BR0210839A - Sistema de recombinação, método para remover uma sequência de dna do dna cromossÈmico de uma célula ou organismo eucarióticos, organismo, cultura de célula, órgão, tecido, parte ou material de propagação transgênico, e, uso de um organismo ou de uma cultura de célula, órgão, tecido, parte ou material de propagação transgênico - Google Patents
Sistema de recombinação, método para remover uma sequência de dna do dna cromossÈmico de uma célula ou organismo eucarióticos, organismo, cultura de célula, órgão, tecido, parte ou material de propagação transgênico, e, uso de um organismo ou de uma cultura de célula, órgão, tecido, parte ou material de propagação transgênicoInfo
- Publication number
- BR0210839A BR0210839A BR0210839-9A BR0210839A BR0210839A BR 0210839 A BR0210839 A BR 0210839A BR 0210839 A BR0210839 A BR 0210839A BR 0210839 A BR0210839 A BR 0210839A
- Authority
- BR
- Brazil
- Prior art keywords
- organism
- tissue
- organ
- cell culture
- transgenic
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 210000000056 organ Anatomy 0.000 title abstract 4
- 230000009261 transgenic effect Effects 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title abstract 3
- 238000005215 recombination Methods 0.000 title abstract 3
- 230000006798 recombination Effects 0.000 title abstract 3
- 239000013611 chromosomal DNA Substances 0.000 title abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 230000001902 propagating effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
"SISTEMA DE RECOMBINAçãO, MéTODO PARA REMOVER UMA SEQuêNCIA DE DNA DO DNA CROMOSSÈMICO DE UMA CéLULA OU ORGANISMO EUCARIóTICOS, ORGANISMO, CULTURA DE CéLULA, óRGãO, TECIDO, PARTE OU MATERIAL DE PROPAGAçãO TRANSGêNICO, E, USO DE UM ORGANISMO OU DE UMA CULTURA DE CéLULA, óRGãO, TECIDO, PARTE OU MATERIAL DE PROPAGAçãO TRANSGêNICO". A invenção diz respeito a sistemas de recombinação e a um método para remover seq³ências do DNA cromossómico de organismos eucarióticos. A invenção também diz respeito a organismos transgênicos (preferivelmente plantas), contendo os ditos sistemas ou produzido pelo dito método.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10131786A DE10131786A1 (de) | 2001-07-04 | 2001-07-04 | Rekombinationssysteme und Verfahren zum Entfernen von Nukleinsäuresequenzen aus dem Genom eukaryotischer Organismen |
| PCT/EP2002/007281 WO2003004659A2 (de) | 2001-07-04 | 2002-07-02 | Rekombinationssysteme und verfahren zum entfernen von nukleinsäuresequenzen aus dem genom eukaryotischer organismen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0210839A true BR0210839A (pt) | 2004-07-13 |
Family
ID=7690173
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0210839-9A BRPI0210839B1 (pt) | 2001-07-04 | 2002-07-02 | Sistema para recombinações múltiplas e sucessivas no mesmo organismo ou dna genômico, e, método para remover uma seqüência de dna do dna cromossômico de uma célula vegetal ou organismo vegetal |
| BR0210839-9A BR0210839A (pt) | 2001-07-04 | 2002-07-02 | Sistema de recombinação, método para remover uma sequência de dna do dna cromossÈmico de uma célula ou organismo eucarióticos, organismo, cultura de célula, órgão, tecido, parte ou material de propagação transgênico, e, uso de um organismo ou de uma cultura de célula, órgão, tecido, parte ou material de propagação transgênico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0210839-9A BRPI0210839B1 (pt) | 2001-07-04 | 2002-07-02 | Sistema para recombinações múltiplas e sucessivas no mesmo organismo ou dna genômico, e, método para remover uma seqüência de dna do dna cromossômico de uma célula vegetal ou organismo vegetal |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7736886B2 (pt) |
| EP (1) | EP1407034B1 (pt) |
| JP (1) | JP2004533267A (pt) |
| CN (1) | CN100451123C (pt) |
| AR (2) | AR034687A1 (pt) |
| AU (1) | AU2002325859B2 (pt) |
| BR (2) | BRPI0210839B1 (pt) |
| CA (1) | CA2451492C (pt) |
| DE (1) | DE10131786A1 (pt) |
| IL (1) | IL159286A0 (pt) |
| MX (1) | MXPA03011844A (pt) |
| WO (1) | WO2003004659A2 (pt) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7102055B1 (en) * | 1997-11-18 | 2006-09-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant |
| WO1999025821A1 (en) * | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Compositions and methods for genetic modification of plants |
| US20100151556A1 (en) * | 2002-03-15 | 2010-06-17 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| AU2003215869B2 (en) * | 2002-03-15 | 2008-04-24 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| WO2009095742A1 (en) * | 2008-01-31 | 2009-08-06 | Cellectis | New i-crei derived single-chain meganuclease and uses thereof |
| WO2004013333A2 (de) | 2002-07-26 | 2004-02-12 | Basf Plant Science Gmbh | Revertierung der negativ-selektiven wirkung von negativen markerproteinen als selektionsverfahren |
| EP3202899B1 (en) | 2003-01-28 | 2020-10-21 | Cellectis | Custom-made meganuclease and use thereof |
| US7476729B2 (en) * | 2003-10-24 | 2009-01-13 | Institut Curie | Dbait and uses thereof |
| ES2320228T3 (es) | 2003-11-18 | 2009-05-20 | Bayer Bioscience N.V. | Insercion mejorada direccionada de dna en las plantas. |
| EP1727906B1 (en) * | 2004-03-17 | 2012-02-22 | BASF Plant Science GmbH | Improved constructs for marker excision based on dual-function selection marker |
| EP3351637B1 (en) | 2004-04-02 | 2020-06-10 | DSM IP Assets B.V. | Filamentous fungal mutants with improved homologous recombination efficiency |
| WO2006032426A2 (en) * | 2004-09-23 | 2006-03-30 | Basf Plant Science Gmbh | Recombination cassettes and methods for sequence excision in plants |
| EP1669456A3 (en) | 2004-12-11 | 2006-07-12 | SunGene GmbH | Expression cassettes for meristem-preferential expression in plants |
| WO2006074956A1 (en) * | 2005-01-14 | 2006-07-20 | Bayer Bioscience N.V. | Improved plant transformation methods |
| EP1869186B1 (en) * | 2005-04-04 | 2010-10-13 | Bayer BioScience N.V. | Methods and means for removal of a selected dna sequence |
| EP1874938B1 (en) * | 2005-04-19 | 2012-04-04 | BASF Plant Science GmbH | Starchy-endosperm and/or germinating embryo-specific expression in mono-cotyledonous plants |
| ES2390132T3 (es) | 2005-07-18 | 2012-11-06 | Pioneer Hi-Bred International Inc. | Sitios de recombinación FRT modificados y métodos de uso |
| ES2582091T3 (es) | 2005-10-18 | 2016-09-09 | Precision Biosciences | Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas |
| US8071383B2 (en) | 2006-03-17 | 2011-12-06 | Basf Plant Science Gmbh | D-amino acid selection for soybean |
| US20090124014A1 (en) * | 2006-04-08 | 2009-05-14 | Marco Alexander Van Den Berg | Method for homologous recombination in fungal cells |
| EP2018434B1 (en) | 2006-05-18 | 2011-03-02 | Biogemma | Method for performing homologous recombination in plants |
| US8367890B2 (en) | 2006-09-28 | 2013-02-05 | Bayer Cropscience N.V. | Methods and means for removal of a selected DNA sequence |
| EP2074219B1 (en) | 2007-02-16 | 2013-11-20 | BASF Plant Science GmbH | Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants |
| US20100162428A1 (en) * | 2007-05-31 | 2010-06-24 | Basf Plant Science Gmbh | Method Of Excising A Nucleic Acid Sequence From A Plant Genome |
| BRPI0812233B1 (pt) | 2007-06-05 | 2022-10-04 | Bayer Cropscience Ag | Processos para troca de uma sequência de dna-alvo no genoma de uma célula de planta ou planta por uma sequência de dna de interesse, e vetor de dna |
| EP2167666A2 (en) | 2007-06-29 | 2010-03-31 | Pioneer Hi-Bred International Inc. | Methods for altering the genome of a monocot plant cell |
| US9267132B2 (en) | 2007-10-08 | 2016-02-23 | Synthetic Genomics, Inc. | Methods for cloning and manipulating genomes |
| JP2011505809A (ja) * | 2007-12-07 | 2011-03-03 | プレシジョン バイオサイエンシズ,インク. | ヒトゲノムのDNase高感受性領域に見出される認識配列を有する合理的に設計されたメガヌクレアーゼ |
| WO2009114321A2 (en) | 2008-03-11 | 2009-09-17 | Precision Biosciencs, Inc. | Rationally-designed meganucleases for maize genome engineering |
| US20100071083A1 (en) * | 2008-03-12 | 2010-03-18 | Smith James J | Temperature-dependent meganuclease activity |
| CA2722797A1 (en) * | 2008-04-28 | 2009-11-05 | Precision Biosciences, Inc. | Fusion molecules of rationally-designed dna-binding proteins and effector domains |
| EP2313498B1 (en) | 2008-07-14 | 2017-03-15 | Precision Biosciences, Inc. | Recognition sequences for i-crei-derived meganucleases and uses thereof |
| SG10201400436PA (en) * | 2009-03-06 | 2014-06-27 | Synthetic Genomics Inc | Methods For Cloning And Manipulating Genomes |
| US20110269119A1 (en) | 2009-10-30 | 2011-11-03 | Synthetic Genomics, Inc. | Encoding text into nucleic acid sequences |
| MX336846B (es) | 2010-01-22 | 2016-02-03 | Sangamo Biosciences Inc | Alteracion genomica dirigida. |
| KR101137819B1 (ko) | 2010-06-28 | 2012-06-27 | 대한민국 | 백합나무의 배발생조직 증식방법 |
| WO2012017329A2 (en) * | 2010-08-02 | 2012-02-09 | Cellectis S.A. | Method for targeted genomic events in algae |
| BR112013003135A2 (pt) | 2010-08-13 | 2017-11-07 | Pioneer Hi Bred Int | polinucletídeo e polipeptídeo isolado ou recombinante, construto de ácido nucleico, célula, planta, explante vegetal, semente transgênica, método para produção de célula vegetal para controle de plantas daninhas e para detecção de um polipeptídeo hppd e um polinucleotídeo. |
| US7919605B1 (en) | 2010-08-30 | 2011-04-05 | Amyris, Inc. | Nucleic acids, compositions and methods for the excision of target nucleic acids |
| JP5740955B2 (ja) * | 2010-12-10 | 2015-07-01 | 三菱レイヨン株式会社 | ロドコッカス属細菌の形質転換のためのランダム遺伝子導入用ツール |
| CN102559704B (zh) * | 2010-12-23 | 2014-08-27 | 中国科学院上海生命科学研究院 | 一种在丙酮丁醇梭菌中敲除基因的方法 |
| CA2831144A1 (en) | 2011-03-23 | 2012-09-27 | Pioneer Hi-Bred International, Inc. | Methods for producing a complex transgenic trait locus |
| US20140173770A1 (en) | 2011-06-06 | 2014-06-19 | Bayer Cropscience Nv | Methods and means to modify a plant genome at a preselected site |
| RU2612902C2 (ru) * | 2011-07-29 | 2017-03-13 | Кембридж Эпидженетикс Лимитед | Способы обнаружения модификации нуклеотидов |
| BR112014003919A2 (pt) | 2011-08-22 | 2017-03-14 | Bayer Cropscience Ag | métodos e meios para modificar um genoma de planta |
| WO2013103366A1 (en) | 2012-01-06 | 2013-07-11 | Pioneer Hi-Bred International, Inc. | A method to screen plants for genetic elements inducing parthenogenesis in plants |
| CN104245940A (zh) | 2012-04-23 | 2014-12-24 | 拜尔作物科学公司 | 植物中的靶向基因组工程 |
| CN102703426A (zh) * | 2012-05-21 | 2012-10-03 | 吴江汇杰生物科技有限公司 | 构建核酸库的方法、试剂及试剂盒 |
| UA119135C2 (uk) | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
| AU2013335451C1 (en) | 2012-10-23 | 2024-07-04 | Toolgen Incorporated | Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof |
| CA2908403A1 (en) | 2013-04-02 | 2014-10-09 | Bayer Cropscience Nv | Targeted genome engineering in eukaryotes |
| CN120574876A (zh) | 2013-08-22 | 2025-09-02 | 纳幕尔杜邦公司 | 使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法 |
| EP3362568A1 (en) | 2015-10-16 | 2018-08-22 | Pioneer Hi-Bred International, Inc. | Methods and compositions for transformation comprising negative selection markers |
| AU2017271575A1 (en) | 2016-05-25 | 2018-11-15 | Pioneer Hi-Bred International, Inc. | Engineered nucleases to generate deletion mutants in plants |
| PL3464333T3 (pl) | 2016-05-26 | 2024-09-30 | Nunhems B.V. | Rośliny wytwarzające bezpestkowe owoce |
| US11359234B2 (en) | 2016-07-01 | 2022-06-14 | Microsoft Technology Licensing, Llc | Barcoding sequences for identification of gene expression |
| US20180004537A1 (en) | 2016-07-01 | 2018-01-04 | Microsoft Technology Licensing, Llc | Molecular State Machines |
| ES2817973T3 (es) | 2016-07-01 | 2021-04-08 | Microsoft Technology Licensing Llc | Almacenamiento a través de la edición iterativa del ADN |
| WO2018111640A1 (en) | 2016-12-14 | 2018-06-21 | Dow Agrosciences Llc | Reconstruction of site specific nuclease binding sites |
| DK3501268T3 (da) | 2017-12-22 | 2021-11-08 | Kws Saat Se & Co Kgaa | Regenerering af planter i tilstedeværelse af histondeacetylase hæmmere |
| EP3508581A1 (en) | 2018-01-03 | 2019-07-10 | Kws Saat Se | Regeneration of genetically modified plants |
| AU2019207409B2 (en) | 2018-01-12 | 2023-02-23 | Basf Se | Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a |
| EP3545756A1 (en) | 2018-03-28 | 2019-10-02 | KWS SAAT SE & Co. KGaA | Regeneration of plants in the presence of inhibitors of the histone methyltransferase ezh2 |
| DK3567111T3 (da) | 2018-05-09 | 2025-10-13 | Kws Saat Se & Co Kgaa | Gen til resistens over for et patogen af slægten heterodera |
| CN112585269B (zh) | 2018-06-15 | 2025-01-07 | 科沃施种子欧洲股份两合公司 | 改善植物中基因组工程化和再生的方法ii |
| AU2019285082B2 (en) | 2018-06-15 | 2024-09-19 | KWS SAAT SE & Co. KGaA | Methods for enhancing genome engineering efficiency |
| EP3806619A1 (en) | 2018-06-15 | 2021-04-21 | Nunhems B.V. | Seedless watermelon plants comprising modifications in an abc transporter gene |
| WO2019238909A1 (en) | 2018-06-15 | 2019-12-19 | KWS SAAT SE & Co. KGaA | Methods for improving genome engineering and regeneration in plant |
| EP3623379A1 (en) | 2018-09-11 | 2020-03-18 | KWS SAAT SE & Co. KGaA | Beet necrotic yellow vein virus (bnyvv)-resistance modifying gene |
| CA3123890A1 (en) | 2019-01-04 | 2020-07-09 | Cargill Incorporated | Engineered nucleases to generate mutations in plants |
| US12606839B2 (en) | 2019-01-29 | 2026-04-21 | The University Of Warwick | Methods for enhancing genome engineering efficiency |
| EP3708651A1 (en) | 2019-03-12 | 2020-09-16 | KWS SAAT SE & Co. KGaA | Improving plant regeneration |
| EP3757219A1 (en) | 2019-06-28 | 2020-12-30 | KWS SAAT SE & Co. KGaA | Enhanced plant regeneration and transformation by using grf1 booster gene |
| JP7753203B2 (ja) | 2019-11-12 | 2025-10-14 | カー・ヴェー・エス ザート エス・エー ウント コー. カー・ゲー・アー・アー | ヘテロデラ属の病原体に対する耐性遺伝子 |
| US12473563B2 (en) | 2020-02-28 | 2025-11-18 | KWS SAAT SE & Co. KGaA | Immature inflorescence meristem editing |
| CN111534538B (zh) * | 2020-05-11 | 2022-02-01 | 山西大学 | 一种快速筛选非转基因定点突变植物的方法 |
| EP4019638A1 (en) | 2020-12-22 | 2022-06-29 | KWS SAAT SE & Co. KGaA | Promoting regeneration and transformation in beta vulgaris |
| EP4019639A1 (en) | 2020-12-22 | 2022-06-29 | KWS SAAT SE & Co. KGaA | Promoting regeneration and transformation in beta vulgaris |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6395959B1 (en) * | 1992-05-05 | 2002-05-28 | Institut Pasteur | Nucleotide sequence encoding the enzyme I SceI and the use thereof |
| US5527695A (en) * | 1993-01-29 | 1996-06-18 | Purdue Research Foundation | Controlled modification of eukaryotic genomes |
-
2001
- 2001-07-04 DE DE10131786A patent/DE10131786A1/de not_active Withdrawn
-
2002
- 2002-07-02 IL IL15928602A patent/IL159286A0/xx unknown
- 2002-07-02 WO PCT/EP2002/007281 patent/WO2003004659A2/de not_active Ceased
- 2002-07-02 JP JP2003510817A patent/JP2004533267A/ja active Pending
- 2002-07-02 BR BRPI0210839-9A patent/BRPI0210839B1/pt not_active IP Right Cessation
- 2002-07-02 CA CA2451492A patent/CA2451492C/en not_active Expired - Lifetime
- 2002-07-02 BR BR0210839-9A patent/BR0210839A/pt active IP Right Grant
- 2002-07-02 CN CNB028133757A patent/CN100451123C/zh not_active Expired - Lifetime
- 2002-07-02 AU AU2002325859A patent/AU2002325859B2/en not_active Expired
- 2002-07-02 MX MXPA03011844A patent/MXPA03011844A/es active IP Right Grant
- 2002-07-02 EP EP02760212.7A patent/EP1407034B1/de not_active Expired - Lifetime
- 2002-07-03 AR ARP020102493A patent/AR034687A1/es not_active Application Discontinuation
-
2004
- 2004-01-05 US US10/750,891 patent/US7736886B2/en not_active Expired - Lifetime
-
2012
- 2012-04-23 AR ARP120101393A patent/AR086031A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003004659A3 (de) | 2003-09-25 |
| US7736886B2 (en) | 2010-06-15 |
| EP1407034A2 (de) | 2004-04-14 |
| CN1628174A (zh) | 2005-06-15 |
| CA2451492A1 (en) | 2003-01-16 |
| MXPA03011844A (es) | 2005-03-07 |
| JP2004533267A (ja) | 2004-11-04 |
| BRPI0210839B1 (pt) | 2019-02-26 |
| DE10131786A1 (de) | 2003-01-16 |
| WO2003004659A8 (de) | 2004-04-22 |
| AR086031A2 (es) | 2013-11-13 |
| CA2451492C (en) | 2014-12-16 |
| AU2002325859B2 (en) | 2008-05-29 |
| CN100451123C (zh) | 2009-01-14 |
| EP1407034B1 (de) | 2016-09-07 |
| WO2003004659A2 (de) | 2003-01-16 |
| US20050172365A1 (en) | 2005-08-04 |
| AR034687A1 (es) | 2004-03-03 |
| IL159286A0 (en) | 2004-06-01 |
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