BR0107954A - Inibidores duplos de sìntese de éster de colesterol e éster de cera para distúrbios de glândula sebácea - Google Patents
Inibidores duplos de sìntese de éster de colesterol e éster de cera para distúrbios de glândula sebáceaInfo
- Publication number
- BR0107954A BR0107954A BR0107954-9A BR0107954A BR0107954A BR 0107954 A BR0107954 A BR 0107954A BR 0107954 A BR0107954 A BR 0107954A BR 0107954 A BR0107954 A BR 0107954A
- Authority
- BR
- Brazil
- Prior art keywords
- acne
- sebaceous gland
- ester
- gland disorders
- synthesis inhibitors
- Prior art date
Links
- 208000015390 Sebaceous gland disease Diseases 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 150000001840 cholesterol esters Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000004164 Wax ester Substances 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 235000019386 wax ester Nutrition 0.000 title 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 5
- 206010000496 acne Diseases 0.000 abstract 5
- -1 2,6-diisopropyl-phenyl ester Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010000503 Acne cystic Diseases 0.000 abstract 1
- 208000020154 Acnes Diseases 0.000 abstract 1
- 208000001348 Chloracne Diseases 0.000 abstract 1
- 206010039792 Seborrhoea Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001886 ciliary effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"INIBIDORES DUPLOS DE SìNTESE DE éSTER DE COLESTEROL E éSTER DE CERA PARA DISTúRBIOS DE GLâNDULA SEBáCEA". A presente invenção fornece um método de tratamento de distúrbios de glândula sebácea compreendendo administrar a um paciente em necessidade do referido tratamento uma quantidade eficaz de um composto denominado éster de 2,6-diisopropil-fenila de ácido [(2,4,6-triisopropilfenil)-acetil]-sulfâmico ou um sal farmaceuticamente aceitável deste. Particularmente, os métodos de tratamento de distúrbios da glândula sebácea são fornecidos quando os referidos distúrbios são selecionados de seborréia, acnes, tais como, por exemplo, a cloracne, a acne ciliar, a acne cística, a acne ceratosa, a acne simples, a acne senil, e a acne medicinal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17977800P | 2000-02-02 | 2000-02-02 | |
| PCT/US2001/002190 WO2001056556A2 (en) | 2000-02-02 | 2001-01-23 | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0107954A true BR0107954A (pt) | 2002-10-22 |
Family
ID=22657957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0107954-9A BR0107954A (pt) | 2000-02-02 | 2001-01-23 | Inibidores duplos de sìntese de éster de colesterol e éster de cera para distúrbios de glândula sebácea |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6730703B2 (pt) |
| EP (1) | EP1263421B1 (pt) |
| JP (1) | JP2003531113A (pt) |
| KR (1) | KR20020073574A (pt) |
| CN (1) | CN1398182A (pt) |
| AP (1) | AP2002002612A0 (pt) |
| AT (1) | ATE295724T1 (pt) |
| AU (1) | AU781563B2 (pt) |
| BG (1) | BG107042A (pt) |
| BR (1) | BR0107954A (pt) |
| CA (1) | CA2398219A1 (pt) |
| CR (1) | CR6712A (pt) |
| DE (1) | DE60110897T2 (pt) |
| DZ (1) | DZ3288A1 (pt) |
| EA (1) | EA004255B1 (pt) |
| EE (1) | EE200200429A (pt) |
| ES (1) | ES2239145T3 (pt) |
| GE (1) | GEP20043286B (pt) |
| HR (1) | HRP20020717A2 (pt) |
| HU (1) | HUP0301010A3 (pt) |
| IL (1) | IL150865A0 (pt) |
| IS (1) | IS6478A (pt) |
| MA (1) | MA26872A1 (pt) |
| MX (1) | MXPA02007309A (pt) |
| NO (1) | NO20023659L (pt) |
| NZ (1) | NZ520330A (pt) |
| OA (1) | OA12173A (pt) |
| PL (1) | PL357041A1 (pt) |
| PT (1) | PT1263421E (pt) |
| SK (1) | SK10972002A3 (pt) |
| UA (1) | UA75345C2 (pt) |
| WO (1) | WO2001056556A2 (pt) |
| YU (1) | YU57502A (pt) |
| ZA (1) | ZA200206075B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1281399A3 (en) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
| US20050031699A1 (en) | 2003-06-26 | 2005-02-10 | L'oreal | Porous particles loaded with cosmetically or pharmaceutically active compounds |
| ATE409470T1 (de) | 2003-10-09 | 2008-10-15 | Warner Lambert Co | Pharmazeutische zusammensetzungen mit malonamid- derivaten zur verringerung der talg-produktion |
| MX2007010374A (es) | 2005-02-24 | 2007-09-25 | Warner Lambert Co | Inhibidor de acat cristalino. |
| FR2903999B1 (fr) * | 2006-07-19 | 2008-09-05 | Galderma Res & Dev S N C Snc | Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee |
| FR2904002A1 (fr) * | 2006-07-19 | 2008-01-25 | Galderma Res & Dev S N C Snc | Modulateurs de la lanosterol synthetase dans le traitement de l'acne ou de l'hyperseborrhee |
| FR2938342A1 (fr) * | 2008-11-13 | 2010-05-14 | Galderma Res & Dev | Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee |
| EP2391342A2 (en) | 2009-01-28 | 2011-12-07 | Nanobio Corporation | Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof |
| US20210260055A1 (en) * | 2018-06-21 | 2021-08-26 | Dermavant Sciences GmbH | Topical formulations of dgat1 inhibitors and their methods of use |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4545977A (en) * | 1985-01-11 | 1985-10-08 | G. D. Searle & Co. | Compositions and methods for treating severe acne with isotretinoin |
| US4751026A (en) | 1986-03-24 | 1988-06-14 | Warner-Lambert Company | Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase |
| US4722927A (en) | 1986-04-28 | 1988-02-02 | Warner-Lambert Company | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
| JPS6323848A (ja) | 1986-07-11 | 1988-02-01 | ワ−ナ−−ランバ−ト・コンパニ− | Ω−（置換フエニルオキシ）−アルカン酸のアリ−ル−およびアラルキルアミド |
| US4716175A (en) | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| US5015644A (en) | 1987-06-02 | 1991-05-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
| IE61716B1 (en) | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
| EP0297610B1 (en) | 1987-07-02 | 1991-03-13 | Warner-Lambert Company | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase |
| US5116848A (en) | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| US4999373A (en) | 1988-03-30 | 1991-03-12 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4948806A (en) | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US5030653A (en) | 1988-03-30 | 1991-07-09 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4923896A (en) | 1989-02-09 | 1990-05-08 | Warner-Lambert Company | N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| US5155127A (en) | 1989-02-09 | 1992-10-13 | Warner-Lambert Company | N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| US4994465A (en) | 1989-02-17 | 1991-02-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds |
| AU632809B2 (en) | 1989-05-25 | 1993-01-14 | Takeda Chemical Industries Ltd. | Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof |
| AU629376B2 (en) | 1989-08-04 | 1992-10-01 | Mitsubishi Chemical Corporation | 1-phenylalkyl-3-phenylurea derivatives |
| WO1991004027A1 (en) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| TW205037B (pt) | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| JPH05310678A (ja) | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | １−フェニルアルキル−３−フェニル尿素誘導体 |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| ATE175196T1 (de) | 1992-01-23 | 1999-01-15 | Pfizer | 4-phenyl-3-(heteroarylureido)-1,2-dihydro-2- oxochinolin derivate, als antihypercholesterolemische und antiatherosklerotische mittel |
| RU94046149A (ru) | 1992-05-28 | 1996-11-27 | Пфайзер Инк. (US) | Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат) |
| US5565472A (en) | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
| US5596001A (en) | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| US5494172A (en) * | 1994-05-12 | 1996-02-27 | Miller Compressing Company | Magnetic pulley assembly |
| US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| WO1999067258A1 (en) * | 1998-06-25 | 1999-12-29 | Tularik Inc. | Arylsulfonanilide phosphates |
| JP2004513090A (ja) * | 2000-09-27 | 2004-04-30 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体 |
-
2001
- 2001-01-23 HU HU0301010A patent/HUP0301010A3/hu unknown
- 2001-01-23 KR KR1020027009943A patent/KR20020073574A/ko not_active Ceased
- 2001-01-23 OA OA1200200234A patent/OA12173A/en unknown
- 2001-01-23 YU YU57502A patent/YU57502A/sh unknown
- 2001-01-23 DE DE60110897T patent/DE60110897T2/de not_active Expired - Fee Related
- 2001-01-23 CN CN01804520A patent/CN1398182A/zh active Pending
- 2001-01-23 ES ES01948936T patent/ES2239145T3/es not_active Expired - Lifetime
- 2001-01-23 SK SK1097-2002A patent/SK10972002A3/sk not_active Application Discontinuation
- 2001-01-23 EA EA200200764A patent/EA004255B1/ru not_active IP Right Cessation
- 2001-01-23 PT PT01948936T patent/PT1263421E/pt unknown
- 2001-01-23 DZ DZ013288A patent/DZ3288A1/fr active
- 2001-01-23 AU AU29718/01A patent/AU781563B2/en not_active Ceased
- 2001-01-23 WO PCT/US2001/002190 patent/WO2001056556A2/en not_active Ceased
- 2001-01-23 EP EP01948936A patent/EP1263421B1/en not_active Expired - Lifetime
- 2001-01-23 PL PL01357041A patent/PL357041A1/xx not_active Application Discontinuation
- 2001-01-23 BR BR0107954-9A patent/BR0107954A/pt not_active Application Discontinuation
- 2001-01-23 CA CA002398219A patent/CA2398219A1/en not_active Abandoned
- 2001-01-23 GE GEAP20016597A patent/GEP20043286B/en unknown
- 2001-01-23 UA UA2002076160A patent/UA75345C2/uk unknown
- 2001-01-23 AP APAP/P/2002/002612A patent/AP2002002612A0/en unknown
- 2001-01-23 NZ NZ520330A patent/NZ520330A/en unknown
- 2001-01-23 HR HR20020717A patent/HRP20020717A2/hr not_active Application Discontinuation
- 2001-01-23 US US10/182,847 patent/US6730703B2/en not_active Expired - Fee Related
- 2001-01-23 MX MXPA02007309A patent/MXPA02007309A/es active IP Right Grant
- 2001-01-23 IL IL15086501A patent/IL150865A0/xx unknown
- 2001-01-23 AT AT01948936T patent/ATE295724T1/de not_active IP Right Cessation
- 2001-01-23 EE EEP200200429A patent/EE200200429A/xx unknown
- 2001-01-23 JP JP2001556248A patent/JP2003531113A/ja active Pending
-
2002
- 2002-07-19 IS IS6478A patent/IS6478A/is unknown
- 2002-07-24 CR CR6712A patent/CR6712A/es not_active Application Discontinuation
- 2002-07-30 ZA ZA200206075A patent/ZA200206075B/en unknown
- 2002-08-01 NO NO20023659A patent/NO20023659L/no not_active Application Discontinuation
- 2002-08-01 MA MA26756A patent/MA26872A1/fr unknown
- 2002-08-29 BG BG107042A patent/BG107042A/bg unknown
-
2004
- 2004-02-06 US US10/773,354 patent/US20040161393A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: A61K 31/00 Ipc: A61K 31/255 (2010.01), A61K 31/18 (2010.01), A61P |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13 E 24 DA LPI |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |