NO985676L - Forbindelser med colchicinstruktur, deres anvendelse som legemidler og blan - Google Patents

Forbindelser med colchicinstruktur, deres anvendelse som legemidler og blan

Info

Publication number: NO985676L
Authority: NO; Norway
Prior art keywords: pct; drugs; compounds; colchicine; functionalization
Prior art date: 1996-06-07

Application number

NO985676A

Other languages

English (en)

Other versions

NO311252B1 (no

NO985676D0 (no

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-07

Filing date

1998-12-04

Publication date

1998-12-04

1998-12-04 Application filed by Indena Spa filed Critical Indena Spa

1998-12-04 Publication of NO985676L publication Critical patent/NO985676L/no

1998-12-04 Publication of NO985676D0 publication Critical patent/NO985676D0/no

2001-11-05 Publication of NO311252B1 publication Critical patent/NO311252B1/no

Links

IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical group C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 title abstract 3
229940079593 drug Drugs 0.000 title 2
239000003814 drug Substances 0.000 title 2
238000007306 functionalization reaction Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000002634 anti-blastic effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
229960001338 colchicine Drugs 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO19985676A 1996-06-07 1998-12-04 Forbindelser med colchicinstruktur, deres anvendelse, fremstilling av legemidler og blandinger som inneholder dem NO311252B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI001168A IT1283110B1 (it)	1996-06-07	1996-06-07	Composti a scheletro colchicinico,loro uso come farmaci e composizioni che li contengono
PCT/EP1997/002577 WO1997047577A1 (en)	1996-06-07	1997-05-21	Colchicine-skeleton compounds, their use as medicaments and compositions containing them

Publications (3)

Publication Number	Publication Date
NO985676L true NO985676L (no)	1998-12-04
NO985676D0 NO985676D0 (no)	1998-12-04
NO311252B1 NO311252B1 (no)	2001-11-05

Family

ID=11374396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19985676A NO311252B1 (no)	1996-06-07	1998-12-04	Forbindelser med colchicinstruktur, deres anvendelse, fremstilling av legemidler og blandinger som inneholder dem

Country Status (19)

Country	Link
US (1)	US6080739A (no)
EP (1)	EP0906262B1 (no)
JP (1)	JP3285361B2 (no)
KR (1)	KR100306430B1 (no)
CN (1)	CN1122657C (no)
AT (1)	ATE222228T1 (no)
AU (1)	AU723752B2 (no)
CZ (1)	CZ294365B6 (no)
DE (1)	DE69714735T2 (no)
DK (1)	DK0906262T3 (no)
ES (1)	ES2182084T3 (no)
HU (1)	HUP0001827A3 (no)
IT (1)	IT1283110B1 (no)
NO (1)	NO311252B1 (no)
PL (1)	PL187528B1 (no)
PT (1)	PT906262E (no)
RU (1)	RU2181354C2 (no)
SK (2)	SK283736B6 (no)
WO (1)	WO1997047577A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9714249D0 (en) *	1997-07-08	1997-09-10	Angiogene Pharm Ltd	Vascular damaging agents
FR2774290B1 (fr) *	1998-02-05	2000-06-16	Synthelabo	Composition pharmaceutique pour l'administration par voie nasale de thiocolchicoside
GB9900334D0 (en)	1999-01-07	1999-02-24	Angiogene Pharm Ltd	Tricylic vascular damaging agents
IT1318401B1 (it) *	2000-03-17	2003-08-25	Indena Spa	Derivati di n-desacetiltiocolchicina e composizioni farmaceutiche cheli contengono.
US6720323B2 (en)	2000-07-07	2004-04-13	Angiogene Pharmaceuticals Limited	Colchinol derivatives as angiogenesis inhibitors
US6825236B2 (en)	2003-04-14	2004-11-30	California Pacific Medical Center	Colchicine derivatives
ITMI20040164A1 (it) *	2004-02-03	2004-05-03	Indena Spa	Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
JP2008524267A (ja) *	2004-12-22	2008-07-10	メステックスアクチェンゲゼルシャフト	バニロイド受容体作用薬と神経再生物質阻害物質との混合物、鎮痛薬を生成するためのそれらの使用、および該鎮痛薬を適用する方法
ITRM20070088A1 (it)	2007-02-19	2008-08-20	Francesco Fringuelli	Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico.
US20110178180A1 (en) *	2010-01-18	2011-07-21	Kurt Nielsen	Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
KR101343443B1 (ko) *	2010-02-18	2013-12-19	재단법인 아산사회복지재단	콜키친 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
KR101130754B1 (ko) *	2010-06-25	2012-03-28	제일약품주식회사	난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL279678A (no) *	1961-06-14
US3442953A (en) *	1963-06-19	1969-05-06	Roussel Uclaf	Novel 7-oxo-7-desacetylaminocolchicine compounds
FR3032M (fr) *	1963-06-19	1964-12-28	Roussel Uclaf	Nouveaux médicaments doués notamment d'activité antimitotique.
US4349548A (en) *	1981-11-20	1982-09-14	Merck & Co., Inc.	Octahydrobenzo[6,7]cyclohept[1,2-b]-1,4-oxazines, compositions and use

1996
- 1996-06-07 IT IT96MI001168A patent/IT1283110B1/it active IP Right Grant
1997
- 1997-05-21 AU AU30278/97A patent/AU723752B2/en not_active Ceased
- 1997-05-21 WO PCT/EP1997/002577 patent/WO1997047577A1/en not_active Ceased
- 1997-05-21 DE DE69714735T patent/DE69714735T2/de not_active Expired - Lifetime
- 1997-05-21 US US09/180,875 patent/US6080739A/en not_active Expired - Fee Related
- 1997-05-21 CZ CZ19984010A patent/CZ294365B6/cs not_active IP Right Cessation
- 1997-05-21 PT PT97924965T patent/PT906262E/pt unknown
- 1997-05-21 EP EP97924965A patent/EP0906262B1/en not_active Expired - Lifetime
- 1997-05-21 JP JP50110898A patent/JP3285361B2/ja not_active Expired - Fee Related
- 1997-05-21 SK SK1679-98A patent/SK283736B6/sk not_active IP Right Cessation
- 1997-05-21 PL PL97330284A patent/PL187528B1/pl not_active IP Right Cessation
- 1997-05-21 KR KR1019980709961A patent/KR100306430B1/ko not_active Expired - Fee Related
- 1997-05-21 DK DK97924965T patent/DK0906262T3/da active
- 1997-05-21 SK SK41-2003A patent/SK283737B6/sk not_active IP Right Cessation
- 1997-05-21 AT AT97924965T patent/ATE222228T1/de not_active IP Right Cessation
- 1997-05-21 CN CN97194988A patent/CN1122657C/zh not_active Expired - Fee Related
- 1997-05-21 RU RU99100326/04A patent/RU2181354C2/ru not_active IP Right Cessation
- 1997-05-21 ES ES97924965T patent/ES2182084T3/es not_active Expired - Lifetime
- 1997-05-21 HU HU0001827A patent/HUP0001827A3/hu unknown
1998
- 1998-12-04 NO NO19985676A patent/NO311252B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20000016387A (ko)	2000-03-25
NO311252B1 (no)	2001-11-05
SK283736B6 (sk)	2003-12-02
WO1997047577A1 (en)	1997-12-18
PT906262E (pt)	2002-11-29
EP0906262A1 (en)	1999-04-07
ITMI961168A0 (it)	1996-06-07
ES2182084T3 (es)	2003-03-01
CZ401098A3 (cs)	1999-05-12
DE69714735T2 (de)	2003-04-24
CN1219924A (zh)	1999-06-16
ITMI961168A1 (it)	1997-12-07
US6080739A (en)	2000-06-27
ATE222228T1 (de)	2002-08-15
DE69714735D1 (de)	2002-09-19
EP0906262B1 (en)	2002-08-14
RU2181354C2 (ru)	2002-04-20
CN1122657C (zh)	2003-10-01
JP2000503669A (ja)	2000-03-28
AU723752B2 (en)	2000-09-07
IT1283110B1 (it)	1998-04-07
NO985676D0 (no)	1998-12-04
DK0906262T3 (da)	2002-12-16
PL187528B1 (pl)	2004-07-30
HUP0001827A2 (hu)	2001-05-28
SK283737B6 (sk)	2003-12-02
HK1019587A1 (en)	2000-02-18
HUP0001827A3 (en)	2001-07-30
AU3027897A (en)	1998-01-07
JP3285361B2 (ja)	2002-05-27
CZ294365B6 (cs)	2004-12-15
SK167998A3 (en)	1999-07-12
KR100306430B1 (ko)	2001-11-30
PL330284A1 (en)	1999-05-10

Legal Events

Date	Code	Title	Description
2011-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
PT672041E (pt)	2002-04-29	Derivados da piridina farmacologicamente activos e processos para a sua preparacao
DK0871606T3 (da)	2000-07-31	Nye forbindelser og deres præparat med anti-inflammatorisk og anti-thrombotisk aktivitet
NO981944D0 (no)	1998-04-29	Lipopolyaminer som transfeksjonsmidler samt farmas÷ytisk anvendelse derav
BR0109161A (pt)	2002-11-26	Beta-carbolinas substituìdas com atividade de inibição de ikb-quinase
MX9504332A (es)	1997-03-29	Derivados de amino(tio)eter y procedimiento para su preparacion.
BR9911160A (pt)	2001-04-03	Ciclosporinas
IT1312377B1 (it)	2002-04-15	Composizioni a base di acido tiottico, cisteina e/o n-acetil cisteinada utilizzarsi in preparazioni farmaceutiche, dietetiche e cosmetiche
NO985676L (no)	1998-12-04	Forbindelser med colchicinstruktur, deres anvendelse som legemidler og blan
BR0109703A (pt)	2003-02-04	Derivados de piperazina
BR9814375A (pt)	2002-05-21	Inibição de raf cinase usando difenil uréias substituìdas simétricas e assimétricas
NO992282D0 (no)	1999-05-11	Benzonaftyridiner som bronkialterapentika
SE9401728D0 (sv)	1994-05-18	New compounds II
BR9811099A (pt)	2002-05-14	Inibidores de urocinase
BR9610480A (pt)	1999-03-16	Inibição do fator alfa de necrose tumoral
DK0804437T3 (da)	2005-11-14	[a]-Annelerede pyrrolderivater og deres anvendelse i farmacien
BR0113590A (pt)	2003-07-22	7-oxo-piridopirimidinas
BRPI0411176A (pt)	2006-07-18	combinação farmacêutica consistindo de modafinil e outra droga
BR9905089A (pt)	2000-08-08	Derivados macrolìdeos
BR9803233A (pt)	2000-05-02	Preparação de combinação farmacêutica de um inibidor do trocador de sódio/hidrogênio e um medicamento para o tratamento de doenças cardiovasculares.
BR0113148A (pt)	2003-07-08	Composições de 2-piridinamina e métodos relacionados
NO995685D0 (no)	1999-11-19	Nye glycosylerte ginkgolidderivater, anvendelse derav som medikamenter og farmasöytiske blandinger
DK0634396T3 (da)	1999-07-05	Aminosyrederivater og deres anvendelse som enkeltfalinaseinhibitorer
AU3862997A (en)	1998-02-20	Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
SE9504662D0 (sv)	1995-12-22	New compounds
SE9802538D0 (sv)	1998-07-13	New pharmaceutically active compounds