BR0213653A - Formulação farmacêutica que contém o 3-(3-dimetil-amino1-etil-2metil-propil) fenol e proporciona uma liberação retardada do ingrediente ativo - Google Patents

Formulação farmacêutica que contém o 3-(3-dimetil-amino1-etil-2metil-propil) fenol e proporciona uma liberação retardada do ingrediente ativo

Info

Publication number
BR0213653A
BR0213653A BR0213653-8A BR0213653A BR0213653A BR 0213653 A BR0213653 A BR 0213653A BR 0213653 A BR0213653 A BR 0213653A BR 0213653 A BR0213653 A BR 0213653A
Authority
BR
Brazil
Prior art keywords
phenol
methyl
propyl
dimethyl
ethyl
Prior art date
Application number
BR0213653-8A
Other languages
English (en)
Other versions
BRPI0213653B8 (pt
BRPI0213653B1 (pt
Inventor
Johannes Bartholomaus
Iris Ziegler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26010444&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0213653(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10152469A external-priority patent/DE10152469A1/de
Priority claimed from DE2002148309 external-priority patent/DE10248309A1/de
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR0213653A publication Critical patent/BR0213653A/pt
Publication of BRPI0213653B1 publication Critical patent/BRPI0213653B1/pt
Publication of BRPI0213653B8 publication Critical patent/BRPI0213653B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

"FORMULAçãO FARMACêUTICA QUE CONTéM O 3-(3-DIMETIL-AMINO-1-ETIL-2-METIL-PROPIL) FENOL E PROPORCIONA UMA LIBERAçãO RETARDADA DO INGREDIENTE ATIVO". A invenção está relacionada com uma formulação farmacêutica que é caracterizada pela liberação lenta do ingrediente ativo. Dita formulação contém o 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol ou um de seus sais farmaceuticamente aceitáveis em uma matriz com liberação lenta do ingrediente ativo. Dita matriz contém entre um 1% e 80% em peso de pelo menos um ou mais polímeros hidrófilos ou hidrófobos como agentes formadores de matriz farmaceuticamente aceitáveis e exibe, in vitro, a seguinte velocidade de dissolução: entre 3% e 35% em peso (sobre a base do 100% de peso do ingrediente ativo) do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após meia hora, entre 5% e 50% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 1 hora, entre 10% e 75% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 2 horas, entre 15% e 82% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 3 horas, entre 30% e 97% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 6 horas, mais do que 50% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 12 horas, mais do que 70% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 18 horas, e mais do que 80% em peso do 3-(3-dimetil-amino-1-etil-2-metil-propil) fenol é liberado após 24 horas.
BRPI0213653A 2001-10-24 2002-10-22 formulação farmacêutica que contém o 3-(3-dimetil-amino1-etil-2metil-propil) fenol e proporciona uma liberação retardada do ingrediente ativo BRPI0213653B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE101524692 2001-10-24
DE10152469A DE10152469A1 (de) 2001-10-24 2001-10-24 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung
DE2002148309 DE10248309A1 (de) 2002-10-16 2002-10-16 3-(3- Dimethylamino-1-ethyl-2-methyl-propyl) phenol enthaltendes Arzeimittel mit verzögerter Wirkstofffreisetzung
PCT/EP2002/011809 WO2003035053A1 (de) 2001-10-24 2002-10-22 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung

Publications (3)

Publication Number Publication Date
BR0213653A true BR0213653A (pt) 2004-10-26
BRPI0213653B1 BRPI0213653B1 (pt) 2018-04-03
BRPI0213653B8 BRPI0213653B8 (pt) 2021-05-25

Family

ID=26010444

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0213653A BRPI0213653B8 (pt) 2001-10-24 2002-10-22 formulação farmacêutica que contém o 3-(3-dimetil-amino1-etil-2metil-propil) fenol e proporciona uma liberação retardada do ingrediente ativo

Country Status (28)

Country Link
US (7) US20050058706A1 (pt)
EP (1) EP1439829B1 (pt)
JP (2) JP4758064B2 (pt)
KR (1) KR100958045B1 (pt)
CN (1) CN100402021C (pt)
AR (1) AR036943A1 (pt)
AT (1) ATE303802T1 (pt)
AU (1) AU2002349001C1 (pt)
BR (1) BRPI0213653B8 (pt)
CA (1) CA2464578C (pt)
CO (1) CO5570662A2 (pt)
CY (1) CY2012022I2 (pt)
DE (1) DE50204198D1 (pt)
DK (1) DK1439829T3 (pt)
EC (1) ECSP045102A (pt)
ES (1) ES2248622T3 (pt)
HU (1) HU230161B1 (pt)
IL (2) IL161587A0 (pt)
MX (1) MXPA04003742A (pt)
MY (1) MY127797A (pt)
NO (2) NO331896B1 (pt)
NZ (1) NZ532999A (pt)
PE (1) PE20030527A1 (pt)
PL (1) PL216535B1 (pt)
PT (1) PT1439829E (pt)
SI (1) SI1439829T1 (pt)
WO (2) WO2003035054A1 (pt)
ZA (1) ZA200403928B (pt)

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BRPI0213653B8 (pt) 2021-05-25
ATE303802T1 (de) 2005-09-15
US20170087103A1 (en) 2017-03-30
WO2003035053A1 (de) 2003-05-01
SI1439829T1 (sl) 2006-02-28
BRPI0213653B1 (pt) 2018-04-03
IL161587A0 (en) 2004-09-27
AR036943A1 (es) 2004-10-13
US20180221308A1 (en) 2018-08-09
CY2012022I1 (el) 2015-08-05
CA2464578A1 (en) 2003-05-01
US20130237608A1 (en) 2013-09-12
HK1068539A1 (en) 2005-04-29
ZA200403928B (en) 2005-07-27
ES2248622T3 (es) 2006-03-16
ECSP045102A (es) 2004-06-28
AU2002349001C1 (en) 2022-04-14
NO2012007I2 (no) 2013-01-02
HUP0402104A2 (hu) 2005-03-29
JP4758064B2 (ja) 2011-08-24
KR20040047964A (ko) 2004-06-05
NO331896B1 (no) 2012-04-30
JP2010280697A (ja) 2010-12-16
DK1439829T3 (da) 2005-10-10
HU230161B1 (en) 2015-09-28
MY127797A (en) 2006-12-29
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CN100402021C (zh) 2008-07-16
US11007156B2 (en) 2021-05-18
IL161587A (en) 2009-12-24
NO2012007I1 (no) 2012-05-21
NZ532999A (en) 2007-06-29
CN1607947A (zh) 2005-04-20
EP1439829A1 (de) 2004-07-28
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WO2003035054A1 (de) 2003-05-01
US20160151309A1 (en) 2016-06-02
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US20050058706A1 (en) 2005-03-17
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AU2002349001B2 (en) 2003-05-06
DE50204198D1 (de) 2005-10-13
US20200038344A1 (en) 2020-02-06
KR100958045B1 (ko) 2010-05-17
PT1439829E (pt) 2005-11-30
NO20041924L (no) 2004-05-11
PL369756A1 (en) 2005-05-02
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JP2005506367A (ja) 2005-03-03
EP1439829B1 (de) 2005-09-07

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