BR0010821A - Derivados de benzenossulfonamidas substituìda com cinamoilaminoalquila - Google Patents

Derivados de benzenossulfonamidas substituìda com cinamoilaminoalquila

Info

Publication number
BR0010821A
BR0010821A BR0010821-9A BR0010821A BR0010821A BR 0010821 A BR0010821 A BR 0010821A BR 0010821 A BR0010821 A BR 0010821A BR 0010821 A BR0010821 A BR 0010821A
Authority
BR
Brazil
Prior art keywords
formula
compounds
cinnamoylaminoalkyl
derivatives
relates
Prior art date
Application number
BR0010821-9A
Other languages
English (en)
Other versions
BR0010821B1 (pt
Inventor
Holger Heitsch
Heinrich Christian Englert
Klaus Wirth
Heinz Goegelein
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0010821A publication Critical patent/BR0010821A/pt
Publication of BR0010821B1 publication Critical patent/BR0010821B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE BENZENOSSULFONAMIDAS SUBSTITUìDA COM CINAMOILAMINOALQUILA". A presente invenção refere-se a derivados de benzenossulfonamida substituída com cinamoilaminoalquila de fórmula (I) onde A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y e Z têm os significados indicados nas reivindicações. Os compostos da fórmula (I) são compostos farmacêuticos ativos valiosos que apresentam, por exemplo, ação inibidora sobre canais de potássio sensíveis a ATP no músculo cardíaco e/ou no nervo cardíaco e são adequados, por exemplo, para o tratamento de distúrbios do sistema cardiovascular tais como doença do coração coronário, arritmias, insuficiência cardíaca ou cardiomiopatias, ou para a prevenção do morte cardíaca súbita ou para melhorar a contratilidade reduzida do coração. A invenção refere-se ainda a processos para a preparação dos compostos da fórmula (1), seu uso e preparações farmacêuticas compreendendo os mesmos.
BRPI0010821-9A 1999-05-20 2000-05-06 derivados de benzenossulfonamida substituìda com cinamoilaminoalquila, processo para a sua preparação e respectiva composição farmacêutica. BR0010821B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19923086.2 1999-05-20
DE19923086A DE19923086A1 (de) 1999-05-20 1999-05-20 Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2000/004091 WO2000071513A1 (en) 1999-05-20 2000-05-06 Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives

Publications (2)

Publication Number Publication Date
BR0010821A true BR0010821A (pt) 2002-03-05
BR0010821B1 BR0010821B1 (pt) 2011-07-12

Family

ID=7908577

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0010821-9A BR0010821B1 (pt) 1999-05-20 2000-05-06 derivados de benzenossulfonamida substituìda com cinamoilaminoalquila, processo para a sua preparação e respectiva composição farmacêutica.

Country Status (30)

Country Link
US (1) US6350778B1 (pt)
EP (1) EP1183236B1 (pt)
JP (1) JP4559640B2 (pt)
KR (1) KR100968729B1 (pt)
CN (1) CN1243730C (pt)
AR (1) AR035625A1 (pt)
AT (1) ATE252554T1 (pt)
AU (1) AU771675B2 (pt)
BR (1) BR0010821B1 (pt)
CA (1) CA2374226C (pt)
CZ (1) CZ302943B6 (pt)
DE (2) DE19923086A1 (pt)
DK (1) DK1183236T3 (pt)
EE (1) EE04611B1 (pt)
ES (1) ES2208342T3 (pt)
HK (1) HK1047574B (pt)
HR (1) HRP20010845B1 (pt)
HU (1) HU229041B1 (pt)
IL (2) IL146372A0 (pt)
ME (1) MEP41508A (pt)
MX (1) MXPA01011725A (pt)
NO (1) NO321558B1 (pt)
PL (1) PL201560B1 (pt)
PT (1) PT1183236E (pt)
RS (1) RS50172B (pt)
RU (1) RU2242462C2 (pt)
SK (1) SK287237B6 (pt)
TR (1) TR200103312T2 (pt)
WO (1) WO2000071513A1 (pt)
ZA (1) ZA200109481B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1237185C (zh) * 2003-06-04 2006-01-18 中国科学院上海药物研究所 Sars冠状病毒3cl蛋白酶三维结构模型与抗sars药物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185180B (de) 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1518816C3 (de) 1965-03-24 1975-05-22 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4066639A (en) 1965-05-06 1978-01-03 Hoechst Aktiengesellschaft Benzene-sulfonyl semicarbazides and process for preparing them
DE1545810A1 (de) * 1965-05-06 1969-12-11 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
DE59401361D1 (de) * 1993-02-23 1997-02-06 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4341655A1 (de) 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
JPH0826995A (ja) * 1994-07-22 1996-01-30 Nisshin Flour Milling Co Ltd ベンズイミダゾール誘導体を含有する抗不整脈剤
DE19505397A1 (de) 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832009A1 (de) 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
TR200100692T2 (tr) 1998-09-10 2001-07-23 Aventis Pharma Deutschland Gmbh Otonom sinir sisteminin disfonksiyonlarının önlenmesinde Benzensulfonil (Tiyo) ürelerin kullanımı
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
US6194458B1 (en) * 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
US6632836B1 (en) * 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors

Also Published As

Publication number Publication date
NO20015636D0 (no) 2001-11-19
AU5393300A (en) 2000-12-12
NO321558B1 (no) 2006-05-29
RU2242462C2 (ru) 2004-12-20
DE60006104D1 (de) 2003-11-27
EE200100609A (et) 2003-02-17
SK287237B6 (sk) 2010-04-07
IL146372A0 (en) 2002-07-25
HRP20010845A9 (hr) 2010-06-30
YU81701A (sh) 2004-07-15
DE19923086A1 (de) 2000-11-23
HK1047574A1 (en) 2003-02-28
DE60006104T2 (de) 2004-08-05
KR20020005046A (ko) 2002-01-16
HRP20010845A2 (en) 2003-04-30
DK1183236T3 (da) 2004-02-23
CZ20014149A3 (cs) 2002-03-13
ATE252554T1 (de) 2003-11-15
CA2374226A1 (en) 2000-11-30
ES2208342T3 (es) 2004-06-16
PL201560B1 (pl) 2009-04-30
HK1047574B (zh) 2006-08-04
CN1243730C (zh) 2006-03-01
MXPA01011725A (es) 2002-04-24
BR0010821B1 (pt) 2011-07-12
AR035625A1 (es) 2004-06-23
AU771675B2 (en) 2004-04-01
ZA200109481B (en) 2002-06-25
SK16692001A3 (sk) 2002-04-04
JP2003500388A (ja) 2003-01-07
HU229041B1 (hu) 2013-07-29
US6350778B1 (en) 2002-02-26
HRP20010845B1 (hr) 2010-08-31
KR100968729B1 (ko) 2010-07-08
CA2374226C (en) 2010-08-31
PL351751A1 (en) 2003-06-16
HUP0201906A2 (en) 2002-09-28
RS50172B (sr) 2009-05-06
NO20015636L (no) 2002-01-15
IL146372A (en) 2007-05-15
EP1183236B1 (en) 2003-10-22
EP1183236A1 (en) 2002-03-06
HUP0201906A3 (en) 2005-04-28
JP4559640B2 (ja) 2010-10-13
CZ302943B6 (cs) 2012-01-25
TR200103312T2 (tr) 2002-04-22
CN1360571A (zh) 2002-07-24
PT1183236E (pt) 2004-03-31
MEP41508A (en) 2011-02-10
EE04611B1 (et) 2006-04-17
WO2000071513A1 (en) 2000-11-30

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.