BR0016087A - Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico - Google Patents

Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico

Info

Publication number
BR0016087A
BR0016087A BR0016087-3A BR0016087A BR0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A
Authority
BR
Brazil
Prior art keywords
oxazolidin
difluorophenyl
benzyl
processes
propanoyl
Prior art date
Application number
BR0016087-3A
Other languages
English (en)
Inventor
Michael Barry Gravestock
Kenneth Edwin Herbert Warren
David Simon Ennis
Angela Charlotte Currie
Debra Ainge
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0016087A publication Critical patent/BR0016087A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSO PARA A FORMAçãO DE UM GRUPO DE MONOFOSFORILA PRIMáRIA EM UMA FUNCIONALIDADE DE 1,2-DIOLPROPANOìLA TERMINAL, PROCESSOS PARA A PREPARAçãO DE 5-(HET-X-METIL)-3-(4-(1-BENZIL-1,2,5,6-TETRAIDROPIRID-4IL)-3 ,5-DIFLUOROFENIL)OXAZOLIDIN-2-ONA, E DE 5-ISOXAZOL3-ILOXIMETIL-3-(4(1-BENZIL-1,2,5,6-TETRAIDROPI RID-4-IL)-3,5DIFLUOROFENIL)OXAZOLIDIN-2-ONA, E, COMPOSTO INTERMEDIáRIO QUìMICO". A invenção diz respeito a processos químicos e intermediários químicos que são úteis na formação seletiva de um grupo de mono-fosforila primária (-OPO(OH~ 2~)) em um sistema contendo 1,2-diol-propanoíla (HOCH~ 2~CH(OH)-CO-) terminal e, a processos químicos e intermediários químicos (e a processos para a sua fabricação) particularmente úteis para a fabricação de agentes bacterianos de oxazolidinona anti-Gram positivo contendo tal funcionalidade, em particular, para a preparação de 5(R)Isoxazol-3-iloximetil-3-(4-(1-(2(S)-hidróxi-3-fosforil-propanoil)-1,2,5 ,6-tetraidropiridi-4-il)3,5-difluorofenil)oxazolidin-2-ona.
BR0016087-3A 1999-12-03 2000-11-28 Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico BR0016087A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9928499.4A GB9928499D0 (en) 1999-12-03 1999-12-03 Chemical processes and intermediates
PCT/GB2000/004527 WO2001040236A2 (en) 1999-12-03 2000-11-28 Phosphorylation of terminal primary alcohol groups

Publications (1)

Publication Number Publication Date
BR0016087A true BR0016087A (pt) 2002-08-06

Family

ID=10865576

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016087-3A BR0016087A (pt) 1999-12-03 2000-11-28 Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico

Country Status (22)

Country Link
EP (1) EP1237895A2 (pt)
JP (1) JP2003515539A (pt)
KR (1) KR20020058072A (pt)
CN (1) CN1433421A (pt)
AR (1) AR026700A1 (pt)
AU (1) AU762241B2 (pt)
BG (1) BG106728A (pt)
BR (1) BR0016087A (pt)
CA (1) CA2395052A1 (pt)
CO (1) CO5271712A1 (pt)
CZ (1) CZ20021912A3 (pt)
EE (1) EE200200282A (pt)
GB (1) GB9928499D0 (pt)
HU (1) HUP0204052A2 (pt)
IL (1) IL149641A0 (pt)
IS (1) IS6401A (pt)
MX (1) MXPA02005396A (pt)
NO (1) NO20022605L (pt)
PL (1) PL364762A1 (pt)
SK (1) SK7862002A3 (pt)
WO (1) WO2001040236A2 (pt)
ZA (1) ZA200203876B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
GB0113297D0 (en) * 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
PT1427711E (pt) 2001-09-11 2005-11-30 Astrazeneca Ab Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
NZ535591A (en) 2002-02-28 2006-07-28 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
AU2003207340A1 (en) 2002-02-28 2003-09-09 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
WO2004014897A1 (en) 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
WO2004045616A1 (en) 2002-11-21 2004-06-03 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
AU2004267007C1 (en) 2003-06-03 2010-04-29 Melinta Subsidiary Corp. Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
KR20130095850A (ko) 2006-09-25 2013-08-28 욱크하르트 리미티드 치환된 피페리디노페닐 옥사졸리디논
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010052615A (ko) * 1998-06-05 2001-06-25 다비드 에 질레스 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물

Also Published As

Publication number Publication date
CA2395052A1 (en) 2001-06-07
EP1237895A2 (en) 2002-09-11
CZ20021912A3 (cs) 2002-08-14
MXPA02005396A (es) 2002-11-29
IS6401A (is) 2002-05-28
IL149641A0 (en) 2002-11-10
CN1433421A (zh) 2003-07-30
JP2003515539A (ja) 2003-05-07
EE200200282A (et) 2003-06-16
GB9928499D0 (en) 2000-02-02
NO20022605L (no) 2002-06-26
KR20020058072A (ko) 2002-07-12
AU762241B2 (en) 2003-06-19
WO2001040236A2 (en) 2001-06-07
SK7862002A3 (en) 2003-02-04
NO20022605D0 (no) 2002-05-31
WO2001040236A3 (en) 2002-05-10
AU1715601A (en) 2001-06-12
BG106728A (en) 2003-02-28
AR026700A1 (es) 2003-02-26
HUP0204052A2 (hu) 2003-03-28
PL364762A1 (en) 2004-12-13
CO5271712A1 (es) 2003-04-30
ZA200203876B (en) 2003-08-15

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]