BRPI0512352A - 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas - Google Patents

3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas

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Publication number
BRPI0512352A
BRPI0512352A BRPI0512352-6A BRPI0512352A BRPI0512352A BR PI0512352 A BRPI0512352 A BR PI0512352A BR PI0512352 A BRPI0512352 A BR PI0512352A BR PI0512352 A BRPI0512352 A BR PI0512352A
Authority
BR
Brazil
Prior art keywords
chemokine receptor
receptor modulators
aminocyclopentanecarboxamides
compounds
modulators
Prior art date
Application number
BRPI0512352-6A
Other languages
English (en)
Inventor
Chu-Biao Xue
Changsheng Zheng
Hao Feng
Michael Xia
Joseph Glenn
Ganfeng Cao
Brian W Metcalf
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of BRPI0512352A publication Critical patent/BRPI0512352A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
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  • Hematology (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

3-AMINOCILOPENTANOCARBOXAMIDAS COMO MODULADORES DE RECEPTORES DE QUIMIOCINAS. A presente invenção refere-se a compostos de Fórmula (1) que são moduladores de receptores de quimiocina. Os compostos da invenção, e composições destes, são úteis no tratamento de doenças relacionadas à expressão e/ou atividade de receptor de quimiocina.
BRPI0512352-6A 2004-06-28 2005-06-27 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas BRPI0512352A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58348204P 2004-06-28 2004-06-28
US62437404P 2004-11-01 2004-11-01
PCT/US2005/022793 WO2006004684A2 (en) 2004-06-28 2005-06-27 3-aminocyclopentanecarboxamides as modulators of chemokine receptors

Publications (1)

Publication Number Publication Date
BRPI0512352A true BRPI0512352A (pt) 2008-03-04

Family

ID=35783293

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512352-6A BRPI0512352A (pt) 2004-06-28 2005-06-27 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas

Country Status (21)

Country Link
US (2) US7449467B2 (pt)
EP (1) EP1763351B9 (pt)
JP (2) JP4116670B2 (pt)
KR (1) KR100856156B1 (pt)
AP (1) AP2006003849A0 (pt)
AR (1) AR049559A1 (pt)
AU (1) AU2005260013A1 (pt)
BR (1) BRPI0512352A (pt)
CA (1) CA2571019C (pt)
CR (1) CR8775A (pt)
EA (1) EA011487B1 (pt)
EC (1) ECSP067120A (pt)
ES (1) ES2614117T3 (pt)
GE (1) GEP20094843B (pt)
IL (1) IL179910A0 (pt)
MA (1) MA28680B1 (pt)
MX (1) MXPA06014672A (pt)
NO (1) NO20070487L (pt)
SG (1) SG156691A1 (pt)
TW (1) TW200608966A (pt)
WO (1) WO2006004684A2 (pt)

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Also Published As

Publication number Publication date
TW200608966A (en) 2006-03-16
GEP20094843B (en) 2009-11-25
WO2006004684A8 (en) 2007-01-04
ECSP067120A (es) 2007-01-26
WO2006004684A3 (en) 2006-10-05
SG156691A1 (en) 2009-11-26
EP1763351B9 (en) 2017-05-31
CA2571019A1 (en) 2006-01-12
JP4116670B2 (ja) 2008-07-09
MA28680B1 (fr) 2007-06-01
JP2008504293A (ja) 2008-02-14
ES2614117T3 (es) 2017-05-29
AU2005260013A1 (en) 2006-01-12
WO2006004684A2 (en) 2006-01-12
EP1763351A4 (en) 2009-08-12
US8470827B2 (en) 2013-06-25
US20060004018A1 (en) 2006-01-05
CR8775A (es) 2007-01-04
MXPA06014672A (es) 2007-03-26
CA2571019C (en) 2012-06-05
IL179910A0 (en) 2007-05-15
NO20070487L (no) 2007-03-05
KR100856156B1 (ko) 2008-09-03
AR049559A1 (es) 2006-08-16
EP1763351B1 (en) 2016-11-30
KR20070026660A (ko) 2007-03-08
EA200602242A1 (ru) 2007-04-27
EP1763351A2 (en) 2007-03-21
AP2006003849A0 (en) 2006-12-31
EA011487B1 (ru) 2009-04-28
US20100119503A1 (en) 2010-05-13
JP2008074877A (ja) 2008-04-03
US7449467B2 (en) 2008-11-11

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