BR0014183A - Composições farmaceuticas e metodos de uso de proteìna relacionada frizzled secretada - Google Patents

Composições farmaceuticas e metodos de uso de proteìna relacionada frizzled secretada

Info

Publication number
BR0014183A
BR0014183A BR0014183-6A BR0014183A BR0014183A BR 0014183 A BR0014183 A BR 0014183A BR 0014183 A BR0014183 A BR 0014183A BR 0014183 A BR0014183 A BR 0014183A
Authority
BR
Brazil
Prior art keywords
methods
pharmaceutical compositions
secreted
related protein
sfrps
Prior art date
Application number
BR0014183-6A
Other languages
English (en)
Inventor
Peter V N Bodine
Original Assignee
American Home Pruducts Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Pruducts Corp filed Critical American Home Pruducts Corp
Publication of BR0014183A publication Critical patent/BR0014183A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: "COMPOSIçõES FARMACEUTICAS E MéTODOS DE USO DE PROTEìNA RELACIONADA FRIZZLED SECRETADA". São apresentadas composições farmacêuticas e métodos de uso na regulação de atividades de formação óssea em mamíferos, da SFRPs (proteínas relacionadas frizzied secretadas). As SFRPs são receptores secretados para Wnts, que são fatores de crescimento polipeptídicos importantes, que, como se conhece, regulam os processos biológicos fundamentais como polaridade tecidual, desenvolvimento embriónico e tumorigênese. Uma SFRP foi isolada em células de osteoblastos humanos e identificadas como SFRP-1 (também conhecida como SARP-2) e apresentada como sendo regulada por agentes osteogênicos nas células hOB de uma maneira seletiva de diferenciação modulando a vida de osteoblastos/pré-osteócitos.
BR0014183-6A 1999-09-13 2000-09-13 Composições farmaceuticas e metodos de uso de proteìna relacionada frizzled secretada BR0014183A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39483299A 1999-09-13 1999-09-13
PCT/US2000/025035 WO2001019855A2 (en) 1999-09-13 2000-09-13 Pharmaceutical compositions and methods of using secreted frizzled related protein

Publications (1)

Publication Number Publication Date
BR0014183A true BR0014183A (pt) 2002-05-14

Family

ID=23560597

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014183-6A BR0014183A (pt) 1999-09-13 2000-09-13 Composições farmaceuticas e metodos de uso de proteìna relacionada frizzled secretada

Country Status (11)

Country Link
EP (1) EP1212355A2 (pt)
JP (1) JP2003512304A (pt)
CN (2) CN102988957A (pt)
AU (1) AU7131200A (pt)
BR (1) BR0014183A (pt)
CA (1) CA2383360A1 (pt)
CZ (1) CZ2002903A3 (pt)
IL (1) IL148421A0 (pt)
MX (1) MXPA02002624A (pt)
NZ (1) NZ529560A (pt)
WO (1) WO2001019855A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064949A2 (en) 2000-02-29 2001-09-07 Alcon Laboratories, Inc. Diagnostics and therapeutics for glaucoma
US6600018B1 (en) 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
EP1318840A2 (en) * 2000-07-19 2003-06-18 Genzyme Corporation PHOSPHATONIN-RELATED GENE AND i METHODS OF USE THEREOF /i
ATE550345T1 (de) * 2001-01-10 2012-04-15 Us Health Sfrp, mit sfrp-interagierende peptidmotive sowie verwendungsverfahren
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US20040265808A1 (en) * 2001-04-05 2004-12-30 Teresa Garcia Genes involved in osteogenesis, and methods of use
US7713526B2 (en) 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
AU2002308557A1 (en) 2001-05-01 2002-11-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
GB0111004D0 (en) * 2001-05-04 2001-06-27 Univ Sheffield Screening method
US20060281179A1 (en) * 2001-11-15 2006-12-14 Yoshiki Sasai Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof
CA2507496C (en) * 2002-12-05 2014-11-04 John D. Shaughnessy Molecular determinants of myeloma bone disease and uses thereof
WO2004090161A1 (en) * 2003-04-14 2004-10-21 Novartis Ag Gene expression associated with osteoblast differentiation
CN104726460A (zh) * 2013-12-22 2015-06-24 上海交通大学医学院 蛋白sFRP-5在治疗银屑病的药物中的应用
CN107073117A (zh) * 2014-08-26 2017-08-18 埃塔根有限公司 用于识别wls蛋白特定基序的抗体和含有其的药物组合物
EP3696192A1 (en) * 2019-02-15 2020-08-19 Consejo Superior De Investigaciones Científicas Therapeutic target and monoclonal antibodies against it for the diagnosis and treatment of alzheimer´s disease
CN110361541A (zh) * 2019-07-23 2019-10-22 上海交通大学医学院附属瑞金医院 sFRP2和PCPE1作为联合靶点在制备纤维化疾病药物中的应用
CN114910454B (zh) * 2022-04-14 2025-06-13 中国人民解放军总医院第一医学中心 一种检测微重力条件下雄激素受体功能的方法
CN120714006A (zh) * 2025-07-11 2025-09-30 昆明理工大学 分泌型卷曲相关蛋白在制备关节炎治疗药物上的应用及关节炎治疗药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681701A (en) * 1993-07-12 1997-10-28 Mayo Foundation For Medical Education And Research Immortalized human fetal osteoblastic cells
DE69520360T2 (de) * 1994-07-04 2001-08-09 Takeda Chemical Industries, Ltd. Phosphonsäure verbindungen imre herstellung und verwendung
AU4981797A (en) * 1996-10-11 1998-05-11 Government Of The United States Of America, The Isolation and method of using tissue growth-inducing frzb protein
AU7704498A (en) * 1997-05-29 1998-12-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Human frp and fragments thereof including methods for using them

Also Published As

Publication number Publication date
CN102988957A (zh) 2013-03-27
AU7131200A (en) 2001-04-17
NZ529560A (en) 2005-05-27
CA2383360A1 (en) 2001-03-22
WO2001019855A2 (en) 2001-03-22
WO2001019855A3 (en) 2002-01-24
CZ2002903A3 (cs) 2002-07-17
CN1387537A (zh) 2002-12-25
JP2003512304A (ja) 2003-04-02
MXPA02002624A (es) 2002-07-30
EP1212355A2 (en) 2002-06-12
IL148421A0 (en) 2002-09-12

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2166 DE 10/07/2012.