BR0010262A - Composição para formar um aerossol, processo de preparação e de aerossolização de uma composição, e, dispositivo gerador de aerossol - Google Patents

Composição para formar um aerossol, processo de preparação e de aerossolização de uma composição, e, dispositivo gerador de aerossol

Info

Publication number
BR0010262A
BR0010262A BR0010262-8A BR0010262A BR0010262A BR 0010262 A BR0010262 A BR 0010262A BR 0010262 A BR0010262 A BR 0010262A BR 0010262 A BR0010262 A BR 0010262A
Authority
BR
Brazil
Prior art keywords
composition
aerosol
active ingredient
aerosolizing
preparing
Prior art date
Application number
BR0010262-8A
Other languages
English (en)
Inventor
Rachel M Thurston
Praful K Shah
Michael E Placke
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of BR0010262A publication Critical patent/BR0010262A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/0255—Discharge apparatus, e.g. electrostatic spray guns spraying and depositing by electrostatic forces only

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSIçãO PARA FORMAR UM AEROSSOL PROCESSO DE PREPARAçãO E DE AEROSSOLIZAçãO DE UMA COMPOSIçãO, E, DISPOSITIVO GERADOR DE AEROSSOL". Uma composição usada em combinação com um dispositivo eletro-hidrodinâmico capaz de fornecer um ingrediente ativo ao sistema aerodigestivo do usuário. A composição compreende três ou opcionalmente quatro componentes básicos; um ingrediente ativo; um material veículo no qual o ingrediente ativo pode ser dissolvido, suspenso, ou emulsificado; um material ajustador de propriedades de aerossol que proporciona a composição com as características físicas requeridas para formar uma nuvem de aerossol por meio eletrostático ou eletro-hidrodinâmico; e opcionalmente pelo menos um excipiente que adicionalmente ajusta, conserva, estabiliza, ou intensifica o desempenho da composição.
BR0010262-8A 1999-05-03 2000-05-02 Composição para formar um aerossol, processo de preparação e de aerossolização de uma composição, e, dispositivo gerador de aerossol BR0010262A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13221599P 1999-05-03 1999-05-03
PCT/US2000/011799 WO2000066206A2 (en) 1999-05-03 2000-05-02 Compositions for aerosolization and inhalation

Publications (1)

Publication Number Publication Date
BR0010262A true BR0010262A (pt) 2002-01-15

Family

ID=22453000

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010262-8A BR0010262A (pt) 1999-05-03 2000-05-02 Composição para formar um aerossol, processo de preparação e de aerossolização de uma composição, e, dispositivo gerador de aerossol

Country Status (11)

Country Link
US (1) US6503481B1 (pt)
EP (1) EP1173245B1 (pt)
JP (1) JP2002543165A (pt)
AT (1) ATE274955T1 (pt)
AU (1) AU4979700A (pt)
BR (1) BR0010262A (pt)
CA (1) CA2370853C (pt)
DE (1) DE60013425T2 (pt)
ES (1) ES2226843T3 (pt)
MX (1) MXPA01011283A (pt)
WO (1) WO2000066206A2 (pt)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
AU2001226029A1 (en) * 2000-01-10 2001-07-24 Dura Pharmaceuticals, Inc. Pharmaceutical formulation and method for pulmonary and oral delivery
US6849257B2 (en) 2000-02-04 2005-02-01 Children's Hospital Research Foundation Lipid hydrolysis therapy for atherosclerosis and related diseases
DE60142043D1 (de) * 2000-04-03 2010-06-17 Battelle Memorial Inst Columbu Ausgabevorrichtungen und flüssigformulierungen
JP2004526674A (ja) * 2000-12-01 2004-09-02 バテル・メモリアル・インスティテュート 液体処方物中における生体分子の安定化のための方法
JP2005501810A (ja) * 2001-03-22 2005-01-20 バテル メモリアル インスティチュート ポリマーおよび懸濁粒子を含有する電気流体力学的噴霧用の液体形成物
WO2002094242A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US7078016B2 (en) 2001-11-21 2006-07-18 Alexza Pharmaceuticals, Inc. Delivery of caffeine through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
ATE415155T1 (de) 2001-05-24 2008-12-15 Alexza Pharmaceuticals Inc Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030157030A1 (en) 2001-11-02 2003-08-21 Insert Therapeutics, Inc. Methods and compositions for therapeutic use of rna interference
WO2003041693A1 (en) 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
AU2002346424A1 (en) * 2001-11-19 2003-06-10 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
EP1578188B1 (en) 2002-10-25 2009-12-30 Battelle Memorial Institute Process for the non-therapeutic treatment of non-human animals
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US6982004B1 (en) 2002-11-26 2006-01-03 Advanced Cardiovascular Systems, Inc. Electrostatic loading of drugs on implantable medical devices
US7849850B2 (en) * 2003-02-28 2010-12-14 Battelle Memorial Institute Nozzle for handheld pulmonary aerosol delivery device
US20040187864A1 (en) * 2003-03-24 2004-09-30 Cindet, Llc Inhalation device and method
US20040234916A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
FR2855069B1 (fr) * 2003-05-22 2006-06-16 Solvay Procede pour la separation d'au moins un compose organique
AU2004317520B2 (en) * 2004-03-10 2011-06-09 Shimoda Biotech (Pty) Ltd Stable injectable diclofenac compositions
KR20050099311A (ko) * 2004-04-09 2005-10-13 에이엔에이치 케어연구소(주) 주사제용 항암제 조성물
CN101098678A (zh) 2004-04-23 2008-01-02 锡德克斯公司 含有磺基烷基醚环糊精的dpi制剂
WO2005115520A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (en) 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
EP1799197A2 (en) 2004-09-14 2007-06-27 Battelle Memorial Institute Highly-aqueous non-respirable aerosols containing biologically-active ingredients method of making and device therefor
JP2008537551A (ja) 2005-03-31 2008-09-18 カランド ファーマシューティカルズ， インコーポレイテッド リボヌクレオチドレダクターゼサブユニット２の阻害剤およびその使用
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
AU2006247077A1 (en) * 2005-05-18 2006-11-23 Pulmatrix Inc. Formulations for alteration of biophysical properties of mucosal lining
US20090297496A1 (en) * 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
WO2007053696A2 (en) 2005-11-01 2007-05-10 Alnylam Pharmaceuticals, Inc. Rnai inhibition of influenza virus replication
WO2007083164A2 (en) * 2006-01-17 2007-07-26 Aerstream Technology Limited Liquid electrostatic spray composition
EP2018224B1 (en) 2006-02-14 2019-03-06 EField Innovations LLC Dissociated discharge ehd sprayer with electric field shield
EP1993611A4 (en) 2006-03-16 2013-05-22 Alnylam Pharmaceuticals Inc RNAi MODULATION OF TGF-BETA AND THERAPEUTIC USES
JP2007254421A (ja) * 2006-03-24 2007-10-04 Canon Inc 吐出用液体、吐出方法、吐出用カートリッジ、吐出装置及び吐出用液体の液滴化方法
CN101489566B (zh) 2006-05-19 2012-04-18 阿尔尼拉姆医药品有限公司 Aha基因的RNAi调控及其治疗性应用
US20090054333A1 (en) * 2006-10-17 2009-02-26 Antonio Giordano Peptide inhibitors of cyclin-dependent kinase activity and uses thereof
US20100143264A1 (en) * 2007-02-01 2010-06-10 Battelle Memorial Institute Compositions for aerosolization of highly conductive solutions
WO2008106646A2 (en) * 2007-03-01 2008-09-04 Introgen Therapeutics, Inc Methods and formulations for topical gene therapy
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
ES2565219T3 (es) 2008-03-17 2016-04-01 Discovery Laboratories, Inc. Adaptador de circuito de ventilación y sistema proximal de administración de aerosol
AU2009232355A1 (en) 2008-04-04 2009-10-08 Calando Pharmaceuticals, Inc. Compositions and use of EPAS1 inhibitors
EP2626098B1 (en) 2008-10-22 2020-08-19 Trudell Medical International Modular aerosol delivery system
MX2011012537A (es) 2009-05-29 2011-12-14 Sumitomo Chemical Co Agente para el tratamiento o prevencion de enfermedades asociadas con actividad de factores neurotroficos.
US20110174304A1 (en) * 2010-01-21 2011-07-21 Triplett Ii Michael D Electrohydrodynamic aerosolization device having a time varying voltage
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
WO2012030645A1 (en) 2010-08-30 2012-03-08 Pulmatrix, Inc. Respirably dry powder comprising calcium lactate, sodium chloride and leucine
CN103200938B (zh) 2010-08-30 2018-07-31 普马特里克斯营业公司 干燥粉末配方及用于治疗肺部疾病的方法
BR112013007304B1 (pt) 2010-09-29 2021-12-14 Pulmatrix, Inc. Pós secos de cátion de metal monovalente para inalação
PT3470057T (pt) 2010-09-29 2021-12-03 Pulmatrix Operating Co Inc Pós secos catiónicos compreendendo sais de magnésio
WO2012090683A1 (en) * 2010-12-28 2012-07-05 Sumitomo Chemical Company, Limited Method of treating target space, and liquid particles
AU2011265562A1 (en) 2011-01-12 2012-07-26 Sumitomo Chemical Company, Limited Method of controlling harmful arthropod, composition, and electrostatic spray device
US20120302954A1 (en) * 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
JP2013070767A (ja) * 2011-09-27 2013-04-22 Panasonic Corp 機能性微粒子放出装置
CN107233569B (zh) 2011-10-25 2021-08-31 普罗西纳生物科学有限公司 抗体制剂和方法
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
AU2014248455B2 (en) 2013-04-01 2018-12-06 Pulmatrix Operating Company, Inc. Tiotropium dry powders
US9802010B2 (en) * 2013-11-22 2017-10-31 Noveome Biotherapeutics, Inc. Interproximal drug delivery device
PL3104853T3 (pl) 2014-02-10 2020-05-18 Respivant Sciences Gmbh Leczenie stabilizatorami komórek tucznych zaburzeń ogólnoustrojowych
ES2792682T3 (es) 2014-02-10 2020-11-11 Respivant Sciences Gmbh Métodos para el tratamiento de enfermedades pulmonares con estabilizadores de mastocitos
NZ728487A (en) * 2014-08-08 2021-07-30 Shenzhen Hightide Biopharmaceutical Ltd Liquid formulation compositions, medicament delivery devices, and methods of preparation and use thereof
WO2016145075A1 (en) 2015-03-11 2016-09-15 Alexza Pharmaceuticals, Inc. Use of antistatic materials in the airway for thermal aerosol condensation process
GB201509820D0 (en) * 2015-05-06 2015-07-22 Nicoventures Holdings Ltd Aerosol delivery device
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2018044942A1 (en) 2016-08-31 2018-03-08 Patara Pharma, LLC Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
EP3522983A4 (en) 2016-10-07 2020-06-03 Respivant Sciences GmbH CROMOLYN COMPOSITION FOR TREATING LUNG FIBROSIS
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
WO2022173689A1 (en) 2021-02-09 2022-08-18 University Of Georgia Research Foundation, Inc. Human monoclonal antibodies against pneumococcal antigens
EP4507720A1 (en) 2022-04-14 2025-02-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Alpha-1-antitrypsin for treating paramyxoviridae or orthomyxoviridae infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152446B1 (en) 1983-08-18 1988-12-21 Imperial Chemical Industries Plc Electrostatic spraying process and apparatus
GB8604328D0 (en) * 1986-02-21 1986-03-26 Ici Plc Producing spray of droplets of liquid
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US6105571A (en) 1992-12-22 2000-08-22 Electrosols, Ltd. Dispensing device
GB9226717D0 (en) 1992-12-22 1993-02-17 Coffee Ronald A Induction-operated electro-hydrodynamic spray device with means of modifying droplet trajectories
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
GB9406255D0 (en) * 1994-03-29 1994-05-18 Electrosols Ltd Dispensing device
GB2327895B (en) 1997-08-08 2001-08-08 Electrosols Ltd A dispensing device
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
GB2334461B (en) 1998-02-20 2002-01-23 Bespak Plc Inhalation apparatus
FR2776538B1 (fr) 1998-03-27 2000-07-21 Centre Nat Rech Scient Moyens de pulverisation electrohydrodynamique
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method

Also Published As

Publication number Publication date
JP2002543165A (ja) 2002-12-17
DE60013425T2 (de) 2005-09-08
WO2000066206A3 (en) 2001-02-08
CA2370853C (en) 2007-07-10
AU4979700A (en) 2000-11-17
MXPA01011283A (es) 2002-11-04
ES2226843T3 (es) 2005-04-01
DE60013425D1 (de) 2004-10-07
EP1173245A2 (en) 2002-01-23
CA2370853A1 (en) 2000-11-09
ATE274955T1 (de) 2004-09-15
WO2000066206A2 (en) 2000-11-09
EP1173245B1 (en) 2004-09-01
US6503481B1 (en) 2003-01-07

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1925 DE 27/11/2007.