BR0014864A - Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem - Google Patents

Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem

Info

Publication number
BR0014864A
BR0014864A BR0014864-4A BR0014864A BR0014864A BR 0014864 A BR0014864 A BR 0014864A BR 0014864 A BR0014864 A BR 0014864A BR 0014864 A BR0014864 A BR 0014864A
Authority
BR
Brazil
Prior art keywords
cells
progenitor cells
differentiated progenitor
methods
embryonic stem
Prior art date
Application number
BR0014864-4A
Other languages
English (en)
Inventor
Jose Cibelli
Michael D West
Robert P Lanza
Original Assignee
Advanced Cell Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Tech Inc filed Critical Advanced Cell Tech Inc
Publication of BR0014864A publication Critical patent/BR0014864A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)

Abstract

"MéTODOS DE PRODUZIR CéLULAS PROGENITORAS DIFERENCIADAS E CéLULAS TRONCO EMBRIÈNICAS DEFEITUOSAS EM LINHAGEM". Um método aperfeiçoado de produzir células progenitoras aperfeiçoadas compreendendo obtendo células de massa de célula interna de um blastócisto e induzindo diferenciação das células de massa de célula interna para produzir células progenitoras diferenciadas. As células progenitoras diferenciadas podem ser transfectadas tais que exista além disso, anulação ou alteração de um gene desejado. As células progenitoras diferenciadas são úteis em terapia de célula e como uma fonte I de células para a produção de tecidos e orgãos para transplantação. Também fornecido é um método para produzir uma célula de tronco embriónica humana defeituosa em linhagem.
BR0014864-4A 1999-10-15 2000-10-13 Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem BR0014864A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15955099P 1999-10-15 1999-10-15
PCT/US2000/028285 WO2001029206A1 (en) 1999-10-15 2000-10-13 Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells

Publications (1)

Publication Number Publication Date
BR0014864A true BR0014864A (pt) 2002-11-19

Family

ID=22573023

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014864-4A BR0014864A (pt) 1999-10-15 2000-10-13 Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem

Country Status (11)

Country Link
US (3) US20050265976A1 (pt)
EP (1) EP1226239A4 (pt)
JP (1) JP2003512052A (pt)
CN (1) CN1413250A (pt)
AU (1) AU782385B2 (pt)
BR (1) BR0014864A (pt)
CA (1) CA2388497A1 (pt)
IL (2) IL149043A0 (pt)
MX (1) MXPA02003733A (pt)
NZ (1) NZ518191A (pt)
WO (1) WO2001029206A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7838289B2 (en) 2001-02-14 2010-11-23 Abt Holding Company Assay utilizing multipotent adult stem cells
NZ536786A (en) * 1999-09-07 2006-09-29 Advanced Cell Tech Inc Method for generating immune-compatible cells and tissues using nuclear transfer techniques
US20020142397A1 (en) 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
KR20030088023A (ko) 2001-01-02 2003-11-15 스템론 인크. 미리 선별된 면역형 및(또는) 유전자형을 갖는 동형접합성간세포 군집의 제조 방법, 그로부터 유래된 이식에 적합한세포, 및 이들을 사용하는 재료 및 방법
WO2003004605A2 (en) * 2001-07-06 2003-01-16 Geron Corporation Mesenchymal cells and osteoblasts from human embryonic stem cell
WO2003075648A1 (es) * 2002-03-13 2003-09-18 Fundacion Ivi Para El Estudio De La Reproduccion Humana (Fivier) Metodos de produccion de lineas celulares
WO2004061092A1 (ja) 2002-12-27 2004-07-22 Mitsubishi Heavy Industries, Ltd. 多能性幹細胞の培養方法とそのための培養装置
RU2265446C2 (ru) * 2003-05-14 2005-12-10 Григорьянц Рубен Исаакович Имплантат для лечения болезни паркинсона
US7893315B2 (en) * 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
CA3015835A1 (en) 2004-11-04 2006-05-18 Astellas Institute For Regenerative Medicine Derivation of embryonic stem cells
RU2283122C1 (ru) * 2005-03-16 2006-09-10 Государственное учреждение Научный центр акушерства, гинекологии и перинатологии Российской академии медицинских наук Способ лечения императивного недержания мочи
EP1878789A4 (en) * 2005-04-14 2008-08-27 Japan As Represented By Genera STEM CELL DERIVED FROM FAT AND USE THEREOF
EP2302034B1 (en) 2005-08-03 2020-10-14 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
KR102651433B1 (ko) 2006-04-14 2024-03-25 아스텔라스 인스티튜트 포 리제너러티브 메디슨 혈관 콜로니 형성 세포
EP2029724A4 (en) 2006-05-03 2010-03-24 Advanced Cell Tech Inc DERIVATION FROM EMBRYONAL STEM CELLS AND EMBRYO-DERIVED CELLS
WO2008063675A2 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
JP2010518857A (ja) 2007-02-23 2010-06-03 アドバンスド セル テクノロジー， インコーポレイテッド 分化した細胞の再プログラムおよび再プログラムされた細胞からの動物および胚幹細胞の生成のための高能率的な方法
JP5748654B2 (ja) 2008-05-06 2015-07-15 オカタ セラピューティクス， インコーポレイテッド 多能性幹細胞に由来する除核赤血球細胞を産生するための方法
EP2712921B1 (en) 2008-05-06 2018-07-11 Astellas Institute for Regenerative Medicine Hemangio colony forming cells and non-engrafting hemangio cells
US10386360B2 (en) 2009-03-13 2019-08-20 University Of Central Florida Research Foundation, Inc. Bio-microelectromechanical system transducer and associated methods
US8815584B1 (en) 2009-04-23 2014-08-26 University Of Central Florida Research Foundation, Inc. Method of co-culturing mammalian muscle cells and motoneurons
US9404140B1 (en) 2009-11-03 2016-08-02 The University Of Central Florida Research Foundation, Inc. Patterned cardiomyocyte culture on microelectrode array
CA2798777C (en) 2010-04-23 2016-09-06 University Of Central Florida Research Foundation, Inc. Formation of neuromuscular junctions in a defined system
JP2010193910A (ja) * 2010-06-14 2010-09-09 Mitsubishi Heavy Ind Ltd 多能性幹細胞の培養方法、多能性幹細胞の培養システム、及び多能性幹細胞培養装置
WO2012022786A1 (de) 2010-08-20 2012-02-23 Hirschmann Automation And Control Gmbh Erweiterung für das simple network management protocol (snmp) um informationen über den status von set-pdus zu ermitteln
EP3636286A1 (en) * 2011-05-18 2020-04-15 The Regents of The University of California Compositions and methods for treating retinal diseases
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
KR102246369B1 (ko) 2011-11-30 2021-04-29 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
US9745551B2 (en) 2012-07-12 2017-08-29 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
WO2014028940A1 (en) 2012-08-17 2014-02-20 University Of Central Florida Research Foundation, Inc. Methods, systems and compositions for functional in vitro cellular models of mammalian systems
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
EP2951281B1 (en) 2013-01-30 2018-06-27 University of Central Florida Research Foundation, Inc. System and method for mimicking heart function
US10935541B2 (en) 2014-08-07 2021-03-02 University Of Central Florida Research Foundation, Inc. Devices and methods comprising neuromuscular junctions
WO2017048193A1 (en) * 2015-09-15 2017-03-23 Agency For Science, Technology And Research (A*Star) Derivation of liver organoids from human pluripotent stem cells
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0669973B9 (en) 1992-10-28 2007-10-10 NeuroSpheres Holdings Ltd. Biological factors and neural stem cells
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5532156A (en) * 1993-10-08 1996-07-02 The United States Of America As Represented By The Secretary Of Agriculture Hepatocyte cell line derived from the epiblast of pig blastocysts
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
CA2262817A1 (en) * 1996-08-19 1998-02-26 James Robl Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
IL133786A0 (en) * 1997-07-03 2001-04-30 Univ Massachusetts Cloning using donor nuclei from non-serum starved, differentiated cells
CA2304206A1 (en) * 1997-09-29 1999-04-08 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
JP2002505100A (ja) * 1998-03-02 2002-02-19 ユニヴァーシティー オヴ マサチューセッツ アパブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ リプレゼンティド バイイッツ アム 種間核移植によって作製された胚性または幹細胞様細胞株
NZ517609A (en) * 1999-09-14 2004-02-27 Univ Massachusetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
WO2004050826A2 (en) * 2002-11-29 2004-06-17 Technion Research & Development Foundation Ltd. Method of dynamically culturing embryonic stem cells

Also Published As

Publication number Publication date
EP1226239A1 (en) 2002-07-31
WO2001029206A1 (en) 2001-04-26
IL149043A0 (en) 2002-11-10
AU1200001A (en) 2001-04-30
US20090104697A1 (en) 2009-04-23
MXPA02003733A (es) 2003-10-14
AU782385B2 (en) 2005-07-21
US8753884B2 (en) 2014-06-17
JP2003512052A (ja) 2003-04-02
IL149043A (en) 2010-11-30
CA2388497A1 (en) 2001-04-26
US20140248700A1 (en) 2014-09-04
CN1413250A (zh) 2003-04-23
EP1226239A4 (en) 2003-02-12
NZ518191A (en) 2004-01-30
US20050265976A1 (en) 2005-12-01

Similar Documents

Publication Publication Date Title
BR0014864A (pt) Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem
Mintz Gene control of mammalian differentiation
Ohyama et al. The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization
WO2003065999A3 (en) Proliferated cell lines and uses thereof
BRPI0516969A (pt) método de preparar uma composição terapêutica, composição terapêutica, e, método de tratar um paciente humano sofrendo de hematopoiese deficiente
BR0107917A (pt) Fonte para tecido de fìgado
BRPI0514641A (pt) cultivação das células tronco embriÈnica humana
WO2002051980A3 (en) In vitro-derived adult pluripotent stem cells and uses therefor
DE602004030254D1 (de) Scaffoldfreies, selbstorganisiertes, 3 dimensionales, synthetisches gewebe
TW200712208A (en) Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
GB2434157A (en) Platelets from stem cells
JP2002538181A5 (pt)
NO972171L (no) Regulering av neural stamcelleproliferasjon
BR0210599A (pt) Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estéril
WO2003014313A3 (en) Alternative compositions and methods for the culture of stem cells
WO2001096532A3 (en) Method of generating pluripotent mammalian cells by fusion of a cytoplast fragment with a karyoplast
Tang et al. Epidermal stem cells: Skin surveillance and clinical perspective
O’Hara-Wright et al. Bioelectric potential in next-generation organoids: electrical stimulation to enhance 3D structures of the central nervous system
Jouneau et al. Reprogramming in nuclear transfer
DE69738822D1 (de) NEUES SÄUGETIERGEN bc1-w, WELCHES ZUR bc1-2 FAMILIE APOPTOSE-KONTROLLIERENDER GENE GEHÖRT
Tamada et al. Recapitulation and investigation of human brain development with neural organoids
IT1228210B (it) Procedimento per la introduzione di dna esogeno nelle cellule somatiche e germinali di animali.
CN103305551B (zh) 一种基于囊胚基因表达水平筛选供体细胞系的方法
BR0013999A (pt) Linhagens de célula embriÈnicas ou semelhantes a células tronco produzidas por transplante nuclear de espécies cruzadas e métodos para melhorar o desenvolvimento embriÈnico por alteração genética de células doadoras ou por condições de cultura de tecido
Chen et al. Mimicking hair disorders by genetic manipulation of organ-cultured human hair follicles

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 22 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.