BRPI0518233A2 - terapia adjunta para depressço - Google Patents
terapia adjunta para depressçoInfo
- Publication number
- BRPI0518233A2 BRPI0518233A2 BRPI0518233-6A BRPI0518233A BRPI0518233A2 BR PI0518233 A2 BRPI0518233 A2 BR PI0518233A2 BR PI0518233 A BRPI0518233 A BR PI0518233A BR PI0518233 A2 BRPI0518233 A2 BR PI0518233A2
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- hydrogen
- group
- depression
- atoms
- Prior art date
Links
- 238000011360 adjunctive therapy Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001923 cyclic compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 nitro, hydroxy Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dry Shavers And Clippers (AREA)
Abstract
TERAPIA ADJUNTA PARA DEPRESSçO. A presente invenção refere-se a um método de tratamento de depressão em um indivíduo compreendendo a etapa da administração de uma quantidade terapeuticamente eficaz de um antidepressivo convencional e, em adição, administração ao indivíduo de uma quantidade terapeutica- mente eficaz de um composto da Fórmula (1) ou um sal ou éster farmaceuticamente aceitável do mesmo onde Rx é um membro selecionado do grupo consistindo em hidrogênio, alquila inferior de 1 a 8 átomos de carbono, halogênio selecionado de F, Cl, Br e 1, alcóxi contendo 1 a 3 átomos de carbono, nitro, hidróxi, trifluormetila e tioalcóxi contendo 1 a 3 átomos de carbono; x é um inteiro de 1 a 3, contanto que R possa ser igual ou diferente quando x for 2 ou 3; R1 e R2 podem ser iguais ou diferentes um do outro e são independentemente selecionados do grupo consistindo em hidrogênio, alquila inferior de 1 a 8 átomos de carbono, ana, arilalquila, cicloalquila de 3 a 7 átomos de carbono; R1 e R2 podem ser unidos para formarem um heterociclo de 5 a 7 membros substituído com um membro selecionado do grupo consistindo em grupos hidrogênio, alquila e arila, onde o composto cíclico pode compreender 1 a 2 átomos de nitrogênio e O a 1 átomo de oxigênio, onde os átomos de nitrogênio não estão diretamente conectados uns aos outros ou com o átomo de oxigênio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62304404P | 2004-10-28 | 2004-10-28 | |
| PCT/US2005/038804 WO2006050037A1 (en) | 2004-10-28 | 2005-10-26 | Adjunctive therapy for depression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518233A2 true BRPI0518233A2 (pt) | 2008-11-11 |
Family
ID=35966035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518233-6A BRPI0518233A2 (pt) | 2004-10-28 | 2005-10-26 | terapia adjunta para depressço |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8729120B2 (pt) |
| EP (1) | EP1819328A1 (pt) |
| JP (1) | JP2008518921A (pt) |
| KR (1) | KR20070083826A (pt) |
| CN (1) | CN101132787A (pt) |
| AU (1) | AU2005302589B2 (pt) |
| BR (1) | BRPI0518233A2 (pt) |
| CA (1) | CA2587481A1 (pt) |
| IL (1) | IL182746A (pt) |
| MX (1) | MX2007005172A (pt) |
| RU (1) | RU2007119648A (pt) |
| WO (1) | WO2006050037A1 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1890684T3 (pl) | 2005-06-08 | 2014-05-30 | Sk Biopharmaceuticals Co Ltd | Leczenie zaburzeń snu i czuwania |
| US8552060B2 (en) | 2005-06-22 | 2013-10-08 | Sk Biopharmaceuticals Co., Ltd. | Methods for treatment of sexual dysfunction |
| CN101568362A (zh) * | 2006-10-30 | 2009-10-28 | 詹森药业有限公司 | 治疗抑郁症的方法 |
| AU2010270971B2 (en) * | 2009-06-22 | 2015-08-20 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating or preventing fatigue |
| ES2447295T3 (es) | 2009-11-06 | 2014-03-11 | Sk Biopharmaceuticals Co., Ltd. | Métodos para el tratamiento del trastorno de déficit de atención/hiperactividad |
| EP2496227B1 (en) | 2009-11-06 | 2019-05-22 | SK Biopharmaceuticals Co., Ltd. | Methods for treating fibromyalgia syndrome |
| US9610274B2 (en) * | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| RU2019114940A (ru) | 2013-03-13 | 2019-06-28 | ЭРИЭЛ БАЙОФАРМА, ЭлЭлСи | Лечение катаплексии |
| CN105848650A (zh) * | 2013-07-12 | 2016-08-10 | 爵士制药国际Iii有限公司 | 促进吸烟停止 |
| DK3021838T3 (da) | 2013-07-18 | 2020-08-24 | Jazz Pharmaceuticals Ireland Ltd | Behandling af fedme |
| TWI655179B (zh) | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| JP6466792B2 (ja) * | 2015-07-03 | 2019-02-06 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 注意欠陥／多動性障害（ａｄｈｄ）の治療方法 |
| CN121202730A (zh) | 2016-09-06 | 2025-12-26 | 爱尔兰贾兹制药有限公司 | (r)-2-氨基-3-苯丙基氨基甲酸酯盐酸盐的制备方法、其组合物及用途 |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| JP7074750B2 (ja) | 2016-10-06 | 2022-05-24 | ジャズ ファーマスティカルズ アイルランド リミテッド | カルバモイルフェニルアラニノール化合物およびその使用 |
| KR20200016889A (ko) | 2017-06-02 | 2020-02-17 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 과다 졸림증을 치료하기 위한 방법 및 조성물 |
| SG11202000817SA (en) | 2017-07-31 | 2020-02-27 | Jazz Pharmaceuticals Ireland Ltd | Carbamoyl phenylalaninol analogs and uses thereof |
| CN110655500B (zh) * | 2018-06-28 | 2020-12-08 | 浙江京新药业股份有限公司 | 氨基甲酸酯衍生物及其制备方法和用途 |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| CN121620365A (zh) | 2023-06-29 | 2026-03-06 | 艾克萨姆治疗股份有限公司 | 向哺乳期妇女施用索安非托的方法 |
| WO2026125068A1 (en) | 2024-12-10 | 2026-06-18 | Noucor Health, S.A. | Process to obtain solriamfetol hydrochloride |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100197892B1 (ko) * | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| US5756817C1 (en) * | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| KR0173863B1 (ko) * | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| CA2417304A1 (en) * | 2000-08-02 | 2002-02-07 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful for the treatment of depression |
| WO2004060374A1 (en) * | 2002-12-27 | 2004-07-22 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders |
| AR042806A1 (es) * | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
-
2005
- 2005-10-26 RU RU2007119648/14A patent/RU2007119648A/ru not_active Application Discontinuation
- 2005-10-26 WO PCT/US2005/038804 patent/WO2006050037A1/en not_active Ceased
- 2005-10-26 US US11/666,521 patent/US8729120B2/en active Active
- 2005-10-26 AU AU2005302589A patent/AU2005302589B2/en not_active Expired
- 2005-10-26 KR KR1020077009567A patent/KR20070083826A/ko not_active Ceased
- 2005-10-26 CA CA002587481A patent/CA2587481A1/en not_active Abandoned
- 2005-10-26 CN CNA2005800368192A patent/CN101132787A/zh active Pending
- 2005-10-26 MX MX2007005172A patent/MX2007005172A/es active IP Right Grant
- 2005-10-26 EP EP05823325A patent/EP1819328A1/en not_active Withdrawn
- 2005-10-26 JP JP2007539126A patent/JP2008518921A/ja active Pending
- 2005-10-26 BR BRPI0518233-6A patent/BRPI0518233A2/pt not_active Application Discontinuation
-
2007
- 2007-04-23 IL IL182746A patent/IL182746A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL182746A (en) | 2014-08-31 |
| CA2587481A1 (en) | 2006-05-11 |
| AU2005302589A1 (en) | 2006-05-11 |
| US20080039529A1 (en) | 2008-02-14 |
| WO2006050037A1 (en) | 2006-05-11 |
| AU2005302589B2 (en) | 2010-09-16 |
| MX2007005172A (es) | 2007-06-22 |
| EP1819328A1 (en) | 2007-08-22 |
| RU2007119648A (ru) | 2008-12-10 |
| JP2008518921A (ja) | 2008-06-05 |
| US8729120B2 (en) | 2014-05-20 |
| KR20070083826A (ko) | 2007-08-24 |
| CN101132787A (zh) | 2008-02-27 |
| IL182746A0 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SK HOLDINGS CO., LTD. (KR) Free format text: ALTERADO DE: SK CORPORATION |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: SK BIOPHARMACEUTICALS CO., LTD. (KR) |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |