ATE199721T1 - Phosphonsäure verbindungen imre herstellung und verwendung - Google Patents
Phosphonsäure verbindungen imre herstellung und verwendungInfo
- Publication number
- ATE199721T1 ATE199721T1 AT95923575T AT95923575T ATE199721T1 AT E199721 T1 ATE199721 T1 AT E199721T1 AT 95923575 T AT95923575 T AT 95923575T AT 95923575 T AT95923575 T AT 95923575T AT E199721 T1 ATE199721 T1 AT E199721T1
- Authority
- AT
- Austria
- Prior art keywords
- ring
- group
- pct
- substituted
- formula
- Prior art date
Links
- 150000003009 phosphonic acids Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
- C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15248294 | 1994-07-04 | ||
| PCT/JP1995/001328 WO1996001267A1 (en) | 1994-07-04 | 1995-07-03 | Phosphonic acid compounds, their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199721T1 true ATE199721T1 (de) | 2001-03-15 |
Family
ID=15541464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95923575T ATE199721T1 (de) | 1994-07-04 | 1995-07-03 | Phosphonsäure verbindungen imre herstellung und verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5716944A (de) |
| EP (1) | EP0769015B1 (de) |
| CN (1) | CN1151744A (de) |
| AT (1) | ATE199721T1 (de) |
| AU (1) | AU2808495A (de) |
| CA (1) | CA2191980A1 (de) |
| DE (1) | DE69520360T2 (de) |
| WO (1) | WO1996001267A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039134A1 (en) * | 1995-06-05 | 1996-12-12 | Takeda Chemical Industries, Ltd. | Osteogenetic promoting pharmaceutical composition |
| US5910492A (en) * | 1995-06-05 | 1999-06-08 | Takeda Chemical Industries, Ltd. | Osteogenic promoting pharmaceutical composition |
| CN1158264C (zh) * | 1997-11-21 | 2004-07-21 | Nps药物有限公司 | 用于治疗中枢神经系统疾病的代谢性谷氨酸受体拮抗剂 |
| WO1999032468A1 (en) * | 1997-12-19 | 1999-07-01 | Takeda Chemical Industries, Ltd. | Anilide derivative, production and use thereof |
| EP1039899A2 (de) | 1997-12-19 | 2000-10-04 | Takeda Chemical Industries, Ltd. | Pharmazeutische zusammensetzung als ccr5 antagoniste enthaltend ein anilid-derivat |
| CA2322487C (en) | 1998-03-06 | 2010-07-20 | Metabasis Therapeutics, Inc. | Novel prodrugs for phosphorus-containing compounds |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| AU5301599A (en) | 1998-08-20 | 2000-03-14 | Takeda Chemical Industries Ltd. | Quaternary ammonium salts and their use |
| AU1690100A (en) | 1998-12-21 | 2000-07-12 | Takeda Chemical Industries Ltd. | Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5 |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| AU4145200A (en) | 1999-05-07 | 2000-11-21 | Takeda Chemical Industries Ltd. | Cyclic compounds and uses thereof |
| WO2000069845A1 (en) | 1999-05-18 | 2000-11-23 | Takeda Chemical Industries, Ltd. | Processes for the preparation of 2,3-dihydrothiepine derivatives |
| AU5426500A (en) | 1999-06-16 | 2001-01-02 | Takeda Chemical Industries Ltd. | Benzazepine derivatives, process for the preparation of the same and uses thereof |
| MXPA02002624A (es) * | 1999-09-13 | 2002-07-30 | Wyeth Corp | Composiciones farmaceuticas y metodos de uso de proteinas secretadas relacionadas con la familia "frizzled". |
| EP2206702B1 (de) | 2001-08-08 | 2011-12-28 | Tobira Therapeutics, Inc. | Bizyklishe Verbindung, ihre Herstellung und Verwendung |
| FR2831166B1 (fr) * | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| AU2003213436A1 (en) * | 2002-03-12 | 2003-09-22 | Ube Industries, Ltd. | Method for preparing 6,7-dihydroxycoumarin-3-carboxy compound |
| CN1649847A (zh) * | 2002-03-12 | 2005-08-03 | 武田药品工业株式会社 | 制备旋光亚砜衍生物的方法 |
| EP2223927B1 (de) | 2002-05-13 | 2014-10-15 | Metabasis Therapeutics, Inc. | Salze einer auf Phosphonsäure basierenden Prodrug von PMEA |
| WO2003095665A2 (en) | 2002-05-13 | 2003-11-20 | Metabasis Therapeutics, Inc. | Pmea and pmpa cyclic producing synthesis |
| BR0315795A (pt) | 2002-10-31 | 2005-09-13 | Metabasis Therapeutics Inc | Pró-medicamentos de monofosfato de citarabina |
| US20060160864A1 (en) * | 2003-02-07 | 2006-07-20 | Mitsuru Shiraishi | Acrylamide derivative, process for producing the same, and use |
| WO2004069834A1 (ja) * | 2003-02-07 | 2004-08-19 | Takeda Pharmaceutical Company Limited | 三環性化合物、その製造方法および用途 |
| US7288654B2 (en) * | 2003-02-07 | 2007-10-30 | Takeda Pharmaceutical Company Ltd | Fused-ring pyridine derivative, process for producing the same, and use |
| RU2403237C2 (ru) * | 2004-05-14 | 2010-11-10 | Эмисфире Текнолоджис, Инк. | Составы и смеси для доставки активных агентов |
| CA2565966A1 (en) | 2004-06-08 | 2005-12-29 | Metabasis Therapeutics, Inc. | Lewis acid mediated synthesis of cyclic esters |
| GB201102468D0 (en) * | 2011-02-11 | 2011-03-30 | Univ Manchester | Biocompatible composite materials |
| AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| EP3191453B1 (de) | 2014-09-09 | 2019-10-23 | Bristol-Myers Squibb Company | Phenyl-(aza)cycloalkylcarbonsäure-gpr120-modulatoren |
| CN104497043B (zh) * | 2014-11-28 | 2016-09-14 | 浙江大学 | 芳醛与h-膦酸酯脱氢偶联制备甲酰基芳基膦酸酯的方法 |
| BR112017013130A2 (pt) | 2014-12-23 | 2017-12-26 | Tobira Therapeutics Inc | processo de fabricação de cenicriviroc e análogos relacionados |
| BR112018076449A2 (pt) | 2016-06-21 | 2019-04-09 | Tobira Therapeutics, Inc. | cenicriviroc purificado e intermediários purificados para fazer cenicriviroc |
| JP2019526628A (ja) | 2016-08-31 | 2019-09-19 | トビラ セラピューティクス， インコーポレイテッド | セニクリビロクメシレートの固体形態及びセニクリビロクメシレートの固体形態を製造するプロセス |
| CN106822089B (zh) * | 2017-01-23 | 2019-09-20 | 广州中大南沙科技创新产业园有限公司 | 一类苯內酰烯酯酰胺类衍生物在制备抗骨质疏松药物中的应用 |
| CN107019687B (zh) * | 2017-05-08 | 2020-10-27 | 上海市伤骨科研究所 | N-(4-氯苯基)-3-羟基-2-萘甲酰胺类化合物的用途 |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85700A0 (en) * | 1987-03-24 | 1988-08-31 | Takeda Chemical Industries Ltd | 1,4-disubstituted piperazine compounds,their production and use |
| EP0318235A3 (de) * | 1987-11-25 | 1991-05-02 | Takeda Chemical Industries, Ltd. | PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung |
| DK656789A (da) * | 1988-12-28 | 1990-06-29 | Takeda Chemical Industries Ltd | Benzoheterocykliske forbindelser |
| DK0460488T3 (da) * | 1990-05-30 | 2001-09-17 | Takeda Chemical Industries Ltd | Svovlholdige heterocykliske forbindelser |
| JP3165866B2 (ja) * | 1990-06-06 | 2001-05-14 | 武田薬品工業株式会社 | 含硫黄複素環化合物 |
| US5300687A (en) * | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
| ATE169924T1 (de) * | 1993-05-18 | 1998-09-15 | Takeda Chemical Industries Ltd | Benzopyran-derivate und ihre verwendung |
-
1995
- 1995-07-03 DE DE69520360T patent/DE69520360T2/de not_active Expired - Fee Related
- 1995-07-03 AT AT95923575T patent/ATE199721T1/de not_active IP Right Cessation
- 1995-07-03 WO PCT/JP1995/001328 patent/WO1996001267A1/en not_active Ceased
- 1995-07-03 US US08/501,022 patent/US5716944A/en not_active Expired - Fee Related
- 1995-07-03 CN CN95193981A patent/CN1151744A/zh active Pending
- 1995-07-03 EP EP95923575A patent/EP0769015B1/de not_active Expired - Lifetime
- 1995-07-03 AU AU28084/95A patent/AU2808495A/en not_active Abandoned
- 1995-07-03 CA CA002191980A patent/CA2191980A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2808495A (en) | 1996-01-25 |
| WO1996001267A1 (en) | 1996-01-18 |
| CA2191980A1 (en) | 1996-01-18 |
| DE69520360T2 (de) | 2001-08-09 |
| CN1151744A (zh) | 1997-06-11 |
| DE69520360D1 (de) | 2001-04-19 |
| EP0769015A1 (de) | 1997-04-23 |
| EP0769015B1 (de) | 2001-03-14 |
| US5716944A (en) | 1998-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |