BR0015780A - Processo para preparar claritromicina - Google Patents

Processo para preparar claritromicina

Info

Publication number
BR0015780A
BR0015780A BR0015780-5A BR0015780A BR0015780A BR 0015780 A BR0015780 A BR 0015780A BR 0015780 A BR0015780 A BR 0015780A BR 0015780 A BR0015780 A BR 0015780A
Authority
BR
Brazil
Prior art keywords
clarithromycin
oxide
metherythromycin
preparing clarithromycin
preparing
Prior art date
Application number
BR0015780-5A
Other languages
English (en)
Inventor
Kwee-Hyun Suh
Mi-Ra Seong
Nam-Du Kim
Gwan-Sun Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BR0015780A publication Critical patent/BR0015780A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA PREPARAR CLARITROMICINA". Claritromicina pode ser facilmente preparada por reagir N-óxido de eritromicina A com um agente de metilação para obter N-óxido de 6-O-metileritromicina A; e tratar N-óxido de 6-O-metileritromicina A obtido acima com um agente redutor com elevado rendimento.
BR0015780-5A 1999-11-24 2000-11-23 Processo para preparar claritromicina BR0015780A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019990052371A KR100336447B1 (ko) 1999-11-24 1999-11-24 클라리스로마이신의 개선된 제조방법
PCT/KR2000/001349 WO2001038340A1 (en) 1999-11-24 2000-11-23 Method of preparing clarithromycin

Publications (1)

Publication Number Publication Date
BR0015780A true BR0015780A (pt) 2002-07-23

Family

ID=19621549

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015780-5A BR0015780A (pt) 1999-11-24 2000-11-23 Processo para preparar claritromicina

Country Status (14)

Country Link
US (1) US6809188B1 (pt)
EP (1) EP1232171B1 (pt)
JP (1) JP4040877B2 (pt)
KR (1) KR100336447B1 (pt)
CN (1) CN1399642A (pt)
AT (1) ATE341559T1 (pt)
AU (1) AU755838C (pt)
BR (1) BR0015780A (pt)
CA (1) CA2391145A1 (pt)
DE (1) DE60031154T2 (pt)
ES (1) ES2272342T3 (pt)
RU (1) RU2225413C1 (pt)
TR (1) TR200201382T2 (pt)
WO (1) WO2001038340A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
AU2578701A (en) * 2000-02-29 2001-09-12 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2005000233A2 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
EP2023721A2 (en) * 2006-06-05 2009-02-18 Auspex Pharmaceuticals Inc. Preparation and utility of substituted erythromycin analogs
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN103172686B (zh) * 2013-04-08 2015-06-24 山东大学 克拉霉素-n-氧化物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
US5872229A (en) * 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
IL135792A0 (en) * 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법

Also Published As

Publication number Publication date
JP4040877B2 (ja) 2008-01-30
DE60031154D1 (de) 2006-11-16
DE60031154T2 (de) 2007-01-11
EP1232171A4 (en) 2002-10-31
WO2001038340A1 (en) 2001-05-31
CA2391145A1 (en) 2001-05-31
ES2272342T3 (es) 2007-05-01
EP1232171B1 (en) 2006-10-04
EP1232171A1 (en) 2002-08-21
ATE341559T1 (de) 2006-10-15
KR20010047939A (ko) 2001-06-15
CN1399642A (zh) 2003-02-26
TR200201382T2 (tr) 2002-10-21
RU2225413C1 (ru) 2004-03-10
JP2003514915A (ja) 2003-04-22
AU1898301A (en) 2001-06-04
AU755838C (en) 2004-07-08
AU755838B2 (en) 2002-12-19
US6809188B1 (en) 2004-10-26
KR100336447B1 (ko) 2002-05-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.