BR0113541A - Meios poliméricos funcionalizados para separação de analitos - Google Patents

Meios poliméricos funcionalizados para separação de analitos

Info

Publication number
BR0113541A
BR0113541A BR0113541-4A BR0113541A BR0113541A BR 0113541 A BR0113541 A BR 0113541A BR 0113541 A BR0113541 A BR 0113541A BR 0113541 A BR0113541 A BR 0113541A
Authority
BR
Brazil
Prior art keywords
functionalized polymeric
separation
functionalized
separation media
polar
Prior art date
Application number
BR0113541-4A
Other languages
English (en)
Other versions
BR0113541B1 (pt
Inventor
Nandkumar V Deorkar
James Farina
Paul A Bouis
Original Assignee
Mallinckrodt Baker Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22857242&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0113541(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Baker Inc filed Critical Mallinckrodt Baker Inc
Publication of BR0113541A publication Critical patent/BR0113541A/pt
Publication of BR0113541B1 publication Critical patent/BR0113541B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F259/00—Macromolecular compounds obtained by polymerising monomers on to polymers of halogen containing monomers as defined in group C08F14/00
    • C08F259/02—Macromolecular compounds obtained by polymerising monomers on to polymers of halogen containing monomers as defined in group C08F14/00 on to polymers containing chlorine
    • C08F259/06—Macromolecular compounds obtained by polymerising monomers on to polymers of halogen containing monomers as defined in group C08F14/00 on to polymers containing chlorine on to polymers of vinylidene chloride
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Graft Or Block Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

"MEIOS POLIMéRICOS FUNCIONALIZADOS PARA SEPARAçãO DE ANALITOS". Separação de uma variedade de analitos que são polares, nãopolares e iónicos usando-se meios poliméricos funcionalizados é descrita. Partículas rígidas pré-formadas de homopolímero altamente reticulado de compostos polivinilideno são funcionalizadas usando-se os grupos vinila residuais sobre os quais compostos monovinila são covalentemente ligados através de polimerização. A funcionalização proporciona desejáveis propriedades de superfície para aplicações de separação tais como cromatografia líquida e extração de fase sólida.
BRPI0113541-4A 2000-08-29 2001-08-21 pérolas de polìmero funcionalizado, processos para preparação das mesmas e processos de separação de um analito de uma solução e em uma mistura. BR0113541B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22845600P 2000-08-29 2000-08-29
US60/228,456 2000-08-29
PCT/US2001/026107 WO2002018464A2 (en) 2000-08-29 2001-08-21 Functionalized polymeric media for separation of analytes

Publications (2)

Publication Number Publication Date
BR0113541A true BR0113541A (pt) 2003-07-15
BR0113541B1 BR0113541B1 (pt) 2011-02-08

Family

ID=22857242

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0113541-4A BR0113541B1 (pt) 2000-08-29 2001-08-21 pérolas de polìmero funcionalizado, processos para preparação das mesmas e processos de separação de um analito de uma solução e em uma mistura.

Country Status (21)

Country Link
US (1) US6875817B2 (pt)
EP (1) EP1313781B2 (pt)
JP (1) JP2004507594A (pt)
KR (1) KR100825656B1 (pt)
CN (1) CN1188440C (pt)
AT (1) ATE332320T1 (pt)
AU (2) AU2001285152B2 (pt)
BR (1) BR0113541B1 (pt)
CA (1) CA2420683C (pt)
CZ (1) CZ297821B6 (pt)
DE (1) DE60121347T3 (pt)
DK (1) DK1313781T3 (pt)
ES (1) ES2266241T3 (pt)
HU (1) HU225306B1 (pt)
IL (2) IL154174A0 (pt)
MX (1) MXPA03001677A (pt)
NO (1) NO20030923D0 (pt)
NZ (1) NZ523914A (pt)
PT (1) PT1313781E (pt)
RS (1) RS50501B (pt)
WO (1) WO2002018464A2 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1628993A4 (en) 2003-05-16 2010-04-07 Rosetta Inpharmatics Llc METHOD AND COMPOSITIONS FOR RNA INTERFERENCE
CN101791541B (zh) * 2004-04-30 2013-06-05 北京九强生物技术股份有限公司 层析颗粒介质的制备方法
CN101791542B (zh) * 2004-04-30 2013-04-10 北京九强生物技术股份有限公司 层析颗粒介质的制备方法
CN1689695B (zh) * 2004-04-30 2010-06-23 北京九强生物技术有限公司 层析颗粒介质的制备方法
CN101791540B (zh) * 2004-04-30 2012-10-03 北京九强生物技术股份有限公司 层析颗粒介质的制备方法
EP2295473B1 (en) * 2005-09-16 2016-12-28 Rohm and Haas Company Swellable particles
EP1842592A1 (de) * 2006-04-04 2007-10-10 Metrohm Ag Ionenaustauschmaterial, Ionenaustauschsäule und Herstellungsverfahren
JP5596560B2 (ja) * 2008-02-05 2014-09-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 分離媒体の製造方法
WO2009130233A1 (en) * 2008-04-25 2009-10-29 Basf Se Modified halogenated polymer surfaces
US20110138935A1 (en) * 2008-08-12 2011-06-16 Wako Pure Chemical Industries, Ltd. Polymer for filler for preprocessing column
CN101444720A (zh) * 2008-11-28 2009-06-03 南开大学 高选择性氢键吸附树脂及用于银杏叶提取物中有效成分的分离纯化
US20210220814A1 (en) * 2011-05-20 2021-07-22 Waters Technologies Corporation Porous materials for solid phase extraction and chromatography and processes for preparation and use thereof
JP6522941B2 (ja) * 2011-05-20 2019-05-29 ウォーターズ・テクノロジーズ・コーポレーション 固相抽出およびクロマトグラフィーのための多孔質材料ならびにその製造方法および使用
CN102335597B (zh) * 2011-07-26 2014-03-19 南开大学 限进型聚(苯乙烯-co-二乙烯苯)包覆硅胶色谱填料及制备方法
EP3137209B1 (en) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Functionalized support material and methods of making and using functionalized support material
CN104587707B (zh) * 2015-01-30 2016-09-07 福州大学 一种纳米复合有机-无机杂化硅胶整体柱及其制备方法
SG10201911134QA (en) * 2015-06-05 2020-01-30 Grace W R & Co Adsorbent bioprocessing clarification agents and methods of making and using the same
CN105542052B (zh) * 2015-12-18 2017-12-26 王金明 一种己内酰胺重排催化剂的生产方法
CN109061009B (zh) * 2018-09-30 2021-09-17 安徽省食品药品检验研究院 一种发酵液中衣康酸含量的测定方法
CN110833821B (zh) * 2019-11-08 2022-04-19 湖北中烟工业有限责任公司 液相选择性吸附材料及其在卷烟烟气分析上的应用
CN110813252B (zh) * 2019-11-08 2022-04-19 湖北中烟工业有限责任公司 多孔矿物粘土负载聚丙烯酰胺的液相吸附材料及其应用
US11612852B2 (en) * 2020-05-28 2023-03-28 Palo Alto Research Center Incorporated Tunable, rapid uptake, aminopolymer aerogel sorbent for direct air capture of CO2
CN115044389B (zh) * 2022-06-10 2024-01-19 北京航天试验技术研究所 一种胶质脱除剂、制备方法、应用以及燃料脱胶质的方法和设备
CN116462837B (zh) * 2023-04-23 2026-04-03 福州大学 一种酸性固体催化剂的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463729A (fr) * 1965-02-24 1966-12-23 Rohm & Haas Enrichissement et éventuellement séparation d'un composé organique par des techniques d'adsorption
CA992877A (en) * 1971-09-16 1976-07-13 Rohm And Haas Company Separation of waste dyestuffs by adsorption processes
CA1083880A (en) * 1975-06-24 1980-08-19 Gary L. Hickernell Method for decaffeinating green coffee
GB2089639B (en) * 1980-12-19 1984-07-18 Gen Foods Corp Process for recovery of aroma volatiles
JPH087197B2 (ja) * 1989-05-23 1996-01-29 積水化学工業株式会社 液体クロマトグラフィー用充填剤とその製造法
JPH087198B2 (ja) * 1989-05-23 1996-01-29 積水化学工業株式会社 糖化ヘモグロビンの定量法
US5021253A (en) * 1989-12-13 1991-06-04 The Dow Chemical Company Decaffeination of liquid medium
JPH0426510A (ja) * 1990-05-18 1992-01-29 Tonen Corp 炭素系粒子、その製造方法及びその用途
US5259936A (en) * 1991-06-19 1993-11-09 Millipore Corporation Purified ion exchange resins and process
JP3164641B2 (ja) * 1992-04-27 2001-05-08 積水化学工業株式会社 液体クロマトグラフィー用充填剤およびその製造方法
US5248321A (en) * 1992-08-06 1993-09-28 The Research Foundation Of State University Of New York At Buffalo Process of removing sulfur oxides from gaseous mixtures
JPH08510486A (ja) * 1993-04-21 1996-11-05 コピイテル，インコーポレイテッド 白色と黒色の電気泳動性粒子及びその製造法
CA2130248A1 (en) * 1994-08-16 1996-02-17 Harald D. H. Stover Method of forming polymer microspheres
JP3333134B2 (ja) * 1997-07-14 2002-10-07 積水化学工業株式会社 液晶表示素子用スペーサ及びそれを用いた液晶表示素子
JPH11189601A (ja) * 1997-10-23 1999-07-13 Sekisui Chem Co Ltd 高分子微粒子の製造方法及び液体クロマトグラフィー用充填剤の製造方法
CA2222833A1 (en) * 1997-11-28 1999-05-28 Brent R. Stranix Functional polymers bearing non-metal oxyacid derivatives on dimethylene spacers
US6114466A (en) * 1998-02-06 2000-09-05 Renal Tech International Llc Material for purification of physiological liquids of organism
JP2000026665A (ja) * 1998-07-15 2000-01-25 Techno Polymer Kk 架橋ポリマー粒子およびその製造方法
JP3822991B2 (ja) * 1999-01-12 2006-09-20 積水化学工業株式会社 液晶表示素子用スペーサ及びその製造方法、並びに、液晶表示素子
US6534554B1 (en) * 1999-10-27 2003-03-18 Basf Aktiengesellschaft Multicomponent ion exchange resins

Also Published As

Publication number Publication date
IL154174A (en) 2007-02-11
EP1313781A2 (en) 2003-05-28
BR0113541B1 (pt) 2011-02-08
NO20030923L (no) 2003-02-27
EP1313781B2 (en) 2017-11-22
HUP0301684A3 (en) 2005-11-28
HUP0301684A2 (hu) 2003-08-28
YU14203A (sh) 2005-11-28
WO2002018464A3 (en) 2002-06-06
JP2004507594A (ja) 2004-03-11
DE60121347T2 (de) 2007-07-05
NO20030923D0 (no) 2003-02-27
MXPA03001677A (es) 2004-11-01
IL154174A0 (en) 2003-07-31
DK1313781T3 (da) 2006-10-30
CA2420683A1 (en) 2002-03-07
EP1313781B1 (en) 2006-07-05
US6875817B2 (en) 2005-04-05
NZ523914A (en) 2004-02-27
RS50501B (sr) 2010-03-02
AU2001285152B2 (en) 2005-11-17
CA2420683C (en) 2010-08-10
KR100825656B1 (ko) 2008-04-29
AU8515201A (en) 2002-03-13
HU225306B1 (en) 2006-09-28
ES2266241T3 (es) 2007-03-01
DE60121347D1 (de) 2006-08-17
CN1449416A (zh) 2003-10-15
CZ2003462A3 (cs) 2003-08-13
US20050032922A1 (en) 2005-02-10
ATE332320T1 (de) 2006-07-15
KR20030041980A (ko) 2003-05-27
WO2002018464A2 (en) 2002-03-07
PT1313781E (pt) 2006-11-30
DE60121347T3 (de) 2018-05-30
CZ297821B6 (cs) 2007-04-04
CN1188440C (zh) 2005-02-09

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/08/2001, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: AVANTOR PERFORMANCE MATERIALS, INC. (US)

Free format text: NOME ALTERADO DE: MALLINCKRODT BAKER, INC.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 12A, 13A E 14A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.