MA26872A1 - Inhibiteurs doubles de la synthese d'ester de cholesterol et d'ester cireux pour des troubles des glandes sebacées. - Google Patents
Inhibiteurs doubles de la synthese d'ester de cholesterol et d'ester cireux pour des troubles des glandes sebacées.Info
- Publication number
- MA26872A1 MA26872A1 MA26756A MA26756A MA26872A1 MA 26872 A1 MA26872 A1 MA 26872A1 MA 26756 A MA26756 A MA 26756A MA 26756 A MA26756 A MA 26756A MA 26872 A1 MA26872 A1 MA 26872A1
- Authority
- MA
- Morocco
- Prior art keywords
- acne
- ester
- treatment
- disorders
- synthesis
- Prior art date
Links
- 208000015390 Sebaceous gland disease Diseases 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 150000001840 cholesterol esters Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000009977 dual effect Effects 0.000 title 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 7
- 206010000496 acne Diseases 0.000 abstract 7
- 238000000034 method Methods 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- -1 2,6-diisopropylphenyl ester Chemical class 0.000 abstract 1
- 206010000503 Acne cystic Diseases 0.000 abstract 1
- 208000001348 Chloracne Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 208000009675 Perioral Dermatitis Diseases 0.000 abstract 1
- 206010039792 Seborrhoea Diseases 0.000 abstract 1
- LXLYXCFZXXKURC-UHFFFAOYSA-N [2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamic acid Chemical compound CC(C)C1=CC(C(C)C)=C(CC(=O)NS(O)(=O)=O)C(C(C)C)=C1 LXLYXCFZXXKURC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001886 ciliary effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000001732 sebaceous gland Anatomy 0.000 abstract 1
- 208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DEPOSANT Société dite : WARNER-LAMBERT COMPANY REVENDICATION DE PRIORITES US 2 Février 2000 60/179,778 Voir en annexe le titre de l'invention et le texte de l'abrégé Inhibiteurs doubles de la synthèse d'ester de cholestérol et d'ester cireux pour des troubles des glandes sébacées La présente invention propose une méthode pour le traitement de troubles des glandes sébacées, comprenant l'administration à un patient nécessitant un tel traitement d'une quantité efficace d'un composé appelé ester 2,6-diisopropyl-phénylique d'acide [(2,4,6-triisopropyl-phényl) -acétyl] -sulfamique ou d'un de ses sels pharmaceutiquement acceptable. Il est proposé en particulier des méthodes pour le traitement de troubles des glandes sébacées, dans lesquelles lesdits troubles sont choisis entre la séborrhée, des acnés, la dermatite péribuccale, l'acné rosacée et les lésions acnéïformes induites par les corticosteroides. La présente invention propose des méthodes pour le traitement d'acnés telles que, par exemple, la chloracné, l'acné ciliaire, l'acné kystique, l'acné kératosique, l'acné vulgaire, l'acné sénile et l'acné médicamenteuse.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17977800P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26872A1 true MA26872A1 (fr) | 2004-12-20 |
Family
ID=22657957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26756A MA26872A1 (fr) | 2000-02-02 | 2002-08-01 | Inhibiteurs doubles de la synthese d'ester de cholesterol et d'ester cireux pour des troubles des glandes sebacées. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6730703B2 (fr) |
| EP (1) | EP1263421B1 (fr) |
| JP (1) | JP2003531113A (fr) |
| KR (1) | KR20020073574A (fr) |
| CN (1) | CN1398182A (fr) |
| AP (1) | AP2002002612A0 (fr) |
| AT (1) | ATE295724T1 (fr) |
| AU (1) | AU781563B2 (fr) |
| BG (1) | BG107042A (fr) |
| BR (1) | BR0107954A (fr) |
| CA (1) | CA2398219A1 (fr) |
| CR (1) | CR6712A (fr) |
| DE (1) | DE60110897T2 (fr) |
| DZ (1) | DZ3288A1 (fr) |
| EA (1) | EA004255B1 (fr) |
| EE (1) | EE200200429A (fr) |
| ES (1) | ES2239145T3 (fr) |
| GE (1) | GEP20043286B (fr) |
| HR (1) | HRP20020717A2 (fr) |
| HU (1) | HUP0301010A3 (fr) |
| IL (1) | IL150865A0 (fr) |
| IS (1) | IS6478A (fr) |
| MA (1) | MA26872A1 (fr) |
| MX (1) | MXPA02007309A (fr) |
| NO (1) | NO20023659L (fr) |
| NZ (1) | NZ520330A (fr) |
| OA (1) | OA12173A (fr) |
| PL (1) | PL357041A1 (fr) |
| PT (1) | PT1263421E (fr) |
| SK (1) | SK10972002A3 (fr) |
| UA (1) | UA75345C2 (fr) |
| WO (1) | WO2001056556A2 (fr) |
| YU (1) | YU57502A (fr) |
| ZA (1) | ZA200206075B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1281399A3 (fr) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Inhibiteurs doubles de la synthèse des des esters de cires et des esters du cholestérol pour inhiber la production de sébum |
| US20050031699A1 (en) | 2003-06-26 | 2005-02-10 | L'oreal | Porous particles loaded with cosmetically or pharmaceutically active compounds |
| ES2313065T3 (es) | 2003-10-09 | 2009-03-01 | Warner-Lambert Company Llc | Composiciones farmaceuticas que comprenden derivados de malonamida para disminuir la produccion de sebo. |
| KR100906288B1 (ko) | 2005-02-24 | 2009-07-06 | 워너-램버트 캄파니 엘엘씨 | 결정질 ａｃａｔ 억제제 |
| FR2904002A1 (fr) * | 2006-07-19 | 2008-01-25 | Galderma Res & Dev S N C Snc | Modulateurs de la lanosterol synthetase dans le traitement de l'acne ou de l'hyperseborrhee |
| FR2903999B1 (fr) * | 2006-07-19 | 2008-09-05 | Galderma Res & Dev S N C Snc | Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee |
| FR2938342A1 (fr) * | 2008-11-13 | 2010-05-14 | Galderma Res & Dev | Ciblage de modulateurs de ces1 et/ou ces3 dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee |
| CA2750233A1 (fr) | 2009-01-28 | 2010-08-05 | Nanobio Corporation | Composition pour le traitement et la prevention de l'acne, procedes de fabrication des compositions, et procedes d'utilisation associes |
| JP2021527634A (ja) * | 2018-06-21 | 2021-10-14 | デルマバント サイエンシズ ゲーエムベーハー | Ｄｇａｔ１阻害剤の局所製剤およびそれらの使用の方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4545977A (en) * | 1985-01-11 | 1985-10-08 | G. D. Searle & Co. | Compositions and methods for treating severe acne with isotretinoin |
| US4751026A (en) | 1986-03-24 | 1988-06-14 | Warner-Lambert Company | Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase |
| US4722927A (en) | 1986-04-28 | 1988-02-02 | Warner-Lambert Company | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
| EP0252524A3 (fr) | 1986-07-11 | 1989-04-19 | Warner-Lambert Company | Dérivés d'aryl- et aralkylamide d'acides oméga-(phényloxy substitué)-alcanoiques comme inhibiteurs d'acyl-CoA: cholestérol-acyltransférase et compositions pharmaceutiques les contenant |
| US4716175A (en) | 1987-02-24 | 1987-12-29 | Warner-Lambert Company | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| US5015644A (en) | 1987-06-02 | 1991-05-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
| IE61716B1 (en) | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
| EP0297610B1 (fr) | 1987-07-02 | 1991-03-13 | Warner-Lambert Company | N-[(phényl 2,6-substitué)urées]-carbamates inhibiteurs de l'acyl-co-enzyme A:cholestérol-acyltransférase |
| US5030653A (en) | 1988-03-30 | 1991-07-09 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4999373A (en) | 1988-03-30 | 1991-03-12 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US5116848A (en) | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| US4948806A (en) | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4923896A (en) | 1989-02-09 | 1990-05-08 | Warner-Lambert Company | N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| US5155127A (en) | 1989-02-09 | 1992-10-13 | Warner-Lambert Company | N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| US4994465A (en) | 1989-02-17 | 1991-02-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds |
| AU632809B2 (en) | 1989-05-25 | 1993-01-14 | Takeda Chemical Industries Ltd. | Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof |
| CA2022346A1 (fr) | 1989-08-04 | 1991-02-05 | Mitsubishi Chemical Corporation | Derives de 1-phenylalkyl-3-phenyluree |
| WO1991004027A1 (fr) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | Nouveaux derives de n-aryle de n-heteroarylamide et d'uree en tant qu'inhibiteurs d'acyl coenzyme a: cholesterol acyl transferase |
| TW205037B (fr) | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| JPH05310678A (ja) | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | １−フェニルアルキル−３−フェニル尿素誘導体 |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| JP2668163B2 (ja) | 1992-01-23 | 1997-10-27 | ファイザー インク． | コレステロール血症および抗アテローム動脈硬化症薬としての４−アリール−３−（ヘテロアリールウレイド）−１，２−ジヒドロ−２−オキソ−キノリン誘導体 |
| WO1993024458A1 (fr) | 1992-05-28 | 1993-12-09 | Pfizer Inc. | Nouveau derives n-aryle et de n-heteroaryluree en tant qu'inhibiteurs de l'acylcoenzime a: cholesterol acyltransferase (acat) |
| US5565472A (en) | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
| US5596001A (en) | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| US5494172A (en) * | 1994-05-12 | 1996-02-27 | Miller Compressing Company | Magnetic pulley assembly |
| US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| AU763687B2 (en) * | 1998-06-25 | 2003-07-31 | Tularik Inc. | Arylsulfonanilide phosphates |
| PE20020453A1 (es) * | 2000-09-27 | 2002-06-06 | Merck & Co Inc | Derivados del acido benzopirancarboxilico para el tratamiento de la diabetes y los trastornos de lipidos |
-
2001
- 2001-01-23 EE EEP200200429A patent/EE200200429A/xx unknown
- 2001-01-23 MX MXPA02007309A patent/MXPA02007309A/es active IP Right Grant
- 2001-01-23 BR BR0107954-9A patent/BR0107954A/pt not_active Application Discontinuation
- 2001-01-23 NZ NZ520330A patent/NZ520330A/en unknown
- 2001-01-23 OA OA1200200234A patent/OA12173A/en unknown
- 2001-01-23 EP EP01948936A patent/EP1263421B1/fr not_active Expired - Lifetime
- 2001-01-23 AU AU29718/01A patent/AU781563B2/en not_active Ceased
- 2001-01-23 DZ DZ013288A patent/DZ3288A1/fr active
- 2001-01-23 WO PCT/US2001/002190 patent/WO2001056556A2/fr not_active Ceased
- 2001-01-23 AT AT01948936T patent/ATE295724T1/de not_active IP Right Cessation
- 2001-01-23 GE GEAP20016597A patent/GEP20043286B/en unknown
- 2001-01-23 PT PT01948936T patent/PT1263421E/pt unknown
- 2001-01-23 US US10/182,847 patent/US6730703B2/en not_active Expired - Fee Related
- 2001-01-23 ES ES01948936T patent/ES2239145T3/es not_active Expired - Lifetime
- 2001-01-23 EA EA200200764A patent/EA004255B1/ru not_active IP Right Cessation
- 2001-01-23 PL PL01357041A patent/PL357041A1/xx not_active Application Discontinuation
- 2001-01-23 JP JP2001556248A patent/JP2003531113A/ja active Pending
- 2001-01-23 HU HU0301010A patent/HUP0301010A3/hu unknown
- 2001-01-23 CN CN01804520A patent/CN1398182A/zh active Pending
- 2001-01-23 AP APAP/P/2002/002612A patent/AP2002002612A0/en unknown
- 2001-01-23 IL IL15086501A patent/IL150865A0/xx unknown
- 2001-01-23 SK SK1097-2002A patent/SK10972002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002398219A patent/CA2398219A1/fr not_active Abandoned
- 2001-01-23 KR KR1020027009943A patent/KR20020073574A/ko not_active Ceased
- 2001-01-23 HR HR20020717A patent/HRP20020717A2/hr not_active Application Discontinuation
- 2001-01-23 YU YU57502A patent/YU57502A/sh unknown
- 2001-01-23 DE DE60110897T patent/DE60110897T2/de not_active Expired - Fee Related
- 2001-01-23 UA UA2002076160A patent/UA75345C2/uk unknown
-
2002
- 2002-07-19 IS IS6478A patent/IS6478A/is unknown
- 2002-07-24 CR CR6712A patent/CR6712A/es not_active Application Discontinuation
- 2002-07-30 ZA ZA200206075A patent/ZA200206075B/en unknown
- 2002-08-01 NO NO20023659A patent/NO20023659L/no not_active Application Discontinuation
- 2002-08-01 MA MA26756A patent/MA26872A1/fr unknown
- 2002-08-29 BG BG107042A patent/BG107042A/bg unknown
-
2004
- 2004-02-06 US US10/773,354 patent/US20040161393A1/en not_active Abandoned
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