BR0014973A - Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 - Google Patents

Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38

Info

Publication number
BR0014973A
BR0014973A BR0014973-0A BR0014973A BR0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A
Authority
BR
Brazil
Prior art keywords
protein kinase
nitrogen heterocycles
kinase inhibitors
heterocycles substituted
bicyclic
Prior art date
Application number
BR0014973-0A
Other languages
English (en)
Inventor
James Patrick Dunn
David Michael Goldstein
William Harris
Ian Edward David Smith
Teresa Rosanne Welch
Original Assignee
Hoffmann La Roche Ag G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche Ag G filed Critical Hoffmann La Roche Ag G
Publication of BR0014973A publication Critical patent/BR0014973A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"HETEROCICLOS DE NITROGêNIO BICìCLICO DE ALQUILAMINO SUBSTITUìDO COMO INIBIDORES DE PROTEìNA QUINASE P38". Derivados de diidropirimido[4,5-d] pirimidinona de alquilamino substituído da fórmula (I) são proporcionados em que R^ 1^-R^ 3^ são como definidos no pedido que são úteis como inibidores de P38, junto com um processo para sua fabricação e preparações farmacêuticas contendo os mesmos.
BR0014973-0A 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 BR0014973A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16080499P 1999-10-21 1999-10-21
US21371800P 2000-06-22 2000-06-22
PCT/EP2000/010077 WO2001029041A1 (en) 1999-10-21 2000-10-13 Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Publications (1)

Publication Number Publication Date
BR0014973A true BR0014973A (pt) 2002-07-16

Family

ID=26857242

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014973-0A BR0014973A (pt) 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38

Country Status (24)

Country Link
US (1) US6642241B1 (pt)
EP (1) EP1226144B1 (pt)
KR (1) KR100537241B1 (pt)
CN (1) CN1156477C (pt)
AR (1) AR026187A1 (pt)
AT (1) ATE349447T1 (pt)
AU (1) AU776695B2 (pt)
BR (1) BR0014973A (pt)
CA (1) CA2388140C (pt)
CO (1) CO5251408A1 (pt)
CZ (1) CZ20021743A3 (pt)
DE (1) DE60032623T2 (pt)
ES (1) ES2277858T3 (pt)
HR (1) HRP20020327A2 (pt)
HU (1) HUP0203477A3 (pt)
IL (1) IL149230A0 (pt)
MA (1) MA26836A1 (pt)
MX (1) MXPA02003841A (pt)
NO (1) NO20021783D0 (pt)
PE (1) PE20010760A1 (pt)
PL (1) PL357494A1 (pt)
TR (1) TR200201058T2 (pt)
WO (1) WO2001029041A1 (pt)
YU (1) YU29202A (pt)

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WO2004004725A2 (en) 2002-07-09 2004-01-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
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US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7112676B2 (en) 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
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JP2006522756A (ja) 2003-04-10 2006-10-05 エフ．ホフマン−ラ　ロシュ　アーゲー ピリミド化合物
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US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
JP2008510690A (ja) 2004-08-31 2008-04-10 エフ．ホフマン−ラ ロシュ アーゲー ３−フェニル−ジヒドロピリミド［４，５−ｄ］ピリミジノンのアミド誘導体、これらの製造、及び医薬品としての使用
BRPI0514750A (pt) 2004-08-31 2008-06-24 Hoffmann La Roche derivados amida de 7-amino-3-fenil-diidropirimido[4, 5-d]pirimidinonas, sua fabricação e uso como inibidores de proteìna cinase
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AU2007211684A1 (en) 2006-01-31 2007-08-09 F. Hoffmann-La Roche Ag 7H-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors
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EP2108641A1 (en) * 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
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LT3495367T (lt) 2012-06-13 2021-02-25 Incyte Holdings Corporation Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
CA2907243C (en) 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor
JP6576325B2 (ja) 2013-03-15 2019-09-18 セルジーン シーエーアール エルエルシー ヘテロアリール化合物およびそれらの使用
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ES3061844T3 (en) 2018-05-04 2026-04-07 Incyte Corp Salts of an fgfr inhibitor
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
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US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TWI891666B (zh) 2019-10-14 2025-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
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CN1150195C (zh) 1998-10-23 2004-05-19 霍夫曼-拉罗奇有限公司 双环氮杂环

Also Published As

Publication number Publication date
CN1156477C (zh) 2004-07-07
CN1382142A (zh) 2002-11-27
KR100537241B1 (ko) 2005-12-19
YU29202A (sh) 2004-12-31
NO20021783L (no) 2002-04-16
KR20020039375A (ko) 2002-05-25
HUP0203477A2 (hu) 2003-01-28
NO20021783D0 (no) 2002-04-16
CZ20021743A3 (cs) 2002-08-14
JP4028236B2 (ja) 2007-12-26
DE60032623D1 (de) 2007-02-08
EP1226144B1 (en) 2006-12-27
CO5251408A1 (es) 2003-02-28
AU1137501A (en) 2001-04-30
HRP20020327A2 (en) 2004-02-29
DE60032623T2 (de) 2007-10-11
MXPA02003841A (es) 2002-09-30
AR026187A1 (es) 2003-01-29
HK1051040A1 (en) 2003-07-18
US6642241B1 (en) 2003-11-04
PE20010760A1 (es) 2001-07-21
MA26836A1 (fr) 2004-12-20
WO2001029041A1 (en) 2001-04-26
CA2388140A1 (en) 2001-04-26
CA2388140C (en) 2008-09-02
ES2277858T3 (es) 2007-08-01
TR200201058T2 (tr) 2002-07-22
HUP0203477A3 (en) 2004-12-28
AU776695B2 (en) 2004-09-16
IL149230A0 (en) 2002-11-10
ATE349447T1 (de) 2007-01-15
EP1226144A1 (en) 2002-07-31
JP2003512377A (ja) 2003-04-02
PL357494A1 (en) 2004-07-26

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.