BR0200114A - Compostos de ciclohepteno, um processo para sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

Compostos de ciclohepteno, um processo para sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BR0200114A
BR0200114A BR0200114-4A BR0200114A BR0200114A BR 0200114 A BR0200114 A BR 0200114A BR 0200114 A BR0200114 A BR 0200114A BR 0200114 A BR0200114 A BR 0200114A
Authority
BR
Brazil
Prior art keywords
sym
group
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BR0200114-4A
Other languages
English (en)
Inventor
Patrick Casara
Thierry Le Diguarher
Gilbert Dorey
John Hickman
Alain Pierre
Gordon Tucker
Nicolas Guilbaud
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0200114A publication Critical patent/BR0200114A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTOS DE CICLOHEPTENO, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS". Compostos de fórmula (I): em que: <sym> X representa uma ligação de um grupo alquileno, CO, S(O)~ n~, -S(O)~ n~-A~ 1~-, -CO-A~ 1~-, -A~ 1~-S(O)~ n~-A'~ 1~- ou -A~ 1~-CO-A'~ 1~-,<sym> Y representa um grupo arila, heteroarila, cicloalquila ou heterocicioalquila, cada um não-substituído ou substituído, <sym> R~ 1~, R~ 2~, R~ 3~ e R~ 4~ cada um independentemente dos outros representa um átomo de hidrogênio ou um grupo arila, heteroaríla, cicloalquila ou heterocicloalquila, cada um não-substituído ou substituído, ou R~ 1~, R~ 2~, R~ 3~ e R~ 4~ tomados aos pares, formam juntamente uma ligação, uma forma de anel benzênico fundido ou aromático fundido ou heterociclo parcialmente não-saturado, <sym> T representa um grupo -CH(R~ 5~)-, -N(R~ 5~)- ou -N(R~ 5~)CO-, <sym> V representa um átomo de hidrogênio ou um grupo arila ou heteroarila, <sym> A~ 2~ representa um grupo [C(R~ 6~)(R'~ 6~)]~ p~, <sym> R~ 7~ e R~ 8~ são como definidos na descrição.
BR0200114-4A 2001-01-18 2002-01-17 Compostos de ciclohepteno, um processo para sua preparação e composições farmacêuticas contendo os mesmos BR0200114A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0100641A FR2819509B1 (fr) 2001-01-18 2001-01-18 Nouveaux composes cycloheptene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0200114A true BR0200114A (pt) 2002-10-22

Family

ID=8858954

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0200114-4A BR0200114A (pt) 2001-01-18 2002-01-17 Compostos de ciclohepteno, um processo para sua preparação e composições farmacêuticas contendo os mesmos

Country Status (17)

Country Link
US (1) US6638962B2 (pt)
EP (1) EP1225170A3 (pt)
JP (1) JP2002265448A (pt)
KR (1) KR100483360B1 (pt)
CN (1) CN1166641C (pt)
AR (1) AR034015A1 (pt)
AU (1) AU781680B2 (pt)
BR (1) BR0200114A (pt)
CA (1) CA2367306C (pt)
EA (1) EA004859B1 (pt)
FR (1) FR2819509B1 (pt)
HU (1) HUP0200204A3 (pt)
MX (1) MXPA02000529A (pt)
NO (1) NO322100B1 (pt)
NZ (1) NZ516684A (pt)
PL (1) PL351732A1 (pt)
ZA (1) ZA200200471B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200066690A (ko) 2017-10-16 2020-06-10 칭화대학교 메발로네이트 경로 억제제 및 이의 약제학적 조성물
CN114573501A (zh) * 2022-03-02 2022-06-03 河南阿尔法医药科技有限公司 一种可规模化生产2,2′:6′,2″-三联吡啶-4′-甲醛的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117580A0 (en) * 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
US5710171A (en) * 1995-05-24 1998-01-20 Merck & Co., Inc. Bisphenyl inhibitors of farnesyl-protein transferase
US6028201A (en) * 1996-01-30 2000-02-22 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU2589497A (en) 1996-03-29 1997-10-22 Trustees Of The University Of Pennsylvania, The Constrained cd4 peptides and methods of using the same
CA2249641A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5922883A (en) * 1996-04-03 1999-07-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000507591A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
EP0944388A4 (en) * 1996-04-03 2001-08-16 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
WO1997036898A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1999010329A1 (en) * 1997-08-27 1999-03-04 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
AU9452998A (en) * 1997-10-22 1999-05-10 Zeneca Limited Imidazole derivatives and their use as farnesyl protein transferase inhibit ors

Also Published As

Publication number Publication date
NZ516684A (en) 2003-06-30
NO20020262L (no) 2002-07-19
KR20020062212A (ko) 2002-07-25
AU781680B2 (en) 2005-06-09
HU0200204D0 (en) 2002-03-28
HK1048471A1 (en) 2003-04-04
JP2002265448A (ja) 2002-09-18
PL351732A1 (en) 2002-07-29
CN1166641C (zh) 2004-09-15
CN1365973A (zh) 2002-08-28
ZA200200471B (en) 2002-07-22
AU1193702A (en) 2002-07-25
EP1225170A2 (fr) 2002-07-24
HUP0200204A2 (hu) 2002-12-28
US20020156113A1 (en) 2002-10-24
EA200200048A1 (ru) 2002-08-29
FR2819509B1 (fr) 2004-04-16
HUP0200204A3 (en) 2003-01-28
NO322100B1 (no) 2006-08-14
AR034015A1 (es) 2004-01-21
CA2367306A1 (fr) 2002-07-18
EA004859B1 (ru) 2004-08-26
US6638962B2 (en) 2003-10-28
NO20020262D0 (no) 2002-01-17
MXPA02000529A (es) 2004-11-01
EP1225170A3 (fr) 2002-08-28
FR2819509A1 (fr) 2002-07-19
CA2367306C (fr) 2006-07-11
KR100483360B1 (ko) 2005-04-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010.