BR0009731A - Produtos naturais de pseudomicina - Google Patents
Produtos naturais de pseudomicinaInfo
- Publication number
- BR0009731A BR0009731A BR0009731-4A BR0009731A BR0009731A BR 0009731 A BR0009731 A BR 0009731A BR 0009731 A BR0009731 A BR 0009731A BR 0009731 A BR0009731 A BR 0009731A
- Authority
- BR
- Brazil
- Prior art keywords
- pseudomycin
- natural
- products
- pseudomycins
- nmr
- Prior art date
Links
- 238000005481 NMR spectroscopy Methods 0.000 abstract 2
- 238000004949 mass spectrometry Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NYRWZRIVFVWNTD-SGRJACMKSA-N (2s)-2-[(3s,6s,9z,12s,15s,18s,21s,24r,27s)-18-(4-aminobutyl)-15,24-bis(2-aminoethyl)-21-(carboxymethyl)-3-[(1s)-2-chloro-1-hydroxyethyl]-9-ethylidene-12-[(1s)-1-hydroxyethyl]-27-[[(3r)-3-hydroxytetradecanoyl]amino]-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4, Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)N[C@H]1COC(=O)[C@H]([C@H](O)CCl)NC(=O)[C@H]([C@H](O)C(O)=O)NC(=O)\C(=C\C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCN)NC1=O NYRWZRIVFVWNTD-SGRJACMKSA-N 0.000 abstract 1
- XDPWWEOIDYYUDN-HCEIJDMSSA-N 2-[(9z)-18-(4-aminobutyl)-15,24-bis(2-aminoethyl)-21-(carboxymethyl)-3-(2-chloro-1-hydroxyethyl)-27-(3,4-dihydroxytetradecanoylamino)-9-ethylidene-12-(1-hydroxyethyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-6-yl]-2-h Chemical compound CCCCCCCCCCC(O)C(O)CC(=O)NC1COC(=O)C(C(O)CCl)NC(=O)C(C(O)C(O)=O)NC(=O)\C(=C\C)NC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCCCN)NC(=O)C(CC(O)=O)NC(=O)C(CCN)NC1=O XDPWWEOIDYYUDN-HCEIJDMSSA-N 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 108010033876 pseudomycin A Proteins 0.000 abstract 1
- 108010033821 pseudomycin B Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Patente de Invenção: "PRODUTOS NATURAIS DE PSEUDOMICINA". A invenção refere-se a produtos naturais de pseudomicina que incluem as pseudomicinas A' e B', aos processos para a obtenção de tais pseudomicinas e aos processos que empregam a atividade antifúngica destas pseudomicinas. RMN e espectrometria de massa indicam a fórmula (I) para a pseudomicina A'. RMN e espectrometria de massa indicam a fórmula (II) para a pseudomicina B'.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12944799P | 1999-04-15 | 1999-04-15 | |
| PCT/US2000/008727 WO2000063237A2 (en) | 1999-04-15 | 2000-04-14 | Pseudomycin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0009731A true BR0009731A (pt) | 2002-03-05 |
Family
ID=22439989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0009731-4A BR0009731A (pt) | 1999-04-15 | 2000-04-14 | Produtos naturais de pseudomicina |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6630147B1 (pt) |
| EP (1) | EP1173471B1 (pt) |
| JP (1) | JP2002542257A (pt) |
| CN (1) | CN1191269C (pt) |
| AT (1) | ATE393773T1 (pt) |
| AU (1) | AU4188700A (pt) |
| BR (1) | BR0009731A (pt) |
| CA (1) | CA2369136A1 (pt) |
| DE (1) | DE60038735T2 (pt) |
| DK (1) | DK1173471T3 (pt) |
| EA (1) | EA004308B1 (pt) |
| ES (1) | ES2304954T3 (pt) |
| HU (1) | HUP0200896A3 (pt) |
| MX (1) | MXPA01010245A (pt) |
| NO (1) | NO20014937L (pt) |
| PT (1) | PT1173471E (pt) |
| WO (1) | WO2000063237A2 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919188B1 (en) | 1999-04-15 | 2005-07-19 | Eli Lilly And Company | Pseudomycin production by Pseudomonas syringae |
| MXPA03001493A (es) * | 2000-08-18 | 2003-06-06 | Univ Montana Res Dev Inst | Seudomicinas utiles contra enfermedades de plantas. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576298A (en) * | 1992-11-30 | 1996-11-19 | Research And Development Institute, Inc. At Montana State University | Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity |
| EP1171576B1 (en) * | 1999-04-15 | 2007-07-11 | Eli Lilly And Company | Pseudomycin production by pseudomonas syringae |
| HUP0200897A2 (en) * | 1999-04-15 | 2002-08-28 | Lilly Co Eli | Antifungal agents isolated from pseudomonas syringae |
| CA2396513A1 (en) * | 1999-12-13 | 2001-06-14 | Yanzhi Zhang | Pseudomycin phosphate prodrugs |
-
2000
- 2000-04-14 DE DE60038735T patent/DE60038735T2/de not_active Expired - Fee Related
- 2000-04-14 EP EP00921593A patent/EP1173471B1/en not_active Expired - Lifetime
- 2000-04-14 AT AT00921593T patent/ATE393773T1/de not_active IP Right Cessation
- 2000-04-14 BR BR0009731-4A patent/BR0009731A/pt not_active Application Discontinuation
- 2000-04-14 ES ES00921593T patent/ES2304954T3/es not_active Expired - Lifetime
- 2000-04-14 US US09/958,995 patent/US6630147B1/en not_active Expired - Fee Related
- 2000-04-14 HU HU0200896A patent/HUP0200896A3/hu unknown
- 2000-04-14 AU AU41887/00A patent/AU4188700A/en not_active Abandoned
- 2000-04-14 CN CNB008062587A patent/CN1191269C/zh not_active Expired - Fee Related
- 2000-04-14 WO PCT/US2000/008727 patent/WO2000063237A2/en not_active Ceased
- 2000-04-14 JP JP2000612327A patent/JP2002542257A/ja active Pending
- 2000-04-14 CA CA002369136A patent/CA2369136A1/en not_active Abandoned
- 2000-04-14 EA EA200101090A patent/EA004308B1/ru not_active IP Right Cessation
- 2000-04-14 PT PT00921593T patent/PT1173471E/pt unknown
- 2000-04-14 MX MXPA01010245A patent/MXPA01010245A/es active IP Right Grant
- 2000-04-14 DK DK00921593T patent/DK1173471T3/da active
-
2001
- 2001-10-10 NO NO20014937A patent/NO20014937L/no not_active Application Discontinuation
-
2003
- 2003-08-07 US US10/636,376 patent/US6793925B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1173471E (pt) | 2008-07-21 |
| EP1173471B1 (en) | 2008-04-30 |
| US6630147B1 (en) | 2003-10-07 |
| CA2369136A1 (en) | 2000-10-26 |
| WO2000063237A3 (en) | 2001-01-04 |
| NO20014937D0 (no) | 2001-10-10 |
| EA200101090A1 (ru) | 2002-06-27 |
| AU4188700A (en) | 2000-11-02 |
| HUP0200896A3 (en) | 2002-09-30 |
| JP2002542257A (ja) | 2002-12-10 |
| DE60038735D1 (de) | 2008-06-12 |
| MXPA01010245A (es) | 2002-03-27 |
| CN1191269C (zh) | 2005-03-02 |
| EA004308B1 (ru) | 2004-02-26 |
| CN1355812A (zh) | 2002-06-26 |
| EP1173471A2 (en) | 2002-01-23 |
| WO2000063237A2 (en) | 2000-10-26 |
| US20040067879A1 (en) | 2004-04-08 |
| DE60038735T2 (de) | 2009-07-02 |
| ES2304954T3 (es) | 2008-11-01 |
| ATE393773T1 (de) | 2008-05-15 |
| US6793925B2 (en) | 2004-09-21 |
| NO20014937L (no) | 2001-12-13 |
| DK1173471T3 (da) | 2008-08-18 |
| HUP0200896A2 (en) | 2002-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 8O COMBINADO COM ART. 13 E ART. 10 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |