BR0013276A - Formulação farmacêutica para uso parenteral que compreende fosfato de estramustina, como ingrediente ativo - Google Patents
Formulação farmacêutica para uso parenteral que compreende fosfato de estramustina, como ingrediente ativoInfo
- Publication number
- BR0013276A BR0013276A BR0013276-4A BR0013276A BR0013276A BR 0013276 A BR0013276 A BR 0013276A BR 0013276 A BR0013276 A BR 0013276A BR 0013276 A BR0013276 A BR 0013276A
- Authority
- BR
- Brazil
- Prior art keywords
- active ingredient
- pharmaceutical formulation
- parenteral use
- estramustine phosphate
- phosphate
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 229960004750 estramustine phosphate Drugs 0.000 title abstract 2
- ADFOJJHRTBFFOF-RBRWEJTLSA-N estramustine phosphate Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)OP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 ADFOJJHRTBFFOF-RBRWEJTLSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"FORMULAçãO FARMACêUTICA PARA USO PARENTERAL QUE COMPREENDE FOSFATO DE ESTRAMUSTINA, COM INGREDIENTE ATIVO". Onde a proporção em peso é conforme descrita no relatório descritivo, útil na terapia antitumor, para ser administrada de acordo com um regime quimioterapêutico associado com um ou mais agentes quimioterapêuticos. Tal formulação possibilita a administração de fosfato de estramustina ausente de efeitos colaterais no local da injeção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9918779.1A GB9918779D0 (en) | 1999-08-09 | 1999-08-09 | Formulations for parenteral use of estramustine phosphate and albumin |
| IT1999MI001998 IT1313629B1 (it) | 1999-09-27 | 1999-09-27 | Formulazioni di estramustina fosfato ed albumina per uso parenterale |
| PCT/EP2000/007678 WO2001010446A2 (en) | 1999-08-09 | 2000-08-03 | Formulations for parenteral use of estramustine phosphate and albumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0013276A true BR0013276A (pt) | 2004-08-03 |
Family
ID=26315835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0013276-4A BR0013276A (pt) | 1999-08-09 | 2000-08-03 | Formulação farmacêutica para uso parenteral que compreende fosfato de estramustina, como ingrediente ativo |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1206266A2 (pt) |
| JP (1) | JP2003506408A (pt) |
| KR (1) | KR20020019967A (pt) |
| CN (1) | CN1511037A (pt) |
| AU (1) | AU6280900A (pt) |
| BR (1) | BR0013276A (pt) |
| CA (1) | CA2380312A1 (pt) |
| CZ (1) | CZ2002376A3 (pt) |
| EA (1) | EA200200234A1 (pt) |
| HU (1) | HUP0202645A3 (pt) |
| IL (1) | IL147745A0 (pt) |
| MX (1) | MXPA02001395A (pt) |
| NO (1) | NO20020631D0 (pt) |
| NZ (1) | NZ517632A (pt) |
| PL (1) | PL353406A1 (pt) |
| SK (1) | SK1782002A3 (pt) |
| WO (1) | WO2001010446A2 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100426450B1 (ko) * | 2002-03-16 | 2004-04-13 | 박래옥 | 구연산, 알부민 및 아연을 함유한 항암 조성물 |
| CN103405405A (zh) * | 2002-12-09 | 2013-11-27 | 阿布拉西斯生物科学有限责任公司 | 组合物和传递药剂的方法 |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| BRPI0408978B8 (pt) | 2003-04-08 | 2021-07-27 | Novo Nordisk As | processos para regenerar uma fase estacionária cromatográfica |
| WO2004089985A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Stable pharmaceutical compositions |
| DE102006024528A1 (de) * | 2006-05-23 | 2007-11-29 | Albupharm Heidelberg Gmbh & Co. Kg | Neue, an der Tumorphysiologie orientierte Formulierung eines Zytostatikums, insbesondere von cis-Platin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59108800A (ja) * | 1982-12-13 | 1984-06-23 | Japan Atom Energy Res Inst | 誘導ミサイル作用および制癌剤の徐放性機能をもつ微粒子 |
| US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
-
2000
- 2000-08-03 CZ CZ2002376A patent/CZ2002376A3/cs unknown
- 2000-08-03 JP JP2001514963A patent/JP2003506408A/ja not_active Withdrawn
- 2000-08-03 MX MXPA02001395A patent/MXPA02001395A/es unknown
- 2000-08-03 IL IL14774500A patent/IL147745A0/xx unknown
- 2000-08-03 NZ NZ517632A patent/NZ517632A/en unknown
- 2000-08-03 SK SK178-2002A patent/SK1782002A3/sk unknown
- 2000-08-03 CN CNA008114420A patent/CN1511037A/zh active Pending
- 2000-08-03 EP EP00949471A patent/EP1206266A2/en not_active Withdrawn
- 2000-08-03 KR KR1020027001700A patent/KR20020019967A/ko not_active Withdrawn
- 2000-08-03 AU AU62809/00A patent/AU6280900A/en not_active Abandoned
- 2000-08-03 HU HU0202645A patent/HUP0202645A3/hu unknown
- 2000-08-03 WO PCT/EP2000/007678 patent/WO2001010446A2/en not_active Ceased
- 2000-08-03 CA CA002380312A patent/CA2380312A1/en not_active Abandoned
- 2000-08-03 PL PL00353406A patent/PL353406A1/xx not_active Application Discontinuation
- 2000-08-03 BR BR0013276-4A patent/BR0013276A/pt not_active IP Right Cessation
- 2000-08-03 EA EA200200234A patent/EA200200234A1/ru unknown
-
2002
- 2002-02-08 NO NO20020631A patent/NO20020631D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK1782002A3 (en) | 2002-05-09 |
| IL147745A0 (en) | 2002-08-14 |
| NO20020631L (no) | 2002-02-08 |
| KR20020019967A (ko) | 2002-03-13 |
| HUP0202645A3 (en) | 2004-06-28 |
| EA200200234A1 (ru) | 2002-06-27 |
| HUP0202645A2 (hu) | 2002-12-28 |
| AU6280900A (en) | 2001-03-05 |
| NZ517632A (en) | 2004-02-27 |
| CA2380312A1 (en) | 2001-02-15 |
| CZ2002376A3 (cs) | 2002-06-12 |
| PL353406A1 (en) | 2003-11-17 |
| WO2001010446A2 (en) | 2001-02-15 |
| EP1206266A2 (en) | 2002-05-22 |
| JP2003506408A (ja) | 2003-02-18 |
| MXPA02001395A (es) | 2002-08-12 |
| NO20020631D0 (no) | 2002-02-08 |
| WO2001010446A3 (en) | 2001-05-25 |
| CN1511037A (zh) | 2004-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |