BR0014973A - Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 - Google Patents

Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38

Info

Publication number
BR0014973A
BR0014973A BR0014973-0A BR0014973A BR0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A BR 0014973 A BR0014973 A BR 0014973A
Authority
BR
Brazil
Prior art keywords
protein kinase
nitrogen heterocycles
kinase inhibitors
heterocycles substituted
bicyclic
Prior art date
Application number
BR0014973-0A
Other languages
English (en)
Inventor
James Patrick Dunn
David Michael Goldstein
William Harris
Ian Edward David Smith
Teresa Rosanne Welch
Original Assignee
Hoffmann La Roche Ag G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche Ag G filed Critical Hoffmann La Roche Ag G
Publication of BR0014973A publication Critical patent/BR0014973A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"HETEROCICLOS DE NITROGêNIO BICìCLICO DE ALQUILAMINO SUBSTITUìDO COMO INIBIDORES DE PROTEìNA QUINASE P38". Derivados de diidropirimido[4,5-d] pirimidinona de alquilamino substituído da fórmula (I) são proporcionados em que R^ 1^-R^ 3^ são como definidos no pedido que são úteis como inibidores de P38, junto com um processo para sua fabricação e preparações farmacêuticas contendo os mesmos.
BR0014973-0A 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 BR0014973A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16080499P 1999-10-21 1999-10-21
US21371800P 2000-06-22 2000-06-22
PCT/EP2000/010077 WO2001029041A1 (en) 1999-10-21 2000-10-13 Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Publications (1)

Publication Number Publication Date
BR0014973A true BR0014973A (pt) 2002-07-16

Family

ID=26857242

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014973-0A BR0014973A (pt) 1999-10-21 2000-10-13 Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38

Country Status (24)

Country Link
US (1) US6642241B1 (pt)
EP (1) EP1226144B1 (pt)
KR (1) KR100537241B1 (pt)
CN (1) CN1156477C (pt)
AR (1) AR026187A1 (pt)
AT (1) ATE349447T1 (pt)
AU (1) AU776695B2 (pt)
BR (1) BR0014973A (pt)
CA (1) CA2388140C (pt)
CO (1) CO5251408A1 (pt)
CZ (1) CZ20021743A3 (pt)
DE (1) DE60032623T2 (pt)
ES (1) ES2277858T3 (pt)
HR (1) HRP20020327A2 (pt)
HU (1) HUP0203477A3 (pt)
IL (1) IL149230A0 (pt)
MA (1) MA26836A1 (pt)
MX (1) MXPA02003841A (pt)
NO (1) NO20021783D0 (pt)
PE (1) PE20010760A1 (pt)
PL (1) PL357494A1 (pt)
TR (1) TR200201058T2 (pt)
WO (1) WO2001029041A1 (pt)
YU (1) YU29202A (pt)

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DE69939168D1 (de) 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
US20040044012A1 (en) * 1998-05-26 2004-03-04 Dobrusin Ellen Myra Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
KR20040103972A (ko) * 2002-04-19 2004-12-09 스미스클라인 비참 코포레이션 신규 화합물
AU2003245989A1 (en) 2002-07-09 2004-01-23 Boehringer Ingelheim Pharma Gmbh And Co. Kg Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
KR100793688B1 (ko) * 2002-08-06 2008-01-10 에프. 호프만-라 로슈 아게 Ｐ-38 미토겐 활성 단백질 키나제 억제제로서6-알콕시-피리도-피리미딘
RU2324695C2 (ru) 2002-08-06 2008-05-20 Ф.Хоффманн-Ля Рош Аг 6-АЛКОКСИПИРИДОПИРИМИДИНЫ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АКТИВНОСТЬЮ ИНГИБИТОРОВ КИНАЗЫ МАР р38
US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7129351B2 (en) * 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
CA2521124A1 (en) * 2003-04-10 2004-10-21 F. Hoffmann-La Roche Ag Pyrimido compounds
WO2005103288A1 (ja) * 2004-04-27 2005-11-03 Takeda Pharmaceutical Company Limited スクリーニング方法
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
EP1789417A1 (en) 2004-08-31 2007-05-30 F.Hoffmann-La Roche Ag AMIDE DERIVATIVES OF 7-AMINO-3-PHENYL-DIHYDROPYRIMIDO [4,5-d]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS
WO2006024486A2 (en) 2004-08-31 2006-03-09 F. Hoffmann-La Roche Ag Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1981886B1 (en) 2006-01-31 2009-08-12 F.Hoffmann-La Roche Ag 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2108641A1 (en) * 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CA2876689C (en) 2012-06-13 2022-04-26 Incyte Corporation Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MY181020A (en) 2013-03-15 2020-12-16 Sanofi Sa Heteroaryl compounds and uses thereof
TWI647220B (zh) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 雜芳基化合物及其用途
PH12015502383B1 (en) 2013-04-19 2023-02-03 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
MA38393B1 (fr) 2014-03-13 2018-11-30 Sanofi Sa Composés hétéroaryle et utilisations associées
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CA2976790C (en) 2015-02-20 2024-02-27 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
ES2927715T3 (es) 2017-10-05 2022-11-10 Fulcrum Therapeutics Inc Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD
KR102956194B1 (ko) 2018-05-04 2026-04-23 인사이트 코포레이션 Fgfr 억제제의 염
RS66310B1 (sr) 2018-05-04 2025-01-31 Incyte Corp Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
GEP20247679B (en) 2019-10-14 2024-10-10 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
GB201915828D0 (en) * 2019-10-31 2019-12-18 Cancer Research Tech Ltd Compounds, compositions and therapeutic uses thereof
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EP4323405A1 (en) 2021-04-12 2024-02-21 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
TW202313610A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環
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DE69939168D1 (de) * 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
PL347432A1 (en) 1998-10-23 2002-04-08 Hoffmann La Roche Bicyclic nitrogen heterocycles

Also Published As

Publication number Publication date
EP1226144B1 (en) 2006-12-27
PE20010760A1 (es) 2001-07-21
CA2388140C (en) 2008-09-02
MA26836A1 (fr) 2004-12-20
TR200201058T2 (tr) 2002-07-22
KR100537241B1 (ko) 2005-12-19
CZ20021743A3 (cs) 2002-08-14
DE60032623D1 (de) 2007-02-08
PL357494A1 (en) 2004-07-26
JP2003512377A (ja) 2003-04-02
AR026187A1 (es) 2003-01-29
AU776695B2 (en) 2004-09-16
YU29202A (sh) 2004-12-31
HUP0203477A2 (hu) 2003-01-28
AU1137501A (en) 2001-04-30
HRP20020327A2 (en) 2004-02-29
DE60032623T2 (de) 2007-10-11
HUP0203477A3 (en) 2004-12-28
CN1382142A (zh) 2002-11-27
ES2277858T3 (es) 2007-08-01
HK1051040A1 (en) 2003-07-18
EP1226144A1 (en) 2002-07-31
CN1156477C (zh) 2004-07-07
NO20021783L (no) 2002-04-16
KR20020039375A (ko) 2002-05-25
CA2388140A1 (en) 2001-04-26
MXPA02003841A (es) 2002-09-30
ATE349447T1 (de) 2007-01-15
CO5251408A1 (es) 2003-02-28
WO2001029041A1 (en) 2001-04-26
IL149230A0 (en) 2002-11-10
JP4028236B2 (ja) 2007-12-26
US6642241B1 (en) 2003-11-04
NO20021783D0 (no) 2002-04-16

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.