BR0210599A - Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estéril - Google Patents
Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estérilInfo
- Publication number
- BR0210599A BR0210599A BR0210599-3A BR0210599A BR0210599A BR 0210599 A BR0210599 A BR 0210599A BR 0210599 A BR0210599 A BR 0210599A BR 0210599 A BR0210599 A BR 0210599A
- Authority
- BR
- Brazil
- Prior art keywords
- maintaining
- carbon monoxide
- vitro
- cell
- well
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title abstract 3
- 229910002091 carbon monoxide Inorganic materials 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title abstract 3
- 210000004102 animal cell Anatomy 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 230000003915 cell function Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"USO DE MONóXIDO DE CARBONO, MéTODO PARA MANUTENçãO DE UMA CéLULA ANIMAL IN VITRO, ARTIGO DE MANUFATURA, BEM COMO MEIO CELULAR ESTéRIL". A presente invenção caracteriza métodos para transplante de órgãos, tecidos e células individuais. São também caracterizados métodos para manter células ín vitro e para realçar a sobrevivência e/ou função de células após o transplante. Os métodos incluem a administração de monóxido de carbono em uma quantidade suficiente para realçar função e/ou sobrevivência da célula.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30028901P | 2001-06-21 | 2001-06-21 | |
| US33434001P | 2001-11-29 | 2001-11-29 | |
| US33797401P | 2001-12-07 | 2001-12-07 | |
| PCT/US2002/019687 WO2003000114A2 (en) | 2001-06-21 | 2002-06-21 | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0210599A true BR0210599A (pt) | 2004-07-20 |
Family
ID=27404726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0210599-3A BR0210599A (pt) | 2001-06-21 | 2002-06-21 | Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estéril |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7238469B2 (pt) |
| EP (2) | EP1404811B1 (pt) |
| JP (1) | JP4521183B2 (pt) |
| KR (1) | KR20040032115A (pt) |
| CN (1) | CN100502650C (pt) |
| AT (1) | ATE413883T1 (pt) |
| AU (2) | AU2002318377B2 (pt) |
| BG (1) | BG108492A (pt) |
| BR (1) | BR0210599A (pt) |
| CA (1) | CA2451266A1 (pt) |
| CY (1) | CY1108798T1 (pt) |
| CZ (1) | CZ20033448A3 (pt) |
| DE (1) | DE60229848D1 (pt) |
| DK (1) | DK1404811T3 (pt) |
| ES (1) | ES2316583T3 (pt) |
| HU (1) | HUP0400371A3 (pt) |
| MX (1) | MXPA03012031A (pt) |
| NO (1) | NO20035637L (pt) |
| NZ (1) | NZ562962A (pt) |
| PL (1) | PL367544A1 (pt) |
| PT (1) | PT1404811E (pt) |
| SG (1) | SG147305A1 (pt) |
| SI (1) | SI1404811T1 (pt) |
| SK (1) | SK15942003A3 (pt) |
| WO (1) | WO2003000114A2 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
| US7678390B2 (en) | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| EP1404811B1 (en) * | 2001-06-21 | 2008-11-12 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
| US7011854B2 (en) * | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
| SG148850A1 (en) | 2002-02-13 | 2009-01-29 | Beth Israel Hospital | Methods of treating vascular disease |
| EA200401365A1 (ru) * | 2002-04-15 | 2005-04-28 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Способы лечения илеуса |
| WO2003088981A1 (en) | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
| WO2003088748A1 (en) | 2002-04-15 | 2003-10-30 | Beth Israel Deaconess Medical Center | Use of heme oxygenase-1 and products of heme degradation |
| EA200401525A1 (ru) | 2002-05-17 | 2006-06-30 | Йейл Юниверсити | Способы лечения гепатита (варианты ) |
| JP2005532351A (ja) * | 2002-06-05 | 2005-10-27 | イエール ユニバーシティ | 血管形成、腫瘍増殖、および転移を治療する方法 |
| WO2004000368A1 (en) * | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
| EP1558084A4 (en) * | 2002-11-07 | 2008-04-30 | Univ Pittsburgh | TREATMENT OF HEMORRHAGIC SHOCK |
| GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| US20070207217A1 (en) * | 2003-02-03 | 2007-09-06 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO |
| EP1684579A1 (en) * | 2003-10-22 | 2006-08-02 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
| EP1552840A1 (en) * | 2004-01-07 | 2005-07-13 | Aga Ab | Use of a xenon/carbon monoxide mixture for the protection of cells |
| AU2006220548B2 (en) | 2005-03-07 | 2011-04-21 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (CO) and nitric ozide (NO) CO to tissue using heme proteins as carriers |
| EP1937059A2 (en) | 2005-07-27 | 2008-07-02 | University Of North Carolina At Charlotte | Composition and method for the restoration and preservation of transplant organs procured from dcd donors |
| US20070207993A1 (en) * | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
| GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
| WO2008063868A2 (en) | 2006-11-07 | 2008-05-29 | The General Hospital Corporation | Attenuation of vasoactive oxygen carrier-induced vasoconstriction |
| KR101661872B1 (ko) | 2009-05-27 | 2016-10-10 | 이노 테라퓨틱스 엘엘씨 | 인덱싱된 밸브와 압축 캐니스터 조립체를 칼라에 결합하고 플런저 조립체로 선형 작동시켜 약물 전달 조절용 장치와 유체 소통상태가 되게 하는 방법 및 장치 |
| CA2671029A1 (en) | 2009-06-30 | 2010-12-30 | James S. Baldassarre | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| CN109925318A (zh) * | 2011-01-14 | 2019-06-25 | 洛杉矶儿童医院 | 用于治疗包括镰状细胞疾病的疾病的一氧化碳溶液 |
| US8927750B2 (en) | 2011-02-04 | 2015-01-06 | Universitaet Zu Koeln | Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules |
| WO2012125955A2 (en) | 2011-03-16 | 2012-09-20 | Mayo Foundation For Medical Education And Research | Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations |
| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| WO2012170843A1 (en) * | 2011-06-10 | 2012-12-13 | Geno Llc | Pressurized vessel of nitric oxide (no) |
| ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
| WO2013022946A1 (en) | 2011-08-09 | 2013-02-14 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating dna damage |
| ES2981406T3 (es) | 2013-03-15 | 2024-10-08 | Mallinckrodt Pharmaceuticals Ireland Ltd | Administración y monitorización de óxido nítrico en fluidos ex vivo |
| US9629358B2 (en) | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
| TW201618795A (zh) * | 2014-04-15 | 2016-06-01 | 波泰里斯股份有限公司 | 用以改良器官功能及延長器官移植物壽命之系統及方法 |
| EP4512819A3 (en) | 2015-08-12 | 2025-08-06 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| CN105288599A (zh) * | 2015-10-22 | 2016-02-03 | 徐州医学院 | 血红素氧化酶-2在制备抑制器官移植免疫排斥制剂中的应用 |
| MX2020001853A (es) | 2017-08-25 | 2020-08-03 | Mallinckrodt Hospital Products Ip Ltd | Métodos para mejorar la viabilidad de los órganos. |
| EP3524290A1 (en) | 2018-02-09 | 2019-08-14 | Julius-Maximilians-Universitaet Wuerzburg | Method and system for monitoring carbon monoxide (co) administration to ex-vivo fluids |
| CN116076484A (zh) * | 2022-11-30 | 2023-05-09 | 武汉大学 | 一种修复肾脏损伤的低温携氧机械灌注液及其应用 |
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| US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| US20050250688A1 (en) | 1999-04-01 | 2005-11-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
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| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
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| WO2003088981A1 (en) * | 2002-04-15 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
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| WO2004000368A1 (en) * | 2002-06-21 | 2003-12-31 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
| EP1558084A4 (en) * | 2002-11-07 | 2008-04-30 | Univ Pittsburgh | TREATMENT OF HEMORRHAGIC SHOCK |
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-
2002
- 2002-06-21 EP EP02747932A patent/EP1404811B1/en not_active Revoked
- 2002-06-21 AU AU2002318377A patent/AU2002318377B2/en not_active Ceased
- 2002-06-21 CN CNB028163443A patent/CN100502650C/zh not_active Expired - Fee Related
- 2002-06-21 EP EP08168801A patent/EP2033514A3/en not_active Withdrawn
- 2002-06-21 DE DE60229848T patent/DE60229848D1/de not_active Expired - Lifetime
- 2002-06-21 CZ CZ20033448A patent/CZ20033448A3/cs unknown
- 2002-06-21 SK SK1594-2003A patent/SK15942003A3/sk not_active Application Discontinuation
- 2002-06-21 KR KR10-2003-7016702A patent/KR20040032115A/ko not_active Abandoned
- 2002-06-21 SI SI200230772T patent/SI1404811T1/sl unknown
- 2002-06-21 SG SG200601852-7A patent/SG147305A1/en unknown
- 2002-06-21 WO PCT/US2002/019687 patent/WO2003000114A2/en not_active Ceased
- 2002-06-21 NZ NZ562962A patent/NZ562962A/en not_active IP Right Cessation
- 2002-06-21 PT PT02747932T patent/PT1404811E/pt unknown
- 2002-06-21 ES ES02747932T patent/ES2316583T3/es not_active Expired - Lifetime
- 2002-06-21 JP JP2003506568A patent/JP4521183B2/ja not_active Expired - Fee Related
- 2002-06-21 DK DK02747932T patent/DK1404811T3/da active
- 2002-06-21 AT AT02747932T patent/ATE413883T1/de not_active IP Right Cessation
- 2002-06-21 MX MXPA03012031A patent/MXPA03012031A/es active IP Right Grant
- 2002-06-21 CA CA002451266A patent/CA2451266A1/en not_active Abandoned
- 2002-06-21 US US10/177,930 patent/US7238469B2/en not_active Expired - Lifetime
- 2002-06-21 HU HU0400371A patent/HUP0400371A3/hu unknown
- 2002-06-21 BR BR0210599-3A patent/BR0210599A/pt not_active IP Right Cessation
- 2002-06-21 PL PL02367544A patent/PL367544A1/xx unknown
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2003
- 2003-12-17 NO NO20035637A patent/NO20035637L/no not_active Application Discontinuation
- 2003-12-22 BG BG108492A patent/BG108492A/xx unknown
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2006
- 2006-04-10 US US11/401,722 patent/US20070202083A1/en not_active Abandoned
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2008
- 2008-09-18 AU AU2008221551A patent/AU2008221551A1/en not_active Ceased
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2009
- 2009-02-09 CY CY20091100145T patent/CY1108798T1/el unknown
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