BRPI0417423A - processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis - Google Patents

processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis

Info

Publication number
BRPI0417423A
BRPI0417423A BRPI0417423-2A BRPI0417423A BRPI0417423A BR PI0417423 A BRPI0417423 A BR PI0417423A BR PI0417423 A BRPI0417423 A BR PI0417423A BR PI0417423 A BRPI0417423 A BR PI0417423A
Authority
BR
Brazil
Prior art keywords
perindopril
pharmaceutically acceptable
acceptable salts
synthesis process
formula
Prior art date
Application number
BRPI0417423-2A
Other languages
English (en)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0417423A publication Critical patent/BRPI0417423A/pt
Publication of BRPI0417423B1 publication Critical patent/BRPI0417423B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO DE SìNTESE DO PERINDOPRIL E DE SEUS SAIS FARMACEUTICAMENTE ACEITáVEIS". A presente invenção refere-se a um processo de síntese industrial do perindopril de fórmula (I) e de seus sais farmaceuticamente aceitáveis.
BRPI0417423A 2003-12-10 2004-12-09 processo de síntese do perindopril e de seus sais farmaceuticamente aceitáveis BRPI0417423B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03293084A EP1420029B9 (fr) 2003-12-10 2003-12-10 Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables
PCT/FR2004/003166 WO2005066198A1 (fr) 2003-12-10 2004-12-09 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
BRPI0417423A true BRPI0417423A (pt) 2007-03-06
BRPI0417423B1 BRPI0417423B1 (pt) 2017-03-28

Family

ID=32116381

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417423A BRPI0417423B1 (pt) 2003-12-10 2004-12-09 processo de síntese do perindopril e de seus sais farmaceuticamente aceitáveis

Country Status (26)

Country Link
US (1) US7279583B2 (pt)
EP (1) EP1420029B9 (pt)
JP (1) JP4377413B2 (pt)
KR (1) KR100825537B1 (pt)
CN (1) CN100453552C (pt)
AR (1) AR047327A1 (pt)
AT (1) ATE386745T1 (pt)
AU (1) AU2004312185B2 (pt)
BR (1) BRPI0417423B1 (pt)
CA (1) CA2548405C (pt)
CY (1) CY1108238T1 (pt)
DE (1) DE60319196T2 (pt)
DK (1) DK1420029T3 (pt)
EA (1) EA012034B1 (pt)
ES (1) ES2300555T3 (pt)
GE (1) GEP20084370B (pt)
MA (1) MA28222A1 (pt)
MY (1) MY139289A (pt)
NO (1) NO20063012L (pt)
NZ (1) NZ547550A (pt)
PL (1) PL211485B1 (pt)
PT (1) PT1420029E (pt)
SI (1) SI1420029T1 (pt)
UA (1) UA84898C2 (pt)
WO (1) WO2005066198A1 (pt)
ZA (1) ZA200604369B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
EP1987828A1 (en) * 2005-01-06 2008-11-05 IPCA Laboratories Limited salts of perindopril and their use in the therapy of hypertension
WO2006131828A1 (en) * 2005-06-08 2006-12-14 Aurobindo Pharma Limited A process for the preparation of perindopril
DK2318365T3 (en) 2008-06-24 2015-11-23 Mylan Lab Ltd NOVEL polymorphic forms of perindopril (L) -arginine AND PROCESS FOR PREPARATION THEREOF
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Also Published As

Publication number Publication date
EP1420029B9 (fr) 2008-11-12
CN1890258A (zh) 2007-01-03
DE60319196T2 (de) 2009-04-30
AU2004312185A1 (en) 2005-07-21
NO20063012L (no) 2006-06-28
CA2548405A1 (fr) 2005-07-21
BRPI0417423B1 (pt) 2017-03-28
DK1420029T3 (da) 2008-06-16
SI1420029T1 (sl) 2008-08-31
UA84898C2 (uk) 2008-12-10
KR100825537B1 (ko) 2008-04-25
MA28222A1 (fr) 2006-10-02
AU2004312185B2 (en) 2010-09-30
HK1095839A1 (zh) 2007-05-18
JP2008505845A (ja) 2008-02-28
EA200601086A1 (ru) 2006-12-29
MY139289A (en) 2009-09-30
JP4377413B2 (ja) 2009-12-02
WO2005066198A1 (fr) 2005-07-21
DE60319196D1 (de) 2008-04-03
EP1420029B1 (fr) 2008-02-20
PT1420029E (pt) 2008-04-14
KR20060097060A (ko) 2006-09-13
CN100453552C (zh) 2009-01-21
ATE386745T1 (de) 2008-03-15
EP1420029A2 (fr) 2004-05-19
US20070093663A1 (en) 2007-04-26
AR047327A1 (es) 2006-01-18
EP1420029A3 (fr) 2004-05-26
ES2300555T3 (es) 2008-06-16
PL380410A1 (pl) 2007-01-22
CY1108238T1 (el) 2014-02-12
PL211485B1 (pl) 2012-05-31
GEP20084370B (en) 2008-05-13
ZA200604369B (en) 2007-11-28
CA2548405C (fr) 2010-07-27
US7279583B2 (en) 2007-10-09
NZ547550A (en) 2009-11-27
EA012034B1 (ru) 2009-06-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2544 DE 08-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.