BR0015425A - N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht - Google Patents

N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht

Info

Publication number
BR0015425A
BR0015425A BR0015425-3A BR0015425A BR0015425A BR 0015425 A BR0015425 A BR 0015425A BR 0015425 A BR0015425 A BR 0015425A BR 0015425 A BR0015425 A BR 0015425A
Authority
BR
Brazil
Prior art keywords
alkyl
aryl
carriers
carbon atoms
substitutable
Prior art date
Application number
BR0015425-3A
Other languages
English (en)
Inventor
Adam Matthew Gilbert
Richard Eric Mewshaw
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0015425A publication Critical patent/BR0015425A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"N-ARIL-(HOMOPIPERAZINIL)-CICLOHEXILAMINAS COMO TRANSPORTADORAS DE 5-HT" A presente invenção refere-se a novos compostos e métodos e composições usando os mesmos no tratamento de distúrbios do sistema nervoso central, incluindo depressão e ansiedade, os compostos tendo a fórmula (I), em que Ar representa um grupo arila, arilalquila ou heteroarila; R~ 1~ e R~ 2~ são independentemente selecionados de hidrogênio, alquila de 1 a 12 átomos de carbono que pode ser substituído por cicloalquila de 3 a 10 átomos de carbono, que pode ser substituído; R~ 3~ é H, alquila que pode ser substituído, alquila cíclica que pode ser substituído, halogênio, alcóxi, haloalquila, OH, nitro, amino, CN, carbóxi, alcoxicarbonila, alquilcarbonila, aminocarbonila e alquilaminocarbonila, ou um sal farmaceuticamente aceitável dos mesmos.
BR0015425-3A 1999-11-08 2000-05-19 N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht BR0015425A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43612999A 1999-11-08 1999-11-08
PCT/US2000/014020 WO2001034597A1 (en) 1999-11-08 2000-05-19 N-aryl-(homopiperazinyl)-cyclohexyl amines as 5-ht transporters

Publications (1)

Publication Number Publication Date
BR0015425A true BR0015425A (pt) 2002-07-16

Family

ID=23731225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015425-3A BR0015425A (pt) 1999-11-08 2000-05-19 N-aril-( homopiperazinil )-ciclohexilaminas como transportadoras de 5-ht

Country Status (8)

Country Link
EP (1) EP1228064A1 (pt)
JP (1) JP2003513969A (pt)
CN (1) CN1420883A (pt)
AU (1) AU5152300A (pt)
BR (1) BR0015425A (pt)
CA (1) CA2390530A1 (pt)
MX (1) MXPA02004554A (pt)
WO (1) WO2001034597A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
SE0103648D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinolone compounds
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
DK0946538T3 (da) * 1996-12-20 2003-11-03 Lundbeck & Co As H Indan- eller dihydroindole derivater

Also Published As

Publication number Publication date
CN1420883A (zh) 2003-05-28
WO2001034597A1 (en) 2001-05-17
MXPA02004554A (es) 2004-09-10
AU5152300A (en) 2001-06-06
EP1228064A1 (en) 2002-08-07
JP2003513969A (ja) 2003-04-15
CA2390530A1 (en) 2001-05-17

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired