EA200200048A1 - Новые соединения циклогептена, способ их получения и содержащие их фармацевтические композиции - Google Patents
Новые соединения циклогептена, способ их получения и содержащие их фармацевтические композицииInfo
- Publication number
- EA200200048A1 EA200200048A1 EA200200048A EA200200048A EA200200048A1 EA 200200048 A1 EA200200048 A1 EA 200200048A1 EA 200200048 A EA200200048 A EA 200200048A EA 200200048 A EA200200048 A EA 200200048A EA 200200048 A1 EA200200048 A1 EA 200200048A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- compounds
- cyclogepten
- new
- production
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Соединения формулы (I)где Х представляет собой связь или алкиленовую, СО, S(O), -S(O)-A-, -CO-A-, -A-S(O)-A'- или -A-CO-A'- группу,Y представляет собой арильную, гетероарильную, циклоалкильную или гетероциклоалкильную группу, каждая из которых незамещена или замещена,R, R, Rи R, каждый независимо от других, представляют собой атом водорода или арильную, гетероарильную, циклоалкильную или гетероциклоалкильную группу, каждая из которых незамещена или замещена, или R, R, Rи R, взятые попарно, вместе образуют связь или образуют слитое бензольное кольцо или слитый ароматический или частично ненасыщенный гетероцикл,Т представляет собой группу -CH(R)-, -N(R)- или -N(R)CO-,V представляет собой атом водорода или незамещенную или замещенную арильную или гетероарильную группу,Aпредставляет собой группу [С(R)(R')],Rи Rимеют значения, указанные в описании,Лекарственные препараты.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0100641A FR2819509B1 (fr) | 2001-01-18 | 2001-01-18 | Nouveaux composes cycloheptene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200048A1 true EA200200048A1 (ru) | 2002-08-29 |
| EA004859B1 EA004859B1 (ru) | 2004-08-26 |
Family
ID=8858954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200048A EA004859B1 (ru) | 2001-01-18 | 2002-01-17 | Новые соединения циклогептена и содержащие их фармацевтические композиции |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6638962B2 (ru) |
| EP (1) | EP1225170A3 (ru) |
| JP (1) | JP2002265448A (ru) |
| KR (1) | KR100483360B1 (ru) |
| CN (1) | CN1166641C (ru) |
| AR (1) | AR034015A1 (ru) |
| AU (1) | AU781680B2 (ru) |
| BR (1) | BR0200114A (ru) |
| CA (1) | CA2367306C (ru) |
| EA (1) | EA004859B1 (ru) |
| FR (1) | FR2819509B1 (ru) |
| HU (1) | HUP0200204A3 (ru) |
| MX (1) | MXPA02000529A (ru) |
| NO (1) | NO322100B1 (ru) |
| NZ (1) | NZ516684A (ru) |
| PL (1) | PL351732A1 (ru) |
| ZA (1) | ZA200200471B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200066690A (ko) | 2017-10-16 | 2020-06-10 | 칭화대학교 | 메발로네이트 경로 억제제 및 이의 약제학적 조성물 |
| CN114573501A (zh) * | 2022-03-02 | 2022-06-03 | 河南阿尔法医药科技有限公司 | 一种可规模化生产2,2′:6′,2″-三联吡啶-4′-甲醛的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117580A0 (en) * | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| US5710171A (en) * | 1995-05-24 | 1998-01-20 | Merck & Co., Inc. | Bisphenyl inhibitors of farnesyl-protein transferase |
| US6028201A (en) * | 1996-01-30 | 2000-02-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU2589497A (en) | 1996-03-29 | 1997-10-22 | Trustees Of The University Of Pennsylvania, The | Constrained cd4 peptides and methods of using the same |
| CA2249641A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5922883A (en) * | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JP2000507591A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
| EP0944388A4 (en) * | 1996-04-03 | 2001-08-16 | Merck & Co Inc | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE |
| WO1997036898A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1999010329A1 (en) * | 1997-08-27 | 1999-03-04 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU9452998A (en) * | 1997-10-22 | 1999-05-10 | Zeneca Limited | Imidazole derivatives and their use as farnesyl protein transferase inhibit ors |
-
2001
- 2001-01-18 FR FR0100641A patent/FR2819509B1/fr not_active Expired - Fee Related
-
2002
- 2002-01-15 MX MXPA02000529A patent/MXPA02000529A/es active IP Right Grant
- 2002-01-16 PL PL02351732A patent/PL351732A1/xx not_active Application Discontinuation
- 2002-01-16 EP EP02290101A patent/EP1225170A3/fr not_active Withdrawn
- 2002-01-16 US US10/050,666 patent/US6638962B2/en not_active Expired - Fee Related
- 2002-01-17 CN CNB021020426A patent/CN1166641C/zh not_active Expired - Fee Related
- 2002-01-17 CA CA002367306A patent/CA2367306C/fr not_active Expired - Fee Related
- 2002-01-17 NO NO20020262A patent/NO322100B1/no unknown
- 2002-01-17 NZ NZ516684A patent/NZ516684A/xx unknown
- 2002-01-17 EA EA200200048A patent/EA004859B1/ru not_active IP Right Cessation
- 2002-01-17 BR BR0200114-4A patent/BR0200114A/pt not_active IP Right Cessation
- 2002-01-18 KR KR10-2002-0002972A patent/KR100483360B1/ko not_active Expired - Fee Related
- 2002-01-18 AR ARP020100173A patent/AR034015A1/es unknown
- 2002-01-18 JP JP2002009645A patent/JP2002265448A/ja active Pending
- 2002-01-18 HU HU0200204A patent/HUP0200204A3/hu unknown
- 2002-01-18 ZA ZA200200471A patent/ZA200200471B/xx unknown
- 2002-01-18 AU AU11937/02A patent/AU781680B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ516684A (en) | 2003-06-30 |
| NO20020262L (no) | 2002-07-19 |
| KR20020062212A (ko) | 2002-07-25 |
| BR0200114A (pt) | 2002-10-22 |
| AU781680B2 (en) | 2005-06-09 |
| HU0200204D0 (en) | 2002-03-28 |
| HK1048471A1 (en) | 2003-04-04 |
| JP2002265448A (ja) | 2002-09-18 |
| PL351732A1 (en) | 2002-07-29 |
| CN1166641C (zh) | 2004-09-15 |
| CN1365973A (zh) | 2002-08-28 |
| ZA200200471B (en) | 2002-07-22 |
| AU1193702A (en) | 2002-07-25 |
| EP1225170A2 (fr) | 2002-07-24 |
| HUP0200204A2 (hu) | 2002-12-28 |
| US20020156113A1 (en) | 2002-10-24 |
| FR2819509B1 (fr) | 2004-04-16 |
| HUP0200204A3 (en) | 2003-01-28 |
| NO322100B1 (no) | 2006-08-14 |
| AR034015A1 (es) | 2004-01-21 |
| CA2367306A1 (fr) | 2002-07-18 |
| EA004859B1 (ru) | 2004-08-26 |
| US6638962B2 (en) | 2003-10-28 |
| NO20020262D0 (no) | 2002-01-17 |
| MXPA02000529A (es) | 2004-11-01 |
| EP1225170A3 (fr) | 2002-08-28 |
| FR2819509A1 (fr) | 2002-07-19 |
| CA2367306C (fr) | 2006-07-11 |
| KR100483360B1 (ko) | 2005-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2225389C2 (ru) | Производные аминометилкарбоновой кислоты и фармацевтическая композиция на их основе | |
| BG107120A (bg) | Нови бавнодействащи бетамиметици, метод за тяхното получаване и приложението им като лекарствени средства | |
| CY1110904T1 (el) | Φαρμακευτικως ενεργα παραγωγα βενζοσουλφοναμιδιου ως αναστολεις πρωτεϊνικων κινασων jun | |
| ATE362910T1 (de) | Matrix metalloprotease inhibitoren | |
| MXPA02003199A (es) | Derivados de sulfonamida farmaceuticamente activos. | |
| EA200000792A3 (ru) | Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции | |
| EA200000431A3 (ru) | Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их | |
| EA200300044A1 (ru) | Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции | |
| EA200100090A2 (ru) | Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции | |
| ES2153019T3 (es) | Derivados de benzo-dioxano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| EA200400806A1 (ru) | Способ получения эхинокандиновых соединений | |
| EA200100059A3 (ru) | Новые бензолсульфонамидные производные, способ их получения и содержащие их фармацевтические композиции | |
| HUP0301553A2 (hu) | Gyógyászati készítmények és alkalmazásuk neurológiai rendellenességek kezelésére | |
| EA200200048A1 (ru) | Новые соединения циклогептена, способ их получения и содержащие их фармацевтические композиции | |
| EA200100597A3 (ru) | Новые 1,1- и 1,2-дизамещенные циклопропановые соединения, способ их получения и содержащие их фармацевтические композиции | |
| AR029468A1 (es) | Derivados de aminoacidos n-mercaptoacilados, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| ATE267832T1 (de) | Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung | |
| FR2766487B1 (fr) | Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant | |
| UA81610C2 (ru) | Изохинолиновые соединения, способ их получения и фармацевтическая композиция, которая их содержит | |
| EA200000598A1 (ru) | Новые ингибиторы металлопротеазы, способ их получения и содержащие их фармацевтические композиции | |
| EA200000527A3 (ru) | Новые бициклические амино-пиразиноновые соединения, способ их получения и фармацевтические композиции, содержащие их | |
| EA200300029A1 (ru) | Новые соединения карбамат и тиокарбамат подофиллотоксина, способ их получения и содержащие их фармацевтические композиции | |
| EA200000261A3 (ru) | Новые замещенные димерные соединения, способ их получения и содержащияся их фармацевтическая композиция | |
| DE69607597D1 (de) | Benzol-derivate | |
| AR037834A1 (es) | Medicamentos que contienen compuestos de piperacina n,n'disustituidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |