BR0014602A - Hexaidrofluoro'2,3-bifuran-3-il-n-{3'(1,3-benzodioxol- 5ilsulfonil)(isobutil)amino-1 -benzil-2-hidroxipropil}carbamato como inibidor da protease retroviral - Google Patents

Hexaidrofluoro'2,3-bifuran-3-il-n-{3'(1,3-benzodioxol- 5ilsulfonil)(isobutil)amino-1 -benzil-2-hidroxipropil}carbamato como inibidor da protease retroviral

Info

Publication number
BR0014602A
BR0014602A BR0014602-1A BR0014602A BR0014602A BR 0014602 A BR0014602 A BR 0014602A BR 0014602 A BR0014602 A BR 0014602A BR 0014602 A BR0014602 A BR 0014602A
Authority
BR
Brazil
Prior art keywords
hexahydrofluoro
bifuran
benzodioxol
carbamate
hydroxypropyl
Prior art date
Application number
BR0014602-1A
Other languages
English (en)
Inventor
Piet Tom Bert Paul Wigerinck
Guangyang Wang
Michael Eissenstat
John W Erickson
Original Assignee
Tibotec Pharm Ltd
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd, Us Health filed Critical Tibotec Pharm Ltd
Publication of BR0014602A publication Critical patent/BR0014602A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Patente de Invenção: "HEXAIDROFLUORO'2,3-BIFURAN-3-IL-N-{3'(1,3-BENZODIOXOL -5-ILSULFONIL)(ISOBUTIL)AMINO-1-BENZIL-2-HIDROXIPROPIL} CARBAMATO COMO INIBIDOR DA PROTEASE RETROVIRAL". A presente invenção refere-se a novos compostos de bistetraidrofurano benzodioxolii sulfonamida os quais são inibidores de protease surpreendentemente eficazes. A invenção também refere-se a composições farmacêuticas, métodos de inibição da protease de retrovírus, em particular proteases de retrovírus resistentes a drogas múltiplas, métodos de tratamento ou combate de infecção ou doença associada à infecção por retrovírus em um mamífero e métodos de inibição da reprodução viral.
BR0014602-1A 1999-10-06 2000-10-06 Hexaidrofluoro'2,3-bifuran-3-il-n-{3'(1,3-benzodioxol- 5ilsulfonil)(isobutil)amino-1 -benzil-2-hidroxipropil}carbamato como inibidor da protease retroviral BR0014602A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785099P 1999-10-06 1999-10-06
PCT/EP2000/009917 WO2001025240A1 (en) 1999-10-06 2000-10-06 HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR

Publications (1)

Publication Number Publication Date
BR0014602A true BR0014602A (pt) 2002-06-11

Family

ID=22565540

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014602-1A BR0014602A (pt) 1999-10-06 2000-10-06 Hexaidrofluoro'2,3-bifuran-3-il-n-{3'(1,3-benzodioxol- 5ilsulfonil)(isobutil)amino-1 -benzil-2-hidroxipropil}carbamato como inibidor da protease retroviral

Country Status (25)

Country Link
US (2) US6649651B1 (pt)
EP (1) EP1222192B8 (pt)
JP (1) JP4951179B2 (pt)
KR (1) KR100792391B1 (pt)
CN (1) CN1191256C (pt)
AP (1) AP1459A (pt)
AT (1) ATE398623T1 (pt)
AU (1) AU781656B2 (pt)
BR (1) BR0014602A (pt)
CA (1) CA2386850C (pt)
CZ (1) CZ300031B6 (pt)
DE (1) DE60039244D1 (pt)
DK (1) DK1222192T3 (pt)
ES (1) ES2307533T3 (pt)
HU (1) HU228938B1 (pt)
IL (2) IL149005A0 (pt)
MX (1) MXPA02003607A (pt)
NO (1) NO327996B1 (pt)
NZ (1) NZ518580A (pt)
OA (1) OA12053A (pt)
PL (1) PL204924B1 (pt)
RU (1) RU2247123C2 (pt)
SK (1) SK287153B6 (pt)
WO (1) WO2001025240A1 (pt)
ZA (1) ZA200202655B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2386850C (en) * 1999-10-06 2010-03-30 Piet Tom Bert Paul Wigerinck Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor
EP1397367A2 (en) 2001-04-09 2004-03-17 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CN100519561C (zh) 2001-09-10 2009-07-29 泰博特克药品有限公司 制备六氢-呋喃并[2,3-b]呋喃-3-醇的方法
US7109230B2 (en) * 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
US7285566B2 (en) * 2002-01-07 2007-10-23 Erickson John W Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
CA2485903C (en) 2002-05-17 2011-08-16 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
OA12893A (en) * 2002-08-02 2006-10-13 Tibotec Pharm Ltd Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors.
EP1589018A4 (en) 2002-12-27 2007-03-14 Sumitomo Chemical Co METHOD OF PREPARING HEXAHYDROFUROFURANOL DERIVATIVES, INTERMEDIATE PRODUCTS AND MANUFACTURING METHOD THEREFOR
WO2005087728A1 (en) * 2004-03-11 2005-09-22 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
KR100698291B1 (ko) * 2004-12-29 2007-03-22 엘지전자 주식회사 조명계
ES2331257T3 (es) 2005-02-25 2009-12-28 Tibotec Pharmaceuticals Sintesis de precursores de inhibidores de proteasas.
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
KR101477822B1 (ko) 2006-07-07 2015-01-02 길리애드 사이언시즈, 인코포레이티드 치료제의 약동학 특성의 모듈레이터
JP2009544708A (ja) * 2006-07-24 2009-12-17 ギリアード サイエンシーズ， インコーポレイテッド ビスフラニルプロテアーゼ阻害剤
RS51675B (sr) 2006-11-09 2011-10-31 Tibotec Pharmaceuticals Metode za dobivanje heksahidrofuro[2,3-b]furan-3-ola
WO2008133734A2 (en) 2006-11-21 2008-11-06 Purdue Research Foundation Method and compositions for treating hiv infections
PT3150586T (pt) 2007-02-23 2020-03-31 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
EP2134336B1 (en) 2007-03-16 2013-12-11 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
KR20100040896A (ko) 2007-07-06 2010-04-21 길리애드 사이언시즈, 인코포레이티드 치료제의 약동학적 특성의 조절제
PT2231628E (pt) 2008-01-04 2015-12-29 Gilead Sciences Inc Inibidores de citocromo p450
WO2009091941A1 (en) * 2008-01-17 2009-07-23 Purdue Research Foundation Small molecule inhibitors of hiv proteases
EP2307345A4 (en) 2008-07-01 2012-05-02 Purdue Research Foundation NON-PEPTIDINHIBITORS OF HIV-1 PROTEASE
US8501961B2 (en) 2008-07-09 2013-08-06 Purdue Research Foundation HIV protease inhibitors and methods for using
ES2600878T3 (es) 2009-12-21 2017-02-13 Janssen Sciences Ireland Uc Implante removible, degradable, para la liberación prolongada de un compuesto activo
US8841467B2 (en) 2010-11-23 2014-09-23 Mylan Laboratories Limited Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol
EP2883858B1 (en) * 2012-08-09 2017-12-27 Sumitomo Chemical Company Limited Method for producing hexahydrofurofuranol derivative
CN103664976B (zh) * 2013-12-12 2015-11-04 惠州市莱佛士制药技术有限公司 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2142998C (en) * 1992-08-25 2008-01-29 Michael L. Vazquez N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
DE122007000045I2 (de) * 1992-08-25 2011-07-21 Gd Searle Llc Gd Searle Llc Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen.
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
ES2127938T3 (es) * 1993-08-24 1999-05-01 Searle & Co Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
PT2336134T (pt) * 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
GB9815567D0 (en) * 1998-07-18 1998-09-16 Glaxo Group Ltd Antiviral compound
CA2386850C (en) * 1999-10-06 2010-03-30 Piet Tom Bert Paul Wigerinck Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor

Also Published As

Publication number Publication date
AP2002002472A0 (en) 2002-06-30
ATE398623T1 (de) 2008-07-15
NO327996B1 (no) 2009-11-02
HUP0203130A2 (hu) 2003-01-28
CN1407987A (zh) 2003-04-02
CN1191256C (zh) 2005-03-02
EP1222192B1 (en) 2008-06-18
KR100792391B1 (ko) 2008-01-08
PL354351A1 (en) 2004-01-12
IL149005A (en) 2006-12-31
JP2003511383A (ja) 2003-03-25
NO20021598D0 (no) 2002-04-04
US6649651B1 (en) 2003-11-18
NZ518580A (en) 2004-01-30
MXPA02003607A (es) 2003-07-28
HUP0203130A3 (en) 2005-01-28
SK5702002A3 (en) 2003-01-09
AU781656B2 (en) 2005-06-02
CZ20021419A3 (cs) 2002-10-16
HK1054746A1 (en) 2003-12-12
PL204924B1 (pl) 2010-02-26
CZ300031B6 (cs) 2009-01-14
HU228938B1 (hu) 2013-06-28
CA2386850C (en) 2010-03-30
OA12053A (en) 2006-05-02
WO2001025240A1 (en) 2001-04-12
EP1222192A1 (en) 2002-07-17
ES2307533T3 (es) 2008-12-01
EP1222192B8 (en) 2008-10-01
NO20021598L (no) 2002-05-29
CA2386850A1 (en) 2001-04-12
US20050261364A1 (en) 2005-11-24
JP4951179B2 (ja) 2012-06-13
RU2247123C2 (ru) 2005-02-27
AP1459A (en) 2005-08-22
US7157495B2 (en) 2007-01-02
DK1222192T3 (da) 2008-10-20
AU7663800A (en) 2001-05-10
SK287153B6 (sk) 2010-01-07
ZA200202655B (en) 2003-09-23
KR20020067503A (ko) 2002-08-22
DE60039244D1 (de) 2008-07-31
IL149005A0 (en) 2002-11-10

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: TIBOTEC PHARMACEUTICALS LTD. (IE) , THE GOVERNMENT

Free format text: SEDE DO 1O TITULAR ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070001806/RJ DE 05/01/2007.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]