BR0109194A - Método para preparar claritromicina em cristais da forma ii - Google Patents

Método para preparar claritromicina em cristais da forma ii

Info

Publication number
BR0109194A
BR0109194A BR0109194-8A BR0109194A BR0109194A BR 0109194 A BR0109194 A BR 0109194A BR 0109194 A BR0109194 A BR 0109194A BR 0109194 A BR0109194 A BR 0109194A
Authority
BR
Brazil
Prior art keywords
clarithromycin
sym
oxime
crystals
trimethylsilyl
Prior art date
Application number
BR0109194-8A
Other languages
English (en)
Inventor
Kwee Hyun Suh
Sang Min Yun
Mi Ra Seong
Gi Jeong Kim
Gwan Sun Lee
Nam Du Kim
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000013033A external-priority patent/KR100361397B1/ko
Priority claimed from KR10-2000-0069834A external-priority patent/KR100367981B1/ko
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BR0109194A publication Critical patent/BR0109194A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"MéTODO PARA PREPARAR CLARITROMICINA EM CRISTAIS DA FORMA II". Claritromicina de alta pureza em cristais da Forma II pode ser preparada facilmente com um alto rendimento por um processo que compreende as etapas de: proteger o grupo hidróxi da 9-oxima da 9-oxima de eritromicina A ou um seu sal com um grupo tropila e os grupos 2' - e 4"-hidróxi com grupos trimetil-silila; reagir 9-<sym>-tropil-oxima de 2',4"-<sym>bis-(trimetil-silil)-eritromicina A com um agente metilante; remover os grupos protetores e o grupo oxima de 9-<sym>-tropiloxima de 2',4"-<sym>-bis-(trimetil-silil)-6-<sym>-metil-eritromicina A, para obter claritromicina bruta; tratar a claritromicina bruta com ácido metano-sulfónico em uma mistura de um solvente orgânico miscível com água e água, para obter mesilato de claritromicina cristalino triidratado; e neutralizar o mesilato de claritromicina cristalino triidratado com solução aquosa de amónea, em uma mistura de um solvente orgânico miscível com água e água.
BR0109194-8A 2000-03-15 2001-03-14 Método para preparar claritromicina em cristais da forma ii BR0109194A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020000013033A KR100361397B1 (ko) 2000-03-15 2000-03-15 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
KR10-2000-0069834A KR100367981B1 (ko) 2000-11-23 2000-11-23 클라리스로마이신 결정형 2의 제조 방법 및 이 방법에사용되는 결정성 클라리스로마이신 메실레이트 삼수화물
PCT/KR2001/000394 WO2001068662A1 (en) 2000-03-15 2001-03-14 Method of preparing clarithromycin of form ii crystals

Publications (1)

Publication Number Publication Date
BR0109194A true BR0109194A (pt) 2003-02-11

Family

ID=36274127

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109194-8A BR0109194A (pt) 2000-03-15 2001-03-14 Método para preparar claritromicina em cristais da forma ii

Country Status (15)

Country Link
US (1) US6515116B2 (pt)
EP (2) EP1134229B1 (pt)
JP (1) JP4119125B2 (pt)
CN (1) CN1193036C (pt)
AT (2) ATE297941T1 (pt)
AU (1) AU771825B2 (pt)
BR (1) BR0109194A (pt)
CA (1) CA2402201C (pt)
DE (2) DE60122791T2 (pt)
ES (2) ES2270226T3 (pt)
HU (1) HUP0300418A3 (pt)
MX (1) MXPA02008861A (pt)
NZ (1) NZ521184A (pt)
RU (1) RU2230748C2 (pt)
WO (1) WO2001068662A1 (pt)

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US20060083759A1 (en) * 2002-07-17 2006-04-20 Aleksander Resman Stabilization of the profile of release of active substances from a formulation
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CA2533358C (en) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258953B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US8715727B2 (en) * 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
WO2006081711A1 (fr) * 2005-02-07 2006-08-10 Zte Corporation Méthode de contrôle de mesure entre systèmes et mesure entre fréquences
WO2007015265A2 (en) * 2005-05-24 2007-02-08 Kopran Research Laboratories Ltd A process for preparing 6,9-imino ether
CA2614412A1 (en) * 2005-07-07 2007-01-18 Elan Pharma International, Limited Nanoparticulate clarithromycin formulations
WO2007036951A2 (en) * 2005-08-31 2007-04-05 Alembic Limited Process to obtain 6-o-methylerythromycin a (clarithromycin)_form ii
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
EP2030613A1 (en) 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) * 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
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HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
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Also Published As

Publication number Publication date
ATE338053T1 (de) 2006-09-15
CN1193036C (zh) 2005-03-16
DE60122791T2 (de) 2007-10-04
DE60111438T2 (de) 2006-05-18
HUP0300418A2 (hu) 2003-06-28
RU2230748C2 (ru) 2004-06-20
EP1134229A2 (en) 2001-09-19
JP2004500398A (ja) 2004-01-08
NZ521184A (en) 2004-02-27
US6515116B2 (en) 2003-02-04
MXPA02008861A (es) 2003-02-10
ATE297941T1 (de) 2005-07-15
AU4282701A (en) 2001-09-24
DE60111438D1 (de) 2005-07-21
AU771825B2 (en) 2004-04-01
ES2242668T3 (es) 2005-11-16
DE60122791D1 (de) 2006-10-12
EP1134229A3 (en) 2002-02-27
EP1469008B1 (en) 2006-08-30
CA2402201A1 (en) 2001-09-20
WO2001068662A1 (en) 2001-09-20
CA2402201C (en) 2007-06-05
RU2002127591A (ru) 2004-02-27
ES2270226T3 (es) 2007-04-01
EP1134229B1 (en) 2005-06-15
JP4119125B2 (ja) 2008-07-16
HUP0300418A3 (en) 2003-09-29
CN1429233A (zh) 2003-07-09
US20010039333A1 (en) 2001-11-08
EP1469008A1 (en) 2004-10-20

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.