BR0012318A - Compostos semelhantes a amino ceramida e métodos terapêuticos de uso - Google Patents
Compostos semelhantes a amino ceramida e métodos terapêuticos de usoInfo
- Publication number
- BR0012318A BR0012318A BR0012318-8A BR0012318A BR0012318A BR 0012318 A BR0012318 A BR 0012318A BR 0012318 A BR0012318 A BR 0012318A BR 0012318 A BR0012318 A BR 0012318A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- amino
- ceramide
- therapeutic methods
- glccer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000002560 therapeutic procedure Methods 0.000 title abstract 3
- HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 abstract 2
- 102000044956 Ceramide glucosyltransferases Human genes 0.000 abstract 2
- -1 amino ceramide Chemical compound 0.000 abstract 2
- 108091000114 ceramide glucosyltransferase Proteins 0.000 abstract 2
- 150000002339 glycosphingolipids Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSTOS SEMELHANTES A AMINO CERAMIDA E MéTODOS TERAPêUTICOS DE USO". São fornecidos novos compostos semelhantes a amino ceramida ( 1 ) que inibem a formação de glicosil ceramida ( GlcCer ) pela inibição da enzima GlcCer sintase, desta forma diminuindo o nível de glicoesfingolipídeos. Os compostos da presente invenção possuem atividade de inibição de GlcCer sintase aumentada e são, desta forma, altamente úteis em métodos terapêuticos para tratamento de várias condições e doenças associadas com níveis alterados de glicoesfingolipídeos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/350,768 US6255336B1 (en) | 1995-09-20 | 1999-07-09 | Amino ceramide-like compounds and therapeutic methods of use |
| PCT/US2000/018935 WO2001004108A1 (en) | 1999-07-09 | 2000-07-07 | Amino ceramide-like compounds and therapeutic methods of use |
| CA002454453A CA2454453A1 (en) | 2000-07-07 | 2003-12-24 | Amino ceramide-like compounds and therapeutic methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012318A true BR0012318A (pt) | 2002-05-28 |
Family
ID=56290039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012318-8A BR0012318A (pt) | 1999-07-09 | 2000-07-07 | Compostos semelhantes a amino ceramida e métodos terapêuticos de uso |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1196406A1 (pt) |
| JP (1) | JP2003521479A (pt) |
| AU (1) | AU774960B2 (pt) |
| BR (1) | BR0012318A (pt) |
| CA (1) | CA2378600A1 (pt) |
| MX (1) | MXPA02000296A (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008519840A (ja) * | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| KR101640263B1 (ko) * | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| US8309593B2 (en) * | 2008-10-03 | 2012-11-13 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| SG10201407881WA (en) * | 2009-11-27 | 2015-01-29 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| CN116239513B (zh) * | 2023-05-05 | 2023-08-18 | 天津凯莱英制药有限公司 | Mmae关键中间体的制备方法、mmae的制备方法和抗体偶联药物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916911A (en) * | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
-
2000
- 2000-07-07 MX MXPA02000296A patent/MXPA02000296A/es unknown
- 2000-07-07 JP JP2001509718A patent/JP2003521479A/ja active Pending
- 2000-07-07 EP EP00945332A patent/EP1196406A1/en not_active Ceased
- 2000-07-07 CA CA002378600A patent/CA2378600A1/en not_active Abandoned
- 2000-07-07 AU AU59296/00A patent/AU774960B2/en not_active Ceased
- 2000-07-07 BR BR0012318-8A patent/BR0012318A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU774960B2 (en) | 2004-07-15 |
| JP2003521479A (ja) | 2003-07-15 |
| AU5929600A (en) | 2001-01-30 |
| MXPA02000296A (es) | 2004-05-21 |
| CA2378600A1 (en) | 2001-01-18 |
| EP1196406A1 (en) | 2002-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |