IL145002A0 (en) | 2002-06-30 |
| EP1165830A1 (en) | 2002-01-02 |
| US20050282275A1 (en) | 2005-12-22 |
| KR20080063426A (ko) | 2008-07-03 |
| CA2366078A1 (en) | 2000-09-14 |
| RU2306335C2 (ru) | 2007-09-20 |
| KR100870508B1 (ko) | 2008-11-25 |
| CA2366078C (en) | 2015-09-01 |
| JP2011078416A (ja) | 2011-04-21 |
| RU2007114846A (ru) | 2008-11-27 |
| AU784580B2 (en) | 2006-05-04 |
| KR20090043612A (ko) | 2009-05-06 |
| US20020076400A1 (en) | 2002-06-20 |
| EP1165830B1 (en) | 2017-07-12 |
| KR100968165B1 (ko) | 2010-07-06 |
| KR100968164B1 (ko) | 2010-07-06 |
| KR20070053359A (ko) | 2007-05-23 |
| AU3522300A (en) | 2000-09-28 |
| WO2000053795A1 (en) | 2000-09-14 |
| KR20020013510A (ko) | 2002-02-20 |
| JP2002537849A (ja) | 2002-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0008552A (pt) | Células tronco e redes derivadas de tecido adiposo | |
| WO2003022988A3 (en) | Adipose-derived stem cells and lattices | |
| Rodeck et al. | Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors | |
| Wang et al. | Modulation of alignment, elongation and contraction of cardiomyocytes through a combination of nanotopography and rigidity of substrates | |
| TW200516149A (en) | Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair | |
| Buttle et al. | Comparative studies of collagen lattice contraction utilizing a normal and a transformed cell line | |
| DE3751843D1 (de) | Herstellung von körperorganen durch kontroliertes zellwachstum auf künstlicher matrix | |
| Seruya et al. | Clonal population of adult stem cells: life span and differentiation potential | |
| WO2002076285A3 (en) | Composition and methods fro the production of biological tissues and tissue constructs | |
| ATE526047T1 (de) | Verbesserung der funktion von organen | |
| GB2414990A (en) | Biologically active native biomatrix composition | |
| DE60018044D1 (de) | Neue biomaterialien | |
| MXPA03001914A (es) | Matrices basadas en fibrina electroprocesada y tejidos. | |
| WO2003014313A3 (en) | Alternative compositions and methods for the culture of stem cells | |
| O'connor et al. | Extracellular matrix substrata alter adipocyte yield and lipogenesis in primary cultures of stromal-vascular cells from human adipose | |
| Kouroupis et al. | Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair | |
| BR0116272A (pt) | Método de criação de um material de implantação a partir de tecido autogênico, alogênico ou xenogênico de mamìfero e material de implantação | |
| Hsu et al. | Bioeffect of ultrasound on endothelial cells in vitro | |
| Hartrianti et al. | Modulating mesenchymal stem cell behavior using human hair keratin‐coated surfaces | |
| CN103497892B (zh) | 一种细胞培养基材及其制备方法和应用 | |
| Ghanavati et al. | Characterization of a three-dimensional organotypic co-culture skin model for epidermal differentiation of rat adipose-derived stem cells | |
| NZ506510A (en) | A permanent skin replacement comprising allogenic epithelial cells cultured in vitro and autologous epithelial cells | |
| Su et al. | Effect of chitosan conduit under a dynamic culture on the proliferation and neural differentiation of human exfoliated deciduous teeth stem cells | |
| Wangkulangkul et al. | Constructed silk fibroin scaffolds to mimic adipose tissue as engineered implantation materials in post-subcutaneous tumor removal | |
| Schlabe et al. | Isolation and culture of different epidermal and dermal cell types from human scalp suitable for the development of a therapeutical cell spray |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 24 E 25 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/077 (2010.01), C12N 5/00 (2006.01), C12N 5/ |