BR0306973A - Anticorpos anti-igf-ir e respectivas aplicações - Google Patents

Anticorpos anti-igf-ir e respectivas aplicações

Info

Publication number
BR0306973A
BR0306973A BR0306973-7A BR0306973A BR0306973A BR 0306973 A BR0306973 A BR 0306973A BR 0306973 A BR0306973 A BR 0306973A BR 0306973 A BR0306973 A BR 0306973A
Authority
BR
Brazil
Prior art keywords
antibodies
igf
receptor
well
applications
Prior art date
Application number
BR0306973-7A
Other languages
English (en)
Other versions
BRPI0306973B1 (pt
BRPI0306973B8 (pt
Inventor
Liliane Goetsch
Nathalie Corvaia
Olivier Leger
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0200654A external-priority patent/FR2834900B1/fr
Priority claimed from FR0200653A external-priority patent/FR2834990A1/fr
Priority claimed from FR0205753A external-priority patent/FR2834991B1/fr
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of BR0306973A publication Critical patent/BR0306973A/pt
Publication of BRPI0306973B1 publication Critical patent/BRPI0306973B1/pt
Publication of BRPI0306973B8 publication Critical patent/BRPI0306973B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"ANTICORPOS ANTI-IGF-IR E RESPECTIVAS APLICAçõES". A presente invenção refere-se a novos anticorpos capazes de se ligarem especificamente ao receptor humano do fator de crescimento I semelhante à insulina IGF-IR e/ou capazes de inibirem especificamente a atividade tirosina quinase desse receptor IGF-IR, notadamente monocionais de origem murina, quiméricas e humanizadas, bem como as sequencias de aminoácido e nucléicos codificando para esses anticorpos. A invenção compreende também a utilização desses anticorpos a título de medicamento para o tratamento profilático e/ou terapêutico de cânceres, bem como em processos ou necessários de diagnóstico de doenças ligadas à superexpressão do receptor IGF-IR. A invenção compreende, enfim, produtos e/ou composições que compreendem esses anticorpos em associação com anticorpos e/ou compostos anti-EGFR e/ou agentes anticancerosos ou conjugados com toxinas e sua utilização para a prevenção e/ou o tratamento de certos cânceres.
BRPI0306973A 2002-01-18 2003-01-20 anticorpos anti-igf-ir, seu método de produção e seus usos, hibridoma murino, ácido nucléico isolado, vetor, composição, kit ou conjunto, e método diagnóstico in vitro de doenças induzidas por uma superexpressão ou uma subexpressão do receptor igf-ir BRPI0306973B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR0200654A FR2834900B1 (fr) 2002-01-18 2002-01-18 Nouvelles compositions a activite anti-igf-ir et anti-egfr et leurs applications
FR0200653 2002-01-18
FR0200653A FR2834990A1 (fr) 2002-01-18 2002-01-18 Nouveaux anticorps anti-igf-ir et leurs applications
FR0200654 2002-01-18
FR0205753 2002-05-07
FR0205753A FR2834991B1 (fr) 2002-01-18 2002-05-07 Nouveaux anticorps anti-igf-ir et leurs applications
PCT/FR2003/000178 WO2003059951A2 (fr) 2002-01-18 2003-01-20 Anticorps anti-igf-ir et leurs applications

Publications (3)

Publication Number Publication Date
BR0306973A true BR0306973A (pt) 2004-11-09
BRPI0306973B1 BRPI0306973B1 (pt) 2020-03-03
BRPI0306973B8 BRPI0306973B8 (pt) 2021-05-25

Family

ID=27248849

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0306973A BRPI0306973B8 (pt) 2002-01-18 2003-01-20 anticorpos anti-igf-ir, seu método de produção e seus usos, hibridoma murino, ácido nucléico isolado, vetor, composição, kit ou conjunto, e método diagnóstico in vitro de doenças induzidas por uma superexpressão ou uma subexpressão do receptor igf-ir

Country Status (16)

Country Link
EP (3) EP1461359B1 (pt)
JP (2) JP4606739B2 (pt)
CN (1) CN100410275C (pt)
AT (1) ATE357460T1 (pt)
AU (2) AU2003216748B2 (pt)
BR (1) BRPI0306973B8 (pt)
CA (1) CA2473039C (pt)
CY (1) CY1106662T1 (pt)
DE (1) DE60312639T2 (pt)
DK (1) DK1461359T3 (pt)
ES (2) ES2283759T3 (pt)
MX (1) MXPA04006980A (pt)
PT (1) PT1461359E (pt)
SI (1) SI1461359T1 (pt)
WO (1) WO2003059951A2 (pt)
ZA (1) ZA200405402B (pt)

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BRPI0306973B1 (pt) 2020-03-03
ATE357460T1 (de) 2007-04-15
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AU2009201674B2 (en) 2012-08-16
WO2003059951A3 (fr) 2004-04-15
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JP2005536181A (ja) 2005-12-02
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EP1806364B1 (fr) 2013-07-31
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SI1461359T1 (sl) 2007-06-30
DE60312639T2 (de) 2007-11-29
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