BR0308525A - Formas cristalinas - Google Patents

Formas cristalinas

Info

Publication number
BR0308525A
BR0308525A BR0308525-2A BR0308525A BR0308525A BR 0308525 A BR0308525 A BR 0308525A BR 0308525 A BR0308525 A BR 0308525A BR 0308525 A BR0308525 A BR 0308525A
Authority
BR
Brazil
Prior art keywords
crystalline forms
amino
pyrrolidinecarboxanide
diphenylpropanoyl
thienylmethyl
Prior art date
Application number
BR0308525-2A
Other languages
English (en)
Inventor
Aeri Kim
Jae-Hyeon Park
Suk-Kyoon Yoon
Bong-Chan Kim
Sung-Ji Kim
Kwan-Hyung Cho
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of BR0308525A publication Critical patent/BR0308525A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"FORMAS CRISTALINAS". A presente invenção diz respeito a formas cristalinas de (2S)-N-5-[amino-(imino)metil]-2-tienilmetil-1-(2R)-2[(carboximetil)amino ]-3,3-difenilpropanoil-2-pirrolidinacarboxaniida - NH~ 2~O.
BR0308525-2A 2002-03-22 2003-03-21 Formas cristalinas BR0308525A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20020015627 2002-03-22
PCT/KR2003/000558 WO2003080601A1 (en) 2002-03-22 2003-03-21 New crystalline forms of (2s)-n-5-[amino(imino)methyl]-2-thienylmethyl-1-(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nh2o

Publications (1)

Publication Number Publication Date
BR0308525A true BR0308525A (pt) 2005-02-01

Family

ID=36649957

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308525-2A BR0308525A (pt) 2002-03-22 2003-03-21 Formas cristalinas

Country Status (13)

Country Link
US (1) US20050113309A1 (pt)
EP (1) EP1487826A4 (pt)
JP (1) JP2005526800A (pt)
KR (1) KR20030076445A (pt)
CN (1) CN1642947A (pt)
AU (1) AU2003210055A1 (pt)
BR (1) BR0308525A (pt)
CA (1) CA2479888A1 (pt)
IL (1) IL164044A0 (pt)
MX (1) MXPA04009100A (pt)
PL (1) PL372597A1 (pt)
RU (1) RU2004131204A (pt)
WO (1) WO2003080601A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA08290520B1 (ar) 2007-08-22 2012-02-22 استرازينيكا ايه بي مشتقات سيكلو بروبيل أميد وتركيبات صيدلية تحتوي عليها لعلاج حالة مرضية سببها مستقبلات هيستامين h3
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
JP5746718B2 (ja) * 2010-02-18 2015-07-08 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ シクロプロピルアミド誘導体からなる固体形態
RU2012139082A (ru) * 2010-02-18 2014-03-27 Астразенека Аб Способы получения производных циклопропиламида и связанных с ними промежуточных соединений

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
AU3855995A (en) * 1994-11-11 1996-06-06 Nippon Soda Co., Ltd. Optically active compound
AU2424499A (en) * 1998-01-26 1999-08-09 Basf Aktiengesellschaft Heterocyclic amidines as callicrein protease inhibitors
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제

Also Published As

Publication number Publication date
IL164044A0 (en) 2005-12-18
JP2005526800A (ja) 2005-09-08
KR20030076445A (ko) 2003-09-26
CA2479888A1 (en) 2003-10-02
US20050113309A1 (en) 2005-05-26
EP1487826A1 (en) 2004-12-22
PL372597A1 (en) 2005-07-25
RU2004131204A (ru) 2005-04-10
CN1642947A (zh) 2005-07-20
MXPA04009100A (es) 2004-12-06
AU2003210055A1 (en) 2003-10-08
WO2003080601A1 (en) 2003-10-02
EP1487826A4 (en) 2005-06-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A, 5A, 6A, 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.