BRPI0510119A - formulação para dpi contendo sulfoaquil éter de ciclodextrina - Google Patents

formulação para dpi contendo sulfoaquil éter de ciclodextrina

Info

Publication number
BRPI0510119A
BRPI0510119A BRPI0510119-0A BRPI0510119A BRPI0510119A BR PI0510119 A BRPI0510119 A BR PI0510119A BR PI0510119 A BRPI0510119 A BR PI0510119A BR PI0510119 A BRPI0510119 A BR PI0510119A
Authority
BR
Brazil
Prior art keywords
sae
dpi
formulation
vehicle
active agent
Prior art date
Application number
BRPI0510119-0A
Other languages
English (en)
Inventor
James D Pipkin
Rupert O Zimmerer
Anthony J Hickey
Diane O Thompson
Hugh D C Smyth
Original Assignee
Cydex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cydex Inc filed Critical Cydex Inc
Publication of BRPI0510119A publication Critical patent/BRPI0510119A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

FORMULAçãO PARA DPI CONTENDO SULFOALQUIL éTER DE CICLODEXTRINA. A presente invenção refere-se a uma formulação inalável em pó seco contendo SAE-CD e um agente ativo que é proporcionada. A formulação é adaptada para administração através de um DPI. O SAE-CD serve como um veículo ao invés de como um intensificador de absorção. O tamanho médio de partícula do SAE-CD é grande o bastante para evitar (pelo menos na maioria) depósito pulmonar do mesmo. Após liberação do dispositivo DPI, as partículas contendo SAE-CD se dissociam das partículas contendo agente ativo na cavidade bucal ou garganta, após o que as partículas contendo agente ativo permanecem mais profundas no trato respiratório. As propriedades físico-químicas e morfológicas do SAE-CD são facilmente modificadas para permitir otimização das interações de agente ativo e veículo. Fármacos tendo uma carga eletrostática positiva, neutra ou negativa podem ser distribuídos através do DPI quando SAE-CD é usado como um veículo.
BRPI0510119-0A 2004-04-23 2005-04-22 formulação para dpi contendo sulfoaquil éter de ciclodextrina BRPI0510119A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56489204P 2004-04-23 2004-04-23
PCT/US2005/014010 WO2005104712A2 (en) 2004-04-23 2005-04-22 Dpi formulation containing sulfoalkyl ether cyclodextrin

Publications (1)

Publication Number Publication Date
BRPI0510119A true BRPI0510119A (pt) 2007-09-25

Family

ID=35242136

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510119-0A BRPI0510119A (pt) 2004-04-23 2005-04-22 formulação para dpi contendo sulfoaquil éter de ciclodextrina

Country Status (19)

Country Link
US (4) US8114438B2 (pt)
EP (3) EP2708225B1 (pt)
JP (4) JP2007534693A (pt)
KR (3) KR20120089705A (pt)
CN (1) CN101098678A (pt)
AU (2) AU2005237523A1 (pt)
BR (1) BRPI0510119A (pt)
CA (1) CA2562585A1 (pt)
DK (2) DK3520779T3 (pt)
ES (2) ES2717248T3 (pt)
HU (2) HUE058227T2 (pt)
IL (1) IL178728A0 (pt)
LT (1) LT2708225T (pt)
MX (1) MXPA06012240A (pt)
PL (1) PL2708225T3 (pt)
PT (2) PT3520779T (pt)
RU (1) RU2006141358A (pt)
SI (1) SI2708225T1 (pt)
WO (1) WO2005104712A2 (pt)

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