BR0014945A - Posttranslational modification of recombinant proteins produced in plants - Google Patents

Posttranslational modification of recombinant proteins produced in plants

Info

Publication number
BR0014945A
BR0014945A BR0014945-4A BR0014945A BR0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A
Authority
BR
Brazil
Prior art keywords
plants
genetically engineered
recombinant proteins
proteins produced
posttranslational modification
Prior art date
Application number
BR0014945-4A
Other languages
Portuguese (pt)
Inventor
Douglas Russell
Siva Manjunath
Ronald Bassuner
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of BR0014945A publication Critical patent/BR0014945A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MODIFICAçãO PóS-TRADUCIONAL DE PROTEINAS RECOMBINANTES PRODUZIDAS EM PLANTAS". A presente invenção se refere a um processo para a produção de proteínas ou polipeptídeos usando-se plantas ou células de plantas geneticamente manipuladas, bem como a plantas ou células de plantas geneticamente manipuladas per se (incluindo partes de plantas geneticamente manipuladas), o material proteico heterólogo (por exemplo, uma proteína, polipeptídeo e semelhantes), o qual é produzido com o auxílio dessas plantas ou células de plantas geneticamente manipuladas, e a polinucleotídeos recombinantes (DNA ou RNA) que são usados para a manipulação genética."POST-TRADITIONAL MODIFICATION OF RECOMBINANT PROTEINS PRODUCED IN PLANTS". The present invention relates to a process for producing proteins or polypeptides using genetically engineered plants or plant cells, as well as genetically engineered plants or cells per se (including genetically engineered plant parts), the proteinaceous material. heterologous (e.g., a protein, polypeptide and the like) which is produced with the aid of such genetically engineered plants or plant cells, and recombinant polynucleotides (DNA or RNA) that are used for genetic manipulation.

BR0014945-4A 1999-10-21 2000-10-20 Posttranslational modification of recombinant proteins produced in plants BR0014945A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16075899P 1999-10-21 1999-10-21
US19528200P 2000-04-07 2000-04-07
PCT/US2000/029027 WO2001029242A2 (en) 1999-10-21 2000-10-20 Post-translational modification of recombinant proteins produced in plants

Publications (1)

Publication Number Publication Date
BR0014945A true BR0014945A (en) 2004-08-31

Family

ID=26857200

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014945-4A BR0014945A (en) 1999-10-21 2000-10-20 Posttranslational modification of recombinant proteins produced in plants

Country Status (5)

Country Link
EP (1) EP1224309A2 (en)
AU (1) AU1573601A (en)
BR (1) BR0014945A (en)
CA (1) CA2388432A1 (en)
WO (1) WO2001029242A2 (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (en) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ES2558160T3 (en) 1998-12-09 2016-02-02 Phyton Holdings, Llc Glycoproteins that have human-type glycosylation
ATE478150T1 (en) * 1999-10-26 2010-09-15 Stichting Dienst Landbouwkundi MAMMAL GLYCOSYLATION IN PLANTS
AT409381B (en) * 2000-03-03 2002-07-25 Gloessl Josef Dr Xylosyltransferase-GEN
EP2206720A1 (en) 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7632983B2 (en) 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
BRPI0206546B1 (en) 2001-01-19 2015-07-21 Phyton Holdings Llc Method for secretory production of human-type sugar chain glycoprotein using plant cell
CA2451765A1 (en) 2001-06-05 2002-12-12 Karen K. Oishi Gene expression and production of tgf-b proteins including bioactive mullerian inhibiting substance from plants
CN1533438A (en) * 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ Method for producing protein in plant
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
AU2008202355B2 (en) * 2002-03-19 2011-04-07 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
KR101070518B1 (en) * 2002-03-19 2011-10-05 스티칭 디엔스트 랜드보위쿤디그 온데조에크 Gntiii expression in plants
CA2478297C (en) * 2002-03-19 2013-05-14 Plant Research International B.V. Optimizing glycan processing in plants
CL2003002461A1 (en) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien IMMUNOGLOBULIN THAT UNDERSTANDS AT LEAST ONE AFUCOSILATED GLICAN, COMPOSITION THAT CONTAINS IT, NUCLEOTIDIC SEQUENCE AND VECTOR THAT UNDERSTANDS IT, PROCEDURE TO PRODUCE IMMUNOGLOBULIN SAID IN PLANTS.
DK1431394T3 (en) * 2002-12-20 2006-12-11 Greenovation Biotech Gmbh Process for Preparation of Heterologous Glycosylated Proteins in Moss Plant Cells
US7781197B2 (en) 2002-12-20 2010-08-24 Greenovation Biotech Gmbh Transformed bryophyte cell having disrupted endogenous alpha 1,3-fucosyl and beta 1,2-xylosyl transferase encoding nucleotide sequences for the production of heterologous glycosylated proteins
EP1576966A4 (en) * 2002-12-27 2006-07-26 Shenzhen Tsinghua Yuanxing Bio Method of preparing a vaccine and anti-tumor vaccines
CN103540600B (en) * 2003-01-22 2017-12-01 罗氏格黎卡特股份公司 Fusion constructs and its for producing the purposes for the antibody that Fc receptor binding affinities and effector function improve
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN100427599C (en) * 2003-12-26 2008-10-22 吉林大学第一医院 ALBSIN/IL－18MATHybrid cytokines
US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
DE602005023332D1 (en) * 2004-09-29 2010-10-14 Collplant Ltd COLLAGENPRODUZIERENDE PLANTS AND METHOD FOR THE PRODUCTION AND THEIR USE
BRPI0707290A2 (en) 2006-01-17 2011-08-16 Biolex Therapeutics Inc compositions and methods for humanization and optimization of n-glycans in plants
EP1816201A1 (en) 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
KR20090079258A (en) * 2006-11-08 2009-07-21 상뜨르 나쇼날 드 라 러쉐르쉬 샹띠피끄 (쎄엔알에스) Sequence set for targeting expression and post-translational modification of recombinant polypeptides
KR101426576B1 (en) 2007-04-17 2014-08-07 스티칭 디엔스트 랜드보위쿤디그 온데조에크 Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
DK2155880T3 (en) * 2007-06-15 2016-12-05 Medicago Inc Modification of glycoproteinproduktion i plants
CA2704108A1 (en) * 2007-10-31 2009-05-07 Bayer Bioscience N.V. Method to produce modified plants with altered n-glycosylation pattern
EP2217625B1 (en) 2007-11-08 2021-08-04 Precision Biologics, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
MX370690B (en) 2008-07-18 2019-12-19 Medicago Inc EPITHOPE OF IMMUNIZATION OF NEW INFLUENZA VIRUS.
EP2773964A4 (en) * 2011-11-03 2015-06-24 Stc Biolog Inc Method for determination of pharmacological properties of recombinant proteins
WO2014130922A1 (en) 2013-02-25 2014-08-28 Trustees Of Boston University Compositions and methods for treating fungal infections
GB201308120D0 (en) * 2013-05-06 2013-06-12 Baden Wuerttemberg Stiftung Gmbh Recombinant protein and method for its production
JP6450381B2 (en) 2013-07-05 2019-01-09 ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション Soluble MIC neutralizing monoclonal antibody for treating cancer
WO2015050005A1 (en) * 2013-10-02 2015-04-09 株式会社ＵｎｉＢｉｏ Protein composition for promoting cell proliferation via egf receptor
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
WO2017181021A1 (en) * 2016-04-15 2017-10-19 Regenxbio Inc. Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab
JP7046828B2 (en) 2016-04-15 2022-04-04 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Composition for the treatment of exudative age-related macular degeneration
US12558434B2 (en) 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
WO2020176972A1 (en) * 2019-03-06 2020-09-10 Plantform Corporation T-dna vectors with engineered 5' sequences upstream of post-translational modification enzymes and methods of use thereof
CA3184940A1 (en) 2020-07-07 2022-01-13 Jennifer Donglan WU Mic antibodies and binding agents and methods of using the same
US20240101673A1 (en) 2021-02-03 2024-03-28 Mozart Therapeutics, Inc. Binding agents and methods of using the same
JP7717832B2 (en) 2021-04-10 2025-08-04 ジェンマブ エー／エス FOLR1-binding agents, conjugates thereof and methods of using same
WO2022226317A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
TW202320857A (en) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 Linkers, drug linkers and conjugates thereof and methods of using the same
US20250334585A1 (en) 2021-07-13 2025-10-30 Keystone Bio, Inc. Diagnostics for porphyromonas gingivalis
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
WO2023092099A1 (en) 2021-11-19 2023-05-25 Ardeagen Corporation Gpc3 binding agents, conjugates thereof and methods of using the same
WO2024030956A2 (en) 2022-08-03 2024-02-08 Mozart Therapeutics, Inc. Cd39-specific binding agents and methods of using the same
LU103006B1 (en) * 2022-09-15 2024-03-15 Phaeosynt Gbr IMMUNOASSAY FOR DETECTING BIOLOGICALLY ACTIVE PROTEINS
CN121194993A (en) 2023-05-24 2025-12-23 莫扎特治疗公司 CD8-specific binding protein and its application methods
AU2024353316A1 (en) 2023-09-26 2026-03-26 Genmab A/S Ptk7 binding agents, conjugates thereof and methods of using the same
WO2025149661A1 (en) 2024-01-10 2025-07-17 Genmab A/S Slitrk6 binding agents, conjugates thereof and methods of using the same
WO2025181219A1 (en) 2024-02-29 2025-09-04 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
WO2025222129A2 (en) 2024-04-19 2025-10-23 Mozart Therapeutics, Inc. Engineered cytokines and targeted cytokine delivery
WO2026039642A1 (en) 2024-08-16 2026-02-19 Ardeagen Corporation Anti-mesothelin antibody conjugates and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723755A (en) * 1995-05-16 1998-03-03 Francis E. Lefaivre Large scale production of human or animal proteins using plant bioreactors
DE19754622A1 (en) * 1997-12-09 1999-06-10 Antje Von Dr Schaewen Plant GntI sequences and the use thereof for obtaining plants with reduced or missing N-acetylglucosaminyltransferase I (GnTI) activity
ES2558160T3 (en) * 1998-12-09 2016-02-02 Phyton Holdings, Llc Glycoproteins that have human-type glycosylation
WO2001031044A1 (en) * 1999-10-26 2001-05-03 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Gonadotrophins in plants
ATE478150T1 (en) * 1999-10-26 2010-09-15 Stichting Dienst Landbouwkundi MAMMAL GLYCOSYLATION IN PLANTS

Also Published As

Publication number Publication date
WO2001029242A2 (en) 2001-04-26
EP1224309A2 (en) 2002-07-24
AU1573601A (en) 2001-04-30
WO2001029242A3 (en) 2002-02-21
CA2388432A1 (en) 2001-04-26

Similar Documents

Publication Publication Date Title
BR0014945A (en) Posttranslational modification of recombinant proteins produced in plants
ATE366814T1 (en) GL50 MOLECULES, AND USES THEREOF
IL212888A0 (en) A transgenic plant comprising mammalian ??-1, 4-galactosyltransferase and ??-1, 3-glucuronyltransferase
EP1711533A4 (en) PROCESS FOR THE PRODUCTION OF PEPTIDES / PROTEINS IN PLANTS AND PEPTIDES / PROTEINS MADE THEREOF
BR0011499A (en) Nucleic acid molecules from plants and transgenic wheat plant cells and their use for the production of modified starch
BR0113864A (en) isolated kcp-type nucleic acids and their encoded proteins
CY1106806T1 (en) DNA AND HUMAN TSLP POLYPEPTIDES
DE69920747D1 (en) METHOD FOR THE PRODUCTION OF RECOMBINANT CELLS
DE69837085D1 (en) CRSP PROTEINS (CYSTEIN RICH, SECRETATED PROTEINS), THE NUCLEIC ACIDS THAT CODE AND THEIR USES
AR027765A1 (en) EXPRESSION AND PURIFICATION OF AUTHENTIC BIOACTIVE POLYPEPTIDES FROM PLANTS
DE69906509D1 (en) PRODUCTION OF INDIVIDUAL GENE PRODUCTS OF A CHIMERAL FUSION PROTEIN BY CUTTING WITH ANYWHERE ENDOPROTEASES
DE60144021D1 (en) FOR CELL CYCLE PROTEINS CODING NUCLEIC ACID AND ITS USE
ATE134219T1 (en) HUMAN MK GENE AND PROTEIN SEQUENCE
NO930428L (en) THE PROTEIN INSTRUCTION FOR PLANT TOXINGELONIN
ATE464320T1 (en) NTB-A, A SURFACE MOLECULE IMPLIED IN THE ACTIVITY OF NATURAL KILLER CELLS (NK)
ATE253639T1 (en) METHOD FOR PRODUCING PEPTIDES
PT704527E (en) DNA sequencing that encodes BIOSAETIC INSULIN PRECURSORS AND PROCESS FOR THE PREPARATION OF INSULIN
BR0008187A (en) Biological control of nematodes
DE59712771D1 (en) Epididymis-specific receptor protein and its use
ATE541920T1 (en) STRESS-RELATED PROTEIN PHOSPHATASE POLYPEPTIDES AND METHOD FOR USE IN PLANTS
NO874704D0 (en) MINACTIVIN MANUFACTURED BY RECOMBINANT DNA TECHNOLOGY.
DE60234377D1 (en) STRESS ASSOCIATED, PROTEIN KINASE-SPECIFIC POLYPEPTIDES AND METHOD FOR USE IN PLANTS
BR1100940A (en) Pure polypeptides, DNA sequences, recombinant DNA molecule, host cell, genetic manipulation process for polypeptide production, and use of a polypeptide
DE60037413D1 (en) RECOMBINANT ADHESINE PROTEINS FROM HAEMOPHILUS INFLUENZAE
ATE103341T1 (en) ANTIBODIES AGAINST HIGHLY CONSERVED AMINO ACID SEQUENCES OF IMMUNOGENIC SUBSTANCES, METHODS FOR THE PRODUCTION OF THESE ANTIBODIES, AND THEIR USE IN IMMUNOASSAYS.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]