ECSP034554A - 3,4-DIHIDRO-PIRIMIDO(1,2-a) PIRIMIDINA Y 3,4-DIHIDRO-PIRAZINO (1,2-a) PIRAMIDINA SUSTITUIDAS - Google Patents

3,4-DIHIDRO-PIRIMIDO(1,2-a) PIRIMIDINA Y 3,4-DIHIDRO-PIRAZINO (1,2-a) PIRAMIDINA SUSTITUIDAS

Info

Publication number
ECSP034554A
ECSP034554A EC2003004554A ECSP034554A ECSP034554A EC SP034554 A ECSP034554 A EC SP034554A EC 2003004554 A EC2003004554 A EC 2003004554A EC SP034554 A ECSP034554 A EC SP034554A EC SP034554 A ECSP034554 A EC SP034554A
Authority
EC
Ecuador
Prior art keywords
dihydro
pyrimidine
pirazino
pyrimid
substituted
Prior art date
Application number
EC2003004554A
Other languages
English (en)
Inventor
Mathias Gerlach
Corinna Maul
Utz Peter Jagusch
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ECSP034554A publication Critical patent/ECSP034554A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L a invención se refiere a 3,4 dihidro-pirimido(1,2-a) pirimidina y 3,4-dihidro-pirazino (1,2-a) pirimidina sustituidas, procedimientos para su preparación bibliotecas de las sustancias que las contienen, medicamento que contienen, medicamentos que contienen estos compuestos el ejemplo de esos compuestos para preparar medicamentos para el tratamiento aurium y/o diarrea, así como las preparaciones farmacéuticas que contienen estos compuestos.
EC2003004554A 2000-10-13 2003-04-11 3,4-DIHIDRO-PIRIMIDO(1,2-a) PIRIMIDINA Y 3,4-DIHIDRO-PIRAZINO (1,2-a) PIRAMIDINA SUSTITUIDAS ECSP034554A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050661A DE10050661A1 (de) 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrimido[1,2-a]pyrimidine und 3,4-Dihydro-pyrazino[1,2-a]pyrimidine

Publications (1)

Publication Number Publication Date
ECSP034554A true ECSP034554A (es) 2003-05-26

Family

ID=7659596

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004554A ECSP034554A (es) 2000-10-13 2003-04-11 3,4-DIHIDRO-PIRIMIDO(1,2-a) PIRIMIDINA Y 3,4-DIHIDRO-PIRAZINO (1,2-a) PIRAMIDINA SUSTITUIDAS

Country Status (25)

Country Link
US (1) US7226924B2 (es)
EP (1) EP1325010B1 (es)
JP (1) JP2004511485A (es)
KR (1) KR20030036923A (es)
CN (1) CN1243753C (es)
AR (1) AR035496A1 (es)
AT (1) ATE294180T1 (es)
AU (1) AU2002214007A1 (es)
BR (1) BR0114735A (es)
CA (1) CA2425685A1 (es)
DE (2) DE10050661A1 (es)
EC (1) ECSP034554A (es)
ES (1) ES2239168T3 (es)
HU (1) HUP0302606A3 (es)
IL (1) IL155379A0 (es)
MX (1) MXPA03003199A (es)
NO (1) NO20031588D0 (es)
NZ (1) NZ525651A (es)
PE (1) PE20020477A1 (es)
PL (1) PL361777A1 (es)
PT (1) PT1325010E (es)
RU (1) RU2003113965A (es)
SK (1) SK4152003A3 (es)
WO (1) WO2002030934A1 (es)
ZA (1) ZA200303634B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1828186A1 (en) 2004-12-13 2007-09-05 Sunesis Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558618A (en) * 1968-04-01 1971-01-26 Dow Chemical Co Novel 4h-pyrazino(1,2-a)pyrimidine-4-ones
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
FI94531C (fi) * 1990-03-13 1995-09-25 Ime Intermed Enterpris Sa Menetelmä farmaseuttisesti aktiivisen 1,3,4,6,7,8-heksahydro-2H-pyrimido-(1,2-a)-pyrimidiinijohdannaisen valmistamiseksi
IT1263804B (it) * 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
AU707530B2 (en) * 1995-09-28 1999-07-15 Otsuka Pharmaceutical Factory, Inc. Analgesic composition

Also Published As

Publication number Publication date
ATE294180T1 (de) 2005-05-15
CN1243753C (zh) 2006-03-01
HK1056558A1 (en) 2004-02-20
HUP0302606A3 (en) 2007-03-28
DE10050661A1 (de) 2002-04-18
NZ525651A (en) 2004-10-29
KR20030036923A (ko) 2003-05-09
EP1325010A1 (de) 2003-07-09
WO2002030934A1 (de) 2002-04-18
CN1469879A (zh) 2004-01-21
AR035496A1 (es) 2004-06-02
EP1325010B1 (de) 2005-04-27
CA2425685A1 (en) 2003-04-11
AU2002214007A1 (en) 2002-04-22
DE50106048D1 (de) 2005-06-02
ZA200303634B (en) 2004-08-12
MXPA03003199A (es) 2004-03-18
BR0114735A (pt) 2003-10-14
IL155379A0 (en) 2003-11-23
PE20020477A1 (es) 2002-06-29
US7226924B2 (en) 2007-06-05
RU2003113965A (ru) 2004-12-10
ES2239168T3 (es) 2005-09-16
NO20031588L (no) 2003-04-08
US20030220322A1 (en) 2003-11-27
PT1325010E (pt) 2005-08-31
SK4152003A3 (en) 2003-10-07
HUP0302606A2 (hu) 2004-07-28
PL361777A1 (en) 2004-10-04
NO20031588D0 (no) 2003-04-08
JP2004511485A (ja) 2004-04-15

Similar Documents

Publication Publication Date Title
GT199700089A (es) Derivados 6.6 o 6.7 -biciclicos sustituidos que contienen pirido o pirimido.
GT200500007A (es) [1,8]naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia.
PA8462401A1 (es) Derivados de la tienopirimidina y de la tienopiridina utiles como agentes anticancerigenos
ES2052629T3 (es) Pirazolo(3,4-d)piridinas, procedimiento para su preparacion y utilizacion como medicamentos.
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
GT199700079A (es) Derivados triciclos sustituidos con fenilamino
ES2191187T3 (es) Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
UY27604A1 (es) Compuestos químicos.
EE200000318A (et) Uudsed ühendid
AR007856A1 (es) Compuestos heterociclicos fusionados como inhibidores de proteina tirosina, quinasa, sus metodos de prepraracion, intermediarios, uso en medicina ycomposiciones farmaceuticas que los contienen
DE60314623D1 (de) Substituierte pyrazolopyrimidine
SV1999000048A (es) Uso de dihidropiriminas como medicamento y nuevas sustancias ref. lea 32 791-sv
EP0695171A1 (en) GONADOTROPINE CONTAINING FREEZER DRIED DROPS
AR025052A1 (es) Derivados de 2-dialquilaminoalquilbifenilo sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estoscompuestos para la preparacion de medicamentos.
UY26370A1 (es) "imidazo-5-il-aminas bicíclicas, medicamentos que las contienen, su uso para la preparación de medicamentos y procedimiento para su preparación".
NO971997D0 (no) Bruk av immunmodulerende midler
AR030662A1 (es) Beta-tio-alfa-aminoacidos, procedimiento para su fabricacion, medicamentos que contienen estos compuestos y el uso de los tioaminoacidos para la preparacion de medicamentos
ES2122085T3 (es) Combinacion antibiotica.
UY27394A1 (es) Pedidos con actividad anti- angiogéna.
AR004484A1 (es) Nuevas 1,2,3,4-tetrahidro-2-naftalenaminas fenilo-sustituidas en el anillo aromatico, su preparacion, sus aplicaciones terapeuticas y las composicionesfarmaceuticas que las contienen.
UY26507A1 (es) Bases de mannich de 1-naftol y 2-naftol sustituidos, procedimiento para su preparación, medicamentos que contienen estos compuestos, así como el uso de estos compuestos para la preparación de medicamentos
NO20020914L (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
ECSP034553A (es) 3,4-DIHIDROPIRIDO (1,2-a)PIRIMIDINAS SUSTITUIDAS
CL2004000978A1 (es) Compuestos derivados de pirazolopirimidinas sustituidos de formula definida, inhibidores de pde; procedimiento para su preparacion; composicion farmaceutica que los contiene y sus usos para preparar medicamentos que sirven para tratar trastornos de l
ECSP003842A (es) Bases de mannich de 1-naftol y 2-naftol sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos, así como el uso de estos compuestos para la preparacion de medicamentos.