BR0011733A - Vacina de dna-pcv - Google Patents

Vacina de dna-pcv

Info

Publication number
BR0011733A
BR0011733A BR0011733-1A BR0011733A BR0011733A BR 0011733 A BR0011733 A BR 0011733A BR 0011733 A BR0011733 A BR 0011733A BR 0011733 A BR0011733 A BR 0011733A
Authority
BR
Brazil
Prior art keywords
pcv
dna
orf1
orf2
hand
Prior art date
Application number
BR0011733-1A
Other languages
English (en)
Other versions
BRPI0011733B1 (pt
Inventor
Jean-Christophe Franc Audonnet
Michel Bublot
Jennifer Maria Perez
Catherine Elisabeth Charreyre
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Publication of BR0011733A publication Critical patent/BR0011733A/pt
Publication of BRPI0011733B1 publication Critical patent/BRPI0011733B1/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"VACINA DE DNA-PCV". A invenção refere-se a preparações ou vacinas imunogênicas compreendendo, por um lado, um plasmídeo codificando e expressando um gene de PCV, em particular selecionado do grupo consistindo em ORF1 de PCV-2, ORF2 de PCV-2, ORF1 de PCV-1, e ORF2 de PCV-1, e, por outro lado, um elemento capaz de aumentar a resposta imune direcionada contra o produto de expressão do gene, que pode ser um carbómero, uma citocina de porco, por exemplo, GM-CSF ou um lipídeo catiónico da fórmula (I), onde R~ 1~, é um radical alifático linear saturado ou insaturado tendo de a partir de 12 a 18 átomos de carbono, R~ 2~ é um outro radical alifático compreendendo de 2 a 3 átomos de carbono e X é um grupo hidroxila ou amino. O lipídeo catiónico pode ser DMRIE, possivelmente acoplado a DOPE.
BRPI0011733A 1999-06-10 2000-06-08 vacina de dna-pcv BRPI0011733B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13835299P 1999-06-10 1999-06-10
PCT/EP2000/005611 WO2000077188A2 (en) 1999-06-10 2000-06-08 Dna pcv vaccine

Publications (2)

Publication Number Publication Date
BR0011733A true BR0011733A (pt) 2002-07-23
BRPI0011733B1 BRPI0011733B1 (pt) 2017-03-28

Family

ID=22481646

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0011733A BRPI0011733B1 (pt) 1999-06-10 2000-06-08 vacina de dna-pcv

Country Status (19)

Country Link
US (1) US6943152B1 (pt)
EP (1) EP1185659B1 (pt)
JP (2) JP4824233B2 (pt)
KR (1) KR100680924B1 (pt)
CN (1) CN1289674C (pt)
AT (1) ATE319832T1 (pt)
AU (1) AU775375C (pt)
BR (1) BRPI0011733B1 (pt)
CA (1) CA2376523A1 (pt)
DE (1) DE60026515T2 (pt)
DK (1) DK1185659T3 (pt)
ES (1) ES2259605T3 (pt)
HU (1) HUP0201438A3 (pt)
MX (1) MXPA01012722A (pt)
PL (1) PL205643B1 (pt)
PT (1) PT1185659E (pt)
TW (1) TWI267551B (pt)
WO (1) WO2000077188A2 (pt)
ZA (1) ZA200110130B (pt)

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Also Published As

Publication number Publication date
PT1185659E (pt) 2006-05-31
CA2376523A1 (en) 2000-12-21
PL205643B1 (pl) 2010-05-31
EP1185659B1 (en) 2006-03-08
DE60026515D1 (de) 2006-05-04
TWI267551B (en) 2006-12-01
ZA200110130B (en) 2002-07-15
HUP0201438A3 (en) 2004-07-28
KR100680924B1 (ko) 2007-02-08
MXPA01012722A (es) 2002-07-22
BRPI0011733B1 (pt) 2017-03-28
AU775375C (en) 2005-02-24
CN1289674C (zh) 2006-12-13
AU775375B2 (en) 2004-07-29
JP2003502303A (ja) 2003-01-21
DK1185659T3 (da) 2006-07-10
JP5410472B2 (ja) 2014-02-05
EP1185659A2 (en) 2002-03-13
JP4824233B2 (ja) 2011-11-30
PL352199A1 (en) 2003-08-11
US6943152B1 (en) 2005-09-13
CN1376200A (zh) 2002-10-23
WO2000077188A3 (en) 2001-05-31
JP2011207897A (ja) 2011-10-20
KR20020020729A (ko) 2002-03-15
ES2259605T3 (es) 2006-10-16
HUP0201438A2 (en) 2002-08-28
WO2000077188A2 (en) 2000-12-21
ATE319832T1 (de) 2006-03-15
AU5078600A (en) 2001-01-02
DE60026515T2 (de) 2006-11-23

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