BR0010014A - Composição farmacêutica compreendendo um inositol e um ìon de metal para melhorar sensibilidade à insulina e metabolismo de glucose - Google Patents
Composição farmacêutica compreendendo um inositol e um ìon de metal para melhorar sensibilidade à insulina e metabolismo de glucoseInfo
- Publication number
- BR0010014A BR0010014A BR0010014-5A BR0010014A BR0010014A BR 0010014 A BR0010014 A BR 0010014A BR 0010014 A BR0010014 A BR 0010014A BR 0010014 A BR0010014 A BR 0010014A
- Authority
- BR
- Brazil
- Prior art keywords
- inositol
- metal ion
- insulin sensitivity
- glucose metabolism
- pharmaceutical composition
- Prior art date
Links
- CDAISMWEOUEBRE-UHFFFAOYSA-N inositol Chemical compound OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 5
- 206010022489 Insulin Resistance Diseases 0.000 title abstract 3
- 230000004153 glucose metabolism Effects 0.000 title abstract 3
- 229910021645 metal ion Inorganic materials 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
- 229960000367 inositol Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 abstract 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- -1 D-chiro-inositol Chemical compound 0.000 abstract 1
- DSCFFEYYQKSRSV-KLJZZCKASA-N D-pinitol Chemical compound CO[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-KLJZZCKASA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 229910052720 vanadium Inorganic materials 0.000 abstract 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA COMPREENDENDO UM INOSITOL E UM ìON DE METAL PARA MELHORAR SENSIBILIDADE à INSULINA E METABOLISMO DE GLUCOSE". A presente invenção refere-se a composições e métodos para aumentar a sensibilidade à insulina e/ ou aumentar o metabolismo de glucose em mamíferos, particularmente humanos. As composições da presente invenção contêm (i) uma fonte de um íon de metal polivalente, como magnésio, manganês, cromo, vanádio e zinco, e (ii) um inositol, como D-quiro-inositol, ou um derivado ou metabólito de um inositol, como D-3-O-metil-quiro-inositol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13123199P | 1999-04-27 | 1999-04-27 | |
| PCT/US2000/011196 WO2000064454A2 (en) | 1999-04-27 | 2000-04-27 | Pharmaceutical composition comprising an inositol and a metal ion for improving insulin sensitivity and glucose metabolism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010014A true BR0010014A (pt) | 2002-01-15 |
Family
ID=22448518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010014-5A BR0010014A (pt) | 1999-04-27 | 2000-04-27 | Composição farmacêutica compreendendo um inositol e um ìon de metal para melhorar sensibilidade à insulina e metabolismo de glucose |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1173188A2 (pt) |
| JP (1) | JP2002542295A (pt) |
| AU (1) | AU4802800A (pt) |
| BR (1) | BR0010014A (pt) |
| CA (1) | CA2371055A1 (pt) |
| WO (1) | WO2000064454A2 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2374269C (en) | 1999-05-20 | 2007-04-24 | Humanetics Corporation | Stimulating transport of glucose into animal tissue by the administration of pinitol |
| AU2002232471A1 (en) * | 2000-10-31 | 2002-05-15 | Nutrition 21, Inc. | Methods and compositions for the treatment of polycystic ovary syndrome with chromium complexes |
| ITMI20110445A1 (it) * | 2011-03-22 | 2012-09-23 | Lo Li Pharma Srl | Formulazione farmaceutica comprendente inositolo. |
| CN106659739B (zh) | 2014-08-08 | 2021-06-18 | 雀巢产品有限公司 | 维生素d和锌的组合产品及其用途 |
| JP7127978B2 (ja) * | 2017-11-01 | 2022-08-30 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7127979B2 (ja) * | 2017-11-01 | 2022-08-30 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| JP7450324B2 (ja) * | 2017-11-01 | 2024-03-15 | 小林製薬株式会社 | Ｄ－ｃｈｉｒｏ－イノシトールを含む組成物 |
| CN111812318A (zh) * | 2020-06-28 | 2020-10-23 | 蒋松 | 血液肌醇作为糖尿病肾病患者肾脏预后诊断标志物的新用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308627A (en) * | 1990-08-07 | 1994-05-03 | Umbdenstock Jr Anthony J | Nutritional supplement for optimizing cellular health |
| TW282398B (pt) * | 1993-12-22 | 1996-08-01 | Bristol Myers Squibb Co |
-
2000
- 2000-04-27 BR BR0010014-5A patent/BR0010014A/pt not_active Application Discontinuation
- 2000-04-27 AU AU48028/00A patent/AU4802800A/en not_active Abandoned
- 2000-04-27 WO PCT/US2000/011196 patent/WO2000064454A2/en not_active Ceased
- 2000-04-27 CA CA002371055A patent/CA2371055A1/en not_active Abandoned
- 2000-04-27 JP JP2000613445A patent/JP2002542295A/ja not_active Withdrawn
- 2000-04-27 EP EP00930159A patent/EP1173188A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2371055A1 (en) | 2000-11-02 |
| WO2000064454A2 (en) | 2000-11-02 |
| WO2000064454A3 (en) | 2001-04-12 |
| AU4802800A (en) | 2000-11-10 |
| WO2000064454A9 (en) | 2002-04-04 |
| EP1173188A2 (en) | 2002-01-23 |
| JP2002542295A (ja) | 2002-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |