BR0010820A - Combinações farmacêuticas para inibidores de nos - Google Patents

Combinações farmacêuticas para inibidores de nos

Info

Publication number
BR0010820A
BR0010820A BR0010820-0A BR0010820A BR0010820A BR 0010820 A BR0010820 A BR 0010820A BR 0010820 A BR0010820 A BR 0010820A BR 0010820 A BR0010820 A BR 0010820A
Authority
BR
Brazil
Prior art keywords
sleep
dysfunctions
inhibitors
nos
nos inhibitors
Prior art date
Application number
BR0010820-0A
Other languages
English (en)
Inventor
Mario David Saltarelli
John Adams Lowe Iii
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0010820A publication Critical patent/BR0010820A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "COMBINAçõES FARMACêUTICAS PARA INIBIDORES DE NOS". A invenção presente refere-se a novas utilizações farmacêuticas de compostos que possuem atividade como inibidores da sintase de óxido nítrico (NOS). Diz especificamente respeito á utilização de inibidores de NOS, e em especial de inibidores seletivos de NOS neuronal (nNOS), por si sós ou em combinação com outros agentes ativos, em particular, quer antagonistas de receptores SSRI ou NK-1, para o tratamento de disfunções ou estados cujo tratamento possa ser levado a cabo ou facilitado alterando os ritmos circadianos. São exemplos dessas disfunções e estados a cegueira, a obesidade, as disfunções afetivas sazonais, a disfunção bipolar, alterações de fuso horário em viajantes de avião, disfunções de alteração de ritmos de sono diário, situações de privação de sono, para-sonias, disfunções do período MRO do sono, hipersonia, disfunções dos tempos de sonodespertar, narcolepsia e disfunções do sono associadas com o trabalho por turnos ou com horários de trabalho irregulares, enurese nocturna, e síndroma das pernas inquietas.
BR0010820-0A 1999-05-21 2000-03-16 Combinações farmacêuticas para inibidores de nos BR0010820A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13552099P 1999-05-21 1999-05-21
PCT/IB2000/000295 WO2000071107A2 (en) 1999-05-21 2000-03-16 New pharmaceutical combinations for nos inhibitors

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BR0010820A true BR0010820A (pt) 2002-03-05

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JP (1) JP2003523941A (pt)
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AP (1) AP2001002326A0 (pt)
AR (1) AR022640A1 (pt)
AU (1) AU2935300A (pt)
BG (1) BG106208A (pt)
BR (1) BR0010820A (pt)
CA (1) CA2374668A1 (pt)
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TR (1) TR200103351T2 (pt)
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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
WO2004113334A1 (en) 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
JP5443342B2 (ja) 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
EP2152270B1 (en) 2007-06-08 2015-03-04 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
PE20100083A1 (es) 2008-06-05 2010-02-17 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CA3142890A1 (en) * 2019-06-14 2020-12-17 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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HN2000000045A (es) 2001-03-02
IS6126A (is) 2001-10-26
EP1178784A1 (en) 2002-02-13
CO5160295A1 (es) 2002-05-30
NO20015651L (no) 2002-01-18
EA200101110A1 (ru) 2002-08-29
BG106208A (en) 2002-09-30
DZ3041A1 (fr) 2004-03-27
PE20010157A1 (es) 2001-02-16
HUP0301287A2 (hu) 2003-08-28
ZA200109555B (en) 2004-04-07
CN1617743A (zh) 2005-05-18
TNSN00106A1 (fr) 2005-11-10
AP2001002326A0 (en) 2001-12-31
WO2000071107A8 (en) 2002-01-24
CA2374668A1 (en) 2000-11-30
OA11943A (en) 2006-04-12
EE200100611A (et) 2003-02-17
UY26148A1 (es) 2000-12-29
IL145955A0 (en) 2002-07-25
JP2003523941A (ja) 2003-08-12
WO2000071107A2 (en) 2000-11-30
PL358538A1 (en) 2004-08-09
KR20020010916A (ko) 2002-02-06
MXPA01011978A (es) 2002-05-06
AR022640A1 (es) 2002-09-04
HRP20010862A2 (en) 2003-06-30
PA8494601A1 (es) 2002-08-29
TR200103351T2 (tr) 2002-06-21
MA26732A1 (fr) 2004-12-20
GT200000071A (es) 2001-11-08
NO20015651D0 (no) 2001-11-20
HUP0301287A3 (en) 2005-03-29
SK16602001A3 (sk) 2003-03-04
AU2935300A (en) 2000-12-12

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