BR0010794A - Emulsão-veìculo para drogas com fraca solubilidade - Google Patents

Emulsão-veìculo para drogas com fraca solubilidade

Info

Publication number
BR0010794A
BR0010794A BR0010794-8A BR0010794A BR0010794A BR 0010794 A BR0010794 A BR 0010794A BR 0010794 A BR0010794 A BR 0010794A BR 0010794 A BR0010794 A BR 0010794A
Authority
BR
Brazil
Prior art keywords
emulsion
vehicle
drugs
polyethylene glycol
vitamin
Prior art date
Application number
BR0010794-8A
Other languages
English (en)
Inventor
Karel J Lambert
Panayiotis P Constantinides
Steven C Quay
Alexander K Tustian
Original Assignee
Sonus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/317,499 external-priority patent/US6660286B1/en
Application filed by Sonus Pharma Inc filed Critical Sonus Pharma Inc
Publication of BR0010794A publication Critical patent/BR0010794A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"EMULSãO-VEìCULO PARA DROGAS COM FRACA SOLUBILIDADE". é revelada uma emulsão que incorpora um ou mais tocóis, um co-solvente e, estabilizada por tensoativos biocompatíveis, como um veículo ou portador para as drogas terapêuticas, a qual é substancialmente livre de etanol e que pode ser administrada a animais ou humanos através de diversas rotas de administração. Também incluída na emulsão está a vitamina C polietilenoglicolada. Os <244>-tocoferóis polietilenoglicolados incluem subunidades de polietileno glicol anexadas por um diéster do ácido succínico no anel hidroxila da vitamina E, e servem como um tensoativo primário, estabilizador e um solvente secundário em emulsões tocóis.
BR0010794-8A 1999-05-24 2000-05-17 Emulsão-veìculo para drogas com fraca solubilidade BR0010794A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31749599A 1999-05-24 1999-05-24
US09/317,499 US6660286B1 (en) 1997-01-07 1999-05-24 Emulsion vehicle for poorly soluble drugs
US15612899P 1999-09-27 1999-09-27
PCT/US2000/013572 WO2000071163A1 (en) 1999-05-24 2000-05-17 Emulsion vehicle for poorly soluble drugs

Publications (1)

Publication Number Publication Date
BR0010794A true BR0010794A (pt) 2002-06-04

Family

ID=27387807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010794-8A BR0010794A (pt) 1999-05-24 2000-05-17 Emulsão-veìculo para drogas com fraca solubilidade

Country Status (9)

Country Link
EP (1) EP1185301A1 (pt)
JP (1) JP2003500368A (pt)
KR (1) KR20070058028A (pt)
AU (1) AU5273200A (pt)
BR (1) BR0010794A (pt)
CA (1) CA2373994A1 (pt)
MX (1) MXPA01011981A (pt)
TW (1) TWI290052B (pt)
WO (1) WO2000071163A1 (pt)

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Also Published As

Publication number Publication date
WO2000071163A1 (en) 2000-11-30
EP1185301A1 (en) 2002-03-13
KR20070058028A (ko) 2007-06-07
CA2373994A1 (en) 2000-11-30
MXPA01011981A (es) 2003-09-04
JP2003500368A (ja) 2003-01-07
TWI290052B (en) 2007-11-21
AU5273200A (en) 2000-12-12

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