BR0307821A - Inalante em pó contendo o antagonista cgrp bibn4096 e processo para preparação do mesmo - Google Patents

Inalante em pó contendo o antagonista cgrp bibn4096 e processo para preparação do mesmo

Info

Publication number
BR0307821A
BR0307821A BR0307821-3A BR0307821A BR0307821A BR 0307821 A BR0307821 A BR 0307821A BR 0307821 A BR0307821 A BR 0307821A BR 0307821 A BR0307821 A BR 0307821A
Authority
BR
Brazil
Prior art keywords
bibn4096
antagonist
powder containing
preparing same
inhalant
Prior art date
Application number
BR0307821-3A
Other languages
English (en)
Inventor
Michael Trunk
Claudius Weiler
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR0307821A publication Critical patent/BR0307821A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"INALANTE EM Pó CONTENDO O ANTAGONISTA CGRP BIBN4096 E PROCESSO PARA PREPARAçãO DO MESMO". A invenção refere-se a um inalante em pó para tratamento de enxaquecas abrangendo o antagonista CGRP 1-[N^ 2^-[3,5-dibromo-N-[[4-(3,4-dihidro-2(1H)-oxoquinazolin-3-il)-1 -piperidinil]carbonil]-D-tirosil]-L-lisil]-4-(4piridinil)-piperazina [BIBN4096] da fórmula I como base de substância -ativa na forma de partículas nanoestruturadas esféricas, assim como a um processo para preparação do mesmo.
BR0307821-3A 2002-02-20 2003-02-17 Inalante em pó contendo o antagonista cgrp bibn4096 e processo para preparação do mesmo BR0307821A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10207026A DE10207026A1 (de) 2002-02-20 2002-02-20 Pulverinhalativum, enthaltend den CGRP-Antagonisten BIBN4096 und Verfahren zu dessen Herstellung
PCT/EP2003/001563 WO2003070215A1 (de) 2002-02-20 2003-02-17 Pulverinhalativum, enthaltend den cgrp-antagonisten bibn4096 und verfahren zu dessen herstellung

Publications (1)

Publication Number Publication Date
BR0307821A true BR0307821A (pt) 2004-12-14

Family

ID=27635158

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307821-3A BR0307821A (pt) 2002-02-20 2003-02-17 Inalante em pó contendo o antagonista cgrp bibn4096 e processo para preparação do mesmo

Country Status (22)

Country Link
EP (1) EP1478338B1 (pt)
JP (1) JP4085063B2 (pt)
KR (1) KR20040089646A (pt)
CN (1) CN1638728A (pt)
AR (1) AR038572A1 (pt)
AT (1) ATE299016T1 (pt)
AU (1) AU2003208862A1 (pt)
BR (1) BR0307821A (pt)
CA (1) CA2476621A1 (pt)
DE (2) DE10207026A1 (pt)
EA (1) EA200401010A1 (pt)
EC (1) ECSP045241A (pt)
ES (1) ES2244922T3 (pt)
HR (1) HRP20040747A2 (pt)
IL (1) IL163559A0 (pt)
MX (1) MXPA04008183A (pt)
NO (1) NO20043865L (pt)
PE (1) PE20030832A1 (pt)
PL (1) PL371315A1 (pt)
TW (1) TW200304376A (pt)
UY (1) UY27674A1 (pt)
WO (1) WO2003070215A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10338407A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Inhalationspulver enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
DE10338399A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mikropartikel, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-Iysyl]-4-(4-pyridinyl)-piperazin, Verfahren zu deren Herstellung sowie deren Verwendung als Inhalaltionspulver
DE10338402A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknetes, amorphes BIBN 4096, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
MD4673C1 (ro) * 2013-06-19 2020-11-30 Aicuris Anti-Infective Cures Gmbh Letermovir amorf şi forme preparative farmaceutice solide ale acestuia pentru administrare orală

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
DE19937304C2 (de) * 1999-08-10 2003-08-21 Boehringer Ingelheim Pharma Verwendung von CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen
DE60025019T2 (de) * 1999-10-29 2006-08-24 Nektar Therapeutics, San Carlos Trockenpulverzusammensetzungen mit verbesserter dispersivität
DE10139410A1 (de) * 2001-08-17 2003-02-27 Boehringer Ingelheim Pharma Verwendung von BIBN4096 in Kombination mit anderen Arzneistoffen gegen Migräne für die Behandlung von Migräne

Also Published As

Publication number Publication date
JP2005529849A (ja) 2005-10-06
TW200304376A (en) 2003-10-01
HRP20040747A2 (en) 2005-02-28
MXPA04008183A (es) 2004-11-26
JP4085063B2 (ja) 2008-04-30
UY27674A1 (es) 2003-09-30
WO2003070215A1 (de) 2003-08-28
PL371315A1 (en) 2005-06-13
IL163559A0 (en) 2005-12-18
PE20030832A1 (es) 2003-11-20
EP1478338B1 (de) 2005-07-06
DE10207026A1 (de) 2003-08-28
ECSP045241A (es) 2004-09-28
KR20040089646A (ko) 2004-10-21
EP1478338A1 (de) 2004-11-24
AR038572A1 (es) 2005-01-19
EA200401010A1 (ru) 2005-02-24
NO20043865L (no) 2004-09-15
CA2476621A1 (en) 2003-08-28
AU2003208862A1 (en) 2003-09-09
ATE299016T1 (de) 2005-07-15
DE50300736D1 (de) 2005-08-11
CN1638728A (zh) 2005-07-13
ES2244922T3 (es) 2005-12-16

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Legal Events

Date Code Title Description
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]