BR0303067A - Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis - Google Patents
Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveisInfo
- Publication number
- BR0303067A BR0303067A BR0303067-9A BR0303067A BR0303067A BR 0303067 A BR0303067 A BR 0303067A BR 0303067 A BR0303067 A BR 0303067A BR 0303067 A BR0303067 A BR 0303067A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- ursodeoxycholic acid
- acid
- preparation
- Prior art date
Links
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 4
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title abstract 4
- 229960001661 ursodiol Drugs 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 title abstract 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 2
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- VFNGKCDDZUSWLR-UHFFFAOYSA-N disulfuric acid Chemical compound OS(=O)(=O)OS(O)(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001180 sulfating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
"PROCESSO DE PREPARAçãO DE DISSULFATO DE áCIDO URSODESOXICóLICO E SEUS SAIS FARMACêUTICAMENTE ACEITáVEIS". Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis compreende a operação de reação do ácido ursodesoxicólico dissolvido em um solvente selecionado a partir do grupo que consiste de dimetilformamida, piridina, acetonitrila, sulfóxido de dimetila, ácido octanóico, anidrido acético e suas misturas, com um agente de sulfatação selecionado a partir do grupo que consiste de anidrido sulfúrico, ácido sulfúrico e complexos que contêm anidrido sulfúrico em razão molar entre grupos sulfónicos e ácido ursodesoxicólico de 2,5:1 a 4:1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002TO000102A ITTO20020102A1 (it) | 2002-02-06 | 2002-02-06 | Procedimento per la preparazione dell'acido ursodesossicolico disolfato e suoi sali farmaceuticamente accettabili. |
| PCT/IB2003/000479 WO2003066657A1 (en) | 2002-02-06 | 2003-02-06 | A process for preparing ursodeoxycholic acid dusulphate and pharmaceutically acceptable salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0303067A true BR0303067A (pt) | 2004-03-09 |
Family
ID=27638823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0303067-9A BR0303067A (pt) | 2002-02-06 | 2003-02-06 | Processo de preparação de dissulfato de ácido ursodesoxicólico e seus sais farmacêuticamente aceitáveis |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU2003244517A1 (pt) |
| BR (1) | BR0303067A (pt) |
| IT (1) | ITTO20020102A1 (pt) |
| WO (1) | WO2003066657A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1393095B1 (it) | 2009-02-19 | 2012-04-11 | Prodotti Chimici Alimentari | Processo per la sintesi del sale disodico dell'acido ursodesossicolico 3,7-disolfato. |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| WO2020117945A1 (en) | 2018-12-04 | 2020-06-11 | President And Fellows Of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| CN120757601A (zh) | 2019-05-10 | 2025-10-10 | 哈佛大学的校长及成员们 | 肠道细菌胆汁酸代谢的小分子调节剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1221734B (it) * | 1983-02-24 | 1990-07-12 | Schiena Michele Giuseppe Di | Ursodesossicolico solfato acido sale sodico |
| US5763435A (en) * | 1995-11-21 | 1998-06-09 | Children's Hospital Medical Center | Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders |
-
2002
- 2002-02-06 IT IT2002TO000102A patent/ITTO20020102A1/it unknown
-
2003
- 2003-02-06 WO PCT/IB2003/000479 patent/WO2003066657A1/en not_active Ceased
- 2003-02-06 AU AU2003244517A patent/AU2003244517A1/en not_active Abandoned
- 2003-02-06 BR BR0303067-9A patent/BR0303067A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003244517A1 (en) | 2003-09-02 |
| ITTO20020102A1 (it) | 2003-08-06 |
| ITTO20020102A0 (it) | 2002-02-06 |
| WO2003066657A1 (en) | 2003-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O E 7O ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2042 DE 23/02/2010. |