BR0014945A - Modificação pós-traducional de proteìnas recombinantes produzidas em plantas - Google Patents
Modificação pós-traducional de proteìnas recombinantes produzidas em plantasInfo
- Publication number
- BR0014945A BR0014945A BR0014945-4A BR0014945A BR0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A
- Authority
- BR
- Brazil
- Prior art keywords
- plants
- genetically engineered
- recombinant proteins
- proteins produced
- posttranslational modification
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 230000004481 post-translational protein modification Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MODIFICAçãO PóS-TRADUCIONAL DE PROTEINAS RECOMBINANTES PRODUZIDAS EM PLANTAS". A presente invenção se refere a um processo para a produção de proteínas ou polipeptídeos usando-se plantas ou células de plantas geneticamente manipuladas, bem como a plantas ou células de plantas geneticamente manipuladas per se (incluindo partes de plantas geneticamente manipuladas), o material proteico heterólogo (por exemplo, uma proteína, polipeptídeo e semelhantes), o qual é produzido com o auxílio dessas plantas ou células de plantas geneticamente manipuladas, e a polinucleotídeos recombinantes (DNA ou RNA) que são usados para a manipulação genética.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16075899P | 1999-10-21 | 1999-10-21 | |
| US19528200P | 2000-04-07 | 2000-04-07 | |
| PCT/US2000/029027 WO2001029242A2 (en) | 1999-10-21 | 2000-10-20 | Post-translational modification of recombinant proteins produced in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0014945A true BR0014945A (pt) | 2004-08-31 |
Family
ID=26857200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0014945-4A BR0014945A (pt) | 1999-10-21 | 2000-10-20 | Modificação pós-traducional de proteìnas recombinantes produzidas em plantas |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1224309A2 (pt) |
| AU (1) | AU1573601A (pt) |
| BR (1) | BR0014945A (pt) |
| CA (1) | CA2388432A1 (pt) |
| WO (1) | WO2001029242A2 (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| NZ512185A (en) | 1998-12-09 | 2004-02-27 | Dow Chemical Co | A method for manufacturing glycoproteins having human- type glycosylation in plant cells |
| AU1738401A (en) | 1999-10-26 | 2001-05-08 | Plant Research International B.V. | Mammalian-type glycosylation in plants |
| AT409381B (de) * | 2000-03-03 | 2002-07-25 | Gloessl Josef Dr | Xylosyltransferase-gen |
| EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | FUSION PROTEINS CONTAINING ALBUMIN |
| US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| CA2434364C (en) | 2001-01-19 | 2013-03-19 | The Dow Chemical Company | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
| JP2005525081A (ja) | 2001-06-05 | 2005-08-25 | カレン ケイ. オオイシ | 植物からの生物活性ミュラー管抑制物質を含むTGF−βタンパク質の遺伝子発現および産生法 |
| CN1533438A (zh) * | 2001-06-08 | 2004-09-29 | �����Ŵ��Ƽ���˾ | 在植物生产蛋白质的方法 |
| PT1463751E (pt) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Proteínas de fusão de albumina |
| EP2319935B1 (en) * | 2002-03-19 | 2016-04-27 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-N-acetylglucosamine:Beta -D mannoside Beta (1,4)-N-acetylglucosaminyltransferase III) expression in plants. |
| EP2339004B1 (en) * | 2002-03-19 | 2015-02-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| AU2008202355B2 (en) * | 2002-03-19 | 2011-04-07 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
| ES2269595T3 (es) * | 2002-12-20 | 2007-04-01 | Greenovation Biotech Gmbh | Metodo para producir proteinas glicosiladas heterologas en celulas de briofita. |
| WO2004057002A2 (en) * | 2002-12-20 | 2004-07-08 | Greenovation Biotech Gmbh | Production of heterologous glycosylated proteins in bryophyte cells |
| JP2006516258A (ja) * | 2002-12-27 | 2006-06-29 | シェンジェンシチンファユアンシンシェンウイヤオカジヨウシャンゴンシ | ワクチンおよび抗腫瘍ワクチンを調製する方法 |
| CZ308720B6 (cs) * | 2003-01-22 | 2021-03-24 | Roche Glycart Ag | Fúzní konstrukty a jejich použití pro přípravu protilátek se zvýšenou vazebnou afinitou k receptorům Fc a efektorovou funkcí |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CN100427599C (zh) * | 2003-12-26 | 2008-10-22 | 吉林大学第一医院 | Albsin/il-18mat杂交细胞因子 |
| EP2357241B1 (en) * | 2004-09-29 | 2015-03-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
| ES2395842T3 (es) | 2006-01-17 | 2013-02-15 | Synthon Biopharmaceuticals B.V. | Composiciones y métodos para la humanización y optimización de N-glicanos en plantas |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| KR20090079258A (ko) * | 2006-11-08 | 2009-07-21 | 상뜨르 나쇼날 드 라 러쉐르쉬 샹띠피끄 (쎄엔알에스) | 타겟팅 발현 및 재조합 폴리펩타이드의 번역 후 변형 조절을 위한 서열 세트 |
| NZ580510A (en) | 2007-04-17 | 2011-06-30 | Stichting Dienst Landbouwkundi | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
| CN104962579A (zh) * | 2007-06-15 | 2015-10-07 | 麦迪卡格公司 | 修饰植物中的糖蛋白产生 |
| US20100242128A1 (en) * | 2007-10-31 | 2010-09-23 | Bayer BioSceince NV | Method to produce modified plants with altered n-glycosylation pattern |
| JP5710978B2 (ja) | 2007-11-08 | 2015-04-30 | ネオジェニックス オンコロジー, インコーポレイテッド | 結腸癌および膵臓癌に対する組み換えモノクローナル抗体および対応抗原 |
| KR101745925B1 (ko) | 2008-07-18 | 2017-06-12 | 메디카고 인코포레이티드 | 신규 인플루엔자 바이러스 면역화 에피토프 |
| WO2013067322A1 (en) * | 2011-11-03 | 2013-05-10 | Stc Biologics, Inc. | Method for determination of pharmacological properties of recombinant proteins |
| US20150366890A1 (en) | 2013-02-25 | 2015-12-24 | Trustees Of Boston University | Compositions and methods for treating fungal infections |
| GB201308120D0 (en) * | 2013-05-06 | 2013-06-12 | Baden Wuerttemberg Stiftung Gmbh | Recombinant protein and method for its production |
| US9803017B2 (en) | 2013-07-05 | 2017-10-31 | University Of Washington Through Its Center For Commercialization | Soluble MIC neutralizing monoclonal antibody for treating cancer |
| JPWO2015050005A1 (ja) * | 2013-10-02 | 2017-03-09 | 株式会社UniBio | Egf受容体を介して細胞増殖を促進するタンパク質組成物 |
| EA038931B9 (ru) | 2014-11-20 | 2022-02-18 | Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. | Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений |
| SG11201808440YA (en) * | 2016-04-15 | 2018-10-30 | Regenxbio Inc | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
| WO2017180936A1 (en) | 2016-04-15 | 2017-10-19 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US12558434B2 (en) | 2018-02-20 | 2026-02-24 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US20220135992A1 (en) * | 2019-03-06 | 2022-05-05 | Plantform Corporation | T-dna vectors with engineered 5' sequences upstream of post-translational modification enzymes and methods of use thereof |
| KR20230152783A (ko) | 2020-07-07 | 2023-11-03 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| KR20230152032A (ko) | 2021-02-03 | 2023-11-02 | 모차르트 쎄라퓨틱스 인코포레이티드 | 결합제 및 이를 사용하는 방법 |
| EP4319820A1 (en) | 2021-04-10 | 2024-02-14 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| JP7742892B2 (ja) | 2021-04-23 | 2025-09-22 | ジェンマブ エー/エス | 抗cd70抗体、そのコンジュゲートおよびこれを使用する方法 |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| US20250334585A1 (en) | 2021-07-13 | 2025-10-30 | Keystone Bio, Inc. | Diagnostics for porphyromonas gingivalis |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| CA3238167A1 (en) | 2021-11-19 | 2023-05-25 | Maria Leia Smith | Gpc3 binding agents, conjugates thereof and methods of using the same |
| WO2024030956A2 (en) | 2022-08-03 | 2024-02-08 | Mozart Therapeutics, Inc. | Cd39-specific binding agents and methods of using the same |
| LU103006B1 (de) * | 2022-09-15 | 2024-03-15 | Phaeosynt Gbr | Immunoassay zum nachweisen biologisch aktiver proteine |
| CN121194993A (zh) | 2023-05-24 | 2025-12-23 | 莫扎特治疗公司 | Cd8特异性结合蛋白及其应用方法 |
| WO2025072406A1 (en) | 2023-09-26 | 2025-04-03 | Profoundbio Us Co. | Ptk7 binding agents, conjugates thereof and methods of using the same |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Slitrk6結合劑、其共軛物及使用彼之方法 |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| WO2025222129A2 (en) | 2024-04-19 | 2025-10-23 | Mozart Therapeutics, Inc. | Engineered cytokines and targeted cytokine delivery |
| US20260048137A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
| DE19754622A1 (de) * | 1997-12-09 | 1999-06-10 | Antje Von Dr Schaewen | Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität |
| NZ512185A (en) * | 1998-12-09 | 2004-02-27 | Dow Chemical Co | A method for manufacturing glycoproteins having human- type glycosylation in plant cells |
| AU1738401A (en) * | 1999-10-26 | 2001-05-08 | Plant Research International B.V. | Mammalian-type glycosylation in plants |
| AU1738301A (en) * | 1999-10-26 | 2001-05-08 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Gonadotrophins in plants |
-
2000
- 2000-10-20 CA CA002388432A patent/CA2388432A1/en not_active Abandoned
- 2000-10-20 BR BR0014945-4A patent/BR0014945A/pt not_active Application Discontinuation
- 2000-10-20 WO PCT/US2000/029027 patent/WO2001029242A2/en not_active Ceased
- 2000-10-20 AU AU15736/01A patent/AU1573601A/en not_active Abandoned
- 2000-10-20 EP EP00978257A patent/EP1224309A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1224309A2 (en) | 2002-07-24 |
| WO2001029242A3 (en) | 2002-02-21 |
| AU1573601A (en) | 2001-04-30 |
| CA2388432A1 (en) | 2001-04-26 |
| WO2001029242A2 (en) | 2001-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |