BR0209191A - Uso de folistatina para aumentar a massa muscular - Google Patents

Uso de folistatina para aumentar a massa muscular

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Publication number
BR0209191A
BR0209191A BR0209191-7A BR0209191A BR0209191A BR 0209191 A BR0209191 A BR 0209191A BR 0209191 A BR0209191 A BR 0209191A BR 0209191 A BR0209191 A BR 0209191A
Authority
BR
Brazil
Prior art keywords
cell
provides
myostatin
muscle
modulating
Prior art date
Application number
BR0209191-7A
Other languages
English (en)
Inventor
Se-Jin Lee
Alexandra C Mcpherron
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of BR0209191A publication Critical patent/BR0209191A/pt

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Abstract

"USO DE FOLISTATINA PARA AUMENTAR A MASSA MUSCULAR". A presente invenção fornece um receptor de fator de diferenciação de crescimento (GDF) substancialmente purificado, incluindo um receptor de GDF-8 (miostatina), como também porções do peptídeo funcional deste. Além disso, a invenção fornece uma representação virtual de um receptor de GDF ou uma porção do peptídeo funcional deste. A presente invenção também fornece um método de modular um efeito de miostatina em uma célula contatando a célula com um agente que afeta a transdução de sinal de miostatina na célula. Além disso, a invenção fornece um método de melhorar a severidade de uma condição patológica, que é caracterizada, pelo menos em parte, por uma quantidade, desenvolvimento ou atividade metabólica anormal do tecido muscular ou adiposo em um indivíduo, modulando a transdução de sinal de miostatina em uma célula do músculo ou uma célula de tecido adiposo no indivíduo. A invenção também fornece um método de modular o crescimento do tecido muscular ou do tecido adiposo em um organismo eucariótico administrando um agente que afeta a transdução de sinal de miostatina ao organismo.
BR0209191-7A 2001-04-24 2002-04-24 Uso de folistatina para aumentar a massa muscular BR0209191A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/841,730 US6891082B2 (en) 1997-08-01 2001-04-24 Transgenic non-human animals expressing a truncated activintype II receptor
PCT/US2002/013103 WO2002085306A2 (en) 2001-04-24 2002-04-24 Use of follistatin to increase muscle mass

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Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
WO2003022228A2 (en) * 2001-09-13 2003-03-20 California Institute Of Technology Method for producing transgenic birds and fish
US7320789B2 (en) * 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
JP4429728B2 (ja) * 2002-02-21 2010-03-10 ワイス エルエルシー フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質
EP1578928B1 (en) * 2002-09-16 2010-03-17 The Johns Hopkins University Metalloprotease activation of myostatin, and methods of modulating myostatin activity
US7261893B2 (en) * 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
KR20110086881A (ko) 2002-12-20 2011-08-01 암겐 인코포레이티드 미오스타틴을 저해하는 결합제
JP5110877B2 (ja) * 2003-06-02 2012-12-26 ワイス・エルエルシー 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用
US20070135336A1 (en) * 2003-09-15 2007-06-14 De Kretser David Follistatin isoforms and uses thereof
US7246056B1 (en) * 2003-09-26 2007-07-17 The Mathworks, Inc. Runtime parameter mapping for system simulation
US7456149B2 (en) 2004-03-02 2008-11-25 Acceleron Pharma, Inc. ALK7 and myostatin inhibitors and uses thereof
JP4688483B2 (ja) * 2004-04-15 2011-05-25 株式会社テクノネットワーク四国 フォリスタチン変異体ポリペプチド
EP3489257A1 (en) 2004-07-23 2019-05-29 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
EP1864138A2 (en) * 2005-03-23 2007-12-12 Wyeth Detection of gdf-8 modulating agents
PL2407486T3 (pl) 2005-08-19 2018-05-30 Wyeth Llc Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
CN100380118C (zh) * 2005-09-07 2008-04-09 集美大学 鲍鱼种类鉴别方法
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
EP2781222B1 (en) 2005-11-23 2017-08-02 Acceleron Pharma, Inc. Activin-actriia antagonists in use for promoting bone growth
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP1968621A2 (en) * 2005-12-06 2008-09-17 Amgen Inc. Uses of myostatin antagonists
CN100347298C (zh) * 2005-12-30 2007-11-07 中国水产科学研究院黄海水产研究所 鱼类肌肉生长抑素mstn基因克隆及其基因打靶载体构建
KR20080108487A (ko) * 2006-02-28 2008-12-15 트르스티스 오브 보스톤 유니버시티 대사 조절인자 및 그의 용도
US20070275036A1 (en) * 2006-05-18 2007-11-29 Celldyne Biopharma, Llc Avian follistatin product
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
WO2008076437A2 (en) * 2006-12-18 2008-06-26 Acceleron Pharma Inc. Activin-actrii antagonists and uses for increasing red blood cell levels
US20100028332A1 (en) * 2006-12-18 2010-02-04 Acceleron Pharma Inc. Antagonists of actriib and uses for increasing red blood cell levels
US8895016B2 (en) * 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
CA2677007A1 (en) * 2007-02-01 2008-08-07 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating or preventing breast cancer
TW201803890A (zh) * 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
EP2481415B1 (en) 2007-02-09 2019-09-11 Acceleron Pharma Inc. Pharmaceutical compositions comprising Activin-ActRIIA antagonists
US7947646B2 (en) * 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US8236751B2 (en) * 2007-03-07 2012-08-07 The Johns Hopkins University Methods of increasing muscle mass using follistatin-like related gene (FLRG)
TW200911237A (en) 2007-08-03 2009-03-16 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
JP2010539236A (ja) 2007-09-18 2010-12-16 アクセルロン ファーマ， インコーポレイテッド アクチビン−ＡｃｔＲＩＩａ拮抗薬およびＦＳＨ分泌を低減または阻害するための使用
US8461108B2 (en) 2008-03-07 2013-06-11 Myoscience, Inc. Subdermal tissue remodeling using myostatin, methods and related systems
CN102131822A (zh) * 2008-06-26 2011-07-20 阿塞勒隆制药公司 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法
TWI626945B (zh) 2008-08-14 2018-06-21 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
NZ627111A (en) 2008-11-26 2015-10-30 Amgen Inc Variants of activin iib receptor polypeptides and uses thereof
AU2010204985A1 (en) * 2009-01-13 2011-08-04 Acceleron Pharma Inc. Methods for increasing adiponectin
CA2993053A1 (en) * 2009-04-27 2010-11-04 Novartis Ag Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
WO2010134686A2 (ko) * 2009-05-20 2010-11-25 강릉원주대학교산학협력단 마이오스타틴 억제 활성을 갖는 가용성 마이오스타틴 프로도메인 재조합 단백질 및 그의 용도
JP5912078B2 (ja) * 2009-06-08 2016-04-27 アクセルロン ファーマ， インコーポレイテッド 熱発生性脂肪細胞を増加させるための方法
EP3290439B1 (en) 2009-06-12 2020-09-02 Acceleron Pharma Inc. Truncated actriib-fc fusion proteins
JP6211767B2 (ja) * 2009-09-09 2017-10-11 アクセルロン ファーマ， インコーポレイテッド ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用
WO2011056896A1 (en) * 2009-11-03 2011-05-12 Acceleron Pharma Inc. Methods for treating fatty liver disease
EP2323133B1 (en) 2009-11-16 2015-10-14 Sony Corporation Disc cartridge
EP3332796A1 (en) 2009-11-17 2018-06-13 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
WO2011102483A1 (ja) * 2010-02-19 2011-08-25 独立行政法人理化学研究所 ヒトTGF-βのLAPに結合する抗体
JP6105838B2 (ja) * 2010-08-24 2017-03-29 国立大学法人 岡山大学 疼痛の治療剤
WO2012040295A2 (en) 2010-09-22 2012-03-29 The Regents Of The University Of Colorado Therapeutic applications of smad7
KR20130132824A (ko) 2010-11-08 2013-12-05 악셀레론 파마 인코포레이티드 Actriia 결합제 및 이의 용도
CN102648977B (zh) * 2011-02-25 2014-12-10 中国科学院上海生命科学研究院 滤泡素抑制素样蛋白1在调节钠钾atp酶活性中的用途
BR112014015003A2 (pt) 2011-12-19 2019-09-24 Amgen Inc composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
SG11201404741VA (en) * 2012-02-07 2014-09-26 Global Bio Therapeutics Usa Inc Compartmentalized method of nucleic acid delivery and compositions and uses thereof
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
MY177331A (en) 2012-06-15 2020-09-12 Pfizer Improved antagonist antibodies against gdf-8 and uses therefor
ES2791778T3 (es) 2012-08-01 2020-11-05 Ikaika Therapeutics Llc Mitigación del daño tisular y la fibrosis a través de anticuerpos anti-LTBP4
EP2912462B1 (en) * 2012-10-24 2019-08-07 Celgene Corporation Biomarker for use in treating anemia
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
SG11201505960VA (en) 2013-02-01 2015-08-28 Santa Maria Biotherapeutics Inc Administration of an anti-activin-a compound to a subject
CA2904329C (en) 2013-03-08 2021-11-30 The Regents Of The University Of Colorado, A Body Corporate Ptd-smad7 therapeutics
HUE052232T2 (hu) 2013-05-06 2021-04-28 Scholar Rock Inc Készítmények és eljárások növekedési faktor modulálására
KR102132144B1 (ko) 2014-06-04 2020-07-09 악셀레론 파마 인코포레이티드 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
MA40008A (fr) 2014-06-13 2021-05-05 Acceleron Pharma Inc Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
US10307480B2 (en) 2014-11-06 2019-06-04 Scholar Rock, Inc. Anti-pro/latent-myostatin antibodies and uses thereof
TWI730949B (zh) 2014-12-03 2021-06-21 美商西建公司 活化素-ａｃｔｒｉｉ拮抗劑及治療貧血之用途
CA2973978A1 (en) 2015-01-14 2016-07-21 The Brigham And Women's Hospital, Inc. Treatment of cancer with anti-lap monoclonal antibodies
CN107636154A (zh) 2015-03-26 2018-01-26 阿塞勒隆制药公司 促滤泡素抑制素相关的融合蛋白及其用途
SI3286206T1 (sl) 2015-04-22 2021-07-30 Biogen Ma Inc. Novi hibridni proteini ligandske pasti actriib za zdravljenje bolezni zaradi izgube mišične mase
PT3922645T (pt) 2015-09-15 2025-05-29 Scholar Rock Inc ¿anticorpos anti-pró-miostatina/miostatina latente e suas utilizações
CN105372276B (zh) * 2015-11-24 2017-09-29 大连工业大学 一种海参加热过程中质构品质无损检测方法
ES2893813T3 (es) * 2016-01-06 2022-02-10 Harvard College El tratamiento con GDF11 previene el aumento de peso, mejora la tolerancia a la glucosa y reduce la hepatoesteatosis
CN115814077A (zh) 2016-01-08 2023-03-21 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法
CA3015277A1 (en) 2016-03-10 2017-09-14 Acceleron Pharma Inc. Activin type 2 receptor binding proteins and uses thereof
JOP20190085A1 (ar) 2016-10-20 2019-04-17 Biogen Ma Inc طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
US11155611B2 (en) 2017-01-06 2021-10-26 Scholar Rock, Inc. Compositions and methods for making and using anti-myostatin antibodies
PL3609431T3 (pl) 2017-04-13 2022-03-28 N.R Soos Technology Ltd. Urządzenia i sposoby do wspierania wytwarzania zarodków żeńskich w jajach
KR101822633B1 (ko) * 2017-08-22 2018-01-26 (주)진셀팜 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도
EP3694552A1 (en) 2017-10-10 2020-08-19 Tilos Therapeutics, Inc. Anti-lap antibodies and uses thereof
KR20200105664A (ko) * 2017-12-29 2020-09-08 아나제네시스 바이오테크놀로지스 에스.에이.에스. Bap 또는 ba 세포를 제조하는 방법
CN109006709A (zh) * 2018-08-17 2018-12-18 孟维巍 一种紧凑式蜚蠊养殖系统
US11130802B2 (en) 2018-10-10 2021-09-28 Tilos Therapeutics, Inc. Anti-lap antibody variants
WO2020132647A1 (en) 2018-12-21 2020-06-25 Northwestern University Use of annexins in preventing and treating muscle membrane injury
WO2020139977A1 (en) 2018-12-26 2020-07-02 Northwestern University Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder
CN110438154A (zh) * 2019-08-10 2019-11-12 湖南文理学院 一种基于转基因增加鲫鱼生长速度的方法
CN112088804B (zh) * 2020-10-13 2021-12-21 四川省旺达饲料有限公司 一种根据家禽体型自动定量出料的饲料投喂装置
WO2022119367A1 (ko) * 2020-12-03 2022-06-09 ㈜라트바이오 마이오스타틴 유전자가 변형된 형질전환 동물
AU2023413166A1 (en) 2022-12-22 2025-07-03 Scholar Rock, Inc. Selective and potent inhibitory antibodies of myostatin activation

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US5206347A (en) 1985-08-06 1993-04-27 La Jolla Cancer Research Foundation Isolation and use of receptors binding to a peptide column
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US6218596B1 (en) 1989-06-30 2001-04-17 The United States Of America As Represented By The Department Of Health And Human Services Enhancement of musculature in non-human mammals expressing c-ski
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
SG46445A1 (en) 1990-01-26 1998-02-20 Immunomedics Inc Vaccines against cancer and infectious diseases
US5265030A (en) 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
US5750342A (en) 1990-06-11 1998-05-12 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5314695A (en) 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
US5885794A (en) 1991-05-10 1999-03-23 The Salk Institute For Biological Studies Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
US6162896A (en) * 1991-05-10 2000-12-19 The Salk Institute For Biological Studies Recombinant vertebrate activin receptors
WO1993001484A1 (en) 1991-07-11 1993-01-21 The Regents Of The University Of California A method to identify protein sequences that fold into a known three-dimensional structure
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US6465239B1 (en) 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
ES2201076T3 (es) 1993-03-19 2004-03-16 The Johns Hopkins University School Of Medicine Factor-8 de diferenciacion del crecimiento.
DK0698094T3 (da) * 1993-05-12 2004-05-03 Inst Genetics Llc BMP-11-sammensætninger
US6008434A (en) 1994-07-08 1999-12-28 Johns Hopkins University School Of Medicine Growth differentiation factor-11 transgenic mice
WO1996001845A1 (en) * 1994-07-08 1996-01-25 The Johns Hopkins University School Of Medicine Growth differentiation factor-11
US5734039A (en) 1994-09-15 1998-03-31 Thomas Jefferson University Antisense oligonucleotides targeting cooperating oncogenes
US5545616A (en) * 1994-09-22 1996-08-13 Genentech, Inc. Method for predicting and/or preventing preterm labor
US5998698A (en) 1995-06-07 1999-12-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Transgenic fish capable of expressing exogenous lytic peptides
US5622699A (en) 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
WO1997015319A1 (en) * 1995-10-23 1997-05-01 Queen's University At Kingston Method and pharmaceutical composition for chondrostimulation with a prostaglandin (e.g. misoprostol) and tgf-beta, optionally in combination with igf-1
DE19626982C1 (de) 1996-07-04 1997-09-25 Siemens Ag Elektromagnetisches Relais und Verfahren zu dessen Herstellung
US5776689A (en) 1996-07-19 1998-07-07 The Regents Of The University Of California Protein recruitment system
EP0959897B1 (en) * 1996-11-27 2009-04-22 Immunex Corporation Method of regulating nitric oxide production
AU6274298A (en) 1997-02-05 1998-08-25 Johns Hopkins University School Of Medicine, The Growth differentiation factor-8
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
IL132922A0 (en) * 1997-05-16 2001-03-19 Procter & Gamble The use of a bone morphogenetic protein (bmp) receptor complex for screening
US5933819C1 (en) 1997-05-23 2001-11-13 Scripps Research Inst Prediction of relative binding motifs of biologically active peptides and peptide mimetics
WO1998053838A2 (en) * 1997-05-30 1998-12-03 Winnacker Ernst Ludwig A soluble laminin receptor precursor and methods to inhibit its interactions
WO1998058053A1 (en) * 1997-06-18 1998-12-23 Merck & Co., Inc. Human receptor tyrosine kinase, kdr
AU8666398A (en) 1997-08-01 1999-02-22 Johns Hopkins University School Of Medicine, The Methods to identify growth differentiation factor (gdf) receptors
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
WO1999010004A2 (en) * 1997-08-29 1999-03-04 Ontogeny, Inc. Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto
JP2001513982A (ja) * 1997-08-29 2001-09-11 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド フォリスタチン−３
US5885779A (en) 1997-09-09 1999-03-23 University Of British Columbia Repressed trans-activator system for characterization of protein-protein interactions
CA2319703C (en) 1998-02-05 2005-09-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6156952A (en) * 1998-04-09 2000-12-05 Constituent Institution Of The University Of Maryland System HIV transgenic animals and uses therefor
DE69941116D1 (de) 1998-05-06 2009-08-27 Metamorphix Inc G von gdf-8
EP1076699B1 (en) * 1998-05-14 2008-10-29 Immunex Corporation Method of inhibiting osteoclast activity
CA2349869A1 (en) 1998-11-13 2000-05-25 Takeda Chemical Industries, Ltd. Novel protein and utilization thereof
NZ513642A (en) * 1999-01-21 2004-02-27 Metamorphix Inc Growth differentiation factor inhibitors and uses therefor
WO2000075289A1 (en) 1999-06-08 2000-12-14 Rutgers, The State University Compositions and methods for targeted gene insertion
US7368534B2 (en) 2000-01-18 2008-05-06 Orico Limited Myostatin and mimetics thereof
TW201803890A (zh) 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途

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WO2002085306A3 (en) 2002-12-12
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NZ528963A (en) 2006-09-29
KR20040002927A (ko) 2004-01-07
CA2448835A1 (en) 2002-10-31
WO2002085306A2 (en) 2002-10-31
EP2340709A1 (en) 2011-07-06
JP2009261402A (ja) 2009-11-12
PL367201A1 (en) 2005-02-21
JP2008289478A (ja) 2008-12-04
AU2002307564B2 (en) 2007-02-08
US8124830B2 (en) 2012-02-28
JP2009159951A (ja) 2009-07-23

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