BR0016087A - Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico - Google Patents
Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmicoInfo
- Publication number
- BR0016087A BR0016087A BR0016087-3A BR0016087A BR0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A
- Authority
- BR
- Brazil
- Prior art keywords
- oxazolidin
- difluorophenyl
- benzyl
- processes
- propanoyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000006747 infectious mononucleosis Diseases 0.000 title abstract 2
- 239000013461 intermediate chemical Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 238000001311 chemical methods and process Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- -1 (S) -hydroxy-3-phosphoryl-propanoyl Chemical group 0.000 abstract 1
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9928499.4A GB9928499D0 (en) | 1999-12-03 | 1999-12-03 | Chemical processes and intermediates |
| PCT/GB2000/004527 WO2001040236A2 (en) | 1999-12-03 | 2000-11-28 | Phosphorylation of terminal primary alcohol groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0016087A true BR0016087A (pt) | 2002-08-06 |
Family
ID=10865576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0016087-3A BR0016087A (pt) | 1999-12-03 | 2000-11-28 | Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1237895A2 (is) |
| JP (1) | JP2003515539A (is) |
| KR (1) | KR20020058072A (is) |
| CN (1) | CN1433421A (is) |
| AR (1) | AR026700A1 (is) |
| AU (1) | AU762241B2 (is) |
| BG (1) | BG106728A (is) |
| BR (1) | BR0016087A (is) |
| CA (1) | CA2395052A1 (is) |
| CO (1) | CO5271712A1 (is) |
| CZ (1) | CZ20021912A3 (is) |
| EE (1) | EE200200282A (is) |
| GB (1) | GB9928499D0 (is) |
| HU (1) | HUP0204052A2 (is) |
| IL (1) | IL149641A0 (is) |
| IS (1) | IS6401A (is) |
| MX (1) | MXPA02005396A (is) |
| NO (1) | NO20022605L (is) |
| PL (1) | PL364762A1 (is) |
| SK (1) | SK7862002A3 (is) |
| WO (1) | WO2001040236A2 (is) |
| ZA (1) | ZA200203876B (is) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| GB0113297D0 (en) * | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
| US7396847B2 (en) | 2001-09-11 | 2008-07-08 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| JP2005524661A (ja) | 2002-02-28 | 2005-08-18 | アストラゼネカ アクチボラグ | ３−シクリル−５−（窒素含有５員環）メチル−オキサゾリジノン誘導体と抗菌剤としてのその使用 |
| IL163643A0 (en) | 2002-02-28 | 2005-12-18 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their forpreparation, and pharmaceutical compositions containing them |
| ES2258234T3 (es) | 2002-08-12 | 2006-08-16 | PHARMACIA & UPJOHN COMPANY LLC | N-aril-2-oxazolidinonas y sus derivados. |
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| JP2006509035A (ja) | 2002-11-21 | 2006-03-16 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物 |
| JP5043428B2 (ja) | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| JP5383037B2 (ja) | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| DE602006019870D1 (de) | 2005-06-08 | 2011-03-10 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
| KR101336510B1 (ko) | 2006-09-25 | 2013-12-03 | 욱크하르트 리미티드 | 치환된 피페리디노페닐 옥사졸리디논 |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200003595T2 (tr) * | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
-
1999
- 1999-12-03 GB GBGB9928499.4A patent/GB9928499D0/en not_active Ceased
-
2000
- 2000-11-24 CO CO00090190A patent/CO5271712A1/es not_active Application Discontinuation
- 2000-11-28 CA CA002395052A patent/CA2395052A1/en not_active Abandoned
- 2000-11-28 EE EEP200200282A patent/EE200200282A/xx unknown
- 2000-11-28 CZ CZ20021912A patent/CZ20021912A3/cs unknown
- 2000-11-28 EP EP00979764A patent/EP1237895A2/en not_active Withdrawn
- 2000-11-28 CN CN00818735A patent/CN1433421A/zh active Pending
- 2000-11-28 HU HU0204052A patent/HUP0204052A2/hu unknown
- 2000-11-28 KR KR1020027007072A patent/KR20020058072A/ko not_active Withdrawn
- 2000-11-28 IL IL14964100A patent/IL149641A0/xx unknown
- 2000-11-28 WO PCT/GB2000/004527 patent/WO2001040236A2/en not_active Ceased
- 2000-11-28 SK SK786-2002A patent/SK7862002A3/sk unknown
- 2000-11-28 PL PL00364762A patent/PL364762A1/xx unknown
- 2000-11-28 AU AU17156/01A patent/AU762241B2/en not_active Ceased
- 2000-11-28 JP JP2001540991A patent/JP2003515539A/ja active Pending
- 2000-11-28 MX MXPA02005396A patent/MXPA02005396A/es unknown
- 2000-11-28 BR BR0016087-3A patent/BR0016087A/pt not_active Application Discontinuation
- 2000-12-01 AR ARP000106370A patent/AR026700A1/es unknown
-
2002
- 2002-05-15 ZA ZA200203876A patent/ZA200203876B/xx unknown
- 2002-05-20 BG BG106728A patent/BG106728A/xx unknown
- 2002-05-28 IS IS6401A patent/IS6401A/is unknown
- 2002-05-31 NO NO20022605A patent/NO20022605L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU762241B2 (en) | 2003-06-19 |
| CA2395052A1 (en) | 2001-06-07 |
| EP1237895A2 (en) | 2002-09-11 |
| KR20020058072A (ko) | 2002-07-12 |
| WO2001040236A3 (en) | 2002-05-10 |
| JP2003515539A (ja) | 2003-05-07 |
| AR026700A1 (es) | 2003-02-26 |
| PL364762A1 (en) | 2004-12-13 |
| NO20022605L (no) | 2002-06-26 |
| IL149641A0 (en) | 2002-11-10 |
| MXPA02005396A (es) | 2002-11-29 |
| GB9928499D0 (en) | 2000-02-02 |
| CO5271712A1 (es) | 2003-04-30 |
| EE200200282A (et) | 2003-06-16 |
| ZA200203876B (en) | 2003-08-15 |
| HUP0204052A2 (hu) | 2003-03-28 |
| AU1715601A (en) | 2001-06-12 |
| IS6401A (is) | 2002-05-28 |
| CN1433421A (zh) | 2003-07-30 |
| NO20022605D0 (no) | 2002-05-31 |
| WO2001040236A2 (en) | 2001-06-07 |
| CZ20021912A3 (cs) | 2002-08-14 |
| BG106728A (en) | 2003-02-28 |
| SK7862002A3 (en) | 2003-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |