AR044200A1 - Composicion de fondaparinux sodico de alta pureza ,un procedimiento de preparacion de esta composicion y composiciones farmaceuticas que la contienen como principio activo - Google Patents
Composicion de fondaparinux sodico de alta pureza ,un procedimiento de preparacion de esta composicion y composiciones farmaceuticas que la contienen como principio activoInfo
- Publication number
- AR044200A1 AR044200A1 ARP040100513A ARP040100513A AR044200A1 AR 044200 A1 AR044200 A1 AR 044200A1 AR P040100513 A ARP040100513 A AR P040100513A AR P040100513 A ARP040100513 A AR P040100513A AR 044200 A1 AR044200 A1 AR 044200A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- pharmaceutical compositions
- high purity
- fondaparinux
- compositions containing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- KANJSNBRCNMZMV-ABRZTLGGSA-N fondaparinux Chemical group O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](OC)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O4)NS(O)(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS(O)(=O)=O)O2)NS(O)(=O)=O)[C@H](C(O)=O)O1 KANJSNBRCNMZMV-ABRZTLGGSA-N 0.000 title 1
- 229960001318 fondaparinux Drugs 0.000 title 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960003661 fondaparinux sodium Drugs 0.000 abstract 1
- XEKSTYNIJLDDAZ-JASSWCPGSA-F fondaparinux sodium Chemical group [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O[C@@H]1[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@H](COS([O-])(=O)=O)[C@H]1O[C@H]1[C@H](OS([O-])(=O)=O)[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](COS([O-])(=O)=O)O4)NS([O-])(=O)=O)[C@H](O3)C(O)=O)O)[C@@H](COS([O-])(=O)=O)O2)NS([O-])(=O)=O)[C@H](C(O)=O)O1 XEKSTYNIJLDDAZ-JASSWCPGSA-F 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Composiciones de fondaparinux sódico de alta pureza (al menos 97 %), procedimientos de preparación de esta composición para su utilización en composiciones farmacéuticas y composiciones farmacéuticas que la contienen como principio activo. Este compuesto es útil para el tratamiento y la prevención de las enfermedades tromboembólicas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37526803A | 2003-02-27 | 2003-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044200A1 true AR044200A1 (es) | 2005-09-07 |
Family
ID=32961215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100513A AR044200A1 (es) | 2003-02-27 | 2004-02-19 | Composicion de fondaparinux sodico de alta pureza ,un procedimiento de preparacion de esta composicion y composiciones farmaceuticas que la contienen como principio activo |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050020536A1 (es) |
| EP (1) | EP1625135B1 (es) |
| JP (1) | JP4594298B2 (es) |
| AR (1) | AR044200A1 (es) |
| AT (1) | ATE427953T1 (es) |
| CY (1) | CY1109168T1 (es) |
| DE (1) | DE602004020459D1 (es) |
| DK (1) | DK1625135T3 (es) |
| ES (1) | ES2322464T3 (es) |
| PT (1) | PT1625135E (es) |
| SI (1) | SI1625135T1 (es) |
| TW (1) | TWI335224B (es) |
| WO (1) | WO2004078105A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| AU2006244563B2 (en) * | 2005-05-05 | 2011-07-21 | Nyse Group, Inc. | Anti-internalization order modifier |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| US8277143B2 (en) * | 2009-05-12 | 2012-10-02 | RSA Protective Technology, LLC | Surface mount vehicle anti-ram security systems |
| WO2011014793A2 (en) * | 2009-07-31 | 2011-02-03 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| US8420790B2 (en) | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
| US20130005954A1 (en) * | 2011-06-28 | 2013-01-03 | Apicore, Llc | Process for preparing heparinoids and intermediates useful in the synthesis thereof |
| CN102659859B (zh) * | 2012-04-11 | 2014-12-10 | 苏州纳微科技有限公司 | 单分散聚甲基丙烯酸酯离子交换层析介质在磺达肝癸钠柱层析纯化中的应用 |
| CN103570774B (zh) * | 2012-08-07 | 2017-08-25 | 博瑞生物医药（苏州）股份有限公司 | 一种戊糖化合物的纯化方法 |
| WO2014066274A1 (en) | 2012-10-22 | 2014-05-01 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| CN103864862B (zh) * | 2012-12-14 | 2017-10-17 | 博瑞生物医药（苏州）股份有限公司 | 一种戊糖化合物的纯化方法 |
| EP3024840B1 (en) | 2013-07-25 | 2019-10-02 | ScinoPharm Taiwan, Ltd. | Process for the production of fondaparinux sodium |
| US9346844B2 (en) | 2013-07-25 | 2016-05-24 | Scinopharm Taiwan, Ltd. | Process for the production of fondaparinux sodium |
| US10072039B2 (en) | 2013-07-25 | 2018-09-11 | Scinopharm Taiwan, Ltd. | Process for the production of Fondaparinux sodium |
| CN103992364B (zh) * | 2014-03-25 | 2016-08-10 | 南京天翔医药科技有限公司 | 一种磺达肝癸钠的分离提取方法 |
| CN103965269B (zh) * | 2014-04-16 | 2018-05-04 | 杭州华东医药集团新药研究院有限公司 | 低水分高纯度的磺达肝癸钠及其制备方法 |
| US9873712B2 (en) * | 2014-10-03 | 2018-01-23 | Amphastar Pharmaceuticals, Inc. | Method of purifying idraparinux sodium |
| US10688249B2 (en) * | 2015-06-11 | 2020-06-23 | Virchow Biotech Pvt. Ltd. | Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same |
| CN105037452B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种快速制备高纯度磺达肝癸钠的精制方法 |
| CN104910217B (zh) * | 2015-06-19 | 2018-04-17 | 天津红日药业股份有限公司 | 用于磺达肝癸钠质量控制的参比化合物 |
| CN107501359B (zh) * | 2017-08-24 | 2020-07-31 | 深圳市海滨制药有限公司 | 一种磺达肝癸钠杂质化合物及其制备方法与应用 |
| CN114478663B (zh) * | 2020-11-12 | 2023-12-01 | 杭州中美华东制药有限公司 | 一种磺达肝癸钠杂质的制备方法 |
| CN114591379A (zh) * | 2021-12-30 | 2022-06-07 | 淮北师范大学 | 一种磺达肝癸钠甲酰化杂质的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE664087A (es) * | 1956-03-29 | |||
| US4025357A (en) * | 1975-04-14 | 1977-05-24 | A. E. Staley Manufacturing Company | Ion exchange enrichment of impure dextrose solutions |
| JPS5577896A (en) * | 1978-12-07 | 1980-06-12 | Meiji Seika Kaisha Ltd | Preparation of high-purity maltose |
| FR2456116A1 (fr) * | 1979-05-11 | 1980-12-05 | Sarget Lab | Nouvelle saponine triterpenique derivee de la caulophyllogenine et ses applications therapeutiques |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| US4502890A (en) * | 1981-03-02 | 1985-03-05 | Calgon Carbon Corporation | Purification of sugar liquors with activated carbon |
| DE3118588C2 (de) * | 1981-05-11 | 1983-07-07 | Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
| JPS5899497A (ja) * | 1981-11-27 | 1983-06-13 | Snow Brand Milk Prod Co Ltd | 新規なオリゴ糖、その製造法及びビフイドバクテリウム菌の増殖促進剤 |
| JPS60102196A (ja) * | 1983-11-07 | 1985-06-06 | Daicel Chem Ind Ltd | 粗グリコシドの精製処理方法 |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| JPS61118336A (ja) * | 1984-11-13 | 1986-06-05 | Yonezawa Kagaku Kogyo Kk | ペンタクロルフエノ−ル及びその誘導体の精製法 |
| JPH0673442B2 (ja) * | 1986-03-13 | 1994-09-21 | 明治製菓株式会社 | 食品の老化防止方法 |
| SE453394B (sv) * | 1986-07-07 | 1988-02-01 | Pharmacia Ab | Forfarande for framstellning av sulfaterade polysackarider genom anvendning av ett reducerande medel for sulfateringsreaktionen |
| JPS6398395A (ja) * | 1986-10-16 | 1988-04-28 | Katakura Chitsukarin Kk | キトサンオリゴ糖の製造法 |
| US5756721A (en) * | 1991-01-16 | 1998-05-26 | National Starch And Chemical Investment Holding Corporation | Purification of polysaccharides |
| US5569756A (en) * | 1995-03-21 | 1996-10-29 | American Maize-Products Company | Purification of chemically modified cyclodextrins |
| DE19543052A1 (de) * | 1995-11-06 | 1997-05-07 | Schering Ag | Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren |
| MXPA02002234A (es) * | 1999-08-30 | 2003-08-20 | Mossi & Ghisolfi Overseas Sa | Procedimiento para la separacion de la sal dipotasica de acido naftalendicarboxilico usando lechos de carbon activado. |
-
2004
- 2004-02-12 AT AT04710418T patent/ATE427953T1/de active
- 2004-02-12 EP EP04710418A patent/EP1625135B1/fr not_active Expired - Lifetime
- 2004-02-12 DE DE602004020459T patent/DE602004020459D1/de not_active Expired - Lifetime
- 2004-02-12 SI SI200431107T patent/SI1625135T1/sl unknown
- 2004-02-12 PT PT04710418T patent/PT1625135E/pt unknown
- 2004-02-12 DK DK04710418T patent/DK1625135T3/da active
- 2004-02-12 ES ES04710418T patent/ES2322464T3/es not_active Expired - Lifetime
- 2004-02-12 WO PCT/FR2004/000314 patent/WO2004078105A2/fr not_active Ceased
- 2004-02-12 JP JP2006505669A patent/JP4594298B2/ja not_active Expired - Fee Related
- 2004-02-19 AR ARP040100513A patent/AR044200A1/es not_active Application Discontinuation
- 2004-02-19 TW TW093104096A patent/TWI335224B/zh not_active IP Right Cessation
- 2004-06-30 US US10/881,250 patent/US20050020536A1/en not_active Abandoned
-
2009
- 2009-06-18 CY CY20091100645T patent/CY1109168T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004078105A2 (fr) | 2004-09-16 |
| EP1625135B1 (fr) | 2009-04-08 |
| DK1625135T3 (da) | 2009-06-22 |
| PT1625135E (pt) | 2009-07-10 |
| TW200501965A (en) | 2005-01-16 |
| JP4594298B2 (ja) | 2010-12-08 |
| TWI335224B (en) | 2011-01-01 |
| ATE427953T1 (de) | 2009-04-15 |
| US20050020536A1 (en) | 2005-01-27 |
| HK1087719A1 (zh) | 2006-10-20 |
| EP1625135A2 (fr) | 2006-02-15 |
| CY1109168T1 (el) | 2014-07-02 |
| JP2006519246A (ja) | 2006-08-24 |
| SI1625135T1 (sl) | 2009-08-31 |
| ES2322464T3 (es) | 2009-06-22 |
| WO2004078105A3 (fr) | 2004-10-28 |
| DE602004020459D1 (de) | 2009-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP034732A (es) | Derivado de fenetanolamina para el tratamiento de enfermedades respiratorias | |
| UY28510A1 (es) | Compuestos quimicos | |
| CU23208A3 (es) | Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea | |
| BRPI0412526A (pt) | composto, uso de um composto, composição farmacêutica, formulação em aerossol farmacêutica, e, método para o tratamento de um paciente humano ou animal com uma condição anti-inflamatória e/ou alérgica | |
| BRPI0418251B8 (pt) | fosfonatos, monofosfonamidatos, bisfosfonamidatos, e, composição farmacêutica os compreendendo | |
| DE602006004451D1 (de) | Mucoadhäsive xyloglucan-haltige formulierung für medizinprodukte und pharmazeutische darreichungsformen | |
| CO5640037A2 (es) | Derivados de la quinazolina para el tratamiento del cancer | |
| MY143795A (en) | Tetrahydropyridoindole derivatives | |
| NO20082477L (no) | Krystallinske former av 1-benzoyl-4-[2-[4-metoksy-7-(3-metyl-1H-1,2,4-triazol-1-yl-1-[(fosfonooksy)metyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioksoetyl]-piperazin | |
| BR0311460A (pt) | Composição farmacêutica de liberação modificada, uso de uma formulação, e, método para tratar um distúrbio cardiovascular em um paciente | |
| SG178975A1 (en) | Indenone derivative and pharmaceutical composition comprising same | |
| ATE470443T1 (de) | Indol-1-yl-essigsäurederivate | |
| ECSP066608A (es) | Suspensiones acuosas de ciclesonide para nebulización | |
| ATE386725T1 (de) | Heterocyclylverbindungen | |
| CR7195A (es) | Nuevos derivados de oxazolidinonas como antibacterianos | |
| CO5611124A2 (es) | Derivados de benzofurano substituidos utiles en el tratamiento de desordenes hiper-proliferativos | |
| BR0308133A (pt) | Forma polimórfica cristalina de cloridrato de irinotecan | |
| ES2340502T3 (es) | Compuestos de 1,4,8-triazaespiro(4,5)decan-2-ona sustituidos para el tratamiento de la obesidad. | |
| BRPI0411702A (pt) | uso de ácido hialurÈnico para preparar composições para o tratamento de aftas da cavidade oral | |
| TW200731975A (en) | Novel combinations of medicaments for the treatment of respiratory diseases | |
| ES2129448T3 (es) | Uso de 2-(2-nitro-4-trifluorometilbenzoil)-1,3-ciclohexanodiona en el tratamiento de tirosinemia y composiciones farmaceuticas. | |
| SE0302570D0 (sv) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| BRPI0409881A (pt) | compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos | |
| BRPI0509667B8 (pt) | composto, processo para a preparação de um composto de fórmula (i), medicamento e uso de um composto | |
| TW200640465A (en) | New pharmaceutically active compounds for the treatment of respiratory diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |